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Acute Effects of Tolvaptan on Renal Hemodynamics in Autosomal Dominant Polycystic Kidney Disease —A Randomized, Cross-Over, Double Blind, Placebo-Controlled Study of Renal Plasma Flow and Glomerular Filtration Rate

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Open Journal of Nephrology 2019年第4期9卷 97-114页

作者： My Helbo Malmberg Frank Holden Mose Rikke Lund Sonderbaek June Anita Ejlersen Jens jorgen Jensen Erling Bjerregaard Pedersen Jesper Norgaard Bech University Clinic in Nephrology and Hypertension Regional Hospital Jutland WestHolstebroDenmark University of Aarhus AarhusDenmark Department of Nuclear Medicine Regional Hospital Jutland WestHolstebroDenmark

Background: Previous studies have shown that reduced renal plasma flow (RPF) may play a role in progression of renal disease in autosomal dominant polycystic kidney disease (ADPKD). Tolvaptan, a vasopressin 2 antagonist, reduces growth of total kidney volume and slows the decrease in estimated glomerular filtration rate (eGFR) in ADPKD. The purpose of this randomized, cross-over, double-blind, placebo-controlled study was to investigate if acute tolvaptan treatment increases RPF in ADPKD patients. Methods: Eighteen ADPKD patients (chronic kidney disease stages I-III) were investigated twice (min. 10 days apart) after acute treatment with either tolvaptan 60 mg or placebo. Two hours after treatment RPF and GFR were estimated by Technetium-99m diethylenetriamine penta-acetic acid (99-mTc-DTPA) renography. During the examination day, central and brachial blood pressures (BP) were measured using Mobil-O-Graph? PWA. We also measured plasma concentrations of vasopressin (p-AVP), renin (PRC), angiotensin II (p-AngII) and aldosterone (p-Aldo), urine excretion of aquaporin 2 (u-AQP2), urine output (OU), urine osmolality (u-Osm) and fractional excretion of sodium (FENa). Results: 99-mTc-DTPA renography showed a similar RPF (673 ± 262 ml/min after tolvaptan vs. 650 ± 209 ml/min after placebo, p = 0.571) and GFR (78 ± 26 ml/min after tolvaptan vs. 79 ± 21 ml/min after placebo p = 0.774) after tolvaptan and placebo treatment. P-AVP and UO increased and u-Osm decreased after tolvaptan and remained unchanged during placebo. Systolic BP tended to decrease during renography during tolvaptan. Very small or insignificant changes were seen in PRC, p-AngII and p-Aldo. Conclusions: Acute tolvaptan treatment did not change renal hemodynamics in ADPKD.

关键词： Autosomal Dominant Polycystic Kidney Disease Renal Plasma Flow Glomerular Filtration Rate Renography Brachial Blood Pressure Central Blood Pressure Vasopressin Renin Angiotensin II Aldosterone

长链脂肪乳剂及中/长链脂肪乳剂水解速率的比较研究

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肠外与肠内营养 2002年第1期9卷 42-44页

作者：吴国豪 Connie Jarstrand jorgen Nordenstrom 上海中山医院普外科上海200032 Department of Clinical Bacteriology

目的 :比较长链脂肪乳剂、物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解速率。　方法 :应用 1 1 4 C甘油棕榈酸标记的长链三酰甘油 (LCT)和 2 ,3 3 H甘油辛酸标记的中链三酰甘油 (MCT) ,分别标记Intralipid ,Lipo fundin及Structol... 详细信息

目的 :比较长链脂肪乳剂、物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解速率。　方法 :应用 1 1 4 C甘油棕榈酸标记的长链三酰甘油 (LCT)和 2 ,3 3 H甘油辛酸标记的中链三酰甘油 (MCT) ,分别标记Intralipid ,Lipo fundin及Structolipid ,在体外添加缓冲液、脂蛋白酯酶和肝酯酶后 ,置 37℃温箱中水浴、孵育。采用气相色谱仪测定核素标记的各种脂肪酸及三酰甘油浓度 ,游离脂肪酸浓度用放射性核素扫描计数测定 ,通过计算培养液中1 4 C标记的长链脂肪酸及3 H标记的中链脂肪酸分别在1 4 C标记LCT及3 H标记MCT中的比例 ,来计算三种脂肪乳剂的水解率。　结果 :物理混合的中 /长链脂肪乳剂及结构脂肪乳剂的水解程度明显高于长链脂肪乳剂 ,差异有统计学意义。物理混合的中 /长链脂肪乳剂水解程度高于结构脂肪乳剂 ,但在水解程度及水解速度上却无统计学差异。　结论 :物理混合的中

关键词：结构脂肪乳剂长链脂肪乳剂物理混合的中/长链脂肪乳剂水解率

The Global Stratotype Section and Point （GSSP） for the base of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

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Episodes 2008年第2期31卷 264-267页

