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Vasorelaxant activity of extracts obtained from Apium graveolens:Possible source for vasorelaxant molecules isolation with potential antihypertensive effect

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Asian Pacific Journal of Tropical Biomedicine 2013年第10期3卷 776-779页

作者： Vergara-Galicia jorge Jimenez-Ramirez luis Angel Tun-Suarez Adrian Aguirre-Crespo Francisco Salazar-Gomez Anuar Estrada-Soto Samuel Sierra-Ovando Angel Hernandez-Nunez Emmanuel Division of Health Sciences University of Quintana rooChetumalQuintana Ron.Mexico Department of Biotechnology Polytechnic University of the State of MorelosJiutepecMorelosMexico College of Pharmacy.University of the State of Morelos CuernavacaMorelosMexico Division of Health Sciences.Juarez Autonomous University of Tabasco VillahermosaTabascoMexico School of Engineering University of YucatanMeridaYucatanMexico

Objective:To investigate the vasorelaxant effect of organic extracts from Apium graveolens(***)which is a part of a group of plants subjected to pharmacological and phytochemical study with the purpose of offering it as an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive ***:An ex vivo method was employed to assess the vasorelaxant *** consisted of using rat aortic rings with and without endothelium precontracted with ***:All extracts caused concentration-dependent relaxation in precontracted aortic rings with and without endothelium;the most active extracts were Dichloromethane and Ethyl Acetate extracts from *** results suggested that secondary metabolites responsible for the vasorelaxant activity belong to a group of compounds of medium ***,our evidence showed that effect induced by dichloromethane and ethyl acetate extracts from *** is mediated probably by calcium ***:*** represents an ideal source for obtaining lead compounds for designing new therapeutic agents with potential vasorelaxant and antihypertensive effects.

关键词： Aortic ring Apium graveolens Medicinal plant Vasorelaxant

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Evaluation of the Use of Inertial Platform for the Generation of Cartography

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Journal of Civil Engineering and Architecture 2014年第9期8卷 1204-1210页

作者： luis Antonio de Lima Diogenes Cortijo Costa jorge Luiz Alves Trabanco Maria Teresa Francoso Technical Department Fototerra Atividades de Aerolevantamento Ltda (Fototerra Aerial Survey Activities Ltd.) San Paulo 03337-000 Brazil Department of Geotechnics and Transportation The State University of Campinas San Paulo 13083-070 Brazil

This study aims to analyze the quality of positioning orthophoto generated through the technique of direct georeferencing using metric digital camera system coupled to the laser system, and both systems were aided inertial navigation platform. For this, we compared the coordinates obtained in 16 control points collected in the field with dual-frequency GNSS （global navigation satellite system） receiver with those obtained in the orthophoto, flight conducted in June 2009 on the campus of the State University of Campinas--UNICAMP, using a medium format digital camera and laser system, with which we obtained images with a spatial resolution of 0.15 m. Taking into account the pattern accuracy cartographic used in Brazil, it is concluded that the products produced have a standard accuracy ＂A＂ to 1：2,000 scale, which represents the best quality level, both for planimetric as for altimetry, and that the procedure reached results consistent with cartographic products in 1：2,000 scale, representing a reduction of steps in the mapping process, necessary for the preparation of cartographic databases with reduction of time for preparation of design basis large civil engineering projects, such as roads, railways, studies of urban road systems, power plants and other infrastructure systems needed to develop the country.

关键词： Orthophotos photogrammetry GNSS.

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Embrionary way to create a fatty liver in portal hypertension

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World Journal of Gastrointestinal Pathophysiology 2017年第2期8卷 39-50页

作者： Maria-Angeles Aller Natalia Arias Isabel Peral Sara García-Higarza jorge-luis Arias Jaime Arias Department of Surgery School of MedicineComplutense University of Madrid UCL Division of Medicine Institute for Liver and Digestive Health Laboratory of Neuros-cience Department of PsychologyUniversity of Oviedo

Portal hypertension in the rat by triple partial portal vein ligation produces an array of splanchnic and systemic disorders, including hepatic steatosis. In the current review these alterations are considered components of a systemic inflammatory response that would develop through three overlapping phenotypes: The neurogenic, the immune and the endocrine. These three inflammatory phenotypes could resemble the functions expressed during embryonic development of mammals. In turn, the inflammatory phenotypes would be represented in the embryo by two functional axes, that is, a coelomic-amniotic axis and a trophoblastic yolk-sac or vitelline axis. In this sense, the inflammatory response developed after triple partial portal vein ligation in the rat would integrate both functional embryonic axes on the liver interstitial space of Disse. If so, this fact would favor the successive development of steatosis, steatohepatitis and fibrosis. Firstly, these recapitulated embryonic functions would produce the evolution of liver steatosis. In this way, this fat liver could represent a yolk-sac-like in portal hypertensive rats. After that, the systemic recapitulation of these embryonic functions in experimental prehepatic portal hypertension would consequently induce a gastrulationlike response in which a hepatic wound healing reaction or fibrosis occur. In conclusion, studying the mechanisms involved in embryonic development could provide key results for a better understanding of the nonalcoholic fatty liver disease etiopathogeny.

