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Interferon-γ and other inflammatory mediators in cardiomyocyte signaling during Chagas disease cardiomyopathy

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World Journal of Cardiology 2014年第8期6卷 782-790页

作者： Ludmila Rodrigues Pinto Ferreira Amanda Farage Frade Monique Andrade Baron Isabela Cunha Navarro jorge kalil Christophe Chevillard Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor)School of MedicineUniversity of S o Paulo05403-001 S o PauloBrazil Division of Clinical Immunology and Allergy School of MedicineUniversity of S o Paulo05403-001 S?o PauloBrazil Institute for Investigation in Immunology (iii) INCT05403-001 S o PauloBrazil Aix-Marseille Université INSERMGIMP UMR_S90613385 MarseilleFrance

Chagas disease cardiomyopathy(CCC), the main consequence of Trypanosoma cruzi(***) infection, is an inflammatory cardiomyopathy that develops in up to 30% of infected individuals. The heart inflammation in CCC patients is characterized by a Th1 T cell-rich myocarditis with increased production of interferon(IFN)-γ, produced by the CCC myocardial infiltrate and detected at high levels in the periphery. IFN-γ has a central role in the cardiomyocyte signaling during both acute and chronic phases of *** infection. In this review, we have chosen to focus in its pleiotropic mode of action during CCC, which may ultimately be the strongest driver towards pathological remodeling and heart failure. We describe here the antiparasitic protective and pathogenic dual role of IFN-γ in Chagas disease.

关键词： Chagas disease Trypanosoma cruzi Interferon-gamma Gene expression Cardiomyopathy

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HLA-DR抗原的单克隆抗体

细胞与分子免疫学杂志 1985年第3期 58-66页

作者： jorge E.kalil ,Mare Fellous ,王笑利沈阳军区总医院

一、绪言当前,小鼠单克隆抗体(以下简称单抗)的生产是用于研究多种细胞表面抗原的一种现行技术。单抗为这些结构的分离、分析和生理作用的研究提供了精确的试剂。并为免疫遗传学的研究开辟了一条新的途径。

关键词：单克隆抗体单抗抗原 HLA-DR DR

Potential therapeutic targets identified by integrated miRNA and mRNA expression profiling in Chagas disease:miRNA-associated pathology Development and Immune Response pathways

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Potential therapeutic targets identified by integrated miRNA...

An approach for QoS measurement and web service selection sureness

第十届全国免疫学学术大会

作者： Ludmila Rodrigues Pinto Ferreira Frederico Moraes Ferreira Monique Andrade Baron Darlan da Silva Candido Laurie Laugier Sandrine Cabantous Amanda Farage Frade Ronaldo Honorato Barros Santos Christophe Chevillard jorge kalil Edecio Cunha-Neto Laboratory of Immunology Heart Institute (InCor) University of Sao PauloSchool of Medicine Division of Clinical Immunology and Allergy University of Sao Paulo School of Medicine Universidade Santo Amaro (UNISA) INSERM U906 Aix-Marseille University AMU Faculte de Medecine Division of Transplantation Heart Institute (InCor) University of Sao PauloSchool of Medicine

Chronic Chagas Cardiomyopathy (CCC) is the severe manifestation of Chagasdisease, caused by infection with the protozoan parasite Trypanosoma *** is characterized by myocardial inflammation, arrhythmias, heart

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High Technology Letters 2013年第3期19卷 283-289页

作者： Shariq Hussain Wang Zhaoshun Ibrahima kalil Toure School of Computer and Communication Engineering University of Science and Technology Beijing

Web services have gained popularity m recent years anu prowue a new moue, u~ w^u, w,,,~,, ,^- cilitates interaction of scientific and business applications through the Internet. More often, several services with similar functionality are available from a large and changing number of service provid- ers. Quality of Service （QoS） is the dominant factor in service selection and is of great importance to users. In this paper, we propose a model for QoS measurement and web services selection. The model consists of QoS model, QoS monitoring, QoS comparison and service selection with a QoS feedback mechanism. The most suitable service is to take into account the agreed QoS, monitoring is done during invocation phase and if any deviation is recorded, next suitable service is selected. Fi- nally the model is proved to be feasible and effective by simulation experiments.

