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Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

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Eye and Vision 2021年第6期8卷 374-384页

作者： jorge l.alio Francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci jorge l.alio del Barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOls by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 lENTIS Mplus lS-313 MF30;(d)33 lENTIS Mplus lS-313 MF15;(e)17 Akkolens lumina;(f)31 AT lISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(lOA)and high-order aberration(HOA)RMS measured by PWS ***:AT lISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;Pllowed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT lISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(Plus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(Pl RMS,lOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(Plusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** lISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOl Extended depth of focus Accommodative IOl

Patients’dissatisfaction with multifocal intraocular lenses managed by exchange with other multifocal lenses of diferent optical profles

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Eye and Vision 2024年第1期10卷 31-40页

作者： Olena Al‑Shymali Colm McAlinden jorge l.alio del Barrio Mario Canto‑Cerdan jorge l.alio Research&Development Department VISSUM Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthalmology Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthalmology School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to evaluate the outcomes of dissatisfed patients reporting poor visual quality following implantation of multifocal intraocular lenses(MF-IOls),managed by IOl exchange with another multifocal optical ***:This is a retrospective series of ***-IOl exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual quality for far distance afected by neuroadaptation *** underwent a bilateral exchange of a MF-IOl with another MF-IOl of a diferent optical *** outcomes and complications were *** including Quality of Vision(QoV),Visual Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were also used for outcome ***:The mean elapsed time from implantation to explantation-reimplantation was 11.8 *** QoV scores improved signifcantly across all the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(Pl acuity improved from 0.24 to 0.12 logMAR after exchange(Pl acuity improved from 0.15 to 0.04 logMAR(Pllowing MF-IOl exchange,80%of the patients reported they would have the MF-IOl reimplantation procedure ***:Patient dissatisfaction with neuroadaptation failure following MF-IOl implantation can be managed in 80%of our cases by MF-IOl exchange with a diferent MF-IOl optical profle.

关键词： Multifocal intraocular lenses IOl exchange Visual acuity Neuroadaptation failure

Corneal collagen cross‑linking epithelium‑on ***‑off:a systematic review and meta‑analysis

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Eye and Vision 2021年第6期8卷 338-352页

作者： Francesco D’Oria Antonio Palazón jorge l.alio Vissum Innovation c/Cabañal103016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXl)techniques compared with standard epi-off ***:We searched MEDlINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias *** considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UDVA and CDVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECD).We also investigated adverse events related to the treatments and treatment ***-analysis was conducted with a fixed or random-effects model using weighted mean difference(MD)with 95%confidence interval(CI)as the effect ***:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this *** analysis revealed significant postoperative differences in CDVA(MD=0.07;95%CI 0.04 to 0.10;Pl corneal thickness(CCT)and ECD(P>0.05).Epi-on CXl protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXl is as effective as epi-off *** for a higher significant improvement in CDVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXl have comparable effects on visual,topographic,pachymetric,and endothelial ***-on CXl has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXl Epithelium-off CXl Epithelium-on CXl Iontophoresis

Corneal transplantation outcomes after the extrusion of an intrastromal keratoprosthesis:a pilot study

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Eye and Vision 2020年第2期7卷 250-254页

作者： Chiara Fariselli Ibrahim Toprak Olena Al-Shymali jorge l.alio del Barrio jorge l.alio Research and Development Department Calle Cabañal1 Edificio Vissum03016 AlicanteSpain Department of Ophthalmology Pamukkale UniversityDenizliTurkey Cornea and Refractive Surgery Department Calle Cabañal1 Edificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain

