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The role of viruses in the pathogenesis of Parkinson’s disease

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Neural Regeneration Research 2021年第6期16卷 1200-1201页

作者： joséFidel Baizabal-Carvallo Marlene alonso-Juarez Department of Science and Engineering University of GuanajuatoMéxico National Polytechnic Institute México

Parkinson’s disease(PD)is a neurological degenerative disorder characterized by loss of dopaminergic neurons in the substantia nigra(SN)and intracellular inclusions called Lewy bodies and Lewy tangles,composed mainly by aggregates of α-*** et al.(2003)proposed that the olfactory epithelium and intestines are the anatomical sites where PD initiates;as pathological aggregates ofα-synuclein are detected in these tissues in very early or prodromal *** this scenario,α-synuclein seems to reach the central nervous system(CNS)by axonal transport through the sympathetic nervous system,the glossopharyngeal and vagus nerves as well as the olfactory pathways(Braak et al.,2003).

关键词： al. epithelium pathogenesis

Crossed Products over Weak Hopf Algebras Related to Cleft Extensions and Cohomology

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Chinese Annals of Mathematics,Series B 2014年第2期35卷 161-190页

作者： josé Nicanor alonso áLVAREZ josé Manuel Fernández VILABOA Ramón González RODRíGUEZ Departamento de Matemáticas Universidad de VigoCampus Universitario Lagoas-Marcosende Departamento de álxebra Universidad de Santiago de Compostela Departamento de Matemática Aplicada II Universidad de VigoCampus Universitario Lagoas-Marcosende

The authors present the general theory of cleft extensions for a cocommutative weak Hopf algebra H. For a right H-comodule algebra, they obtain a bijective corre- spondence between the isomorphisms classes of H-cleft extensions AH → A, where AH is the subalgebra of coinvariants, and the equivalence classes of crossed systems for H over AH. Finally, they establish a bijection between the set of equivalence classes of crossed systems with a fixed weak H-module algebra structure and the second cohomology group H2φZ（AH）（H, Z（AH））, where Z（AH） is the center of AH.

关键词： Monoidal category Weak Hopf algebra Cleft extension Weak crossedproduct Sweedler cohomology for weak Hopf algebras

Yetter–Drinfeld Modules over Weak Braided Hopf Monoids and Center Categories

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Acta Mathematica Sinica,English Series 2014年第4期30卷 567-590页

作者： jos Nicanor alonso LVAREZ Ramón GONZLEZ RODRIGUEZ Carlos SONEIRA CALVO Departamento de Matemticas Universidad de VigoCampus Universitario Lagoas-Marcosende Departamento de Matema'tica Aplicada II Universidad de VigoCampus Universitario Lagoas-Marcosende Departamento de Pedagoxía e Didctica Universidade da CoruaCampus Universitario de Elvia

In this paper, we introduce several centralizer constructions in a monoidal context and establish a monoidal equivalence with the category of Yetter-Drinfeld modules over a weak braided Hopf monoid. We apply the gener... 详细信息

关键词： Weak (braided) Hopf monoid Yetter-Drinfeld module center

Biomarkers and subtypes of deranged lipid metabolism in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2019年第24期25卷 3009-3020页

作者： josé M Mato Cristina alonso Mazen Noureddin Shelly C Lu CIC bioGUNE Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd)Technology Park of BizkaiaDerio 48160BizkaiaSpain OWL Metabolomics Technology Park of BizkaiaDerio 48160BizkaiaSpain Division of Digestive and Liver Diseases Comprehensive Transplant CenterCedars-Sinai Medical CenterLos AngelesCA 90048United States

Nonalcoholic fatty liver disease(NAFLD)is a heterogeneous and complex disease that is imprecisely diagnosed by liver *** covers a spectrum that ranges from simple steatosis,nonalcoholic steatohepatitis(NASH)with varying degrees of fibrosis,to cirrhosis,which is a major risk factor for hepatocellular *** and eating habit changes during the last century have made NAFLD the most common liver disease linked to obesity,type 2 diabetes mellitus and dyslipidemia,with a global prevalence of 25%.NAFLD arises when the uptake of fatty acids(FA)and triglycerides(TG)from circulation and de novo lipogenesis saturate the rate of FAβ-oxidation and verylow density lipoprotein(VLDL)-TG *** lipid metabolism is also associated with NAFLD progression from steatosis to NASH,and therefore,alterations in liver and serum lipidomic signatures are good indicators of the disease’s development and *** review focuses on the importance of the classification of NAFLD patients into different subtypes,corresponding to the main alteration(s)in the major pathways that regulate FA homeostasis leading,in each case,to the initiation and progression of *** concept also supports the targeted intervention as a key approach to maximize therapeutic efficacy and opens the door to the development of precise NASH treatments.

