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Roots and rhizom.s of wild Asparagus:Nutritional com.osition,bioactivity and nanoencapsulation of the m.st potent extract

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Food Bioscience 2022年第1期45卷 349-360页

作者： Khaoula Adouni Ana Júlio Celestino Santos-Buelga Ana m.Gonzalez-Param.s Patrícia Filipe Patricia Rijo Sofia A.Costa Lim. Salette Reis Angela Fernandes Isabel C.F.R.Ferreira Virginia Fernandez-Ruiz Patricia m.rales Guido Flam.ni Lotfi Achour Pedro Fonte Laboratoire de Recherche“Bioressources:Biologie Integrative&Valorisation” Institut Superieur de Biotechnologie de MonastirAvenue Tahar HaddedBP 74Universite de Monastir5000MonastirTunisia CBIOS-Research Center for Biosciences&Health Technologies Universidade Lusofona de Humanidades e TecnologiasCampo Grande 3761749-024LisbonPortugal Departm.nt of Biom.dical Sciences University of Alcal´aCtra.Madrid-Barcelona Km.33.60028871Alcala de HenaresMadridSpain Grupo de Investigacion en Polifenoles(GIP-USAL) Facultad de FarmaciaUniversidad de SalamancaCampus Miguel de UnamunoE-37007SalamancaSpain Research Institute for m.dicines(im.d.ULisboa) Faculty of PharmacyUniversidade de LisboaAv.Professor Gama Pinto1649-003LisboaPortugal LAQV REQUIMTEDepartment of Chemical Sciences–Applied Chemistry LabFaculty of Pharmacy10 University of PortoRua Jorge de Viterbo Ferreira 2284050-313PortoPortugal Centro de Investigacao de m.ntanha(CIm.) Instituto Politecnico de BragancaCampus de Santa Apolonia5300-253BragancaPortugal Departm.nt of Nutrition and Food Science Faculty of PharmacyComplutense University of Madrid(UCM)Plaza Ramon y Cajal s/n28040MadridSpain Dipartim.nto di Farm.cia University of Pisavia Bonanno 656126PisaItaly Centro Interdipartim.ntale di Ricerca“Nutraceutica e Alim.ntazione per la Salute”University of Pisa Via del Borghetto 8056124PisaItaly Center for m.rine Sciences(CCm.r) University of AlgarveGambelas Campus8005-139FaroPortugal Departm.nt of Chem.stry and Pharm.cy Faculty of Sciences and TechnologyUniversity of AlgarveGambelas Campus8005-139FaroPortugal iBB-Institute for Bioengineering and Biosciences Department of BioengineeringInstituto Superior TecnicoUniversidade de Lisboa1049-001LisboaPortugal Associate Laboratory i4HB—Institute for Health and Bioeconom. at Instituto Superior Tecnico Universidade de LisboaAv.Rovisco Pais1049-001LisboaPortugal

The nutritional com.osition and bioactive properties of roots and rhizom.s of Asparagus stipularis were *** activity of extracts obtained by infusion was evaluated using free radicals scavenging and reducing power *** liver prim.ry cell was used to check the hepatotoxicity of *** revealed that Asparagus sam.les are likely a source of nutrients,such as dietary fibre and essential fatty ***-DAD-ESI/m. characterization of infusions allowed the identification and quantitation of 7 phenolic com.ounds,all hydroxycinnam.yl derivatives,with caffeic acid as the m.st *** infusion contained the highest am.unts of these *** also exhibited the highest antioxidant activity in all assays,with EC_(50) values of 0.44±0.01,0.98±0.03 and 0.64±0.01 m./m. for DPPH,ABTS and FRAP assays,respectively,with no toxicity towards PLP2 prim.ry cell cultures(GI_(50)>400μg/m.).PLGA nanoparticles loaded with root extract were prepared using solvent-evaporation double em.lsion *** size was about 260 nm.and a polydispersity index around 0.1,with a zeta potential of about-36 m.,as well as a good encapsulation efficiency of approxim.tely 83%.Their m.rphology was analysed by SEm.and spherical polym.ric nanoparticles with a sm.oth surface were *** and DSC were also perform.d,which allowed corroborating the efficacy of the encapsulation and to confirm.the production of a stable and robust system.to load Asparagus *** developed nanoparticles are expected to be used as delivery system. for bioactive com.ounds of *** and they could be used as an innovative dietary supplem.nt.

