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On-surface activation of benzylic C-H bonds for the synthesis of pentagon-fused graphene nanoribbons

Nano Research 2021年第12期14卷 4754-4759页

作者： Xiushang Xu Marco Di Giovannantonio josé i.urgel Carlo A.Pignedoli Pascal Ruffieux Klaus Müllen Roman Fasel Akimitsu Narita Present address:istituto di Struttura della Materia-CNR(iSM-CNR) via Fosso del Cavaliere 10000133RomaItaly Present address:iMDEA Nanoscience C/Faraday 9Campus de Cantoblanco28049MadridSpain Max Planck institute for Polymer Research 55128MainzGermany Empa Swiss Federal Laboratories for Materials Science and Technologynanotech@surfaces Laboratory8600DübendorfSwitzerland Organic and Carbon Nanomaterials Unit Okinawa Institute of Science and Technology Graduate University1919-1 TanchaOnna-sonKunigami-gunOkinawa904-0495Japan institute of Physical Chemistry Johannes Gutenberg University MainzDuesbergweg 10-1455128MainzGermany

Graphene nanoribbons (GNRs) have potential for applications in electronic devices. A key issue, thereby, is the fine-tuning of their electronic characteristics, which can be achieved through subtle structural modifications. These are not limited to the conventional armchair, zigzag, and cove edges, but also possible through incorporation of non-hexagonal rings. On-surface synthesis enables the fabrication and visualization of GNRs with atomically precise chemical structures, but strategies for the incorporation of non-hexagonal rings have been underexplored. Herein, we describe the on-surface synthesis of armchair-edged GNRs with incorporated five-membered rings through the C-H activation and cyclization of benzylic methyl groups. Ortho-Tolyl-substituted dibromobianthryl was employed as the precursor monomer, and visualization of the resulting structures after annealing at 300 °C on a gold surface by high-resolution noncontact atomic force microscopy clearly revealed the formation of methylene-bridged pentagons at the GNR edges. These persisted after annealing at 340 °C, along with a few fully conjugated pentagons having singly-hydrogenated apexes. The benzylic methyl groups could also migrate or cleave-off, resulting in defects lacking the five-membered rings. Moreover, unexpected and unique structural rearrangements, including the formation of embedded heptagons, were observed. Despite the coexistence of different reaction pathways that hamper selective synthesis of a uniform structure, our results provide novel insights into on-surface reactions en route to functional, non-benzenoid carbon nanomaterials.

关键词： graphene nanoribbons on-surface synthesis scanning-tunneling microscope noncontact atomic force microscope C-H activation

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria Moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Cohomology of Associative H-Pseudoalgebras

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Algebra Colloquium 2023年第4期30卷 541-554页

作者： josé i.Liberati Ciem-CONiCET Medina Allende y Haya de la TorreCiudad Universitaria(5000)CórdobaArgentina

We define the cohomology of associative H-pseudoalgebras,and we show that it describes module extensions,abelian pseudoalgebra extensions,and pseudoalgebra first-order *** same results for the special case of associat... 详细信息

关键词： associative pseudoalgebra associative conformal algebra cohomology

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class ii(MHCii) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Universal Deformation Rings of Modules over Self-injective Cluster-Tilted Algebras Are Trivial

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Algebra Colloquium 2021年第2期28卷 269-280页

作者： i.D.M.Gaviria joséA.Vélez-Marulanda Peng Shan Universidad Nacional de Colombia Bogota D.C.Colombia Department of Mathematics Valdosta State UniversityValdostaGAUSA 不详

Let k be a fixed algebraically closed field of arbitrary characteristic,let Λ be a finite dimensional self-injective k-algebra,and let ∨ be an indecomposable non-projective left Λ-module with finite dimension over *** prove that if τΛ∨ is the Auslander-Reiten translation of ∨,then the versal deformation rings R(Λ,∨)and R(Λ,τΛ∨)(in the sense of *** and the second author)are *** use this to prove that if Λ is further a cluster-tilted k-algebra,then R(Λ,∨)is universal and isomorphic to k.

关键词： self-injective cluster tilted algebras Frobenius algebras (uni)versal deformation rings

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Stringer-panel model to support the seismic design and response veriﬁcation of building diaphragms

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Resilient Cities and Structures 2023年第1期2卷 46-67页

作者： Sergio E.Godínez joséi.Restrepo University of California San DiegoMatthews LaneSME building4thﬂoorsuite 443CSan DiegoCAUSA92161 University of California San DiegoMatthews LaneSME building4thﬂoorsuite 444HSan DiegoCAUSA92161

Diaphragms are essential structural elements of the earthquake-resisting system in a *** are the building slabs subjected to in-plane forces which are transferred to the vertical elements of the earthquakeresisting ***-plane forces can arise from inertial loads and from self-equilibrating forces caused by the interaction between elements of the vertical earthquake-resisting system of different *** analysis and design of diaphragms is one of the most challenging tasks in design of buildings *** paper describes a stringer-panel model used as a macro-element for the modeling of building diaphragms in linear and nonlinear time-history *** element was coded in the open-sourceﬁnite element software *** linear version of the element isﬁrst used to support the design of diaphragms in a ***,the nonlinear response of the diaphragms is assessed with the nonlinear version of the *** response parameters of diaphragms modeled with the dynamic stringer-panel method in a high-rise building of complex geometry are *** show signiﬁcant redistribution of internal forces occurs through the diaphragm after cracking,leading to a general reduction of the tensile forces and an increase in the compressive *** clear load path,computational stability,effciency,and highly design-oriented representation of the results of this method make it an attractive alternative for its use in the modeling and design of diaphragms in performance-based seismic design.