关键词： S-adenosylmethionine Methionine adenosyltransferase Lipid metabolism Multiomics Lipidomics Nonalcoholic steatohepatitis One-carbon metabolism Very low-density lipoproteins Steatosis Precision medicine

Projections of weak braided Hopf algebras

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Science China Mathematics 2011年第5期54卷 877-906页

作者： alonso LVAREZ jos Nicanor FERNNDEZ VILABOA jos Manuel GONZLEZ RODRíIGUEZ Ramón SONEIRA CALVO Carlos Departamento de Matemticas Universidad de Vigo Vigo E-36310 Spain Departamento de lxebra Universidad de Santiago de Compostela Santiago de Compostela E-15771 Spain Departamento de Matemtica Aplicada II Universidad de Vigo Vigo E-36310 Spain Departamento de Matemticas Universidad de Vigo Vigo E-36004 Spain

In this paper we study the projections of weak braided Hopf algebras using the notion of Yetter-Drinfeld module associated with a weak braided Hopf algebra. As a consequence, we complete the study ofthe structure of weak Hopf algebras with a projection in a braiding setting obtaining a categorical equivalencebetween the category of weak Hopf algebra projections associated with a weak Hopf algebra H living in abraided monoidal category and the category of Hopf algebras in the non-strict braided monoidal category ofleft-left Yetter-Drinfeld modules over H.

关键词： weak Yang-Baxter operator Yetter-Drinfeld module weak (braided) Hopf algebra weak Hopf algebra projection

Measuring the model risk-adjusted performance of machine learning algorithms in credit default prediction

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Financial Innovation 2022年第1期8卷 1930-1964页

作者： Andrés alonso Robisco joséManuel CarbóMartínez Banco de España Calle de Alcalá4828014 MadridSpain

Implementing new machine learning(ML)algorithms for credit default prediction is associated with better predictive performance;however,it also generates new model risks,particularly concerning the supervisory validation *** industry surveys often mention that uncertainty about how supervisors might assess these risks could be a barrier to *** this study,we propose a new framework to quantify model risk-adjustments to compare the performance of several ML *** address this challenge,we first harness the internal ratings-based approach to identify up to 13 risk components that we classify into 3 main categories—statistics,technology,and market ***,to evaluate the importance of each risk category,we collect a series of regulatory documents related to three potential use cases—regulatory capital,credit scoring,or provisioning—and we compute the weight of each category according to the intensity of their mentions,using natural language processing and a risk terminology based on expert ***,we test our framework using popular ML models in credit risk,and a publicly available database,to quantify some proxies of a subset of risk factors that we deem *** measure the statistical risk according to the number of hyperparameters and the stability of the *** technological risk is assessed through the transparency of the algorithm and the latency of the ML training method,while the market conduct risk is quantified by the time it takes to run a post hoc technique(SHapley Additive exPlanations)to interpret the output.

关键词： Artificial intelligence Machine learning Credit risk Interpretability Bias Internal ratings based model IRB model Natural language processing NLP

Study of reverse osmosis membranes fouling by inorganic salts and colloidal particles during seawater desalination

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Chinese Journal of Chemical Engineering 2020年第3期28卷 733-742页

作者： Santiago Gutiérrez Ruiz Juan Antonio López-Ramírez Mohammed Hassani Zerrouk Agata Egea-Corbacho Lopera joséMaría Quiroga alonso Department of Environmental Technologies Faculty of Marine and Environmental SciencesUniversity of Cadiz11510Puerto RealCadizSpain

Fouling phenomenon is considered among the major reasons that cause significant increase of operating cost of desalination plants equipped with reverse osmosis(RO)*** phenomenon is studied in the present work in the case of RO polyamide aromatic membranes using model seawater containing inorganic salts and colloidal *** solubility conditions of CaCO3 and CaSO4 were applied to study RO performances with and without colloid *** experiments,the membrane permeate fluxes were continuously ***,studies of chemical composition,structure,and morphology of the materials deposited on the membrane surface were conducted using energy dispersive microanalysis(EDS)X-ray diffraction and scanning electronic microscopy(SEM).Results show that in conditions of calcium carbonate oversaturation there is a reduction in the permeate flow of 11.2%due to fouling of the membrane by the precipitation of this *** in the same conditions of calcium sulphate oversaturation the reduction of the flow is 5%,so we can conclude that in conditions of oversaturation of both salts,calcium carbonate produces a greater fouling of the membrane that in its view causes greater decrease in the flow of *** this based on the results of the test with both salts in oversaturated *** in the formation of calcite and gypsum crystals onto the membranes as XRD analyses *** presence of colloidal silica in those conditions intensifies strongly the fouling,leading until to 24.1%of permeate flux decrease.