This short report includes 5 eyes of 5 patients(mean age 63.2±12 years)who underwent a tectonic keratoplasty[deep anterior lamellar keratoplasty(DAlK)or penetrating keratoplasty(PK)]in order to rehabilitate the eye after the extrusion of the non-perforating keratoprosthesis(Kpro)KeraKlear(KeraMed,USA).The non-perforating Kpro was extruded after a mean period of 21.4±21.8 months due to *** two cases,the keratoplasty was performed the same day of the non-perforating Kpro removal due to a severe melting,while in the other three cases it was performed one to 3 months *** eyes received a DAlK,but in 3 eyes a macroscopic Descemet membrane perforation forced the conversion into a *** mean follow-up period after the keratoplasty was 16.8±6.6 *** cases of rejection were *** the 5 eyes achieved“anatomical success”(transparent graft,with no signs of infection or inflammation).Two eyes showed limited“functional success”because the achievement of the best visual potential was prevented by the development of glaucomatous optic atrophy during the follow-up *** conclusion,this short report presents an unexpected success of a keratoplasty performed with a tectonic purpose after the extrusion of the non-perforating Kpro because the corneal graft remained transparent,without neovascularization or scarring during the follow-up *** initial evidence shows some encouraging results regarding graft survival rate and the achievement of a useful visual rehabilitation with keratoplasty after a nonperforating Kpro failure instead of repeating the Kpro implantation.

关键词： Keratoprosthesis Extrusion Keratoplasty Corneal transplantation

The use of intracorneal ring segments in keratoconus

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Eye and Vision 2016年第1期3卷 66-72页

作者： Alfredo Vega-Estrada jorge l.alio Keratoconus Unit Vissum AlicanteCalle Cabanal1 Edificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernandezAlicanteSpain

Keratoconus is a corneal degeneration that usually appears during puberty and may seriously deteriorate the quality of life of the *** corneal disease is today the first indication of corneal transplantation in young *** the last decade of the XX century,keratoplasty procedures were the only alternative to treat this pathological *** the beginning of the XXI century,intracorneal ring segments implantation was proposed as a therapeutic choice for treating keratoconus *** then,several published articles have reported the benefits of this surgical procedure in treating this type of corneal ectatic *** purpose of the present investigative work is to summarize the characteristic of the intracorneal ring segments and also to review the different features published in the literature in relation to this surgical technique for the treatment of keratoconus patients.

关键词： Keratoconus Corneal ectasia Intracorneal rings

Corneal surgery in keratoconus: which type, which technique, which outcomes?

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Eye and Vision 2016年第1期3卷 8-21页

作者： Francisco Arnalich-Montiel jorge l.aliodel Barrio jorge l.alio IRYCIS.Ophthalmology Department Ramon y Cajal University HospitalMadridSpain Cornea Unit Hospital Vissum MadridMadridSpain Cornea and External Diseases Service Moorfields Eye HospitalLondonUK Cornea Cataract and Refractive Surgery UnitVissum CorporacionAlicanteSpain Division of Ophthalmology Universidad Miguel HernandezAlicanteSpain

Keratoconus is a disease characterized by progressive thinning,bulging,and distortion of the *** cases usually present with loss of vision due to high irregular astigmatism.A majority of these cases require surgical *** review provides an update on the current treatment modalities of corneal surgery available for the management of advanced corneal ectasias.

关键词： Keratoconus Deep anterior lamellar keratoplasty Penetrating keratoplasty Corneal transplant Rejection

Reply to the letter to the editor

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Eye and Vision 2021年第1期8卷 462-463页

作者： jorge l.alio Francesco Versaci Francesco D’Oria Vissum Miranza AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly

We appreciate the interest of Miguel Faria Ribeiro in our paper[1],as well as the comments made to *** interest of the topic is sound,as nowadays an enormous amount of new so-called“premium lenses”are appearing in the market,with different optical profiles which obviously lead to different light distributions and different quality of retinal *** is why our interest in this topic is longstanding and we have published extensive summaries about the outcomes and complications of multifocal lenses over the last years[2,3].

