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One image is worth more than a thousand words:producing an atlas of medical signs for teaching clinical and forensic toxicology

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Forensic Sciences Research 2022年第4期7卷 815-822页

作者： Ricardo jorge Dinis-Oliveira TOXRUN-Toxicology Research Unit University Institute of Health SciencesAdvanced Polytechnic and University Cooperative(CESPU)CRLGandraPortugal Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal UCIBIO-REQUIMTE Laboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal

Clinical and forensic toxicology are critically involved in the acquisition of basic skills to correctly suspect intoxication,collect biological and non-biological materials for toxicological analysis,comprehend the complexities inherent to laboratory activity,and understand the fundamentals of toxicokinetics and toxicodynamics that underlie the interpretation of *** works presents a pedagogical innovation proposal for the teaching of clinical and forensic toxicology based on a compilation of more than 3000 cases where the image was fulcra for *** experience in this article follows the model practiced in bachelors,masters,and PhD degrees,as well as in other continuing training courses,where we are teaching toxicology for more than 15 *** these levels of education are considered fundamental to the sound development of this *** approach aims also to offer strength to the intervention of the true toxicologist in all the toxicological phases,besides the classic analytical ***,it is impossible to provide effective clinical and forensic toxicological interpretations without a proper and broad education,and not thinking exclusively in terms of laboratory *** the future,it will be interesting to evaluate knowledge retention and to propose a database of videos of signs related to intoxications.

关键词： Forensic sciences clinical and forensic toxicology teaching learning signs of exposure pre-analytical phase

Helicobacter pylori and skin autoimmune diseases

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World Journal of Gastroenterology 2014年第6期20卷 1510-1516页

作者： Eli Magen jorge-Shmuel Delgado Allergy and Clinical Immunology Unit Faculty of Health Sciences Ben-Gurion University of The Negev Barzilai Medical Center Faculty of Health Sciences Ben-Gurion University of The Negev Department of Gastroenterology and Hepatology Faculty of Health Sciences Ben-Gurion University of The Negev

Autoimmune skin diseases are characterized by dysregulation of the immune system resulting in a loss of tolerance to skin self-antigen(s). The prolonged interaction between the bacterium and host immune mechanisms makes Helicobacter pylori(H. pylori) a plausible infectious agent for triggering autoimmunity. Epidemiological and experimental data now point to a strong relation of H. pylori infection on the development of many extragastric diseases, including several allergic and autoimmune diseases. H. pylori antigens activate cross-reactive T cells and induce autoantibodies production. Microbial heat shock proteins(HSP) play an important role of in the pathogenesis of autoimmune diseases because of the high level of sequence homology with human HSP. Eradication of H. pylori infection has been shown to be effective in some patients with chronic autoimmune urticaria, psoriasis, alopecia areata and Schoenlein-Henoch purpura. There is conflicting and controversial data regarding the association of H. pylori infection with Beh et's disease, scleroderma and autoimmune bullous diseases. No data are available evaluating the association of H. pylori infection with other skin autoimmune diseases, such as vitiligo, cutaneous lupus erythematosus and dermatomyositis. The epidemiological and experimental evidence for a possible role of H. pylori infection in skin autoimmune diseases are the subject of this review.

关键词： Autoimmune Skin Helicobacter pylori Infection

Predatory journals and meetings in forensic sciences:what every expert needs to know about this“parasitic”publishing model

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Forensic Sciences Research 2021年第3期6卷 303-309页

作者： Ricardo jorge Dinis-Oliveira ToXrUn-Toxicology research Unit University institute of health sciences(iUc)CESPUCRLGandraPortugal Department of Public health and Forensic sciences and Medical educationFaculty of MedicineUniversity of PortoPortoPortugal UCIBIO REQUIMETLaboratory of ToxicologyDepartment of Biological sciencesFaculty of PharmacyUniversity of PortoPortoPortugal

