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World Journal of Cardiology 2015年第4期7卷 224-229页

作者： Juan Bautista Soumoulou Tomás Francisco Cianciulli Andrea Zappi Alberto Cozzarin María Cristina Saccheri jorge Alberto Lax Robert Guidoin Ze Zhang Department of Cardiology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155 AHDArgentina Researcher of the Ministry of Health Government of the City of Buenos Aires Department of Pathology Hospital "Dr.Cosme Argerich"Ciudad Autónoma de Buenos Aires C1155AHDArgentina Department of Surgery and Radiology Laval University and Québec Biomaterials InstituteCHUQQuebec G1K 7P4Canada

Pannus formation is a rare complication and occurs almost exclusively in mechanical prosthetic *** consists of fibrous tissue that covers the surface of the prosthesis either concentrically or eccentrically,resulting in valve *** pathophysiology seems to be associated to a chronic inflammatory process that explains the late and insidious clinical *** diagnosis should be considered in patients with high transvalvular gradients on transthoracic echo,and workup should be completed with fluoroscopy and transesophageal *** is always surgical and recurrence is *** present a case of pannus formation in a prosthetic aortic valve and a review of the literature regarding this disorder.

关键词： Pannus formation Prosthetic aortic valve Fluoroscopy Transthoracic echocardiography Transesophageal echocardiography

Simulation and Modeling of a Reciprocating Plunger Steam Engine to Obtain Two Indicator Diagrams

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Journal of Mechanics Engineering and Automation 2022年第2期12卷 46-56页

作者： JoséD.Barón Pinilla jorge E.Arango Gómez Fabio E.Sierra Vargas Luis Hernando Concha Rodriguez Investigation Group MDL&GE Faculty of Mechanical and Mechatronic EngineeringUniversidad NacionalBogotá111311Colombia Investigation Group GIATME Faculty of Engineering Universidad ECCIBogotá111311Colombia

Located at the National University in Bogotá,Colombia,this paper presents the development of the integration of kinematics,simplified kinetic and zero-dimensional models of indicator diagram of a double-acting,single-cylinder steam engine;the model integration is done for two configurations of the distribution system to simulate the instantaneous torque and the *** simulations are carried out at different steam entry conditions and an advance angle of 0°for the distribution system,fed with the data obtained from the characterization and metrological survey of the VE(vapor engine)parts in a CAD(computer-aided design)*** is verified that integrating the models constitutes a simulation tool that allows for the instantaneous torque deliveries and average torque of the accurate operation’s VE.

关键词： Kinematics kinetics indicator diagram live steam expanding steam

*** hypertension promotes early mitochondrial fragmentation in retinal endothelial cells in a mouse model of glaucoma

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Annals of Eye Science 2018年第1期 424-424页

作者： jorge L.Cueva Vargas Yoko Ito Khalil Miloudi Ariel M.Wilson Christine Vande Velde Przemyslaw Sapieha Adriana Di Polo Department of Neuroscience University of Montreal Hospital Research Center(CR-CHUM)MontrealQuebecCanada Department of Biochemistry Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Ophthalmology Maisonneuve-Rosemont Hospital Research CentreUniversity of MontrealMontrealQuebecCanada Department of Neuroscience McGill UniversityMontrealQuebecCanada

Background:Retinal endothelial cells are very active and contribute to the integrity of the neurovascular *** dysfunction has been proposed to contribute to the pathogenesis of ***,we evaluated the hypothesis that ocular hypertension triggers mitochondrial alterations in endothelial cells impairing the integrity of the blood retinal barrier(BRB).Methods:Ocular hypertension was induced by injection of magnetic microbeads into the anterior chamber of EndoMito-EGFP mice,a strain expressing green fluorescent protein selectively in the mitochondria of endothelial *** density,mitochondrial volume,and the number of mitochondrial components were quantified in 3D-reconstructed images from whole-mounted retinas using Imaris ***-related protein(DRP-1),mitofusin-2(MFN-2)and optic atrophy-1(OPA-1)expression were assessed by western blot analysis of enriched endothelial *** structure was evaluated by transmission electron microscopy(TEM)and oxygen consumption rate was monitored by Seahorse *** integrity of the BRB was evaluated by quantifying Evans blue ***:Our data demonstrate that two and three weeks after ocular hypertension induction,the total mitochondria volume in endothelial cells decreased from 0.140±0.002µm3 from non-injured retinas to 0.108±0.005 and 0.093±0.007µm3,respectively in glaucomatous eyes(mean±S.E.M,ANOVA,P<0.001;N=6/group).Frequency distribution showed a substantial increase of smaller mitochondria complexes(<0.5µm3)in endothelial cells from glaucomatous *** upregulation of DRP-1 was found in vessels isolated from glaucomatous retinas compared to the intact retinas,while MFN-2 and OPA-1 expression was not *** alteration in endothelial cell mitochondria was confirmed by TEM,which were accompanied by a 1.93-fold reduction in the oxygen consumption rate as well as 2.6-fold increase in vasculature leakage in glaucomatous retinas(n=3-6/group).In additi

