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“Aesthetic Visions”审美视觉展

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现代装饰 2018年第9期 112-118页

作者： Raw Material Helene Morbu Youth Editions Merve Kahraman Effetto Vetro jorge Varela Rodrigo Bravo ZPSTUDIO Les Ottomans Caroline Ficker Spolia Alissa Volkchova Paolo Giordano Simona Cardinetti Hagit Pincovici Ahryun Lee 彭佳 Mettlesome Design

这场展览的主题名为＂审美视觉＂（Aesthetic Visions）,是Manfredi Style在Fuorisalone城市外围展Brera设计区策划举办的展览。该展集结来自不同大陆的众多设计师,丰富地呈现了他们极具独创性的现代风格的作品。从这场展览,观众可以获... 详细信息

这场展览的主题名为＂审美视觉＂（Aesthetic Visions）,是Manfredi Style在Fuorisalone城市外围展Brera设计区策划举办的展览。该展集结来自不同大陆的众多设计师,丰富地呈现了他们极具独创性的现代风格的作品。从这场展览,观众可以获悉国际设计领域的最新趋势,领略设计师们精致的设计美学以及考究的设计细节。

关键词：视觉审美设计师现代风格设计美学展览

Virulence Factor Profile of Staphylococcus aureus Isolated from Bovine Milk from Brazil

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Food and Nutrition Sciences 2014年第15期5卷 1496-1505页

作者： Verena M.Santos Hellen B.Martins Izadora S.Rezende Maysa S.Barbosa Ewerton F.Andrade Simone G.Souza Guilherme B.Campos Pollianna S.Oliveira Daniel S.Sousa Danilo C.C.Da Silva Aline T.Amorim jorge Timenetsky Mariluze P.Cruz Regiane Yatsuda Lucas M.Marques Instituto Multidisciplinar em Saúde Núcleo de Tecnologia em SaúdeUniversidade Federal da BahiaVitoria da ConquistaBrazil Instituto de Ciências Biomédicas Departamento de MicrobiologiaUniversidade de Sao PauloSao PauloBrazil

This study investigates the biofilm formation, presence and distribution of virulence genes and the capacity to induce an inflammatory response in strains of Staphylococcus aureus isolated from milk samples in Bahia, Brazil. A total of 132 samples of raw milk were collected from four dairy farms (designated A to D) located in southwestern Bahia, in the municipality of Vitória da Conquista, from October/2009 to September/2010. After processing of the samples, 94 (71.2%) S. aureus isolates were obtained. These strains were subjected to the antibiogram method MIC (Minimum Inhibitory Concentration). As for the pathogenicity, tests were performedin vitrobiofilm formation induced by glucose. Moreover, we performed PCR for their virulence genes: sea (enterotoxin A), seb (B), sec (C), pvl (Panton-Valentine Leukocidin), clfA (Clumping Factor A) and spa (protein A) and analysis of cytokine induction in the inflammatory response of J774 macrophages by exocellular lipoteichoic acid. No isolates were resistant to oxacillin and vancomycin. In biofilm production, 5.31% (5/94) isolates did not produce biofilm, 5.31% (5/94) of the samples were poor producers, 15.96% (15/94) strains were moderate producers, 18.09% (17/94) were producers and 55.32% (55/94) of isolates were strong biofilm producers. One (1.06%) isolate expressed the seb gene, one (1.06%) sec, 18 (19.2%) cflA and 44 (46.8%) had spa. There was no expression of sea and pvl between isolates analyzed. The analysis of cytokine induction in the inflammatory response did not show statistical difference in the levels of IL-6, TNF-α and IL-10 induction. However, there was statistical difference in IL-1 induction between isolates from different farms. Thus, it appears that the results obtained in this study show significant effects for the region studied, since it is an important dairy region, hence the need for further studies, with the intent of attracting funding that contributes to improving prevention and control in both dai

关键词： Milk Staphylococcus aureus Resistance Virulence Factors

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死亡的样板

Use of a selective enzymatic debridement agent(Nexobrid■)for wound management:Learning curve

作者： (阿根廷)豪尔赫·路易斯·博尔赫斯(jorge Luis Borges)，阿道夫·比奥伊·卡萨雷斯(Adolfo Bioy Casares)

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World Journal of Dermatology 2017年第2期6卷 32-41页

作者： Ricardo Palao jorge Aguilera-Sáez Jordi Serracanta Jose Manuel Collado Bruce Patrik Dos Santos Juan Pedro Barret Plastic Reconstructive and Burns Unit ServiceVall d'Hebron University Hospital

AIM To evaluate the efficacy of Nexobrid~? in the initial management of burns and lessons learned with the *** From January 27^(th) 2015 until January 25^(th) 2016, 25 patients aged between 18-94 years old with deep partial and full thickness burns were treated with Nexobrid~? covering 1%-30% of their total body surface area(TBSA). The debridement was applied in the first 96 h post-injury following the protocol suggested for Nexobrid~?. In patients with burns of more than 15% TBSA a second application of Nexobrid~? was performed. After the removal of the product-4 h post application and after a 2 h period of wet dressing-we used several products to cover the wound like Suprathel~?, Biobrane~?, Mepitel~? with wet dressing, silver sulphadiazine 1% cream, and in some cases even autografts. We treated patients with inhalation injury as well. All the procedures were done under deep sedation, regional blocks in extremities or general anaesthesia in the intensive care unit room or in the operating *** After these first 25 cases, we have observed that patients with partial thickness burns treated with Nexobrid~?, experienced great benefits in the reduction of the need for autografting compared with the standard of care. This isbecause after selective enzymatic debriding of the burn scar we can distinguish different wound beds, which can coexist in the same patient, and we also managed to associate each one to its ability to epithelize. In major burns, besides the improvement in wound healing, we observed an important improvement in their general state. This may be because SIRS significantly improved through a bloodless debridement of necrotic tissue, decreasing the requirements of vasoactive drugs and fluid resuscitation. Circumferential burns also benefited from enzymatic debridement, observing a decrease in the number of compartment syndromes and the need for escharotomies. At present, we have not observed a positive effect in the evolution and o