关键词： web services quality of service ( QoS) QoS measurement ranking web serviceselection

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An adaptive routing protocol based on relative positions in VANETs

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High Technology Letters 2012年第1期18卷 13-19页

作者： Wang Lei Yang Yang Wang Xiaobo Ibrahima kalil Toure Mi Zhenqiang School of Computer and Communication Engineering University of Science and Technology BeijingBeijing 100083P.R.China

After presenting weaknesses of several classic routing protocols applied in vehicular ad hoc networks （VANETs） by a qualitative comparison, this paper proposes a novel self-adaptive routing protocol, named ARPP. With respect to the specific characteristics of VANETs, the proposed routing protocol adopts a dynamic topology establishment and time-varying control message sending mechanism. A direction-based forwarding strategy and a specific warning solution enhance the routing performance in ARPP. Simulation results show that the ARPP protocol outperforms the classic AODV in urban vehicle environment.

关键词： vehicular ad hoc networks(VANETs) routing protocol relative positions self-adaptivemechanism

Human leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina U Melere Flavia H Feier jorge Neumann Antônio N kalil Juliana de M Montagner Luiza S Nader Carolina S da Silva Marco Aurélio F Junior Gabriela P Coral Guilherme P Bobsin Cristina T Ferreira Department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Department of Hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgraduation Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROUND Antibody-mediated rejection following liver transplantation(LT)has been increasingly recognized,particularly with respect to the emergence of de novo donor-specific antibodies(DSAs)and their impact on graft *** substantial evidence for adult populations exists,research focusing on pediatric LT outcomes remains *** To investigate the prevalence of human leukocyte antigen(HLA)mismatches and DSA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients underwent HLA testing at Santa Casa de Porto Alegre,Brazil,between December 2013 and December *** patients who survived for>30 days after LT with at least one DSA analysis were *** classes I and II and cross-matches were *** presence of de novo DSA(dnDSA)was evaluated at least 3 months after LT using the Luminex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant DSA(class I or II)was detected in 28.3%of patients,and dnDSA was detected in 48.4%.The median time to DSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDSA was significantly associated with rejection(36%vs 3%,P<0.001).The rejection-free survival rates at 12 and 24 months were 76%vs 100%and 58%vs 95%for patients with dnDSA anti-DQ vs those without,*** Our findings highlight the importance of incorporating DSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may include immunosuppression minimization strategies based on this analysis in pediatric LT recip

关键词： Human leukocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

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四川生理科学杂志 2020年第4期42卷 451-451页

作者： Andre C kalil From the University of Nebraska Medical Center Omaha (A.C.K. L.L.) University of Texas Health San Antonio University Health and the South Texas Veterans Health Care System San Antonio (T.F.P. P.O.P. B.S.T.) UT Southwestern Medical Center Parkland Health and Hospital System (M.K.J.) and Baylor Scott and White Health (U.S.) Dallas and Baylor College of Medicine Houston (H.M.E.S.) — all in Texas Emory University (A.K.M. N.G.R. Y.S. V.C.M. V.D.C.) and Grady Memorial Hospital (V.D.C.) Atlanta and Atlanta Veterans Affairs Medical Center Decatur (V.C.M.) — both in Georgia the National Institute of Allergy and Infectious Diseases National Institutes of Health (K.M.T. V.G. R.T.D. M.P. G.A.D. W.D. S.U.N. L.E.D. J.H.B.) and the Infectious Disease Clinical Research Program Uniformed Services University of the Health Sciences (T.H.B.) Bethesda and Emmes (J.F. M.G. M.M.) and Clinical Monitoring Research Program Directorate Frederick National Laboratory (T.B.) Rockville — both in Maryland Duke University Durham NC (C.R.W. E.R.K. J.J.E.) Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (G.M.R.-P.) and Instituto Nacional de Enfermedades Respiratorias (J.R.P.) Mexico City University of California Irvine Irvine (L.H. A.N.A. M.W.) Cedars–Sinai Medical Center Los Angeles (V.T.) University of California San Diego La Jolla (D.A.S.) University of California San Francisco San Francisco (A.F.L.) University of California Davis Davis (S.H.C.) and Stanford University Stanford (N.A.) — all in California University of Minnesota Medical School Minneapolis (S.K. J.B.) University of Florida Gainesville (N.M.I. M.-C.E.) University of Rochester Rochester NY (A.R.B.) National Center for Infectious Diseases Tan Tock Seng Hospital Lee Kong Chian School of Medicine and Yong Loo Lin School of Medicine (D.C.L.) and Changi General Hospital (S.Y.T.) Singapore University of Massachusetts Medical School Worcester (R.W.F.) University of Virginia Charlottesville (P.E.H.J.

Background:Severe coronavirus disease 2019(Covid-19)is associated with dysregulated *** effects of combination treatment with baricitinib,a Janus kinase inhibitor,plus remdesivir are not ***:We conducted a double-blind,randomized,placebo-controlled trial evaluating baricitinib plus remdesivir in hospitalized adults with *** the patients received remdesivir(≤10 days)and either baricitinib(≤14 days)or placebo(control).The primary outcome was the time to *** key secondary outcome was clinical status at day 15.