关键词： Glaucoma endothelial cells mitochondria vascular leakage

有效管理合规义务--有效应用ISO 37301:2021降低不合规风险

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中国认证认可 2022年第4期 17-18页

作者：伊丽莎白•塔勒乔治•布拉沃李文远(译) 不详

ISO 373012021为组织管理合规风险提供了一个国际化、专业化和系统化的管理框架;合规管理体系对于组织的可持续发展至关重要,必将得到组织的广泛应用,因此而具有良好的发展前景;认证机构可将合规管理体系作为一个全新的管理体系认证项目... 详细信息

ISO 373012021为组织管理合规风险提供了一个国际化、专业化和系统化的管理框架;合规管理体系对于组织的可持续发展至关重要,必将得到组织的广泛应用,因此而具有良好的发展前景;认证机构可将合规管理体系作为一个全新的管理体系认证项目,从而也有助于认证机构的可持续发展。

关键词：认证机构合规风险可持续发展管理框架管理体系认证有效应用 ISO 发展前景

创伤后深静脉血栓的预防机械预防和药物预防的前瞻性、随机性比较

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骨科动态 2006年第3期2卷 155-160页

作者： JAMES P. STANNARD ROBERT R. LOPEZ-BEN DAVID A. VOLGAS EDWARD R. ANDERSON MATT BUSBEE DONNA K. KARR GERALD R. McGWIN JR. jorge E. ALONSO 罗从风（译）费起礼（校） Investigation performed at the University of Alabama at Birmingham Birmingham Alabama 上海第六人民医院骨科 200233 天津市天津医院 300211

背景：骨创伤后的深静脉血栓是十分重要的问题，但相关研究甚少。本研究的目的是评估两种不同方法对预防钝性创伤后深静脉血栓和肺栓塞的有效性。方法：共有224例住院患者参与此项预防创伤后静脉血栓形成的前瞻性随机性研究。200例患者... 详细信息

背景：骨创伤后的深静脉血栓是十分重要的问题，但相关研究甚少。本研究的目的是评估两种不同方法对预防钝性创伤后深静脉血栓和肺栓塞的有效性。方法：共有224例住院患者参与此项预防创伤后静脉血栓形成的前瞻性随机性研究。200例患者最终完成研究，比较两种不同的预防方案。A组患者在钝性创伤后24-48h内使用依诺肝素（30mg，皮下，每天两次）。B组患者在人院后使用脉冲式足泵并延迟使用依诺肝素。所有患者在出院前均行静脉核磁共振和超声检查。结果：A组共97例患者，B组共103例患者。22例患者（A组13人，B组9人）有深静脉血栓形成，其中A组2例还发生了肺栓塞。本组深静脉血栓的发生率为11％，A组13．4％，B组8．7％；A组和B组之间的差异无统计学意义。A组出现大的或闭塞性血栓共11例（发生率11．3％），B组仅3例（发生率2．9％）（p=0．025）。A组肺栓塞的发生率为2．1％，B组为0。A组有21例患者出现伤口并发症，B组为20例。住院期间发生深静脉血栓的患者人均用血7.4单位，无深静脉血栓的患者人均用血3．9单位（p〈0．05）。结论：结果显示严重的肌肉骨骼创伤后，早期使用机械预防（足泵）并延迟使用依诺肝素对预防深静脉血栓是相当有效的。比较两组患者，B组患者大的或闭塞性血栓的发生率明显低于A组患者。可信水平：治疗性研究，Ⅰ级。详细的可信水平描述参见作者须知。

关键词：深静脉血栓形成药物预防创伤后随机性机械依诺肝素住院期间肌肉骨骼

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在阿根廷生产性投资问题研究

上海商学院学报 2014年第5期15卷 26-28页

作者： Darío Rajmilovich jorgeTisocco Rosario Crescimbeni Yang K'e-Hua 布宜诺斯艾利斯大学阿根廷布宜诺斯艾利斯999071 UMSA 元智大学文学院

在阿根廷进行直接生产性投资,投资者必须准备一份详尽的项目计划,以评估各种可能出现的情况,并测算经风险调节后的投资回报率,同时考虑运营、财务、会计、法律及税务等诸多方面的问题.

