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Gold nanoshells： Contrast agents for cell imaging by cardiovascular optical coherence tomography

Nano Research 2018年第2期11卷 676-685页

作者： Jie Hu Francisco Sanz-Rodríguez Fernando Rivero Emma Martín Rodríguez Río Aguilar Torres Dirk H. Ortgies josé garcía solé Fernando Alfonso Daniel Jaque Fluorescence Imaging Group Departamento de Física de Materiales Instituto Nicolás Cabrera Facultad de Ciencias Universidad Autónoma de Madrid Madrid Spain Instituto Ramón y Cajal de Investigación Sanitaria Hospital Ramón y Cajal Madrid Spain Departamento de Biología Universidad Autónoma de Madrid Madrid Spain Cardiology Department Hospital Universitario de la Princesa IIS-IP Universidad Autónoma de Madrid Madrid Spain

Optical coherence tomography （OCT） has gained considerable attention in interventional cardiovascular medicine and is currently used in clinical settings to assess atherosclerotic lesions and to optimize stent placement. Artery imaging at the cellular level constitutes the first step towards cardiovascular molecular imaging, which represents a major advance in the development of personalized noninvasive therapies. In this work we demonstrate that cardiovascular OCT can be used to detect individual cells suspended in biocompatible fluids. Importantly, the combination of this catheter-based clinical technique with gold nanoshells （GNSs） as intracellular contrast agents led to a substantial enhancement in the backscattered signal produced by individual cells. This cellular contrast enhancement was attributed to the large backscattering cross-section of GNSs at the OCT laser wavelength （1,300 nm）. A simple intensity analysis of OCT cross-sectional images of suspended cells makes it possible to identify the sub-population of living cells that successfully incorporated GNSs. The generalizability of this method was demonstrated using two different cell lines （HeLa and Jurkat cells）. This work provides novel insights into cardiovascular molecular imaging using specifically modified GNSs.

关键词： optical coherencetomography (OCT)intravascular imaging gold nanoparticles three-dimensional (3D)imaging

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Comparing Fine-Tuning, Zero and Few-Shot Strategies with Large Language Models in Hate Speech Detection in English

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2849-2868页

作者： Ronghao Pan joséAntonio garcía-Díaz Rafael Valencia-garcía Departamento de Informática y Sistemas Universidad de MurciaCampus de EspinardoMurcia30100Spain

Large Language Models(LLMs)are increasingly demonstrating their ability to understand natural language and solve complex tasks,especially through text *** of the relevant capabilities is contextual learning,which involves the ability to receive instructions in natural language or task demonstrations to generate expected outputs for test instances without the need for additional training or gradient *** recent years,the popularity of social networking has provided a medium through which some users can engage in offensive and harmful online *** this study,we investigate the ability of different LLMs,ranging from zero-shot and few-shot learning to *** experiments show that LLMs can identify sexist and hateful online texts using zero-shot and few-shot approaches through information ***,it is found that the encoder-decoder model called Zephyr achieves the best results with the fine-tuning approach,scoring 86.811%on the Explainable Detection of Online Sexism(EDOS)test-set and 57.453%on the Multilingual Detection of Hate Speech Against Immigrants and Women in Twitter(HatEval)***,it is confirmed that the evaluated models perform well in hate text detection,as they beat the best result in the HatEval task *** error analysis shows that contextual learning had difficulty distinguishing between types of hate speech and figurative ***,the fine-tuned approach tends to produce many false positives.

关键词： Hate speech detection zero-shot few-shot fine-tuning natural language processing

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The immune system:uncharted pathways between senses and the brain

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Neural Regeneration Research 2024年第6期19卷 1173-1174页

作者： Noelia Casares Mar Cuadrado-Tejedor Ana garcía-Osta Juan joséLasarte Immunology and Immunotherapy Program Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Division of Gene Therapy for Neurological Disorders Centre for Applied Medical Research(CIMA)University of NavarraIDISNAPamplonaSpain Pathology Anatomy and Physiology DepartmentSchool of MedicineUniversity of NavarraIDISNAPamplonaSpain

Humans and animals use the classic five senses-sight,hearing,touch,smell,and taste-to detect and monitor their environment,with the sense of position and movement often referred to as the sixth *** perception of external signals through the senses is essential to an organism's survival,transmitting signals to the central nervous system(CNS)and prompting physiological changes in other biological *** addition to the direct effects of sense-induced mediators in the brain.

