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Clustering of voltage-gated ion channels as an evolutionary trigger of myelin formation

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Neural Regeneration Research 2024年第8期19卷 1631-1632页

作者： Henrike Ohm Simone rey Christian Klambt Institut fur Neuro-und Verhaltensbiologie MunsterGermany

Neurons carry apical dendrites that perceive information and a basal axon that transmits the computed information towards its to *** axon originates at the axon hillock which is followed by the axon initial ***,action potentials are initiated that are based on millisecond long openings of specific voltagegated sodium and potassium channels that are conserved in all parahoxozoa(Placozoa,Cnidaria,Bilateria)(Li et al.,2015).

关键词： initiated carry potassium

Predicting intensive care unit-acquired weakness:A multilayer perceptron neural network approach

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World Journal of Clinical Cases 2024年第12期12卷 2023-2030页

作者： Carlos Martin ardila Daniel González-Arroyave Mateo Zuluaga-Gómez Department of Basic Sciences University of AntioquiaMedellín 52-59Colombia Department of Surgery Pontificia Universidad BolivarianaMedellín 0057Colombia Department of Emergency Universidad Pontificia BolivarianaMedellín 0057Colombia

In this editorial,we comment on the article by Wang and Long,published in a recent issue of the World Journal of Clinical *** article addresses the challenge of predicting intensive care unit-acquired weakness(ICUAW),a neuromuscular disorder affecting critically ill patients,by employing a novel processing strategy based on repeated machine *** editorial presents a dataset comprising clinical,demographic,and laboratory variables from intensive care unit(ICU)patients and employs a multilayer perceptron neural network model to predict *** authors also performed a feature importance analysis to identify the most relevant risk factors for *** editorial contributes to the growing body of literature on predictive modeling in critical care,offering insights into the potential of machine learning approaches to improve patient outcomes and guide clinical decision-making in the ICU setting.

关键词： Intensive care units Intensive care unit-acquired weakness Risk factors Machine learning Computer neural network

Insights on ZEB1-AS1:emerging role from cancer to neurodegeneration

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Neural Regeneration Research 2024年第6期19卷 1187-1188页

作者： Stephana Carelli Federica rey Erika Maghraby Cristina Cereda Pediatric Research Center“Romeo ed Enrica Invernizzi” Department of Biomedical and Clinical SciencesUniversity of MilanMilanItaly Center of Functional Genomics and Rare Diseases Department of PediatricsBuzzi Children’s HospitalMilanItaly Department of Biology and Biotechnology“L.Spallanzani” University of PaviaPaviaItaly

Implications for lncRNAs in the central nervous system:Transcriptional dysregulation is a key contributor to the pathogenesis of a wide range of diseases and long non-coding RNAs(lncRNAs)are highly expressed in the nervous ***,amongst the over 50,000 lncRNAs expressed in the human genome,more than 40%are specifically expressed in the brain where their roles in brain development,neuron functions,maintenance.

关键词： ZEB1 diseases pathogenesis

Addressing mucosal ulcers during orthodontic treatment:An urgent call for preventive strategies

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World Journal of Clinical Cases 2024年第30期12卷 6420-6424页

作者： Carlos M ardila Basic Sciences Biomedical Stomatology Research GroupUniversidad de Antioquia U de AMedellín 050010Colombia

Mucosal ulcers are a common yet often overlooked complication during orthodontic treatment,significantly impacting patient comfort and *** letter aims to highlight the prevalence,potential causes,and management strategies for mucosal ulcers in orthodontic *** reviewing recent literature and clinical observations,we underscore the necessity for proactive measures and tailored interventions to mitigate the incidence and severity of these *** the role of patient education and the use of protective devices,we call for a multidisciplinary approach to enhance patient care and treatment *** discussion is particularly relevant in the context of evolving orthodontic techniques and materials,which necessitate continuous adaptation of clinical practices to ensure patient safety and well-being.

关键词： Mucosal ulcers Orthodontic treatment Patient comfort Preventive strategies Clinical management Protective devices

Precision at scale:Machine learning revolutionizing laparoscopic surgery

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World Journal of Clinical Oncology 2024年第10期15卷 1256-1263页

作者： Carlos M ardila Daniel González-Arroyave Biomedical Stomatology Research Group Universidad de Antioquia U de AMedellín 0057Colombia Department of Surgery Pontificia Universidad BolivarianaMedellín 0057Colombia

In their recent study published in the World Journal of Clinical Cases,the article found that minimally invasive laparoscopic surgery under general anesthesia demonstrates superior efficacy and safety compared to traditional open surgery for early ovarian cancer *** editorial discusses the integration of machine learning in laparoscopic surgery,emphasizing its transformative po-tential in improving patient outcomes and surgical *** learning algorithms analyze extensive datasets to optimize procedural techniques,enhance decision-making,and personalize treatment *** imaging modalities like augmented reality and real-time tissue classification,alongside robotic surgical systems and virtual reality simulations driven by machine learning,enhance imaging and training techniques,offering surgeons clearer visualization and precise tissue *** promising advancements,challenges such as data privacy,algorithm bias,and regulatory hurdles need addressing for the responsible deployment of machine learning *** collaborations and ongoing technological innovations promise further enha-ncement in laparoscopic surgery,fostering a future where personalized medicine and precision surgery redefine patient care.

