检索结果-南通市图书馆

Generating oligodendroglia from adult mesenchymal cells for transplantation:cell reprogramming or direct lineage conversion?

引用

Neural Regeneration Research 2023年第7期18卷 1493-1494页

作者： Jorge Pascual-Guerra JoséA.Rodríguez-Navarro Carlos L.Paíno Service of Neurobiology-Research Ramón y Cajal University Hospital-IRYCISMadridSpain Department of Cellular Biology Complutense UniversityMadridSpain

Cell replacement therapy has long been proposed as a treatment for the damaged nervous system.One of the most challenging aspects of such a strategy,however,is finding sources of donor cells for transplantation.Autologous neural cells are rarely an option as every cell in the nervous system has a defined function that would be lost if that cell was to be removed.One possibility would be sourcing precursor or differentiated cells from fetal tissues;however,aside from ethical issues,heterologous cells are at risk of immunological rejection in the long term.Methodological improvements over the past 15 years have led to the possibility that autologous non-neural cells could be used for cell transplantation through their conversion into neural derivatives.

关键词： neural programming removed

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using GEDI lidar data and airborne laser scanning to assess height growth dynamics in fast-growing species:a showcase in Spain

引用

Forest Ecosystems 2021年第1期8卷 182-198页

作者： Juan guerra-Hernández Adrián pascual 3edata Centro de iniciativas empresariaisFundación CEL.O Palomar s/n27004 LugoSpain Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisbonPortugal Center for Global Discovery and Conservation Science Arizona State UniversityHiloHA 96720USA

Background:The NASA’s Global Ecosystem Dynamics Investigation(GEDI)satellite mission aims at scanning forest ecosystems on a multi-temporal short-rotation basis.The GEDI data can validate and update statistics from nationwide airborne laser scanning(ALS).We present a case in the Northwest of Spain using GEDI statistics and nationwide ALS surveys to estimate forest dynamics in three fast-growing forest ecosystems comprising 211,346 ha.The objectives were:i)to analyze the potential of GEDI to detect disturbances,ii)to investigate uncertainty source regarding non-positive height increments from the 2015–2017 ALS data to the 2019 GEDI laser shots and iii)to estimate height growth using polygons from the Forest Map of Spain(FMS).A set of 258 National Forest Inventory plots were used to validate the observed height dynamics.Results:The spatio-temporal assessment from ALS surveying to GEDI scanning allowed the large-scale detection of harvests.The mean annual height growths were 0.79(SD=0.63),0.60(SD=0.42)and 0.94(SD=0.75)m for Pinus pinaster,Pinus radiata and Eucalyptus spp.,respectively.The median annual values from the ALS-GEDI positive increments were close to NFI-based growth values computed for Pinus pinaster and Pinus radiata,respectively.The effect of edge border,spatial co-registration of GEDI shots and the influence of forest cover in the observed dynamics were important factors to considering when processing ALS data and GEDI shots.Discussion:The use of GEDI laser data provides valuable insights for forest industry operations especially when accounting for fast changes.However,errors derived from positioning,ground finder and canopy structure can introduce uncertainty to understand the detected growth patterns as documented in this study.The analysis of forest growth using ALS and GEDI would benefit from the generalization of common rules and data processing schemes as the GEDI mission is increasingly being utilized in the forest remote sensing community.

关键词： Forest inventory Productivity Multi-temporal LiDAR Full-waveform(FW) Satellite mapping

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Intertwined leukocyte balances in tumours and peripheral blood as robust predictors of right and left colorectal cancer survival

引用

World Journal of Gastrointestinal Oncology 2022年第1期14卷 295-318页

作者： Ramón Cantero-Cid Karla Marina Montalbán-Hernández Jenny Guevara Alejandro pascual-Iglesias Elisa Pulido JoséCarlos Casalvilla Cristóbal Marcano Cristina Barragán Serrano Jaime Valentín Gloria Cristina Bonel-Pérez JoséAvendaño-Ortiz Verónica Terrón Roberto Lozano-Rodríguez Alejandro Martín-Quirós Elvira Marín Eva Pena Laura guerra-Pastrián Eduardo López-Collazo Luis Augusto Aguirre Tumor Immunology Laboratory The Innate Immune Response GroupHospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Digestive Surgery Service La Paz University HospitalMadrid 28046Spain Emergency Department and Emergent Pathology Research Group Hospital La Paz Institute for Health Research(IdiPAZ)Madrid 28046Spain Pathologic Anatomy Service Hospital La PazMadrid 28046Spain

BACKGROUND Colorectal cancer(CRC)accounts for 9.4%of overall cancer deaths,ranking second after lung cancer.Despite the large number of factors tested to predict their outcome,most patients with similar variables show big differences in survival.Moreover,right-sided CRC(RCRC)and left-sided CRC(LCRC)patients exhibit large differences in outcome after surgical intervention as assessed by preoperative blood leukocyte status.We hypothesised that stronger indexes than circulating(blood)leukocyte ratios to predict RCRC and LCRC patient outcomes will result from combining both circulating and infiltrated(tumour/peritumour fixed tissues)concentrations of leukocytes.AIM To seek variables involving leukocyte balances in peripheral blood and tumour tissues and to predict the outcome of CRC patients.METHODS Sixty-five patients diagnosed with colon adenocarcinoma by the Digestive Surgery Service of the La Paz University Hospital(Madrid,Spain)were enrolled in this study:43 with RCRC and 22 with LCRC.Patients were followed-up from January 2017 to March 2021 to record overall survival(OS)and recurrence-free survival(RFS)after surgical interventions.Leukocyte concentrations in peripheral blood were determined by routine laboratory protocols.Paraffin-fixed samples of tumour and peritumoural tissues were assessed for leukocyte concentrations by immunohistochemical detection of CD4,CD8,and CD14 marker expression.Ratios of leukocyte concentration in blood and tissues were calculated and evaluated for their predictor values for OS and RFS with Spearman correlations and Cox univariate and multivariate proportional hazards regression,followed by the calculation of the receiver-operating characteristic and area under the curve(AUC)and the determination of Youden’s optimal cutoff values for those variables that significantly correlated with either RCRC or LCRC patient outcomes.RCRC patients from the cohort were randomly assigned to modelling and validation sets,and clinician-friendly nomograms were developed to predict OS and RFS from the

关键词： Left colorectal cancer Leukocyte ratios Prognostic variables Recurrence-free survival Right colorectal cancer Overall survival

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：