关键词： prompt system transmitting

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How inflammation influences psychiatric disease

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World Journal of Psychiatry 2024年第3期14卷 342-349页

作者： Eduardo Ferat-Osorio joséLuis Maldonado-garcía Lenin Pavón División de Investigación Clínica de la Coordinación de Investigación en Salud Instituto Mexicano del Seguro SocialMexico City 06720Mexico Departamento de Bioquímica Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoCoyoacán 04510Ciudad de MéxicoMexico Departamento de Inmunología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Psicoinmunología Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizMexico City 14370Mexico

Recent studies highlight the strong correlation between infectious diseases and the development of neuropsychiatric *** this editorial,we comment on the article“Anti-infective therapy durations predict psychological stress and laparoscopic surgery quality in pelvic abscess patients”by Zhang et al,published in the recent issue of the World Journal of Psychiatry 2023;13(11):*** discussion highlighted the potential consequences of anxiety,depression,and psychosis,which are all linked to bacterial,fungal,and viral infections,which are relevant to the impact of inflammation on the sequelae in mental health as those we are observing after the coronavirus disease 2019 *** focus specifically on the immune mechanisms triggered by inflammation,the primary contributor to psychiatric ***,pathophysiological mechanisms such as organ damage,post-injury inflammation,and infectioninduced endocrine alterations,including hypocortisolism or autoantibody formation,significantly contribute to the development of chronic low-grade inflammation,promoting the emergence or development of psychiatric alterations in susceptible *** inflammation can have long-term effects on patients,a multidisciplinary treatment plan can avoid complications and debilitating health issues,and it is crucial to recognize and address the mental health implications.

关键词： Inflammation infection Depression Pelvic inflammatory disease Psychiatric complication

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Wear protection assessment of ultralow viscosity lubricants in high-power-density engines:A novel wear prediction algorithm

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Friction 2024年第8期12卷 1785-1800页

作者： Javier BLANCO-RODRÍGUEZ Jacobo PORTEIRO joséA.LÓPEZ-CAMPOS MartíCORTADA-garcÍA Silvia FERNÁNDEZ-CASTEJÓN CINTECX Universidade de VigoLagoas-Marcosende s/nVigo 36310Spain Repsol SA MadridSpain

Durability and reliability have been studied for decades through intensive trial-error ***,there are numerous fields of application where the costs associated with this approach are not *** lubricated machines with severe dynamic loads,such as high-power-density engines,simulation tools offer clear advantages over intensive *** and multiple scenarios can be cost-effectively simulated to assess different lubricants and engine *** work presented here details the study of wear based on a validated elastohydrodynamic(EHD)simulation model of the connecting rod journal *** model accounts for elastic deformation through a connecting rod finite element model(FEM).In addition,multiple lubricant rheological and tribological dependences,determined by specific experimental tests,are applied in the model through their interaction with the simulation ***,a novel wear algorithm is proposed to predict wear depth over time evolution along a proposed wear cycle based on the typical working ranges of high-performance engines.A final assessment is presented to compare 4 different ultralow-viscosity lubricants in their protective performance under severe *** results show the evolution of the wear load and wear depth over the wear *** evaluation is key to describing a lubricant selection procedure for high-power-density engines.

关键词： wear modelling finite element modelling mixed lubrication elastohydrodynamic(EHD) internal combustion engines bearings

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Stress tensors and quantification of fracture patterns to analyze connectivity and potential fluid flow in a mesa landform of the Northern Andes

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Journal of Mountain Science 2024年第1期21卷 271-291页

作者： garcÍA-ARIAS Sergio VELANDIA Francisco ALVAREZ Angélica SANABRIA-GÓMEZ joséD TARAZONA Yessenia VARGAS María Camila Escuela de Geología Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia Escuela de Física Universidad Industrial de SantanderCra.27 Calle 9BucaramangaColombia

This work applies stress tensors inversions and quantification of fracture patterns along the Mesa de Los Santos, in the Eastern Cordillera of Colombia, to better understand the potential fluid flow. It thus contributes to the conceptual hydrogeological model. The area was subdivided into three blocks, separated by the NW Potreros and the Los Santos faults, having minor inner faults of different orientations. This separation facilitates the analysis of the fractures measured in the field, which in general show high dip angles and a conjugate geometry in the northern block, tension fractures(Mode I) in the central block, and a random distribution in the southwestern block. WinTensor treatment of slickensides yielded a maximum horizontal stress(SHmax) of 111o, which coincides with the WNW-ESE tensor observed from the conjugate and tension joints. We then used Frac Pa Q to generate interpolation maps of fracture intensity and density. The maps show the highest values in the central block and the lowest in the northern block,where the precipitation is higher, causing intensive rock weathering and homogenization of the fracture planes. Although the highest values of connectivity by line are found to the south of the mesa, we suggest the possibility of greater flow from the recharge zone(NE) along bedding planes and open NW-SE fractures.

