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Application of antigenic biomarkers for Mycobacterium tuberculosis

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第11期21卷 856-870页

作者： Elba RODRIGUEZ-HERNANDEZ Laura Itzel QUINTAS-GRANADOS Susana FLORES-VILLALVA jorge germinal canto-alarcon Feliciano MILIAN-SUAZO Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias(INIFAP)Centro Nacional de Investigacion Disciplinaria en Fisiologia y Mejoramiento AnimalKm.1 Carretera a ColonAjuchitlan Colon76280ColonQueretaroMexico Universidad Mexiquense del Bicentenario Unidad de Estudios Superiores de TultitlanAvenida Ex-Hacienda de Portales s/nVilla EsmeraldaTultitlan Estado de Mexico54910TultitlanMexico Universidad Autonoma de Queretaro Facultadde Ciencias NaturalesAvenida de las Ciencias s/nJuriquillaDelegacion Santa Rosa Jauregui76230QueretaroMexico

The study and characterization of biomolecules involved in the interaction between mycobacteria and their hosts are crucial to determine their roles in the invasion process and provide basic knowledge about the biology and pathogenesis of *** new biomarkers for diagnosis and immunotherapy have emerged *** is an ancient pathogen that has developed complex strategies for its persistence in the host and environment,likely based on the complexity of the network of interactions between the molecules involved in *** biomarkers have received recent attention in the process of developing rapid and reliable detection techniques for *** the most widely investigated antigens are CFP-10(10-kDa culture filtrate protein),ESAT-6(6-kD a early secretory antigenic target),Ag85 A,Ag85 B,CFP-7,and *** of these antigens have been proposed as biomarkers to assess the key elements of the response to infection of both the pathogen and *** design of novel and accurate diagnostic methods is essential for the control of tuberculosis ***,the diagnostic methods are based on the identification of molecules in the humoral response in infected ***,these tests depend on the capacity of the host to develop an immune response,which usually is *** the last 20 years,special attention has been given to the design of multiantigenic diagnostic methods to improve the levels of sensitivity and *** this review,we summarize the state of the art in the study and use of mycobacterium biomolecules with the potential to support novel tuberculosis control strategies.

关键词： Mycobacterium tuberculosis Recombinant antigen Diagnostics Biomarker

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Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men

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Asian Journal of Andrology 2017年第2期19卷 184-190页

作者： Lidia Minguez-alarcon jorge E Chavarro JJaime Mendiola Manuela Roca Cigdem Tanrikut Jesus Vioque Niels jorgensen Alberto M Torres-Cantero Department of Environmental Health Harvard School of Public Health Boston Massachusetts USA Department of Health and Social Sciences Division of Preventive Medicine and Public Health University of Murcia School of Medicine IMIB-Arrixaca Espinardo (Murcia) Spain Department of Nutrition Harvard School of Public Health Boston Massachusetts USA Department of Epidemiology Harvard School of Public Health Boston Massachusetts USA Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston Massachusetts USA Roca Fertility Advanced Clinic Management SLU Murcia Spain Department of Urology Massachusetts General Hospital Boston Massachusetts USA Department of Surgery Harvard Medical School Boston Massachusetts USA ClBER Epidemiology and Public Health (ClBERESP) Institute of Health Ill (ISClII) Madrid Spain Department of Public Health Miguel Hernandez University EIche-Alicante Spain Department of Growth and Reproduction University of Copenhagen Rigshospitalet Copenhagen Denmark Regional Campus of International Excellence 'Campus Mare Nostrum' University of Murcia Murcia Spain

Emerging evidence suggests that dietary fats may influence testicular function. However, most of the published literature on this field has used semen quality parameters as the only proxy for testicular function. We examined the association of fat intake with circulating reproductive hormone levels and testicular volume among healthy young Spanish men. This is a cross-sectional study among 209 healthy male volunteers conducted between October 2010 and November 2011 in Murcia Region of Spain. Participants completed questionnaires on lifestyle, diet, and smoking, and each underwent a physical examination, and provided a blood sample. Linear regression was used to examine the association between each fatty acid type and reproductive hormone levels and testicular volumes. Monounsaturated fatty acids intake was inversely associated with serum blood levels of calculated free testosterone, total testosterone, and inhibin B. A positive association was observed between the intake of polyunsaturated fatty acids, particularly of omega-6 polyunsaturated fatty acids, and luteinizing hormone concentrations. In addition, the intake of trans fatty acids was associated with lower total testosterone and calculated free testosterone concentrations （Ptrend = 0.01 and 0.02, respectively）. The intake of omega-3 polyunsaturated fatty acids was positively related to testicular volume while the intake of omega-6 polyunsaturated fatty acids and trans fatty acids was inversely related to testicular volume. These data suggest that fat intake, and particularly intake of omega 3, omega 6, and trans fatty acids, may influence testicular function.