The emergence of the internet has transformed all areas of *** includes the universe of scientific publications,with several publishers now exclusively focusing on the electronic format and open access model while expanding to a megajournal *** this context,the pandemic of predatory open access journals(POAJs)and meetings are of grave concern to the academic and research *** new shift within academia produces a variety of new victims;namely,the authors *** turn,scientific knowledge is often discredited,with the public placing less trust in *** more than ever,performing research with integrity and selecting a journal in which to publish requires close attention and ***“predatory movement”has developed increasingly sophisticated techniques for misleading people into believing what seem to be credible professional layouts and legitimate *** such as the Jeffrey Beall’s list,the Cabell’s Scholarly Analytics and *** offer some guidance to uncover the“parasitic”intervention of predatory journals and meetings,but specific education in this field is sorely *** work aims to review the main characteristics of predatory journals and meetings and to analyze this topic in the context of forensic and legal medicine research.

关键词： Forensic sciences predatory open access journals predatory meetings Jeffrey Beall’s list research integrity peer review scientific publishing

Physical exercises for preventing injuries among adult male football players:A systematic review

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Journal of Sport and Health Science 2022年第1期11卷 115-122页

作者： jorge Pérez-Gómez JoséCarmelo Adsuar Pedro EAlcaraz jorge Carlos-Vivas Health EconomyMotricity and Education(HEME)Research GroupFaculty of Sports SciencesUniversity of ExtremaduraCaceres 10003Spain UCAM Research Center for High Performance Sport Catholic University of MurciaMurcia 30107Spain Faculty of Sport Sciences Catholic University of MurciaMurcia 30107Spain

Background:Football is the most practised sport in the world and is associated with the risk of injuries in the *** studies have been published that identify injury prevention programs,but there is no review of the full body of evidence on injury prevention programs for use by football *** aim of this article was to carry out a systematic review of published studies on injury prevention programs for adult male footballers,identify points of common understanding and establish recommendations that should be considered in the design of injury prevention ***:PubMed and EMBASE databases were used to identify relevant published articles using the following keywords:"soccer"AND"injury"AND"prevention".Results:A total of 2512 studies were identified initially,but only 11 studies met the inclusion criteria,and their outcomes are *** revealed that injury prevention programs in football have focused on strength training,proprioceptive training,multicomponent programs(balance,core stability,and functional strength and mobility),and warm-up ***:Based on results from the studies analyzed,football players can lower the incidence of match and training injuries by participating in dynamic warm-up programs that include preventive exercises before games or during training sessions,and by adding strength,balance,and mobility training to the training sessions.

关键词： Balance Core stability Injury prevention programs Soccer Warm-up

Surgical options for correction of refractive error following cataract surgery

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Eye and Vision 2014年第1期1卷 2-8页

作者： Ahmed A Abdelghany jorge L Alio Clinical research fellow in Vissum Corporación Alicante Universidad Miguel HernándezAlicanteSpain Minia University MiniaEgypt Vissum Corporación AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Avda de Denia s/n Edificio VissumAlicante 03016Spain.

Refractive errors are frequently found following cataract surgery and refractive lens *** biometric analysis,selection and calculation of the adequate intraocular lens(IOL)and modern techniques for cataract surgery all contribute to achieving the goal of cataract surgery as a refractive procedure with no refractive ***,in spite of all these advances,residual refractive error still occasionally occurs after cataract surgery and laser in situ keratomileusis(LASIK)can be considered the most accurate method for its ***-based procedures,such as IOL exchange or piggyback lens implantation are also possible alternatives especially in cases with extreme ametropia,corneal abnormalities,or in situations where excimer laser is *** our review,we have found that piggyback IOL is safer and more accurate than IOL *** aim is to provide a review of the recent literature regarding target refraction and residual refractive error in cataract surgery.

