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Plethysmograph training:A refinement for collection of respiration data in mice

动物模型与实验医学(英文) 2023年第4期6卷 369-374页

作者： jorid b.sørli Karin s.Hougaard Niels Hadrup Chemical Work Environment The National Research Centre for the Working EnvironmentCopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Research Group for Risk-benefit National Food InstituteTechnical University of DenmarkLyngbyDenmark

Inhaled chemicals can harm the *** effects can result in distinct changes in respiratory patterns;the type of change indicates where and how the respiratory system is ***,changes in respiratory patterns may be detected at much lower substance concentrations than those that cause more serious effects,such as histopathological *** in respiratory patterns can be studied experimentally by monitoring the breathing of mice placed in plethysmographs and exposing head-out to the test *** method is well established;however,it is not known if training mice in being restrained in the plethysmograph could increase the quality of data *** we report the results of training mice to be restrained in plethysmographs for 5 consecutive days,with respect to body weight,respiratory parameters,and time spent in the plethysmograph,before they are removed because of unstable breathing *** mice tolerated the procedure better(measured by time in the plethysmograph)on the second day of training than the first *** did not change the breathing parameters between *** parameters stabilized within 5 min after the mice were placed in the plethysmographs on all *** was an average of 3%weight loss between the first and last days of the training,indicating that the training procedure placed some strain on the *** reduces the number of mice attempting to escape from the plethysmograph.

关键词： Alarie assay refinement sensory irritation

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