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Nutritional Supplement ocoxin® combined with Gemcitabine-Based chemotherapy in Patients with Advanced Pancreatic Adenocarcinoma

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open Journal of gastroenterology 2024年第8期14卷 267-287页

作者： mayté Lima-Pérez jorge luis soria.o-ga.cía.ma.iel gonzález-meisozo jorge luis soria.o-Lorenzo Vilma Fleites-calvo Dunia Morales-Morgado carlos Domínguez-Álvarez Iván Ramón-concepción Raidel Rodríguez-Barrios Alicia Tarinas-Reyes Ivis Mendoza-Hernández Rolando Uranga-Piña clinical oncology Department Ameijeiras Hospital Havana Cuba clinical Pathology Department Ameijeiras Hospital Havana Cuba clinical Section National Coordinating Centre for Clinical Trials Havana Cuba Biostatistics Section National Coordinating Centre for Clinical Trials Havana Cuba

Background: the quality of life (QoL) of patients with pancreatic ductal adenocarcinoma (PDAc), with its limited survival, can be affected by chemotherapy-induced toxicity. The main objective was to evaluate the effect of introducing ocoxin oral solution (ooS) in combination with standard therapy on quality of life. Methods: Thirty patients were enrolled in an exploratory, prospective, single-centre clinical trial in the oncology department of “Hermanos Ameijeiras” University Hospital in Havana, cuba. Quality of life was measured using the EoRTc QLQ-c30 questionnaire and toxicity was assessed using the NcI-cTc-AE classification version 5.0. Results: There was stability in the scores over time for overall QoL and the functional scale criteria, while in terms of symptoms, fatigue, pain and loss of appetite were reduced. No grade 3 - 4 adverse events (AEs) were recorded, and only 14.9% of toxicities were classified as grade 2, and these were considered to be unrelated to ooS. Biochemical and nutritional parameters were normalised at 12 months compared to the baseline values. conclusions: This clinical study is the first report of the use of ooS in patients with advanced pancreatic cancer, and demonstrates that it is able to maintain optimal quality of life with reduced severity of toxicity during and after combination treatment with gemcitabine-based chemotherapy.

关键词： EoRTc QLQ-c30 ocoxin chemotherapy Pancreatic cancer Quality of Life

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Within-brood body size and immunological differences in Blue Tit(cyanistes caeruleus)nestlings relative to ectoparasitism

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Avian Research 2022年第3期13卷 362-368页

作者： jorge garrido-Bautista Antonio soria cristina E.Trenzado Amalia Pérez-Jiménez Eliana Pintus José luis Ros-Santaella Nicola Bernardo mar comas Stanislav Kolencík Gregorio Moreno-Rueda Departamento de Zoología Facultad de CienciasUniversidad de Granada18071GranadaSpain Departamento de Biología celular Facultad de CienciasUniversidad de Granada18071GranadaSpain Department of Veterinary Sciences Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life Sciences PragueKamýck a 12916500Prague 6SuchdolCzech Republic Estaci on Biol ogica de Do~nana EBD-CSICAv.Am erico Vespucio 2641092SevilleSpain Department of Biological Sciences Dartmouth CollegeNH03755HanoverUSA Department of Biology University of NevadaNV89557RenoUSA

Several ectoparasites parasitise nestlings decreasing their body condition,growth and *** minimise any loss of fitness due to ectoparasites,birds have developed a wide variety of defence mechanisms,potentially including hatching *** to the Tasty chick Hypothesis(TcH),the cost of parasitism would be reduced if ectoparasites tend to eat on less immunocompetent nestlings,typically the last-hatched chick in asynchronously hatched broods,as they are in poor body *** predictions of the TcH are that immune capacity is lower in smaller nestlings than in larger ones and that parasites should provoke a more negative effect on smaller ***,we test these predictions in a population of Blue Tits(cyanistes caeruleus)whose broods are parasitised by Hen Fleas(ceratophyllus gallinae)and Blowflies(Protocalliphora azurea).We recorded the presence of both ectoparasites and analysed the immunocompetence(number of leucocytes per 10,000 erythrocytes and cutaneous immune response to phytohaemagglutinin)and body condition of smaller and larger nestlings within individual *** leucocyte count was higher in smaller nestlings than in larger ones,whereas the cutaneous immune response did not differ between smaller and larger *** nestlings,but not larger nestlings,had lower body mass when fleas were ***,by contrast,had no detectable negative effect on ***,our findings provide partial support to the *** immune capacity in smaller nestlings than in larger ones was not supported,but Hen Fleas seemed to negatively impact on smaller nestlings more than on larger ones.

关键词： Blowflies Blue tit cyanistes caeruelus Ectoparasites Hen fleas Immunocompetence Tasty chick Hypothesis

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