关键词： Diaphragms Transfer diaphragms Stringer-panel Reinforced concrete Seismic design

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Preferences for pre-exposure prophylaxis among U.S. military men who have sex with men:results of an adaptive choice based conjoint analysis study

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Military Medical Research 2022年第2期9卷 141-151页

作者： joséi.Gutierrez Alex Dubov Frederick L.Altice David Vlahov Yale School of Nursing 400 West Campus DriveOrangeCT 06477USA Philip R.Lee institute for Health Policy Studies University of CaliforniaSan Francisco3333 California StSan FranciscoCA 94118USA Loma Linda University Griggs Hall 11065Loma LindaCA 92350USA Yale School of Medicine Section of Infectious Diseases135 College StreetSuite 323New HavenCT 06510USA Department of Epidemiology-Microbial Diseases Yale School of Public Health60 College StNew HavenCT 06510USA

Background: Pre-exposure prophylaxis(PrEP) prevents human immunodeficiency virus(HiV) infection, but its use remains low among U.S. military men who have sex with men(MSM), likely due to mis-matching with personal preferences. We conducted a study to characterize preferences to PrEP measures within this ***: HiV-negative military MSM were recruited through a closed, Lesbian, Gay, Bisexual, and Transgendered(LGBT) military social media group. The survey was anonymous, and consisted of five experimentally varied attributes in service delivery: dosing method, provider type, visit location, lab work evaluation location, and dispensing *** importance and part-worth utility scores were generated using hierarchical bayes(HB) estimation, and the randomized first choice model was used to examine participation interest across eight possible PrEP program ***: A total of 429 participants completed the survey. Among the eight scenarios with varying attributes, the most preferred scenario featured a daily tablet, PrEP injection or implant, along with a military provider, smartphone/telehealth visit, and on-base locations for lab evaluation and medication pick-up. The results also emphasized the importance for providers to be familiar with PrEP prescription knowledge, and to provide interactions sensitive to sexual identity and mental ***: A PrEP program consisting of daily tablet is preferred in military healthcare settings is preferred. Longacting implants and injections are also desired.

关键词： Conjoint analysis Pre-exposure prophylaxis Preference Decision science Human immunodeficiency virus Military health infectious disease

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The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza i.Torrado-Tapias iris K.Salgado jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA institute of Neurobiology San JuanPRUSA

in addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

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impact of coronary angioplasty in elderly patients with non-ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2020年第8期17卷 449-454页

作者： Fernando F.Goncalves josé P.Guimaraes Sara C.Borges Pedro S.Mateus josé i.Moreira Cardiology Department Centro Hospitalar de Trás-os-Montes e Alto DouroVila RealPortugal

Background As treatment of coronary artery disease improved over the last years,management of elder patients remained a matter of debate since this age group has been underrepresented in most *** study aimed to evaluate a population of patients with≥85 years old with non-ST-segment elevation myocardial infarction(NSTEMi)and compare the prognosis according to coronary revascularization *** We retrospectively studied 324 patients included in a national multicenter registry between October 2010 and October 2018,who underwent coronary angiography and had at least one stenosis≥50%.Results in this population,73.1%of the patients underwent percutaneous coronary intervention(PCi)and 26.9%of the patients underwent optimized medical treatment(OMT).The OMT group had more past history of diabetes,stroke and *** coronary angiography,the PCi group used more often the femoral artery access and single-vessel lesions were also more ***-vessel disease was more common in the OMT *** hospitalization,there were more major bleeding events and death in the PCi *** the one-year follow-up,there were no significant differences in all-cause mortality *** Very old patients with NSTEMi submitted to OMT had more comorbidities and more three-vessel disease,factors that could have influenced the therapeutic *** undergoing PCi had more in-hospital major bleeding events and mortality,with no significant differences after one year.

关键词： Coronary artery disease Revascularization The elderly

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Multiple primary colorectal cancer: individual or familial predisposition?

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World Journal of Gastrointestinal Oncology 2015年第12期7卷 434-444页

作者： josé A Pajares josé Perea Department of Gastreoenterology Gregorio Maranon University Hospital Department of Surgery 12 de Octubre University Hospital

Colorectal carcinoma(CRC) is one of the most frequent cancers. Along the surface of the large bowel, several foci of CRC may appear simultaneously or over the time. The development of at least two different tumours has been defined as multiple primary CRC(MPCRC):When more than one tumour is diagnosed at the same time, it is known as synchronous CRC(SCRC), while when a second neoplasm is diagnosed some time after the resection and/or diagnosis of the first lesion, it is called metachronous CRC(MCRC). Multiple issues can promote the development of MPCRC, ranging from different personal factors, such as environmental exposure, to familial predisposition due to hereditary factors. However, most studies do not distinguish this dichotomy. High- and low-pentrance genetic variants are involved in MPCRC. An increased risk for MPCRC has been described in Lynch syndrome, familial adenomatous polyposis, and serrated polyposis. Non-syndromic familial CRCs should also be considered as risk factors for MPCRC. Environmental factors can promote damage to colon mucosae that enable the concurrence of MPCRC. Epigenetics are thought to play a major role in the carcinogenesis of sporadic MPCRC. The methylation state of the DNA depends on multiple environmental factors(e.g., smoking and eating foods cooked at high temperatures), and this can contribute to increasing the MPCRC rate. Certain clinical features may also suggest individual predisposition for MPCRC. Different etiopathogenic factors are suspected to be involved in SCRC and MCRC, and different familial vs individual factors may be implicated. MCRC seems to follow a familial pattern, whereas individual factors are more important in SCRC. Further studies must be carried out to know the molecular basis of risks for MPCRC in order to modify, if necessary, its clinical management, especially from a preventive point of view.

关键词： Multiple primary colorectal cancer Synchronous colorectal cancer Metachronous colorectal cancer Chromosomal instability Microsatellite instability CpG island methylator phenotype

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