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Effects of Resistant Starch on Symptoms,Fecal Markers,and Gut Microbiota in Parkinson’s Disease—The RESISTA-PD Trial

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 274-287页

作者： Anouck Becker Georges Pierre Schmartz Laura Groger Nadja Grammes Valentina Galata Hannah Philippeit Jacqueline Weiland Nicole Ludwig Eckart Meese Sascha Tierling jorn walter Andreas Schwiertz Jorg Spiegel Gudrun Wagenpfeil Klaus Faßbender Andreas Keller Marcus M.Unger Department of Neurology Saarland UniversityD-66421 HomburgGermany Chair for Clinical Bioinformatics Saarland UniversityD-66123 SaarbruckenGermany Department of Human Genetics Saarland UniversityD-66421 HomburgGermany Department of Genetics/Epigenetics Saarland UniversityD-66123 SaarbruckenGermany Institute of Microecology D-35745 HerbornGermany Institute of Medical Biometry Epidemiology and Medical InformaticsSaarland UniversityD-66421 HomburgGermany Department of Neurology Stanford UniversityPalo AltoCA 94305USA

The composition of the gut microbiota is linked to multiple diseases,including Parkinson’s disease(PD).Abundance of bacteria producing short-chain fatty acids(SCFAs)and fecal SCFA concentrations are reduced in *** exert various beneficial functions in *** the interventional,monocentric,open-label clinical trial “Effects of Resistant Starch on Bowel Habits,Short Chain Fatty Acids and Gut Microbiota in Parkinson’s Disease”(RESISTA-PD;ID:NCT02784145),we aimed at altering fecal SCFAs by an 8-week prebiotic intervention with resistant starch(RS).We enrolled 87 subjects in three study-arms:32 PD patients received RS(PD+RS),30 control subjects received RS,and 25 PD patients received solely dietary *** performed paired-end 100 bp length metagenomic sequencing of fecal samples using the BGISEQ platform at an average of 9.9 *** was *** the PD+RS group,fecal butyrate concentrations increased significantly,and fecal calprotectin concentrations dropped significantly after 8 weeks of RS ***,we observed a reduction in non-motor symptom load in the PD+RS *** reference-based analysis of metagenomes highlighted stable alpha-diversity and beta-diversity across the three groups,including bacteria producing ***-free analysis suggested punctual,yet pronounced differences in the metagenomic signature in the PD+RS ***-PD highlights that a prebiotic treatment with RS is safe and well-tolerated in *** stable alpha-diversity and beta-diversity alongside altered fecal butyrate and calprotectin concentrations call for long-term studies,also investigating whether RS is able to modify the clinical course of PD.

关键词： Parkinson’s disease Short-chain fatty acid Microbiota Metagenomics Intestinal inflammation

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Data-driven Simulations of Magnetic Field Evolution in Active Region 11429:Magneto-frictional Method Using PENCIL CODE

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Research in Astronomy and Astrophysics 2024年第2期24卷 74-82页

作者： P.Vemareddy jorn Warnecke Ph.A.Bourdin Indian Institute of Astrophysics Sarjapur roadII BlockKoramangalaBengaluru-560034India Max-Planck-Institut für Sonnensystemforschung Justus-von-Liebig-Weg 3D-37077 GöttingenGermany Institute of Physics University of GrazUniversitätsplatz 5A-8010 GrazAustria

Coronal magnetic fields evolve quasi-statically over long timescales and dynamically over short *** of now there exist no regular measurements of coronal magnetic fields,and therefore generating the coronal magnetic field evolution using observations of the magnetic field at the photosphere is a fundamental requirement to understanding the origin of transient phenomena from solar active regions(ARs).Using the magneto-friction(MF)approach,we aim to simulate the coronal field evolution in the solar AR *** MF method is implemented in the open source PENCIL CODE along with a driver module to drive the initial field with different boundary conditions prescribed from observed vector magnetic fields at the *** order to work with vector potential and the observations,we prescribe three types of bottom boundary drivers with varying free-magnetic *** MF simulation reproduces the magnetic structure,which better matches the sigmoidal morphology exhibited by Atmospheric Imaging Assembly(AIA)images at the pre-eruptive *** found that the already sheared field further driven by the sheared magnetic field will maintain and further build the highly sheared coronal magnetic configuration,as seen in AR ***-driven MF simulation is a viable tool to generate the coronal magnetic field evolution,capturing the formation of the twisted flux rope and its eruption.