作者： Mike Walker Sigfus Johnsen Sune Olander Rasmussen jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar Konrad Hughen Peter Kershaw Bernd Kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob Schwander Department of Archaeology and Anthropology University of Wales Lampeter Wales SA48 7ED UK. Centre for Ice and Climatel The Niels Bohr Institute University of Copenhagen Juliane Maries Vej 30 DK2100 Copenhagen Denmark. Stable Isotope Laboratory Institute of Arctic and Alpine Research University of Colorado Boulder Co 80302 USA. Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN UK. Department-of Physical Geography University of Utrecht Heidelberglaan 2 3508 TC Utrecht The Netherlands. Department of Geography Royal Holloway University of London Egham Surrey TW20 0EX UK. Institute for Arctic and Alpine Research University of Colorado Campus Box 450 Boulder Co 80309 USA. GeoBiosphere Science Centre Quaternary Sciences Lund University S/51veg 12 SE-223 62 Lund Sweden. Department of Biology University of New Brunswick Fredericton New Brunswick Canada E3B 6E1. Department of Marine Chemistry and Geochemistry Woods Hole Oceanographic Institution Woods Hole MA 02543 USA. School of Geography and Environmental Science Monash University Victoria 3800 Australia. Heidelberg Academy of Sciences University of Heidelberg 1NF 229 D-69120 Heidelberg Germany. Institute for Palaeontology University of Bonn Nussallee 8 D-53115 Bonn Germany. Department of Earth and Ocean Sciences University of Waikato Private Bag 3105 Hamilton New Zealand. Department of Geography University of Newcastle Newcastle-upon-Tyne NE 1 7RU UK. School of Geography University of Plymouth Drake Circus Plymouth PIA 8AA UK. Climate and Environmental Physics Physics Institute University of Bern Sidlerstrasse 5 CH-3012 Bern Switzerland.

The Greenland ice core from NorthGRIP （NGRIP） contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to be located with a high degree of precision.

关键词：地球全新世第四纪地质时代周期

应用双能源X线吸收法测定营养不良病人机体组成

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肠外与肠内营养 2000年第4期7卷 253-254页

作者：吴国豪,吴肇汉,吴肇光,jorgen Nordenstrom 上海医科大学附属中山医院普外科上海医科大学附属中山医院普外科上海医科大学附属中山医院普外科 Department of Surgery Huddinge University Hospital Karolinska Institute!Sweden

应用双能源X线吸收测定法,检测营养不良病人的机体组成改变.以中等程度以上营养不良住院病人56例,其中男性32例,女性24例,年龄为39～66(平均51±14)岁作为研究对象.

关键词：营养不良机体组成双能源病人

Intralipid对巨噬细胞产生一氧化氮的抑制作用

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外科理论与实践 2000年第1期5卷 37-38页

作者：吴国豪 Connie Jarstrand jorgen Nordenstrom 上海医科大学附属中山医院普外科 200032 Department of Clinical Bacteriology and Surgery

测定Ｉｎｔｒａｌｉｐｉｄ在体外是否影响内毒素和细胞因子所致的巨噬细胞的一氧化氮自由基的产生。方法：采用腹腔灌洗收集２０只ＳＤ大鼠的腹腔巨噬细胞，在体外置３７℃、５％ＣＯ培养箱中孵育，应用大肠杆菌脂多糖和γ－干扰素刺激... 详细信息

测定Ｉｎｔｒａｌｉｐｉｄ在体外是否影响内毒素和细胞因子所致的巨噬细胞的一氧化氮自由基的产生。方法：采用腹腔灌洗收集２０只ＳＤ大鼠的腹腔巨噬细胞，在体外置３７℃、５％ＣＯ培养箱中孵育，应用大肠杆菌脂多糖和γ－干扰素刺激巨噬细胞。实验分单纯巨噬细胞组和加用Ｉｎｔｒａｌｉｐｉｄ组，采用Ｇｒｉｅｓｓ反应测定ＮＯ的产生量。结果：经ＬＰＳ、ＩＦＮ－γ刺激后，巨噬细胞的ＮＯ产生量明显增高（Ｐ＜０．０５）；脂肪乳剂可明显降低各种状态下巨噬细胞的ＮＯ产生量（Ｐ＜０．０５）。结论：Ｉｎｔｒａ－ｌｉｐｉｄ在体外可抑制巨噬细胞介导的一氧化氮自由基的产生。

关键词：巨噬细胞 Intarlipid 一氧化氮肠外营养

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搞好猪舍卫生的原则

国外畜牧学（猪与禽） 2002年第1期22卷 41-42页

作者：顾永明(译) 李伟潮(校) jorgen Svendsen 不详瑞典猪研究小组

良好的卫生状况不仅是使猪场中房舍和设施保持清洁的问题。现代养猪生产是很复杂的。

关键词：猪舍卫生隔离措施房舍布局清扫消毒

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请注意!消费者的决策历程已改变

商学院 2009年第9期 66-68页

作者： David Court Dave Elzinga Susan Mulder Ole jorgen Vetvik 麦肯锡达拉斯分公司芝加哥分公司波士顿分公司奥斯陆分公司