关键词： Mesa de Los Santos Colombia Win-Tensor FracPaQ Strike-slip faults Fractured aquifers

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Utilizing neural networks to supplant chemical kinetics tabulation through mass conservation and weighting of species depletion

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Energy and AI 2024年第2期16卷 101-110页

作者： Franz M.Rohrhofer Stefan Posch Clemens Gößnitzer joséM.garcía-Oliver Bernhard C.Geiger Know-Center GmbH Sandgasse 36Graz8010StyriaAustria LEC GmbH Inffeldgasse 19Graz8010StyriaAustria Universitat Politècnica de València Camíde VeraValència46022ValènciaSpain

Artificial Neural Networks(ANNs)have emerged as a powerful tool in combustion simulations to replace memory-intensive tabulation of integrated chemical *** reaction mechanisms,however,present a challenge for standard ANN approaches as modeling multiple species typically suffers from inaccurate predictions on minor *** paper presents a novel ANN approach which can be applied on complex reaction mechanisms in tabular data form,and only involves training a single ANN for a complete reaction *** approach incorporates a network architecture that automatically conserves mass and employs a particular loss weighting based on species *** modifications are used to improve the overall ANN performance and individual prediction accuracies,especially for minor species mass *** validate its effectiveness,the approach is compared to standard ANNs in terms of performance and ANN *** distinct reaction mechanisms(H_(2),C_(7)H_(16),C_(12)H_(26),OME_(34))are used as a test cases,and results demonstrate that considerable improvements can be achieved by applying both modifications.

关键词： Neural network approach Chemical kinetics Flamelet tabulation Mass conservation Species loss weighting

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco garcía-garcía Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Electrifying Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ) for focalized heating in oxygen transport membranes

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Journal of Energy Chemistry 2024年第4期91卷 99-110页

作者： Marwan Laqdiem Julio garcía-Fayos Laura Almar Alfonso J.Carrillo Álvaro Represa joséM.López Nieto Sonia Escolástico David Catalán-Martinez jose M.Serra Instituto de Tecnología Química(Universitat Politècnica de València–Consejo Superior de Investigaciones Científicas) Av.Los Naranjos s/nE-46022 ValenciaSpain

Industry decarbonization requires the development of highly efficient and flexible technologies relying on renewable energy resources,especially biomass and solar/wind *** the case of pure oxygen production,oxygen transport membranes(OTMs)appear as an alternative technology for the cryogenic distillation of air,the industrially-established process of producing ***,OTMs could provide oxygen from different sources(air,water,CO_(2),etc.),and they are more flexible in adapting to current processes,producing oxygen at 700^(-1)000℃.Furthermore,OTMs can be integrated into catalytic membrane reactors,providing new pathways for different *** first part of this study was focused on electrification on a traditional OTM material(Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)),imposing different electric currents/voltages along a capillary *** to the emerging Joule effect,the membrane-surface temperature and the associated O_(2) permeation flux could be ***,the OTM is electrically and locally heated and reaches 900℃on the surface,whereas the surrounding of the membrane was maintained at 650℃.The O_(2)permeation flux reached for the electrified membranes was~3.7 NmL min^(-1)cm^(-2),corresponding to the flux obtained with an OTM non-electrified at 900℃.The influence of depositing a porous Ce_(0.8)Tb_(0.2)O_(2-δ) catalytic/protective layer on the outer membrane surface revealed that lower surface temperatures(830℃)were detected at the same imposed electric ***,the electrification concept was demonstrated in a catalytic membrane reactor(CMR)where the oxidative dehydrogenation of ethane(ODHE)was carried *** reaction is very sensitive to temperature,and here,we demonstrate an improvement of the ethylene yield by reaching moderate temperatures in the reaction chamber while the O_(2) injection into the reaction can be easily fine-tuned.

关键词： Oxygen permeation Oxidative dehydrogenation of ethane Oxygen transport membranes Joule effect Mixed ionic-electronic conductors Catalytic membrane reactors

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CO₂ Transformation at Controlled Temperature with Lithium Hydroxide solution and Metallic Lithium

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Journal of Minerals and Materials Characterization and Engineering 2024年第3期12卷 189-203页

作者： Elizabeth Teresita Romero-Guzmán josé Luis Iturbe-garcía Departamento de Quí mica Gerencia de Ciencias B&#225sicas Instituto Nacional de Investigaciones Nucleares Carretera M&#233xico-Toluca S/N. La Marquesa Ocoyoac&#225c Estado de M&#233xico Mexico

This paper presents a study on CO2 atmospheric transformation which was reacted directly with lithium hydroxide solution and metallic lithium. This solution was obtained through the reaction between metallic lithium and deionized water where hydrogen is produced and by exposing the metal at ambient conditions. In the transformation process, atmospheric CO2 gas reacts directly with LiOH solution, in both cases, the CO2 transformation kinetics was different. For this purpose, reactions between CO2 and LiOH solution were carried out under controlled temperature and the second process only with metallic lithium, which was exposed at room temperature, however, in these two processes lithium carbonate oxide was formed and identified. According to the results, the efficiency in CO2 transformation is a function of temperature value which was variable until completely obtaining the by-product, its XRD characterization indicated the formation only of Li2CO3 in both procedures. Under laboratory conditions lithium compounds selectively reacted with CO2. In the same way, there is an alternative procedure to obtain LiOH and Li2CO3 for different applications in various areas.

关键词： Metallic Lithium Lithium Hydroxide solution Hydrogen Atmospheric CO2 Transformation Lithium Carbonate

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