关键词： Inflammation Non-alcoholic fatty liver disease Hepatic steatosis Extraembryonic functions Fibrosis Portal hypertension

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Immediate effects of Tuina techniques on working-related musculoskeletal disorder of professional orchestra musicians

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Journal of Integrative Medicine 2015年第4期13卷 257-261页

作者： Cláudia Maria Sousa luis Moreira Daniela Coimbra jorge Machado Henry J.Greten University of Porto Institute of Biomedical Sciences Abel Salazar Jean Piaget Health Superior School Research in Education and Community Intervention–RECI Porto Polytechnic Institute Superior School of Music and Performing Arts German Society of Traditional Chinese Medicine Heidelberg School of Chinese Medicine

BACKGROUND：Musicians are a prone group to suffer from working-related musculoskeletal disorder（WRMD）.Conventional solutions to control musculoskeletal pain include pharmacological treatment and rehabilitation programs but their effi ciency is sometimes ***：The aim of this research is to study the immediate effects of Tuina techniques on WRMD of professional orchestra musicians from the north of ***,SETTING,PARTICIPANTS AND INTERVENTIONS：We performed a prospective,controlled,single-blinded,randomized *** orchestra musicians with a diagnosis of WRMD were randomly distributed into the experimental group（n=39）and the control group（n=30）.During an individual interview,Chinese diagnosis took place and treatment points were *** acupoints were treated by Tuina techniques into the experimental group and non-specifi c skin points were treated into the control *** was measured by verbal numerical scale before and immediately after ***：After one treatment session,pain was reduced in 91.8%of the cases for the experimental group and 7.9%for the control ***：Although results showed that Tuina techniques are effectively reducing WRMD in professional orchestra musicians of the north of Portugal,further investigations with stronger measurements,double-blinding designs and bigger simple sizes are needed.

关键词： diagnosis(TCM) stress Tuina musicians musculoskeletal disorders

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Transmission of cryptococcosis by liver transplantation:A case report and review of literature

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World Journal of Hepatology 2020年第5期12卷 253-261页

作者： Gustavo de Sousa Arantes Ferreira Andre luis Conde Watanabe Natalia de Carvalho Trevizoli Fernando Marcus Felippe jorge Carolina de Fatima Couto Priscila Brizolla de Campos Gabriel Oliveira Nunes Caja Department of Liver Transplantation Instituto de Cardiologia do Distrito FederalBrasilia 70673900Brazil

BACKGROUND Cryptococcosis is a fungal infection caused by the yeast-like encapsulated basidiomycetous fungus of the Cryptococcus neoformans(***)species *** fungi are ubiquitous in soil and bird droppings,and infection by them is an important global health concern,particularly in immunosuppressed patients,such as organ transplant recipients and those infected by the human immunodeficiency *** fungus usually enters the body through the respiratory tract,but extremely rare cases of infection acquired by transplantation of solid organs have been *** SUMMARY We report a case of disseminated cryptococcosis in a liver transplant recipient,diagnosed 2 wk after the *** patient initially presented with fever,hyponatremia and elevated transaminase levels,manifesting intense headache after a few *** cultures were positive for *** biopsy showed numerous fungal elements surrounded by gelatinous matrix and sparse granulomatous *** resonance imaging of the brain showed multiple small lesions with low signal in T2,peripheric enhancement and edematous halo,diffuse through the parenchyma but more concentrated in the subcortical *** with amphotericin B for 3 wk,followed by maintenance therapy with fluconazole,led to complete resolution of the *** recipients of both kidneys from the same donor also developed disseminated cryptococcosis,confirming the transplant as the source of *** organ donor lived in a rural area,surrounded by tropical rainforest,and had negative blood cultures prior to organ *** This case highlights the risk of transmission of fungal diseases,specifically of ***,through liver graft during liver transplantation.

