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国际医学放射学杂志 2017年第3期 357-357页

作者： P.B.Julián m.G.Alicia m.David A.S.mariano L.Belén A.Elena 王大伟 Laboratory of mathematical Oncology Edificio Politécnico Institutode Matemática Aplicada a la Ciencia y la IngenieríaUniversidad de Castilla-La Mancha Avenida de Camilo José Cela

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中... 详细信息

摘要背景通过mRI数据进行胶质母细胞瘤的肿瘤体积测量并预测病人预后一直存在争议,胶质母细胞瘤生长的数学模型表明肿瘤的形态特征与其浸润性密切相关。方法基于117例首发胶质母细胞瘤T1增强扫描影像,对肿瘤的体积及形态学参数进行多中心回顾性研究。对临床变量进行收集、肿瘤分割,测量参数包括:强化方式、坏死、体积、肿瘤最大直径、等效球径度增强宽幅及其他几个强化"边缘"的形态学参数。应用比例风险分析与Kaplan meier生存曲线进行

关键词：胶质母细胞瘤几何形态学初等数学 mRI T1

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Practical Approach Design Piezoresistive Pressure Sensor in Circular Diaphragm

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材料科学与工程（中英文B版） 2019年第3期9卷 85-91页

作者： Renan Gabbi Luiz Antonio Rasia Daniel Curvello de mendonca müller Jorge Ramírez Beltrán jose Antonio Gonzalez da Silva manuel martin Perez Reimbold Federal Institute of Education Science and Technology FarroupilhaCampus PanambiPanambi 98280-000Brazil Department of Exact Sciences and Engineering Regional University of the Northwest of the State of Rio Grande do SulPanambi 98280-000Brazil University Veterinary Hospital Federal University of Santa MariaSanta Maria 97105-900Brazil Technological University of Habana joséAntonio Echeverría Havana 62644Cuba

This paper presents a methodology for analytical calculation and computational simulation using the finite element method for piezoresistive graphite sensor element on flexible polymer substrate,A4 *** computer simulation aims to find the region of greatest mechanical tension and deflection of the circular diaphragm set in the circumference *** steps for simulation are geometry definition,mesh generation,inclusion of material physical properties and simulation *** mathematical modeling of maximum mechanical stress and deflection is described analytically and *** analytical calculations were compared with the computer simulation and presented a relative percentage error of 3.38%for the maximum *** results show that the piezoresistor should be positioned at the edges of the circular diaphragm to take advantage of maximum mechanical stress by defining the best location for graphite film deposition for sensor device designs and fabrications.

关键词： Piezoresistivity sensor element finite elements and mathematical modeling

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心室肥厚有和无高血压均可使NT-proBNP增高

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 33-33页

作者： Rivera Otero J.m. Talens-Visconti R. Salvador A. 任付先 Research Centerla Fe Hospital JoséMara Haro 59 Puerta 59 46022 Valencia Spain

Background: It has been published that hypertension (HT)-must be taken into a ccount when using NT-proBNP, but left ventricular (LV) hypertrophy without HT c ould be a cause of NT-proBNP elevation. In a population study we compared NT-p roBNP in subjects with hypertrophy, with and without diagnosis of HT. methods: W e studied 215 subjects from a random sample of 432 people who had declared to su ffer from dyspnea. These 432 subjects were referred to their hospital where bloo d samples were taken, an echo-Doppler study was performed and a specific questi onnaire was completed. We got a positive answer from 215, and 52 (24%) have LV hypertrophy. Results: When we compared NT-proBNP in non-hypertrophic populatio n, 148±286 pg/ml, with NT-proBNP in LV hypertrophic population, 202±209 pg/ml , we found Pmpared NT-proBNP (199 ±201 pg/ml) in normotensive subjects (LV mass index 170±70 g/m2, Vp 50±18 cm/ s, LVEF 62±8) with NT-proBNP (205±220 pg/ml) in subjects with diagnosis of HT (LVmass index 169±37 g/m2, Vp 55±20 cm/s, LVEF 64±10), we found NS. Conclusi ons: This population study shows that NT-proBNP is elevated in patients with LV hypertrophy with or without HT. In LV hypertrophy the presence of HT does not i nfluence the peptide levels significantly.

关键词：心室肥厚 NT-proBNP 左室肥厚患者重量指数呼吸困难多普勒检查显著性差别正常受试者本项

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巨脑性白质脑病伴皮层下囊肿:一个黎巴嫩家系的研究和文献回顾(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 6-6页

作者： Koussa S. Roukoz H. Rizk T. mégarbané A. 方伯言 Htel-Dieu de France Université Saint-Jos- eph Beyrouth Lebanon

Introduction. megalencephalic leukoencephalopathy with subcortical cysts is a rare disease with autosomal recessive inheritance. materials and methods. Two br others born from a consanguineous marriage, presenting with the phenotype of the disease, their parents, brothers and sisters were examined. magnetic resonance imaging of the brain was performed for the two patients. Sequence analysis of mL C1 (GenBank mRNA accession no. Nm 015166) was performed for the patients using i ntronic primers. PCR restriction fragment length polymorphism analysis was done in patients, their parents and in 100 Lebanese controls in order to exclude gene ***. The clinical features were characteristic of the disease, consisting of an early-onset macrocephaly followed by slowly progressive ataxia , pyramidal tract involvement and epileptic seizures. In one patient, the clinic al manifestations were aggravated by a trivial brain trauma. In his brother and in one female cousin, a status epilepticus was precipitated by a febrile syndrom e. The diffuse cerebral white matter lesions and the subcortical temporo-polar and frontal cysts, best seen on mRI,allowed making the *** genet ics revealed a new mutation involving the mLC1 gene (263G→T, exon 3). As a cons equence, it affects the second transmembrane domain predict (G88V) of the mLC pr otein (protein sequence NP 055981). The mutation was confirmed by PCR restrictio n fragment length polymorphism analysis. Conclusion. megalencephalic leucoenceph alopathy with subcortical cysts may be individualized on clinical and radiologic al basis and confirmed by molecular genetics. In this Lebanese family, a new mut ation of the mLC1 gene is reported.

关键词：白质脑病巨脑文献回顾脑白质癫痫持续状态近亲婚配共济失调基因多态性锥体束囊性变

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