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The GSTP1 gene variant rs1695 is not associated with an increased risk of multiple sclerosis

Cellular & Molecular Immunology 2015年第6期12卷 777-779页

作者： Jose AG Agundez Elena Garcia-Martin Carmen Martinez Julian Benito-Leon Julian Benito-Leon jorge millan-pascualmaria diaz-sanchez Patricia Calleja Diana Pisa Laura Turpin-Fenoll Hortensia Alonso-Navarro Lucia Ayuso-Peralta Dolores Torrecillas Esteban Garcla-Albea Jose Francisco Plaza-Nieto Felix Javier Jimenez-Jimenez Department of Pharmacology University of Extremadura CAceres Spain Department of Biochemistry and Molecular Biology University of Extremadura Caceres Spain CiBERNED Centro de InvestigaciOn BiomEdica en Red de Enfermedades Neurodegenerativas Instituto de Salud Carlos III Spain Service of Neurology Hospital Universitario Doce de Octubre Madrid Spain Department of Medicine University Complutense Madrid Spain Section of Neurology Hospital La Mancha-Centro Alcazar de San Juan (Ciudad Real) Spain Centro de Biologfa Molecular Severo Ochoa (CSIC-UAM) Facultad de Ciencias Universidad Autonoma Cantoblanco 28049 Madrid Spain Department of Medicine-Neurology Hospital 'Principe de Asturias' Universidad de Alcala Alcala de Henares (Madrid) Spain Section of Neurology Hospital Universitario del Sureste Arganda del Rey (Madrid) Spain Correspondence: Dr FJ Jimenez-Jimenez C/Marroquina 14 3° B E-28030 Madrid Spain.

We analyzed the allelic and genotypic frequencies of the glutathione-S-transferase P1 （GSTPI） rs1695 single nucleotide polymorphism （SNP） in 290 patients with multiple sclerosis （MS） and in 310 healthy controls. We found no significant association between the rs1695 variant and MS. Among MS patients, there was no relationship between the rs1695 variant and either gender, clinical type of MS or the age of onset of MS.

关键词：多发性硬化多态性单核苷酸发病年龄谷胱甘肽基因性别特性一氧化氮胰岛素

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Isolated Gross Hematuria or Associated to Acute Retention of Urine as a Sign of Urologic Malignant Pathology

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Journal of Health Science 2014年第1期2卷 56-61页

作者： Angel Tomas Ibanez Concejo Marco Antonio Castillo Juan sanchez-Verde Bilbao jorge Short Apellaniz Ambar Deschamps Perdomo Joaquin Garcia Canete Emergency Department Fundaeion Jimenez-Diaz Hospital Madrid 28760 Spain

The causes oflGH （Isolated gross hematuria）, as the only symptom or associated with ARU （acute retention of urine） caused by clots in the urinary tract in patients who do not have a previous diagnosis of urological malignant pathology and to study the immediate mortality in patients with that sign are described. A descriptive observational study of the etiologies of patients shows the above mentioned symptomatology from the 1 st of January to the 30th of June of 2008 in the Emergency Department which received follow-up treatment up to December 2010. It also describes the mortality before the definitive diagnosis and the days between receiving attention in the Emergencies Department and the diagnostic tests. One hundred and four cases with the criteria described above were evaluated. Of these, 20.0% turned out to have bladder, prostate or kidney cancer; the bladder being the most affected organ. Of all the pathology, benign and malignant, the most frequent one is the benign hypertrophy of the prostate （49.8% of the total）. Of the total, 4.8% of the patients died in the following weeks before finishing the diagnostic study. Isolated gross hematuria is a clinical symptom closely related to urological malignant pathology and it does not have an insignificant mortality rate in a short period of time. For these reasons it is necessary to accelerate the diagnostic tests as soon as the patient presents the symptom.

关键词： Gross hematuria bladder cancer prostate cancer benign hypertrophy of the prostate urothelioma.

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