关键词： Cryptococcosis Liver transplantation Cryptococcus neoformans Case report Immunosuppression Fungal infection

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IL-1β, TNF-α and Sambucus nigra Reactive Serum Proteins as Biomarkers of Mild Cognitive Impairment and Alzheimer Disease Progression

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Advances in Alzheimer's Disease 2015年第4期4卷 99-109页

作者： luis Manuel Castillo Enrique Moreno Yaneth Rodriguez-Agudelo MireyaChavez-Oliveros Zoila Trujillo Blanca Espinosa Emma Rodriguez-Maldonado luis Felipe Montano jorge Guevara Departamento de Bioquimica Facultad de MedicinaUniversidad Nacional Autonoma de MexicoMexico CityMexico Departamento de Neuropsicologia Instituto Nacional de Neurologia y NeurocirugiaMexico CityMexico Geriatra Instituto Nacional de Neurologia y Neurocirugia Mexico CityMexico Laboratorio de Bioquimica Instituto Nacional de Enfermedades RespiratoriasMexico CityMexico Departamento de Fisiología Instituto Nacional de CardiologiaMexico CityMexico Departamento de Biologia Celular y Tisular Facultad de MedicinaUniversidad Nacional Autonoma de MexicoMexico CityMexico

Amyloid-β (Aβ) can induce a chronic inflammatory immune response that is associated, amongst many others, to abnormal glycosylation, inducible nitric oxide synthase (iNOS) and nitric oxide (NO). The relation between development of Mild Cognitive Impairment (MCI) and Alzheimer’s disease progression and these serum markers has not been evaluated. Serum levels of iNOs, NO, TNF-α, IL-1β, IL-6, IL-8, IL-10, and IL-12 are determined with commercially available kits. Sialylation of albumin-free serum patterns is determined by Western blot analysis with Sambucus nigra (specific for sialic acid attached to terminal galactose in α2,6 linkage) lectin. Apolipoprotein E (ApoE) haplotype is determined by Western blot using specific anti-ApoE 2, 3 or 4 antibodies. A mini-mental state examination (MMSE) test is also performed in the 10 MCI patients, 19 Alzheimer’s disease (AD) patients and 46 healthy age-matched controls evaluated. The results show an increase of iNOS in MCI and AD but significantly higher NO concentrations are only found in MCI patients. TNF-α and IL-1β concentrations are the only significantly increased cytokines in MCI patients;no differences between control and MCI or AD patients are found in regard to the other cytokines. An abnormal MMSE test result only correlates with a decrease in serum NO concentration in MCI patients. The terminal sialic acid linkage pattern of serum proteins also shows highly significant differences between MCI and AD patient. ApoE3/4 or 4/4 haplotypes are characteristic of MCI and AD patients. Our results imply that increased serum TNF-α, IL-1β, iNOS, NO and alterations of serum proteins glycosylation patterns in adult individuals with an abnormal MMSE test may serve as an early biomarker of MCI and AD development.

关键词： Alzheimer Disease Mild Cognitive Impairment Nitric Oxide Inflammatory Cytokines Glycosylation Apolipoprotein E4

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火地岛森林管理:是对环境的又一个威胁还是可持续发展的一个机会?

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产业与环境 2000年第2期22卷 75-78页

作者： jorge luis Frangi Director LISEA(Laboratorio de Investigación de Sistemas Ecológicos y Ambientales)Universidad Nacional de La PlataDiagonal 113 Nro 4691900 La PlataArgentina

为这片世界最南端的森林提出的一个主要森林管理和家具木材生产方案的可能影响 ,已经引起广泛关注 .对这些原始森林的未来所给予的注意 ,突出说明了环境保护 /生物多样性保护与经济效益之间的冲突 .火地岛的公共当局和居民处在一个能指... 详细信息

为这片世界最南端的森林提出的一个主要森林管理和家具木材生产方案的可能影响 ,已经引起广泛关注 .对这些原始森林的未来所给予的注意 ,突出说明了环境保护 /生物多样性保护与经济效益之间的冲突 .火地岛的公共当局和居民处在一个能指定他们合意的生活方式与环境质量的地位 ,而且能参与旨在以适合于其社会、经济和生态的条件和期望的方式确保可持续性的决策 .