关键词： fat intake reproductive health reproductive hormones trans fatty acids young healthy men

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Effects of drying method on bioactive compounds contents,rumen fermentation parameters and in vitro methane output of waste dried País grape(Vitis vinifera L.)marc

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Food Bioscience 2023年第1期51卷 1324-1330页

作者： Sandra Tatiana Suescun-Ospina jorge Avila-Stagno Nelson Vera-Aguilera Rita Astudillo-Neira Igor Trujillo-Mayol Julio alarcon-Enos Facultad de Ciencias Veterinarias Universidad de ConcepcionChillanChile Escuela de Ciencias Animales Universidad de los LlanosVillavicencioMetaColombia Centro de Estudios Agrícolas y Alimentarios Programa de Ciencia y Tecnología de AlimentosUniversidad del Valle de GuatemalaGuatemala CiudadGuatemala Departamento de Ciencias Basicas Grupo de Investigacion en Química y Biotecnología de Productos Naturales BioactivosFacultad de CienciasUniversidad del Bio BioChillanChile

Grape marc(GM)from País winery is an abundant resource with potential use in animal feed in Chile,but information on its chemical composition,bioactive compounds and enteric methane(CH4)emissions is not *** conditions could change the chemical composition and bioactive compounds of País GM,and affect CH4 ***,the objectives of this study were to assess the effects of drying conditions on the chemical composition and bioactive compounds of País GM,and rumen fermentation parameters and CH4 *** first experiment evaluated the effects of three drying conditions(freeze-drying,and oven drying at 40℃/72-h and 60℃/48-h)on the contents of bioactive compounds,antioxidant capacity and chemical composition of País *** second experiment evaluated and compared rumen fermentation parameters and CH4 output of dried País ***-dried País GM had the highest concentrations of phenolic compounds(p=0.001),but oven-dried País GM(60℃/48-h)showed the highest content of proanthocyanidins(p=0.043).Ash(p=0.003),ether extract(p=0.042)and non-fiber carbohydrate(p=0.033)contents were higher in oven-dried País GM,as opposed to neutral detergent fiber or acid detergent *** drying GM at 60℃/48-h reduced dry matter disappearance(p<0.001),and gas production(p=0.001),but also showed lower CH_(4)production(p<0.001)and yield(p=0.001)as compared to freeze dried *** suggest that oven-drying is useful to conserve GM chemical value,extend its’shelf-life and allows use of País GM as ruminant feed with potential positive environmental effects on enteric CH4 emissions but further in vitro and in vivo studies with GM as a dietary ingredient are required.

关键词： Wine by-products Bioactive compounds Mitigation Livestock

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Acute postoperatory visual loss following bilateral lung transplantation surgery:a case series

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 822-825页

作者： Rosa Gutierrez-Bonet jorge Ruiz-Medrano Maria alarcon-Tomas Mónica Hijos Pilar Cifuentes-Canorea Puerta de Hierro University Hospital Ophthalmology Department Madrid 28222 Spain Jules Gonin Eye Hospital Lausanne 1002 Switzerland Clinico San Carlos University Hospital Madrid 28040 Spain

Dear Editor,I am Rosa Gutiérrez Bonet,former ophthalmology resident at Puerta de Hierro University Hospital,Madrid,Spain.I write to present four cases of cortical blindness（CB）after bilateral lung transplant（LT）.