关键词： Reverse osmosis Desalination Fouling Seawater Scaling

Integrated nuclear techniques for sedimentation assessment in Latin American region

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International Soil and Water Conservation Research 2020年第4期8卷 406-409页

作者： joséLuis Peralta Vital Reinaldo Honorio Gil Castillo Yanna Llerena Padrón Yusleidy Milagro Cordovi Miranda Naymi Labrada Arevalo Leroy alonso Pino Environmental Impact Assessment Group Center of Radiation Protection and HygieneLa HabanaZip Code 10600Cuba

The paper shows the novel techniques introduction in the region of Latin America and the Caribbean in order to strengthen the surveillance and monitoring of the sedimentation phenomenon in the surface water *** integrated use of the nuclear techniques allows a more complete assessment of water and land *** the development of a regional project,supported by the International Agency of Atomic Energy,Cuba participates as technical leader for 15 countries,to encourage and implement the integrated application of 3 nuclear techniques(Fallout Radionuclides(137Cs,7Be,210pb),Compound Specific Stable Isotopes(fatty acids of the(e)13C)and the Isotopic Hydrology(18O,2H,3H).The methodology used in the last studies referred to RLA 5076 Project is to apply the integration of these three techniques allows evaluating,in the hydraulic facilities and surface water reservoirs,the negative sedimentation impacts in natural and anthropic process as environmental and social *** techniques evaluate the sedimentation process and its synergy,obtaining since the soil quantification in the landscape,definition the soil origin deposited until the dynamic characterization of the water body as soil *** integrated application of these nuclear techniques in the Project RLA-5076 confirms it as a useful tool to support the decisions makers in the definition of the national strategies and programs related to the land and the water resources *** the support of the IAEA projects in the Latin American and Caribbean region,has been evidenced an important increment in the use of these novel techniques.

关键词： Nuclear technique Sedimentation Water reservoir Soil Land Hydric resources

Mesenchymal stem cell therapy in retinal and optic nerve diseases: An update of clinical trials

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World Journal of Stem Cells 2016年第11期8卷 376-383页

作者： Sonia Labrador-Velandia María Luz alonso-alonso Sara Alvarez-Sanchez Jorge González-Zamora Irene Carretero-Barrio josé Carlos Pastor Iván Fernandez-Bueno Girish Kumar Srivastava Instituto Universitario de Oftalmobiología Aplicada Universidad de Valladolid 47011 Valladolid Spain Facultad de Medicina Universidad de Valladolid 47005 Valladolid Spain Centro en Red de Medicina Regenerativa y Terapia Celular de Castilla y León 47011 Valladolid Spain Red Temática de Investigación Cooperativa Sanitaria del Instituto de Salud Carlos Ⅲ. Oftared 28029 Madrid Spain Hospital Clínico Universitario de Valladolid 47003 Valladolid Spain

Retinal and optic nerve diseases are degenerative ocular pathologies which lead to irreversible visual loss. Since the advanced therapies availability, cell-based therapies offer a new all-encompassing approach. Advances in the knowledge of neuroprotection, immunomodulation and regenerative properties of mesenchymal stem cells(MSCs) have been obtained by several preclinical studies of various neurodegenerative diseases. It has provided the opportunity to perform the translation of this knowledge to prospective treatment approaches for clinical practice. Since 2008, several first steps projecting new treatment approaches, have been taken regarding the use of cell therapy in patients with neurodegenerative pathologies of optic nerve and retina. Most of the clinical trials using MSCs are in Ⅰ/Ⅱ phase, recruiting patients or ongoing, and they have as main objective the safety assessment of MSCs using various routes of administration. However, it is important to recognize that, there is still a long way to go to reach clinical trials phase Ⅲ-Ⅳ. Hence, it is necessary to continue preclinical and clinical studies to improve this new therapeutic tool. This paper reviews the latest progress of MSCs in human clinical trials for retinal and optic nerve diseases.

关键词： Mesenchymal stem cells Cell therapy Optic nerve diseases Clinical trials Retinal diseases