关键词： placebo clinical des

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Evolution of a Holocene banner bank controlled by morphodynamics and structural setting of a macrotidal coast: Saint-Brieuc Bay (NW-Europe)

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Geoscience Frontiers 2021年第5期12卷 166-181页

作者： kalil Traoréa David Menier Erwan Gensac Pascal Le Roy Clément Lambert Paul Bessin Kevin Pedoja Anne Duperret Romain Le Gall Laboratoire Géoscience Océan UMR 6538CNRSUniversitéBretagne SudCampus de Tohannic56000 VannesFrance Laboratoire Géoscience Océan UMR 6538CNRSIUEMUniversitéBretagne Occidentale29280 PlouzanéFrance Laboratoire de Planétologie et Géodynamique UMR 6112CNRSLe Mans UniversitéAvenue Olivier Messiaen72085 Le Mans CEDEX 9France Laboratoire Morphodynamique Continentale et Côtière UMR 6143CNRSUniversitéCaen Normandiecampus 12-4Rue des Tilleuls14000 Caen cedexFrance Laboratoire Ondes et Milieux Complexes UMR 6294CNRSUniversitéLe Havre Normandie53 rue de PronyCS8054076058 Le Havre cedexFrance

The morphology and internal structure of the Horaine Bank(Bay of Saint-Brieuc,NW France)are described based on multibeam echosounder and high-resolution seismic datasets coupled with vibro-core *** Horaine Bank shows large-scale bedforms in the lee of a submerged rocky shoal,which allowed defining it as a Banner *** internal structure of the sandbank reveals four seismic units(U1-U4)on a Cambrian basement(U0).The basal unit U1 is interpreted as reworked lowstand fluvial sediments those infilled micro incised valleys during a rise in sea *** unit is overlain by paleo-coastal barrier sand-spit(U2)whose development was controlled by swell in the context of a rapid rise in sea *** successive prograding unit(U3)is interpreted as flooding deposits in continuity with unit *** unit U4 is characterized by oblique reflectors oriented in two opposite *** last unit,dated post 3500 yr BP,corresponds to migrating dunes superimposed on the bank and observable in the high-resolution bathymetric *** strong correlation between tidal currents and the apparent clockwise migration of dune crests suggests the presence of a tidal gyre controlling the present-day dynamics of most of the Horaine bank *** study proposes a new model for the construction of banner banks characterized by the gradual transition of a sand spit to a banner bank during marine transgression and ensuing hydrodynamic variability.

关键词： Sand banks Banner bank Holocene climate Geomorphology Sea level rise Tidal gyre

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Lightweight Key Management Scheme Using Fuzzy Extractor for Wireless Mobile Sensor Network

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Computers, Materials & Continua 2022年第4期71卷 1695-1712页

作者： Eid Rehman Ibrahima kalil Toure Kashif Sultan Muhammad Asif Muhammad Habib Najam Ul Hasan Oh-Young Song Aaqif Afzaal Abbasi Department of Software Engineering Foundation UniversityIslamabad44000Pakistan Centre Informatique Universite Gamal Abdel Nasser deConakryGuinea Department of Software Engineering Bahria University Islamabad CampusIslamabadPakistan GDC Ahmad Karak Higher Education DepartmentKhyber PakhtunkhwaPakistan Department of Electrical and Computer Engineering Dhofar UniversitySalalahOman Department of Software Sejong UniversitySeoul05006Korea

The mature design of wireless mobile sensor network makes it to be used in vast verities of applications including from home used to the security *** such types of applications based on wireless mobile sensor network are generally using real time data,most of them are interested in real time communication directly from cluster head of cluster instead of a base station in cluster *** would be possible if an external user allows to directly access real time data from the cluster head in cluster wireless mobile sensor network instead of accessing data from base *** this leads to a serious security breach and degrades the performance of any security protocol available in this *** existing schemes for authentication and cluster key management for external users,exchange a number of messages between cluster head and base station to allow external to access real time data from the base station instead of cluster *** increase communication cost and delay in such real time access *** handle this critical issue in cluster wireless mobile sensor network,we propose a lightweight authentication and key management scheme using a fuzzy *** this scheme,any external user can access data directly from the cluster head of any cluster without the involvement of the base *** proposed scheme only uses the one-way hash functions and bitwise XOR operations,apart from the fuzzy extractor method for the user biometric verification at the login *** presented scheme supports scalability for an increasing number of nodes using *** proposed scheme increases the life-time of the network by decreasing the key pool size.

关键词： Fuzzy extractor user authentication key management cluster session key wireless mobile sensor network