检索结果-南通市图书馆

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta Lara Ordónez-gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Species Diversity of Entomopathogenic Fungi Infecting the Sugarcane Aphid <i>Melanaphis sacchari</i>: A Recently Introduced Pest in Mexico

在线全文

学校读者我要写书评

暂无评论

Advances in Microbiology 2019年第1期9卷 38-55页

作者： jorge Zambrano-gutiérrez Raquel Alatorre-Rosas María G. Carrillo-Benítez J. Refugio Lomelí-Flores Remigio A. Guzmán-Plazola Ausencio Azuara-Domínguez Antonio P. Terán-Vargas Programa de Fitosanidad Colegio de Postgraduados Texcoco Mexico Posgrado en Biología Instituto Tecnológico de Ciudad Victoria Ciudad Victoria Mexico Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias Campo Experimental Las Huastecas Cuauhtémoc Mexico

The sugarcane aphid, Melanaphis sacchari, is a key pest that affects sorghum in Mexico. During 2014 to 2016, in South of Tamaulipas sites and Bajio region in Guanajuato, the populations of this aphid were infected by different species of Hypocrealean fungi. Based in the morphometric identification and molecular characterization, the species associated with sugarcane aphid in South of Tamaulipas were Lecanicillium longisporum, Beauveria bassiana and Isaria javanica. In this region, the higher infection levels were caused by L. longisporum, mortality range from 30.0% to 50.0%. The presence of I. javanica and B. bassiana represented less than 26.0% and 10.0%, respectively. In Guanajuato, the species found corresponded to L. longisporum and B. bassiana. The infection levels of both species in sugarcane aphid populations in Guanajuato sites were less than 1.00%. The natural occurrence of entomopathogenic fungi on sugarcane aphid populations was associated with climactic factors such as temperature and relative humidity and development of infections was possibly affected by abiotic factors such as crop phenological stage and applications of chemical insecticides realized by farmers for control of this aphid. Further studies on the ecology and physiology of these fungi and trials to determine virulence and persistence in M. sacchari populations are needed. This is the first report on natural presence of L. longisporum, B. bassiana and I. javanica causing disease on Melanaphis sacchari in Guanajuato and Tamaulipas, Mexico.

关键词： Aphid Sorghum Hypocrealean Fungi Native Isolates Identification

Effect of logging on rodent scatter-hoarding dynamics in tropical forests:implications for plant recruitment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2011年第2期6卷 74-80页

作者： Gabriel gutiérrez-GRANADOS Department of Zoology Institute of BiologyNational Autonomous University of MexicoMexico DFMexico

The present study tested the hypothesis that logging affects the scatter-hoarding behavior of rodents,which,in turn,negatively affects the quantity and quality of Pouteria campechiana(Sapotaceae)seed dispersal.A series of seed stations was established in logged and unlogged forests of ejido Senor,Yucatan Peninsula,and comparisons were made between logged and unlogged forests in terms of:(i)seed removal;(ii)number of seeds hoarded;(iii)hoarding distance;and(iv)the number of recruits and the survival of hoarded *** number of both hoarded and removed seeds was significantly higher in unlogged ***,the mean distance of hoarding was greater in unlogged compared with logged *** recruitment and survival were present in both logged and unlogged sites,there were more surviving seedlings in unlogged *** data indicate that both the quantity and quality of seed dispersal are negatively affected by logging because of a change in the rodent scatter-hoarding *** changes suggest that plant-animal interactions are crucial to the understanding of the ecology and conservation of managed tropical forests.

关键词： Dasyprocta punctata seed caching timber extraction Yucatan Peninsula

A building energy models calibration methodology based on inverse modelling approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2022年第11期15卷 1883-1898页

作者： Vicente gutiérrez González Carlos Fernández Bandera Installations construction and structuresSchool of ArchitectureUniversity of NavarraCampus UniversitarioPamplona31009NavarraSpain

Nowadays,building energy models(BEMs)are widely used,particularly in the assessment of energy consumption in buildings to address the potential savings that can be *** realisation of a dynamic energy model based on high-fidelity physics(white-box models)requires a tuning process to fit the model to reality,due to many uncertainties *** some research trends try to reduce this performance gap by modulating different types of experimental parameters such as:capacitances or *** EnergyPlus simulation software,in its latest versions,has implemented an object:HybridModel:Zone that calculates the infiltration and internal mass of buildings using an inverse modelling approach that employs only the measured indoor temperature data to invert the heat balance equation for the zone under *** main objective of this paper is to reduce the execution time and uncertainties in the development of quality energy models by generating a new calibration methodology that implements this *** uses,as a starting point,a research created by the authors of this study,which was empirically and comparatively validated against the energy models developed by the participants in Annex *** is also worth highlighting the empirical validation of the HybridModel:Zone object,since it was activated in all scenarios where its execution is possible:periods of seven days or more of free oscillation and periods in which the building is under *** findings are *** data generated with the new methodology,if compared with those produced by the baseline model,improve their resemblance to the real ones by 22.9%.While those of its predecessor did it by 15.6%.For this study,the two dwellings foreseen in Annex 58 of the IEA ECB project have been modelled and their real monitoring data have been used.