关键词： Cataract surgery Target refraction Residual refractive error Refractive surprise Excimer laser surgery Photorefractive keratectomy Intraocular lens exchange Piggyback lens

Combination of hydrotreating and delayed coking technologies for conversion of residue

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Chinese Journal of Chemical Engineering 2023年第11期63卷 209-219页

作者： José A.D.Munoz Gabriel Páez jorge Ancheyta Instituto Mexicano del Petróleo Eje Central Lázaro Cárdenas Norte 152Col.San Bartolo AtepehuacanMéxico City 07730México

Residue conversion by combining catalytic hydrotreating and delayed coking has been evaluated comparatively with both processes *** operating conditions are defined to achieve the greatest economic benefit for upgrading an atmospheric residue from a heavy crude oil.A literature model was adapted to simulate the hydrotreating reactor,and for delayed coking,correlations reported in the literature were *** results with both approaches were employed to calculate the techno-economic feasibility of the combined process *** combination of hydrotreating and delayed coking presented an increase in light fractions of 29% and a reduction in coke production of 47.8%.Based on the calculated net benefit values,it was demonstrated that the combination of hydrotreating and delayed coking is technically and economically better than using each process alone,with highest benefit of 57.7 USD·m^(-3).

关键词： Economic benefit Heavy oil Hydrotreating Delayed coking

Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

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Eye and Vision 2021年第6期8卷 374-384页

作者： jorge L.Alio Francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci jorge L.Alio del Barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS ***:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;P<0.05),followed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT LISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOL Extended depth of focus Accommodative IOL

Accommodative intraocular lenses:where are we and where we are going

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Eye and Vision 2017年第1期4卷 81-92页

作者： jorge L.Alió jorge L.Aliódel Barrio Alfredo Vega-Estrada Cornea Cataract and Refractive Surgery UnitVissum CorporaciónAvda de Denia s/nEdificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain

Presbyopia still remains the last frontier of refractive *** surgical management is under constant evolution due to the limitations that exist today with respect to its management,which is probably in relation with the multifactorial basis in which presbyopia is clinically developed in the *** currently,virtually all surgical techniques that have been proposed for its correction are based on the induction of pseudoaccommodation in the presbyopic eye,including ***,the real restoration of accommodation is more complex,and it has been tried by the use of different,so called,“accommodative”pseudophakic intraocular lenses(AIOL).Overall,the reported results with these lenses by independent authors have been modest in relation with the restoration of the accommodative power of the eye and these modest benefits are usually lost with time due to the long term changes in the capsular *** fact made these lenses to be almost abandoned in the last few years,but there are currently other AIOL models being used with innovative mechanisms of action and different anatomical support outside the capsular bag that offer encouraging preliminary results that could bring a new potential of application to these types of *** this article,we will update the modern refractive surgeon about the fundamentals and provide updated information about the outcomes of AIOLs by reviewing the concept of accommodation,the different attempts that have been accomplished in the past,their demonstrated published results in human clinical trials,and the future alternatives that may arrive in the near future.

关键词： Accommodation Accommodative intraocular lens Presbyopia

Triply heavy baryons in the constituent quark model

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Chinese Physics C 2020年第2期44卷 33-41页

作者： Gang Yang Jialun Ping Pablo GOrtega jorge Segovia Department of Physics and State Key Laboratory of Low-Dimensional Quantum Physics Tsinghua UniversityBeijing 100084China Department of Physics and Jiangsu Key Laboratory for Numerical Simulation of Large Scale Complex Systems Nanjing Normal UniversityNanjing 210023China Grupo de Física Nuclear and Instituto Universitario de Física Fundamental y Matemáticas(IUFFyM) Universidad de SalamancaE-37008 SalamancaSpain Departamento de Sistemas Físicos Químicos y NaturalesUniversidad Pablo de OlavideE-41013 SevillaSpain

The constituent quark model is used to compute the ground and excited state masses of QQQ baryons containing either c or b *** quark model parameters previously used to describe the properties of charmonium and bottomonium states were used in this *** non-relativistic three-body bound state problem is solved by means of the Gaussian expansion method which provides sufficient accuracy and simplifies the subsequent evaluation of the matrix *** low-lying states with quantum numbers J^P=1/2^±,3/2^±,5/2^±and 7/2^+are *** compare the results with those obtained by the other theoretical *** is a general agreement for the mass of the ground state in each sector of triply heavy ***,the situation is more puzzling for the excited states,and appropriate comments about the most relevant features of our comparison are given.

关键词： Quantum Chromodynamics quark models properties of baryons exotic baryons