关键词： Burns Eschar Debridement Enzymatic debridement Wound bed Nexobrid■ Epithelialization Dermis preservation Autograft

P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析

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中华医学杂志 2016年第33期96卷 2611-2615页

作者：冯斯婷严妍范婧尧王晓郑文聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo jorge Saucedo Jose R Conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 100029 University Hospital Alvaro Cunqueiro Vigo Spain Academic Medical Center Amsterdam the Netherlands Dipartimento di Scienze Mediche Divisione di Cardiologia Citta della Salute e della Scienza Turin Italy North Shore University Hospital Chicago USA University Clinical Hospital of Santiago de Compostela Santiago de compostela Spain Libin Cardiovascular Institute of Alberta Calgary Canada San Carlos Hospital Madrid Spain Bellvitge University Hospital Barcelona Spain University Patras Hospital Athens Greece Kerckhoff Heart and Thorax Center Frankfurt Germany Graduate School of Medicine Kyoto University Kyoto Japan University Clinical Hospital Warsaw Poland Hospital Sao Rafael Salvador Brazil Kanazawa University Graduate School of Medicine Kanazawa Japan University Clinic of Cardiology Skopje Macedonia

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分... 详细信息

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PCI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PCI术的患者，分为PPI组及非PPI组并随访1年，主要临床终点为全因死亡／再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类，将入组患者分为氯吡格雷组及替格瑞洛组，并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者，PPI组占54．8％，具有更多高危因素。Cox回归结果提示PPI组较非PPI组全因死亡／再发心肌梗死复合事件的发生差异无统计学意义（HR1．00，95％CI 0．86—1．18）。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组，不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异，联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险，尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。

关键词：急性冠脉综合征氯吡格雷质子泵抑制剂患者结局评价替格瑞洛

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基于智能手机的人类活动识别

国外科技新书评介 2015年第6期 24-24页

作者： jorge Luis Reyes Ortiz 李亚宁不详中国科学院自动化研究所

人体行为识别是模式识别技术的一种，目前处在动作识别阶段，而动作识别可以看成是特征提取和分类器设计相结合的过程。特征提取过程受到遮挡，动态背景，移动摄像头，视角和光照变化等因素的影响而具有很大的挑战性。其应用背景很广泛... 详细信息

人体行为识别是模式识别技术的一种，目前处在动作识别阶段，而动作识别可以看成是特征提取和分类器设计相结合的过程。特征提取过程受到遮挡，动态背景，移动摄像头，视角和光照变化等因素的影响而具有很大的挑战性。其应用背景很广泛，主要集中在智能视频监控，

关键词：模式识别技术人类活动智能手机智能视频监控动作识别特征提取分类器设计行为识别

Interstitial lung disease in rheumatoid arthritis:Current concepts in pathogenesis,diagnosis and therapeutics

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World Journal of Rheumatology 2015年第1期5卷 1-22页

作者： Eva M Olivas-Flores David Bonilla-Lara jorge I Gamez-Nava Alberto D Rocha-Muoz Laura Gonzalez-Lopez Hospital General Regional 180 Instituto Mexicano del Seguro Social (IMSS) Centro Universitario de Ciencias de la Salud (CUCS) Universidad de Guadalajara Hospital de Especialidades Centro Medico Nacional de Occidente Instituto Mexicano del Seguro Social (IMSS) Hospital General Regional 110 Departamento de Medicina Interna-Reumatologia Instituto Mexicano del Seguro Social (IMSS)

Rheumatoid arthritis(RA) is the most common chronic autoimmune inflammatory joint disease. RA-associated interstitial lung disease(RA-ILD) is a major extraarticular complication and causes symptoms that lead to a deterioration in the quality of life, high utilization of health resources, and an increased risk of earlier mortality. Early in the course of RA-ILD, symptoms are highly variable, making the diagnosis difficult. Therefore, a rational diagnostic strategy that combines an adequate clinical assessment with the appropriate use of clinical tests, including pulmonary function tests and high-resolution computed tomography, should be used. In special cases, lung biopsy or bronchioalveolar lavage should be performed to achieve an early diagnosis. Several distinct histopathological subtypes of RA-ILD are currently recognized. These subtypes also have different clinical presentations, which vary in therapeutic response and prognosis. This article reviews current evidence about the epidemiology of RA-ILD and discusses the varying prevalence rates observed in different studies. Additionally, aspects of RA-ILD pathogenesis, including the role of cytokines and other molecules such as autoantibodies, as well as the evidence linking several drugs used to treat RA with lung damage will be discussed. Some aspects of the clinical characteristics of RA-ILD are noted, and diagnostic strategies are reviewed. Finally, this article analyzes current treatments for RA-ILD, including immunosuppressive therapies and biologic agents, as well as other therapeutic modalities. The prognosis of this severe complication of RA is discussed. Additionally, this paper examines updated evidence from studies identifying an association between drugs used for the treatment of RA and the development of ILD.

关键词： Rheumatoid arthritis Interstitial lung disease Pathogenesis Diagnosis Therapeutic