关键词： internal thermal mass energy simulation EnergyPlus inverse model Annex 58 infiltration

Summing Boolean Algebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2004年第5期20卷 949-960页

作者： Antonio AIZPURU Antonio guti■rrez-D■VILA Departamento de Matemáticas Universidad de CádizApdo4011510-Puerto Real(Cádiz)Spain

In this paper we will study some families and subalgebras■of■(N)that let us character- ize the unconditional convergence of series through the weak convergence of subseries ∑_(i∈A)x_i,A∈(?). As a consequence,we obtain a new version of the Orlicz Pettis theorem,for Banach *** also study some relationships between algebraic properties of Boolean algebras and topological properties of the corresponding Stone spaces.

关键词： Unconditionally convergent series (weak)Summation Orlicz Pettis theorem Boolean Algebras

Nodal user’s demand response based on incentive based programs

在线全文

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2017年第1期5卷 79-90页

作者： Nestor GONZáLEZ-CABRERA Guillermo gutiérrez-ALCARAZ Instituto Tecnolo´gico Superior de Irapuato Irapuato 36620Mexico Instituto Tecnolo´gico de Morelia Morelia 58120Me´xico

This paper describes a practical approach to identify nodal price compensation payment for nodal consumers willing to reduce their energy consumption(consumers’ demand response). The implementation of a nodal reliability service pricing is based on contingency assessment of N-2 order for transmission lines. A representative annualized demand curve is used to reflect the system’s operation condition by seasons. Such curve is used to access the nodal reliability impact trough a whole year in order to determine back-payments(incentive payment) to users for service interruption. The IEEE_RTS 24 nodes system is used to implement the proposed approach.

关键词： Nodal demand response Demand side management Reliability assessment Incentive based programs(IBP)

Induced pluripotent stem cells from Huntington's disease patients:a promising approach to define and correct disease-related alterations

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第5期14卷 769-770页

作者： Azra Fatima Ricardo gutiérrez-Garcia David Vilchez Institute for Genetics and Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases(CECAD) University of Cologne

Adult somatic cells such as skin or blood cells from either health donors or patients can be reprogrammed into induced pluripotent stem cells(iPSCs).Given their unlimited self-renewal and differentiation capacities,iPSCs are an invaluable resource to generate terminally differentiated ***,iPSCs can facilitate the study of human diseases and drug screening,holding great promise for regenerative *** significant advantage of iPSC disease-modeling is that normal and mutant proteins are expressed at endogenous *** addition,subtle phenotypes and the effects of genetic background variations can be assessed by comparison between iPSC lines obtained from different patients and healthy donors as well as isogenic lines,in which disease-related mutations are corrected.

关键词： Adult somatic cells skin or blood cells Huntington’s disease patients

Ursane derivatives isolated from leaves of Hylocereus undatus inhibit glycation at multiple stages

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2018年第11期16卷 856-865页

作者： ROSA MARTHA Pérez-gutiérrez SUSANA GABRIELA Enriquez-Alvirde Research Laboratory of Natural Products School of Chemical Engineering and Extractive Industries National Polytechnic Institute

The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products(AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12-en-28-oic acid(1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic acid(2), as well as four known triterpenes 2α, 3β, 23-tetrahydroxy-urs-11-en-28-oic acid(3), 3β-acetoxy-28-hydroxyolean-12-ene(4), 3β, 16α-dihidroxyolean-12-ene(5) and 3β-acetoxy-olean-12-ene(6). Our results revealed that triterpenes 1–3 were able to inhibit the formation of AGEs in all tested assays. The data indicated that the triterpenes had inhibitory activity at the múltiple stages of glycation and that there might be a high potential for decreasing protein oxidation and protein glycation that can enhance glycative stress in diabetic complications.

关键词： Hylocereus undatus Advanced glycation end product Triterpenes

Deep Neural Network-Based 4-Quadrant Analog Sun Sensor Calibration

在线全文

学校读者我要写书评

暂无评论

Space(Science & Technology) 2023年第1期3卷 193-205页

作者： Qinbo Sun Jose Luis Redondo gutiérrez Xiaozhou Yu School of Astronautics Northwestern Polytechnical UniversityXi’anChina Institute of Space Systems German Aerospace CenterCologneGermany Dalian University of Technology DalianChina

Many error sources influence the calibration experiment of 4-quadrant sun sensors,making the calibration of sun sensors cumbersome and its accuracy difficult to *** continuous function on a bounded closed set can be approximated by a deep neural *** paper uses the deep neural network model to approximate the error *** data-driven training network is adopted to continuously modify the model parameters to fit the error compensation model and ensure that the accuracy reaches the target requirements after *** that the deep neural network model needs a considerable amount of data,the neural network model training is divided in 2 *** the preliminary stage,cubic surface fitting is used to generate a dataset,which is small in size and *** the completion of the initial training,the experimental data are used to fine-tune the model to achieve error *** accuracy can be improved from 1°(1σ)to 0.1°(1σ)after the incident angle of the sun sensor is *** error compensation model eliminates the loss of accuracy caused by the distortion of light spots at the edge of the field angle and provides a favorable condition for the expansion of the field angle of the 4-quadrant analog sun sensor.

关键词： neural Deep network