关键词：生产性投资阿根廷投资问题投资回报率项目计划投资者财务会计

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新领导的100天行动计划

菲律宾、马尼拉、菲律宾总医院结核病人的耐药特征和多种药物耐药结核病的预测指标

作者： (美)乔治B. 布拉特(George B. Bradt) (美)杰米A. 切克(Jayme A. Check) (美)乔治E. 佩德拉萨(jorge E. Pedraza)

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国际结核病与肺部疾病杂志 1997年第1期 33-37页

作者： M.T.Mendoza A.J.Gonzaga C.Roa M.A.Velmonte M.jorge J.C.Montoya T.TanTorres M.Ong.M.Y.C.Barez C.F.Ang 屠德华 philippine General Hospital Manilaphilippines

背景:本研究在菲律宾、马尼拉、菲律宾大学—菲律宾总医院(UP-PGH)进行。目的:确定肺结核病人耐药特征和多种药物耐药结核病的临床预测指标。设计:前瞻性分析描述。方法:对结核分支杆菌培养阳性的病人进行会面,了解有关抗结核治疗既往史... 详细信息

背景:本研究在菲律宾、马尼拉、菲律宾大学—菲律宾总医院(UP-PGH)进行。目的:确定肺结核病人耐药特征和多种药物耐药结核病的临床预测指标。设计:前瞻性分析描述。方法:对结核分支杆菌培养阳性的病人进行会面,了解有关抗结核治疗既往史,卡介苗接种史,胸部X线检查及家庭接触情况,从299名病人中分离的结核杆菌应用浸没纸片比例法,进行了利福平、异烟肼(INH),乙胺丁醇和链霉素的敏感性测定。用标准实验室粉剂在7H10培养基中测定吡嗪酰胺(PZA)的敏感性。结果:在299名分离的结核杆菌中17％对五种主要药物全敏感,54％对二种或二种以上药物耐药(多种药物耐药结核病,MDR-TB)。初始耐药率乙胺丁醇(39％)和INH(17％)是高的,MDR-TB明显地与既往抗结核治疗史相关(优势比[OR]2.44,95％可信限)。不正规抗结核治疗超过三个月增加MDR-TB的可能性(OR4.6,P<0.0001)。结论:高的MDR-TB率与既往抗结核治疗情况有关,当不正规的先期抗结核治疗超过三个月时发生MDR-TB的机会明显增加。

关键词：结核病肺耐药 MDR-TB(多种药物耐药结核病) 耐药性

D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation

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World Journal of Transplantation 2014年第3期4卷 206-215页

作者： Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick jorge D Reyes James D Perkins Division of Transplant Surgery Department of Surgery University of California San Diego CA 92103-8401 United States Division of Transplantation Department of Surgery University of Washington Seattle WA 98195 United States Division of Gastroenterology Department of Medicine University of Washington Seattle WA 98195 United States

AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after ***: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was ***: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant ***: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient.

关键词： Liver transplantation The product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age Donor/recipient matching Markov microsimulation Model for End-Stage Liver Disease Donor age

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图像技术

国外科技新书评介 2014年第3期 23-23页

作者： jorge L. C. Sanz 张进兴不详中国科学院空间科学与应用研究中心

自20世纪60年代起，图像处理和机器视觉领域的研究就一直备受研究人员的关注。目前，图像技术已在商业和工业中广泛应用，并获得了不同商业领域越来越多的认可。新的算法和新的电子器件的问世，为创造更大、更复杂的图像应用程序铺平了... 详细信息

自20世纪60年代起，图像处理和机器视觉领域的研究就一直备受研究人员的关注。目前，图像技术已在商业和工业中广泛应用，并获得了不同商业领域越来越多的认可。新的算法和新的电子器件的问世，为创造更大、更复杂的图像应用程序铺平了道路。

关键词：图像技术商业领域应用程序研究人员机器视觉图像处理电子器件算法