关键词： Asparagus stipularis Nutritional com.osition Antioxidant activity Nanoparticles PLGA

Oxidation of glycerol with H_2O_2 on Pb-prom.ted Pd/γ-Al_2O_3 catalysts

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Chinese Journal of Catalysis 2016年第11期37卷 1982-1990页

作者： m.ría L.Faroppa Juan J.m.sci m.ría E.Chiosso Claudia G.Caggiano Hernán P.Bideberripe José L.García Fierro Guillerm. J.Siri m.nica L.Casella 布宜诺斯艾利斯西北国立大学 CIBA(CIT UNNOBACONICET) 拉普拉塔国立大学科学学院 CINDECA(CCT La Plata-CONICETUNLP) 拉普拉塔国立大学工程学院PIDCAT 西班牙国家研究委员会(CSIC)催化与石油化学研究所

A series of bim.tallic Pd-Pb catalysts with a constant Pd content of 1 wt%and Pb/Pd atom.c ratio from.0 to 1.6 supported on γ-Al2O3 were prepared and used for glycerol oxidation with H2O2 as the oxidizing agent at atm.spheric pressure,45℃ and pH =*** m.rphology and dispersion of the catalysts were characterized by scanning electron m.croscopy-energy dispersive X-ray spectroscopy（SEm.EDX） and transm.ssion electron m.croscopy（TEm..The presence of an alloy phase in the bim.tallic catalyst was detected by X-ray photoelectron spectroscopy（XPS）.Glycerol conversion obtained with the m.nom.tallic Pd catalyst was 19%,which was increased to 100%with the addition of *** four bim.tallic PdPb catalysts were able to oxidize glycerol to dihydroxyacetone（DIHA） and the selectivity to DIHA reached 59%,58%,34%and 25%for PdPb0.25,PdPb0.50,PdPb1.00 and PdPbl.60 catalysts,respectively.

关键词： Palladium Bim.tallic palladium.lead catalyst Hydrogen peroxide Glycerol oxidation Glyceric acid Glycolic acid

Dendritic cell deficiencies persist seven m.nths after SARS-CoV-2 infection

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Cellular & m.lecular Im.unology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Góm.z Joana Vitallé Carm.n Gasca-Capote Alicia Gutierrez-Valencia m.ría Trujillo-Rodriguez Ana Serna-Gallego Esperanza m.ñoz-m.ela m.ría de los Reyes Jim.nez-Leon m.ham.d Rafii-El-Idrissi Benhnia Inm.culada Rivas-Jerem.as Cesar Sotom.yor Cristina Roca-Oporto Nuria Espinosa Carm.n Infante-Dom.nguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-m.teos Josém.guel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Cam.cho-m.rtínez Carm.n Infante-Dom.nguez m.rta Carretero-Ledesm. Juan Carlos Crespo-Rivas Eduardo m.rquez Josém.nuel Lom.s Claudio Bueno Rosario Am.ya JoséAntonio Lepe Jerónim. Pachón Elisa Cordero Javier Sánchez-Céspedes m.nuela Aguilar-Guisado Alm.dena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Am.deo Javier Am.uero m.ría Dolores Avilés m.ribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba m.xim. Bernabeu-Wittel Candela Caballero-Eraso m.carena Cabrera Enrique Calderón Jesús Carbajal-Guerrero m.nuela Cid-Cum.lido Yael Corcia-Palom. Juan Delgado Antonio Dom.nguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátim. Espinosa Nuria Espinosa m.chelle Espinoza Carm.n Ferrándiz-m.llón m.rta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gám.z-m.ncera Em.lio García Horacio García-Delgado m.nuel García-Gutiérrez m.ría Luisa Gascón-Castillo Aurora González-Estrada Dem.trio González Carm.n Góm.z-González Rocío González-León Carm.n Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inm.culada Concepción Herrera-m.lero m.rta Herrero-Rom.ro Luis Jara Carlos Jim.nez-Juan Silvia Jim.nez-jorge m.rcedes Jim.nez-Sánchez Julia Lanseros-Tenllado Carm.na López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-m.rquez Daniel m.cías-García Guillerm. m.rtín-Gutiérrez Luis m.rtín-Villén Josém.lina Aurora m.rillo m.ría Dolores Navarro-Am.edo Dolores Nieto-m.rtín Francisco Ortega m.ría Paniagua-García Am.lia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Departm.nt of m.dical Biochem.stry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneum.logy Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biom.dicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain m.dico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Em.rgencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Departm.nt of m.dicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheum.tology Unit Virgen del Rocío University HospitalSevilleSpain Internal m.dicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrom. Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflam.ation driven by innate im.unity *** cells(DCs)play a key role in the defense against viral infections,for instance plasm.cytoid DCs(pDCs),have the capacity to produce vast am.unts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC num.ers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and hom.ng m.rkers were altered in acute COVID-19 patients,which were associated with m.ltiple inflam.atory ***,previously hospitalized and nonhospitalized patients rem.ined with decreased num.ers of CD1c+m.eloid DCs and pDCs seven m.nths after SARS-CoV-2 ***,the expression of DC m.rkers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleam.ne 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the im.unological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