关键词： Sun corona-Sun evolution-Sun magnetic fields-Sun photosphere

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德国历史哲学传统中的理念论及其批判

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世界哲学 2024年第4期 54-62页

作者：尉佩云 [德]J.吕森山西大学历史文化学院埃森高等人文研究所

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直... 详细信息

在德国的学术传统中,历史哲学具有漫长的学术历程,它伴随着历史学职业化的过程而形成、发展。在初创及此后的语境中,它成为一种思考过去的全新的学术领域和学术形式。在德国历史哲学开端之处,理念论便主导了这个思想传统,这种影响一直延续至今。我们可以从四个方面来审视理念论在德国历史哲学中的影响,以启蒙运动之后的德国历史哲学演变的四个先后相序的阶段或形式为题,这分别是理念论的历史哲学,理念论的历史方法论,理念论的历史认识论和理念论视角下诗性与修辞的历史书写。在今天,理念论失去了在方法论上的合理性,但如果历史学还是建立在人类生活形式的解释学基础之上的学科,那么理念论的学术思考就仍然有必要进行批判性反思。将人类受难等现实主义思考纳入其中,在我们将这种现实主义进行人文化的时候,理念论在当下语境中应该获得进一步批判性思考。

关键词：理念论历史哲学史学职业化历史认识论诗性史学

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阿多诺对利盖蒂的影响——对二者通信的考察兼论歌剧《伟大的死亡》

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中央音乐学院学报 2024年第1期174卷 58-68,142页

作者： [德]约恩·彼得·希克尔孙冰洁(译) 班丽霞(校) 德国德累斯顿卡尔·玛利亚·冯·韦伯音乐学院新音乐学系中央音乐学院中央音乐学院音乐学系

作曲家利盖蒂长期以来与哲学家阿多诺保持着通信联系,而且利盖蒂对20世纪后半叶的新音乐发展也具有重要的参照作用,但这些方面一直被人们所忽视。作者在考证大量史料的基础上,以开放的“音乐现代主义”概念为前提,结合对《伟大的死亡》... 详细信息

作曲家利盖蒂长期以来与哲学家阿多诺保持着通信联系,而且利盖蒂对20世纪后半叶的新音乐发展也具有重要的参照作用,但这些方面一直被人们所忽视。作者在考证大量史料的基础上,以开放的“音乐现代主义”概念为前提,结合对《伟大的死亡》①等作品的分析与阐释,剖析了利盖蒂与阿多诺之间的理念关联,特别是阿多诺《困境》一文对利盖蒂的影响,重新审视了作曲家在现代主义中的地位与立场。本文最终认为,利盖蒂深受阿多诺的“否定性”与“非形象音乐”等理念的影响,以具有表现性与意象性的音乐瞬间来表达死亡等方式,瓦解了“保守”与“先锋”之间的二元对立,展现出“主观性”与“客观性”相结合的悖论美学。

关键词：利盖蒂阿多诺《伟大的死亡》音乐现代主义

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Dietary fats may impact semen quantity and quality

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Asian Journal of Andrology 2012年第4期14卷 511-512页

作者： jorn Olsen Cecilia Host Ramlau-Hansen Department of Public Health Section of Epidemiology Aarhus University 8000 Aarhus C Denmark

This recently published cross-sectional study that included 99 men from Massachusetts General Hospital Fertility Center, Boston, MA, USA, reports that a high intake of saturated fats was inversely associated with sperm concentration and total sperm count and a high intake of omega-3 polyunsaturated fats （PUFAs） was positively associated with sperm morphology. Although the study is based upon a highly selected group of males and is of cross-sectional nature, the findings are of interest, since poor semen quality is a frequent problem in some parts of the world and identification of modifiable risk factors is highly wanted.

关键词： MEN

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Schoolchildren from disadvantaged backgrounds present a loss of lean tissue mass and significant increase of body fat mass during the COVID-19 lockdown in Germany:results from the MEDdirect study

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World Journal of Pediatrics 2022年第5期18卷 363-367页

作者： David Muhmann Marvin Droste jorn Schulz Frederike Linge Lea Ladewig Ursula Eisenberg Susanne Roder Rainer Buscher University Hospital Essen PediatricsⅡHufelandstr.5545147 EssenGermany Be Strong for Kids E.V Sundernholz 10845134 EssenGermany Schule Am Steeler Tor Engelbertstr.445127 EssenGermany

Children from socio-economically disadvantaged backgrounds receive unequal opportunities to succeed in school,which will lead to a decreased health literacy as adults[U].This is not only directly associated with an impaired eco-nomic and mental health and wellbeing of young people,but above all with an in creased adult mortality[1-4].While this problem is well known and described,only few and even fewer pediatric studies suggest how to interrupt this downward spiral consistently[5,6].