关键词： editor letter enormous

Artificial neural network to guide intracorneal ring segments implantation for keratoconus treatment:a pilot study

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Eye and Vision 2020年第2期7卷 189-200页

作者： Chiara Fariselli Alfredo Vega-Estrada Francisco Arnalich-Montiel jorge l.alio Research and Development Department VissumCalle Cabañal1.Edificio Vissum03016 AlicanteSpain Department of Experimental Diagnosticand Specialty Medicine(DIMES)Ophthalmology ServiceSt.Orsola-Malpighi Teaching HospitalUniversity of BolognaBolognaItaly Cornea and Refractive Surgery Department VissumAlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Cornea and Refractive Surgery Department VissumMadridSpain

Background:To analyze the clinical results of an artificial neural network(ANN)that has been processed in order to improve the predictability of intracorneal ring segments(ICRS)implantation in ***:This retrospective,comparative,nonrandomized,pilot,clinical study included a cohort of 20 keratoconic eyes implanted with intracorneal ring segments KeraRing(Mediphacos,Belo Horizonte,Brazil)using the ANN(ANN group)and 20 keratoconic eyes implanted with KeraRing using the manufacturer’s nomograms(nomogram group).Uncorrected distance visual acuity(UDVA),corrected distance visual acuity(CDVA)(visual acuity is expressed in decimal value and in logMAR value in brackets),manifest refraction,corneal topography,tomography,aberrometry,pachymetry and volume analysis(Sirius ***,Firenze,Italy)were performed during the preoperative visit;and the two groups,ANN group and nomogram group,did not differ significantly preoperatively in all of the parameters *** preoperative values were compared with the results obtained at the third-month ***-Whitney test and Wilcoxon test were used for the statistical ***:The spherical equivalent and the keratometric values decreased significantly in both *** CDVA improved from 0.60±0.23(0.22 logMAR)pre-operatively to 0.73±0.21(0.14 logMAR)post-operatively in the ANN group(plogMAR)pre-operatively to 0.62±0.19(0.21 logMAR)post-operatively in the nomogram group(plly significant difference between the two groups(plike aberrations decreased significantly in the ANN group,while in the nomogram group they did not change significantly,but no statistically significant difference was found between the two ***:ANN to guide ICRS provides an increase in the visual acuity,reduction in the spherical equivalent and improvement in the optical quality of keratoconus *** gives better results wh

关键词： Keratoconus Intracorneal ring segments Artificial intelligence Visual acuity Corneal aberrations

Simultaneous tectonic Descemet stripping endothelial keratoplasty and tectonic Bowman layer transplant for the management of corneal perforation

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International Journal of Ophthalmology(English edition) 2023年第9期16卷 1549-1554页

作者： Abdo Karim Tourkmani Colm McAlinden David F.Anderson jorge l.alio del Barrio jorge l.Alió Royal Gwent Hospital NewportWales NP202UBUK Ophthalmology Department Universidad Miguel HernándezAlicante 03202Spain Ulster University Northern IrelandBelfast BT151EDUK Southampton General Hospital Southampton SO166YDEnglandUK Cornea Cataract&Refractive Surgery UnitVissum(Miranza Group)Alicante 03106Spain

AIM:To report the outcomes of three cases of corneal perforation managed with simultaneous tectonic Descemet stripping endothelial keratoplasty(t-DSEK)and tectonic Bowman layer transplant(t-BlT)as an alternative to tectonic penetrating keratoplasty(t-PKP).METHODS:Three eyes of three patients receiving simultaneous t-DSEK and t-BlT for corneal perforation were *** technique for DSEK was modified depending on individual *** t-BlT technique was standardised using an 8 mm graft and fixated with a running *** was measured by the ability of this procedure to close a corneal ***:All three cases achieved tectonic eye globe restoration and remained stable during the minimum 3-month observation *** were relatively common:2 cases required amniotic membrane transplant for persistent epithelial *** case required DSEK *** case developed angle closure glaucoma requiring surgical peripheral ***:Simultaneous t-DSEK and t-BlT may be a useful strategy for the management of corneal perforation as an alternative management to t-PKP for selected cases.

关键词： tectonic corneal graft Descemet stripping endothelial keratoplasty Bowman layer transplant penetrating keratoplasty