"如果说营销有一个目标的话,那就是在最能够影响消费者决策的那一刻出现在他们面前。"Jason是一家日化企业的首席营销官,"宝洁公司在很久以前先制作广播节目,然后又推出电视节目,向最可能购买产品的观众进行宣传——肥皂剧一词就是从这... 详细信息

"如果说营销有一个目标的话,那就是在最能够影响消费者决策的那一刻出现在他们面前。"Jason是一家日化企业的首席营销官,"宝洁公司在很久以前先制作广播节目,然后又推出电视节目,向最可能购买产品的观众进行宣传——肥皂剧一词就是从这儿来的。"而现在情况发生了变化。"把现在的消费低迷完全看做是消费者在危机中的谨慎就太简单化了,事实上他们的购买决策在发生深刻的变化。"消费者正在摆脱原有的"漏斗式"选购法,开始改变他们研究和购买商品的方式。如果你的营销方式还没有做出相应的改变,现在正值其时。

关键词：消费者决策首席营销官日化企业广播节目宝洁公司电视节目购买决策简单化

A Modified Treatment Failure Classification System with Complete and Exhaustive Accounting of Any Adverse Events Related to the Previous Percutaneous Coronary Intervention

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World Journal of Cardiovascular Diseases 2014年第9期4卷 405-415页

作者： Anders MGalloe jorgen LJeppesen Soren Boesgaard John Godtfredsen Niels Bligaard Jens FLassen Henning Kelbaek Anders Junker Jan Ravkilde Peter Riis Hansen Carsten TLarsen Ghita BStephansen Ulrik Abildgaard Department of Cardiology Copenhagen University HospitalRoskildeDenmark Department of Medicine Copenhagen University HospitalGlostrupDenmark Department of Cardiology Copenhagen University HospitalRigshospitaletDenmark Department of Cardiology Copenhagen University HospitalHerlevDenmark Department of Cardiology Copenhagen University HospitalGentofteDenmark Department of Cardiology Aarhus University HospitalSkejbyDenmark Department of Cardiology Odense University HospitalDenmark Department of Cardiology Aalborg University HospitalDenmark

Objectives: To determine the clinical outcome related to treatment failure of the percutaneous coronary intervention (PCI) itself. Background: When considering the addition of PCI to the medical treatment of angina, it is necessary to know the balance between the benefit and the risk of the PCI itself, but the latter remains unknown. The usual outcome measures are imprecise because they contain events unrelated to the previous PCI and because some events clearly caused by PCI treatment failures are omitted. Methods: In total, 2098 unselected patients were randomized to receive either sirolimus-(n = 1065) or paclitaxel-(n = 1033) eluting coronary stents and followed for five years in the SORT OUT II. Any death, cardiac death, myocardial infarction (MI), stent thrombosis and documented stenosis was classified and combined to a “patient oriented clinical outcome” (POCO), the classical “major adverse cardiac events” (MACE) and the new “PCI-treatment oriented clinical outcome” (TOCO). Results: POCO occurred in 746 patients (35.6%), MACE in 467 patients (22.3%) and TOCO in 293 patients (14.0%), thus TOCO amounted to 39% of the POCO and to 63% of the MACE. Conclusion: By introduction of the present PCI treatment failure classification system, the clinical outcome of PCI-treatment itself may be credulously estimated by the rate of TOCO and eventually PCI is substantially better than what might be perceived from the classically used POCO and MACE rates.

关键词： PCI Angina Clinical Outcome

THE ROLE OF PRESS FABRIC PRESSURE UNIFORMITY AND PORE SIZE ON DEWATERING AND REWET DURING PRESSING

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天津科技大学学报 2004年第S2期 327-327页

作者： Mary Toney,jorgen Gullbrand,Fawaad Qamar Albany International Research Co. 777 West Street Mansfield MA 02048 USA Albany International AB S-30 80 Halmstad Sweden Albany International Research Co. 777 West Street Mansfield MA 02048 USA

New procedures for measuring the pressure uniformity and pore size of press fabrics have been developed to study their role in the dewatering efficiency of a wet paper sheet and fabric system during pressing. The press nip profile of a single nip can be simulated in the laboratory using a custom built Servo-hydraulic Press Nip Simulator (SPNS) and is used to evaluate the final dryness and rewet of a handsheet with press fabric(s). Pressure uniformity can be measured with a flexible high-resolution transducer and pore size; both tests measured using water as the fluid are performed on compressed press fabric samples. A strong correlation is found between pressure uniformity parameters, mean flow pore size and final dryness for different sheets. Rewet is measured "directly" using a tracer fluid in the press fabric in our SPNS tester. Preliminary results indicate a significant reduction in rewet for some sheets with the use of an anti-rewet layer in combination with certain press fabric designs.

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