关键词： lung Acute postoperatory visual loss following bilateral lung transplantation surgery a case series case

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婴儿常见胃肠道症状的实用处理法则(三)

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临床儿科杂志 2013年第9期31卷 898-900页

作者： Yvan Vandenplas Pedro Gutierrez-Castrellon Carlos Velasco-Benitez jorge Palacios Domingo Jaen Hugo Ribeiro Lynette Pei-Chi Shek Bee-Wah Lee Pedro alarcon 布鲁塞尔自由大学国家围生期学研究中心瓦莱大学圣卡洛斯大学委内瑞拉中央大学巴伊亚联邦大学研究中心新加坡国立大学雅培营养

1牛奶蛋白过敏症（CMPA）尽管缺乏系统的流行病学研究，但已知牛奶是全球婴幼儿及低龄儿童食物过敏的最常见原因之一。CMPA通常表现为胃肠道功能障碍，如呕吐和腹泻。明确诊断对于治疗的选择非常关键，因为避免摄入CMP可消除相关症状，... 详细信息

1牛奶蛋白过敏症（CMPA）尽管缺乏系统的流行病学研究，但已知牛奶是全球婴幼儿及低龄儿童食物过敏的最常见原因之一。CMPA通常表现为胃肠道功能障碍，如呕吐和腹泻。明确诊断对于治疗的选择非常关键，因为避免摄入CMP可消除相关症状，而不必要的饮食限制和禁忌则可导致婴儿生长发育受到影响或出现营养不良。1．

关键词：婴儿生长发育胃肠道症状胃肠道功能障碍用处蛋白过敏症流行病学食物过敏低龄儿童

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婴儿常见胃肠道症状的实用处理法则(二)

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临床儿科杂志 2013年第8期31卷 797-800页

作者： Yvan Vandenplas Pedro Gutierrez-Castrellon Carlos Velasco-Benitez jorge Palacios Domingo Jaen Hugo Ribeiro Lynette Pei-Chi Shek Bee-Wah Lee Pedro alarcon 布鲁塞尔自由大学比利时布鲁塞尔国家围生期学研究中心墨西哥墨西哥城瓦莱大学哥伦比亚卡利圣卡洛斯大学危地马拉危地马拉城委内瑞拉中央大学委内瑞拉巴伊亚联邦大学研究中心巴西萨尔瓦多新加坡国立大学新加坡雅培营养美国俄亥俄州哥伦布

1烦躁、腹部胀气伴哭闹很多婴儿因为烦躁和腹部胀气而表现出痛苦的样子,但同时几乎所有这些婴儿都会经常哭闹,因而照护者更倾向于关注婴儿的哭闹而非其他症状或体征。因此,在这种情况下,完善病史信息非常关键。婴儿经常通过哭闹来沟通... 详细信息

1烦躁、腹部胀气伴哭闹很多婴儿因为烦躁和腹部胀气而表现出痛苦的样子,但同时几乎所有这些婴儿都会经常哭闹,因而照护者更倾向于关注婴儿的哭闹而非其他症状或体征。因此,在这种情况下,完善病史信息非常关键。婴儿经常通过哭闹来沟通和表达自己。而哭闹可有多种原因：饥饿或希望得到关注,或者出现了严重的威胁生命的疾病。健康婴儿从出生后不久便开始哭闹,每天20 min至3.5 h[1]。

关键词：健康婴儿胃肠道症状用处腹部胀气哭闹烦躁

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婴儿常见胃肠道症状的实用处理法则(一)

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临床儿科杂志 2013年第7期31卷 697-700页

在婴儿,特别是配方奶喂养的婴儿中功能性胃肠道（GI）症状较为常见[1]。应对这一问题,儿科医师常采用更换配方奶的方式来处理。由于治疗婴儿功能性GI症状的双盲的、安慰剂对照的、前瞻性干预的试验非常有限,本文在世界各地儿童胃肠病专... 详细信息

在婴儿,特别是配方奶喂养的婴儿中功能性胃肠道（GI）症状较为常见[1]。应对这一问题,儿科医师常采用更换配方奶的方式来处理。由于治疗婴儿功能性GI症状的双盲的、安慰剂对照的、前瞻性干预的试验非常有限,本文在世界各地儿童胃肠病专科医师和过敏症专科医师一致意见的基础上,制定了婴儿常见GI的实用处理法则,并具体介绍各种婴幼儿.