关键词：火地岛森林管理环境可持续发展南美洲

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A systematic literature review of the management of chronic venous ulcers with autologous fibrin matrix with or without growth factors

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Plastic and Aesthetic Research 2018年第4期5卷 28-35页

作者： Alejandra García Botero jorge Ernesto Cantini Ardila luis David Devoz Borja Viviana Gómez-Ortega Plastic and Reconstructive Surgery Department Hospital de San JoséFundación Universitaria de Ciencias de la SaludBogotá110111Colombia Plastic and Reconstructive Surgery Department Fundación Santa Féde BogotáBogotá110111Colombia

Aim: To evaluate available evidence for the effective management of venous leg ulcers with fibrin matrix with or without growth factors. Methods: A systematic review of the literature was performed to evaluate the use of fibrin matrices with or without growth factors for the management of chronic venous ulcers in lower limbs. Article searches were performed in MEDLINE, EMBASE, COCHRANE, LILACS and ongoing clinical trials at ***. Results: The search in MEDLINE and EMBASE identified three articles;one was a pilot study evaluating the use of fibrin matrix and autologous growth factors that included patients with chronic ulcers of different etiology. The second article was a description of the product used in the previous study, and the third consisted of a series case reports of patient treated with cultured keratinocytes in a fibrin matrix. A COCHRANE searched resulted in one study assessing the cost effectiveness of using different fibrin matrices. The search in *** and LILACS did not result in any findings. Conclusion: The study did not provide a conclusive evidence for the use of fibrin matrices in patients with venous leg ulcers.

关键词： Venous ulcers legs fibrin matrix growth factors

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Corticosteroids for severe influenza pneumonia: A critical appraisal

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World Journal of Critical Care Medicine 2016年第1期5卷 89-95页

作者： Wagner luis Nedel David Garcia Nora jorge Ibrain Figueira Salluh Thiago Lisboa Pedro Póvoa Intensive Care Unit Hospital Nossa Senhora da Concei??o Intensive Care Unit Vila Franca de Xira Hospital D’or Institute for Research and Education Critical Care Department Hospital de Clinicas de Porto Alegre Post-Graduation Program (PPG) Pneumology Universidade Federal do Rio Grande do Sul Polyvalent Intensive Care Unit S?o Francisco Xavier Hospital Centro Hospitalar de Lisboa Ocidental Nova Medical School CEDOC New University of Lisbon

Influenza pneumonia is associated with high number of severe cases requiring hospital and intensive care unit(ICU) admissions with high mortality. Systemic steroids are proposed as a valid therapeutic option even though its effects are still controversial. Heterogeneity of published data regarding study design, population demographics, severity of illness, dosing, type and timing of corticosteroids administered constitute an important limitation for drawing robust conclusions. However, it is reasonable to admit that, as it was not found any advantage of corticosteroid therapy in so diverse conditions, such beneficial effects do not exist at all. Its administration is likely to increase overall mortality and such trend is consistent regardless of the quality as well as the sample size of studies. Moreover it was shown that corticosteroids might be associated with higher incidence of hospital-acquired pneumonia and longer duration of mechanical ventilation and ICU stay. Finally, it is reasonable to conclude that corticosteroids failed to demonstrate any beneficial effects in the treatment of patients with severe influenza infection. Thus its current use in s evere influenza pneumonia should be restricted to very selected cases and in the setting of clinical trials.

关键词： Influenza Mechanical ventilation Pneumonia Corticosteroids Respiratory failure

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Intermittent chaos for ergodic light trapping in a photonic fiber plate

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Light(Science & Applications) 2016年第1期5卷 209-215页

作者： Marina Mariano Gregory Kozyreff luis G Gerling Pablo Romero-Gomez Joaquim Puigdollers jorge Bravo-Abad Jordi Martorell ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)08860Spain Département de Physique UniversitéLibre de Bruxelles(ULB)Campus de la PlaineBruxelles B-1050Belgium Departament Enginyeria Electrònica Universitat Politècnica de CatalunyaBarcelona 08034Spain Departamento de Física Teórica de la Materia Condensada and Condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid 28049Spain Departament de Física Universitat Politècnica de CatalunyaTerrassa 08222Spain

Extracting the light trapped in a waveguide,or the opposite effect of trapping light in a thin region and guiding it perpendicular to its incident propagation direction,is essential for optimal energetic performance in illumination,display or light harvesting *** we demonstrate that the paradoxical goal of letting as much light in or out while maintaining the wave effectively trapped can be achieved with a periodic array of interpenetrated fibers forming a photonic fiber *** entering perpendicular to that plate may be trapped in an intermittent chaotic trajectory,leading to an optically ergodic *** fabricated such a photonic fiber plate and showed that for a solar cell incorporated on one of the plate surfaces,light absorption is greatly *** this,we found the unexpected result that a more chaotic photon trajectory reduces the production of photon scattering entropy.

关键词： chaos ergodicity fiber light-guiding plate light harvesting light trapping

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