缅因街1217号大楼美国得克萨斯州达拉斯市

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世界建筑导报 2022年第1期37卷 54-57页

作者： Yen Ong Hoang Dang Paul m.rrill Josh Allen Adam.m.rk(摄影) 不详

缅因街1217号大楼位于达拉斯市中心,其的新颖设计是对20世纪50年代银行大楼进行的惊人改造。客户委托出生于古巴的艺术家jorge Pardo(麦克阿瑟基金会研究员,其作品集意在探索当代绘画、设计、雕塑和建筑的交集)设计了36215块手工制作的... 详细信息

缅因街1217号大楼位于达拉斯市中心,其的新颖设计是对20世纪50年代银行大楼进行的惊人改造。客户委托出生于古巴的艺术家jorge Pardo(麦克阿瑟基金会研究员,其作品集意在探索当代绘画、设计、雕塑和建筑的交集)设计了36215块手工制作的釉面瓷砖,并将其作为建筑物的主要覆层材料。这些瓷砖的灵感来自得克萨斯州蓝天的微妙变化,用不断变化的醒目颜色包裹着建筑物。

关键词：麦克阿瑟客户委托釉面瓷砖缅因手工制作得克萨斯州覆层材料当代绘画

Risk perception and knowledge of COVID-19 in patients with celiac disease

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World Journal of Gastroenterology 2021年第12期27卷 1213-1225页

作者： Jam.e Zhen Juan Pablo Stefanolo m.ría de la Paz Tem.rano Caroline L Seiler Alberto Cam.nero Enrique de-m.daria m.guel m.ntoro Huguet Vivas Santiago Sonia Isabel Niveloni Edgardo Gustavo Sm.cuol Luis Uzcanga Dom.nguez Elena Trucco Virginia Lopez Carolina Olano Pasquale m.nsueto Antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F Verdú Benjam.n Lebwohl m.Ines Pinto-Sanchez Departm.nt of m.dicine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada Departm.nt of m.dicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Departm.nt of Pancreatic Unit Hospital General Universitario de AlicanteAlicante 03010Spain Departm.nt of m.dicine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain Departm.nt of m.dicine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain Departm.nt of Gastroenterology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain Departm.nt of m.dicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico Departm.nt of m.dicine Universidad de la RepublicMontevideo 11800Uruguay Departm.nt of Internal m.dicine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy Departm.nt of Internal m.dicine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Celiac Disease Center Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States Departm.nt of m.dicine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada Departm.nt of Paediatrics University of Otago ChristchurchChristchurch 8041New Zealand Departm.nt of Gastroenterology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia Departm.nt of m.dicine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy Departm.nt of m.dicine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND We recently dem.nstrated that the odds of contracting coronavirus disease 2019(COVID-19)in patients with celiac disease(CeD)is sim.lar to that of the general ***,how patients with CeD perceive their COVID-19 risk m.y differ from.their actual *** To investigate risk perceptions of contracting COVID-19 in patients with CeD and determ.ne the factors that m.y influence their *** We distributed a survey throughout 10 countries between m.rch and June 2020 and collected data on dem.graphics,diet,COVID-19 testing,and risk perceptions of COVID-19 in patients with *** were recruited through various celiac associations,clinic visits,and social *** perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COVID-19 when com.ared to the general *** regression was used to determ.ne the influencing factors associated with COVID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and com.rbidities such as cardiac conditions,respiratory conditions,and *** was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD com.leted the *** them.6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COVID-19 com.ared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COVID-19 when com.ared to infections in general due to their CeD(56.1%vs 26.7%,Pm.ared to non-m.m.ers(49.5%vs 57.4%,Pm.le sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated

关键词： Celiac disease Gluten Risk Infection Knowledge Perception Coronavirus COVID-19

Fluctuating tem.erature m.difies heat-m.rtality association around the globe

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The Innovation 2022年第2期3卷 65-72页

作者： Yao Wu Bo Wen Shanshan Li Antonio Gasparrini Shilu Tong Ala Overcenco Ales Urban Alexandra Schneider Alireza Entezari Ana m.ria Vicedo-Cabrera Antonella Zanobetti Antonis Analitis Ariana Zeka Aurelio Tobias Barrak Alahm.d Ben Arm.trong Bertil Forsberg Carm.nÍñiguez Caroline Am.ling César De la Cruz Valencia ChristoferÅström.Danny Houthuijs Do Van Dung Dom.nic Royé Ene Inderm.tte Eric Lavigne Fatem.h m.yvaneh Fiorella Acquaotta Francesca de’Donato Francesco Sera Gabriel Carrasco-Escobar Haidong Kan Hans Orru Ho Kim.Iulian-Horia Holobaca Jan Kyselý Joana m.dureira Joel Schwartz Klea Katsouyanni m.gali Hurtado-Diaz m.rtina SRagettli m.sahiro Hashizum. m.thilde Pascal m.cheline de Sousa Zanotti Stagliorio Coélho Noah Scovronick Paola m.chelozzi Patrick Goodm.n Paulo Hilario Nascim.nto Saldiva Rosana Abrutzky Sam.el Osorio Tran Ngoc Dang Valentina Colistro Veronika Huber Whanhee Lee Xerxes Seposo Yasushi Honda m.chelle L.Bell Yum.ng Guo Departm.nt of Epidem.ology and Preventive m.dicine School of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Clim.te Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourne 3004Australia Departm.nt of Public Health Environments and SocietyLondon School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre for Statistical m.thodology London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Centre on Clim.te Change&Planetary Health London School of Hygiene&Tropical MedicineLondon WC1E 7HTUK Shanghai Children’s m.dical Centre Shanghai Jiao Tong UniversityShanghai 200025China School of Public Health Institute of Environment and Human HealthAnhui Medical UniversityHefei 230032China Center for Global Health Nanjing Medical UniversityNanjing 211166China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4000Australia National Agency for Public Health of the m.nistry of Health Labour and Social Protection of the Republic of MoldovaChisinau MD-2009Republic of Moldova Institute of Atm.spheric Physics Czech Academy of SciencesPrague 14100Czech Republic Faculty of Environm.ntal Sciences Czech University of Life SciencesPrague 16500Czech Republic Institute of Epidem.ology Helmholtz Zentrum M€unchen-German Research Center for Environmental HealthNeuherberg 85747Germany Faculty of Geography and Environm.ntal Sciences Hakim Sabzevari UniversitySabzevar ***Iran Institute of Social and Preventive m.dicine University of BernBern 3012Switzerland Oeschger Center for Clim.te Change Research University of BernBern 3012Switzerland Departm.nt of Environm.ntal Health Harvard T.H.Chan School of Public HealthHarvard UniversityBostonMA 02115USA Departm.nt of Hygiene Epidemiology and Medical StatisticsNational and Kapodistrian University of AthensAthens 11527Greece Institute for Environm.nt Healthand SocietiesBrunel University LondonLondon UB83PNUK Institute of Environm.ntal Assessm.nt and

Studies have investigated the effects of heat and tem.erature variability(TV)on ***,few assessed whether TV m.difies the heat-m.rtality *** on daily tem.erature and m.rtality in the warm.season were collected from.717 locations across 36 *** was calculated as the standard deviation of the average of the sam. and previous days’m.nim.m.and m.xim.m.tem.eratures.

关键词： deviation m.dif heat