关键词： disadvantage adult impaired

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作者： jorn Leonhard

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s age at puberty associated with semen quality ant ＇eproductive hormones in young adult life？

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Asian Journal of Andrology 2017年第6期19卷 625-632页

作者： Lea LB Lauridsen Linn H Arendt Henrik Stovring jorn Olsen Cecilia H Ramlau-Hansen 1Department of Public Health Section for Epidemiology Aarhus University 8000 Aarhus C Denmark Department of Public Health Section for 8iostatistics Aarhus University 8000 Aarhus C Denmark Department of Clinical Epidemiology Aarhus University Hospital 8200 Aarhus N Denmark

The evidence is scarce on the association between age at puberty and semen quality. A cohort of 320 Danish men aged 18-21 years enrolled in the ＂Healthy Habits for Two＂ birth cohort provided self-reported data on pubertal indicators and delivered semen and blood samples. The results indicated an association between older age at pubertal development and lower semen quality and altered reproductive hormones concentrations as measured in young adult life. Men who had their first nocturnal emission, start of pubic hair growth and first voice break episode when older than 15 years had 37.0%, 45.0% and 32.7% lower sperm concentration; 37.8%, 44.2% and 29.1% lower total sperm count; 7.4%, 13.4% and 15.3% lower testosterone concentration; and 21.3%, 1.5% and 3.7% lower inhibin B concentration, respectively, compared with the men who were younger than 13 years at their first pubertal indicators. Only few of the results were statistically significant, but similar tendencies were seen in several of the reproductive parameters suggesting an association between the timing of pubertal development and reproductive health later in life.

关键词： pubertal development puberty reproductive health reproductive hormones semen quality

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Threat recognition and response in an avian brood-parasite host from New Caledonia

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Current Zoology 2021年第3期67卷 255-262页

作者： Alfredo Attisaino Kasper Hlebowicz Roman Gula jorn Theuerkauf Museum and Institute of Zoology Polish Academy of SciencesWarsawPoland Conservation Research New Caledonia La FoaNew Caledonia

Nest predation and avian brood parasitism are the main sources of nest failure in many passerine *** predators threaten both brood and parents,whereas brood parasites pose only a danger to eggs or *** fan-tailed gerygone Gerygone flavolateralis from New Caledonia is subjected to high rates of nest predation by the New Caledonian crow Corvus moneduloides(responsible for about 20-40%of predation)and moderate rates of brood parasitism by the shining bronze-cuckoo Chalcites lucidus(parasitizing about 18%of nests),which also depredates nests that are too advanced for parasitism(13%of nests).To test if fan-tailed gerygones are able to discriminate predators from brood parasites,we presented 3 bird models at active gerygone nests:a brood parasite/small nest predator(shining bronze-cuckoo),a large nest predator(crow),and a small non-native bird(common chaffinch Fringilla coelebs),which is unknown to the gerygone,as a *** assessed the response of adult gerygones to the presentation of each model by measuring the minimum approach distance,number of alarm calls,number of attacks,and time to first nest visit after the presentation(latency).Adult gerygones often attacked the cuckoo,approached but never attacked the chaffinch and always avoided the *** was shorter after an attack response and during brooding,but similar among *** did not find any link between the cuckoo model presentation and later ejection of cuckoo *** conclude that adult fan-tailed gerygones discriminate between different models and respond accordingly to the level of threat but do not show awareness of parasitism risk and increase of nestling ejection rates following exposure to the cuckoo model.

关键词： brood parasitism enemy recognition frontline defense mobbing nest defense nest predation

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Implementation of an in-house flow cytometric analysis of DNA fragmentation in spermatozoa

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Asian Journal of Andrology 2020年第3期22卷 246-251页

作者： Anne Sofie Rex Chunsen Wu jorn Aagaard Jens Fedder Centre of Andrology and Fertility Clinic Odense University HospitalOdense 5000Denmark Aagaard Gynaecological Clinic Skejby 8200AarhusDenmark Research Unit of Gynaecology and Obstetrics Faculty of HealthUniversity of Southern DenmarkOdense 5000Denmark.

An increased amount of DNA fragme ntation in the spermatozoa(SDF)is linked to male in *** Sperm Chromati n Structure Assay(SCSA)is widely used for analysis of ***,the current software(SCSASoftR)linked to this assay is licensed and often located within larger diagnostic *** this study,we present a protocol for using other types of software than SCSASoftR to determine the SDF index(DFI)with clinical *** protocol is engineered after collect!ng and analyzing 254 samples from fertility patients and sperm donors over a 15-month *** is analyzed using a strict protocol where the spermatozoa are treated with a strong acid(pH 1.2)followed by acridine *** is determined by a standard flow cytometric software,FACSDiva *** of the outcome of the fertility treatment is included for 137 patients receiving either intrauterine inseminations(IUI)or timed coitus(TC).The results show that the chance of pregnancy decli nes as DFI in *** also found that the male DFI affects the chanee of pregnancy independent of the female *** have shown that a standard flow cytometric software can be used when determi ning a clinical releva nt *** findings are a sign ificant step toward impleme nting the an alysis as a part of the routi ne,in・house diag no sing of the male fertility patient and subseque ntly optimizing the treatme nt course of the couple with reduced human and financial costs.

关键词： DNA fragme ntation flow cytometry in-house an alysis in trauteri ne in semi natio n Sperm Chromati n Structure Assay spermatozoa

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