关键词：胃肠道症状婴儿用处配方奶喂养专科医师安慰剂对照儿科医师功能性

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*** imaging of retinal pericytes:evidence for early calcium uptake,capillary constriction and vascular dysregulation in ocular hypertension glaucoma

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Annals of Eye Science 2018年第1期 417-417页

作者： Luis alarcon-Martinez jorge L.Cueva Vargas Nicolas Belforte Deborah Villafranca-Baughman Adriana Di Polo Department of Neuroscience University of Montreal Hospital Research Center(CR-CHUM)MontrealQuebecCanada

Background:Pericytes are contractile cells that wrap along the walls of *** the brain,pericytes play a crucial role in the regulation of capillary diameter and vascular blood flow in response to metabolic *** contribution of pericytes to microvascular deficits in glaucoma is currently *** address this,we used two-photon excitation microscopy for longitudinal monitoring of retinal pericytes and capillaries in a mouse glaucoma ***:Ocular hypertension was induced by injection of magnetic microbeads into the anterior chamber of albino mice expressing red fluorescent protein selectively in pericytes(NG2-DsRed).Minimally invasive,multiphoton imaging through the sclera of live NG2-DsRed mice was used to visualize pericytes and capillary diameter at one,two and three weeks after glaucoma *** vivo fluctuations in pericyte intracellular calcium were monitored with the calcium indicator *** vivo stereological analysis of retinal tissue prior to and after injection of microbeads was used to confirm our in vivo ***:Live two-photon imaging of NG2-DsRed retinas demonstrated that ocular hypertension induced progressive accumulation of intracellular calcium in *** uptake correlated directly with the narrowing of capillaries in the superficial,inner,and outer vascular plexuses(capillary diameter:naïve control=4.7±0.1μm,glaucoma=4.0±0.1μm,n=5-6 mice/group,Student’s t-test P<0.05).Frequency distribution analysis showed a substantial increase in the number of small-diameter capillaries(≤3μm)and a decrease in larger-diameter microvessels(≥5-9μm)at three weeks after induction of ocular hypertension(n=5-6 mice/group,Student’s t-test P<0.05).Conclusions:Our data support two main ***,two-photon excitation microscopy is an effective strategy to monitor longitudinal changes in retinal pericytes and capillaries in live animals at glaucoma onset and ***,ocular hypertension triggers rapid int

关键词： Glaucoma pericytes capillaries in vivo two-photon microscopy

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Diffuse Large B-Cell Lymphoma with Anaplastic Clear Cells: A Rare Variant

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Open Journal of Pathology 2012年第4期2卷 150-154页

作者： Mónica Belinda Romero-Guadarrama Leslie Elizmara Aguilar-Ayala German Ott jorge Pérez-Espinosa Department of Clinical Pathology Robert-Bosch-Hospital Stuttgart Germany Unit Pathology Hospital General de México OD and Medicine School Autonomous National University of Mexico Mexico City Mexico

Introduction: Diffuse Large B-Cell Lymphoma (DLBCL) is a heterogeneous group conformed by morphological and clinical varieties of neoplasms;it originates from peripheral B-cells and is distinguished into three groups: germinal center (GC), activated B lymphocyte (ABL), and the third type. The existence of DLBCL with anaplastic morphology and expression of CD30 without t (2;5) translocation is rare. The aim of the present article is to describe this morphologic variant in a 54-year-old woman and a 74-year-old man, respectively. Materials and Methods: Patients diagnosed with DLBCL with anaplastic variant were identified from the surgical pathology records. Results: Out of 357 biopsies with this diagnosis, 11 (3%) corresponded to the anaplastic variant, 2 presented morphological clear cells;they became visible because of an increase in volume in the cervical area of 4 months of evolution, usually associated to diaphoresis and weight loss with clinical fulminating progression. An autopsy study was performed to one patient and it showed infiltration in supraclavicular lymph nodes, thyroid, and lung. The neoplastic cells presented abundant clear cytoplasm and pleomorphic nuclei that expressed CD20, CD30 and CD45. Conclusion: This variation is rare. The clinical presentation and prognosis are controversial;we present the morphological and immunophenotype changes of this variant. The differential diagnosis from other clear cell neoplasms should be made.

关键词： B-Cell Anaplastic Lymphoma with Clear Cells

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