关键词： Machine learning Computer neural network Minimally invasive surgical procedures Hand-assisted laparoscopy Laparoscopy

Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia Castillo-González Elena González-rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

A new technique for separation of partial discharge sources and electromagnetic noise in radiofrequency measurements using energy ratios of different antennas

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High Voltage 2021年第3期6卷 525-530页

作者： jorg. a.ardila‐rey Matias Cerda‐Luna Rodrigo Rozas‐Valderrama Bruno Albuquerque de Castro AndréLuiz Andreoli Benjamin Cevallos Departamento de Ingeniería Eléctrica Universidad Técnica Federico Santa MaríaSantiago de ChileChile Department of Electrical Engineering São Paulo State University(UNESP)School of Engineering BauruBauru‐SPBrazil

One of the main tools for monitoring the condition of high voltage equipment is the measurement of partial discharges(PD).The electromagnetic(EM)radiation originated from this degradation phenomenon can be captured by various types of ultra‐high fre-quency(UHF)antennas carefully designed and optimised for specific frequency ***,the presence of environmental noise may limit the use of this *** types of monopole antennas normally used in UHF PD measurement have been evaluated in order to validate the performance of a novel separation technique of EM ***,a new separation technique based on the energy ratio of the captured signals was developed,considering noise *** results revealed that the new technique allows an adequate separation,even when three sources act simultaneously.

关键词： antennas separation noise

Rare dentin defects:Understanding the pathophysiological mechanisms of COLXVA1 mutations

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Genes & Diseases 2024年第5期11卷 1-5页

作者： Isaac Maximiliano Bugueno Tristan rey Alexandra Jimenez-Armijo Marzena Kawczynski Naji Kharouf Marie-Cecile Maniere Yann Herault Agnes Bloch-Zupan Virginie HaushalterLaugel Institute of Genetics and Molecular and Cellular Biology(IGBMC) CNRS-UMR7104INSERM U1258Universitede StrasbourgIllkirch 67400France Faculty of Dentistry Universitede StrasbourgStrasbourg 67000France Institute of Advanced Studies(USIAS) Universitede StrasbourgStrasbourg 67045France Reference Center for Rare Oral and Dental Diseases(CRMR-O-Rares) Oral Medicine and Surgery DepartmentHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Rare Diseases Health Network“TETE COU”&European Reference Network ERN CRANIO Strasbourg 67000France “Institut de Genetique Medicale d’Alsace” Laboratory of Genetic DiagnosticHopitaux Universitaires de Strasbourg(HUS)Strasbourg 67000France Biomaterials and Bioengineering Laboratory Inserm UMR_S 1121Strasbourg 67000France Orofacial Development and Regeneration Faculty of MedicineInstitute of Oral BiologyCentre of Dental MedicineUniversity of ZurichZurich 8032Switzerland

Dentin is a mineralized tissue with a chemical composition similar to bone but with a higher mineralized density and *** constitutes the central structure of the tooth between the internal pulp and external enamel toward the oral cavity or cementum toward the underlying *** dentin defects occur in a variety of rare genetic *** can manifest as“isolated”occurrences such as in dentinogenesis imperfecta(DI)or dentin dysplasia(DD)or can be associated with other symptoms in diseases such as osteogenesis imperfecta,Goldblatt syndrome,microcephalic osteodysplastic primordial dwarfism type Ⅱ,among others.

关键词： diseases den rigidity

鄂尔多斯盆地西缘李105井奥陶系乌拉力克组笔石生物地层研究

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地球学报 2024年

作者：王传尚胡勇 jorg.Maletz 危凯古生物与地质环境演化湖北省重点实验室中国地质调查局武汉地质调查中心长江大学资源与环境学院柏林自由大学地质研究所

本文通过对鄂尔多斯盆地西缘李105井奥陶系乌拉力克组的笔石化石的研究,划分出两个笔石生物带,即Nemagraptus gracilis带和Cilmacograptus bicornis带,其时限为桑比期。根据乌拉力克组的沉积学特征,结合最新的岩相古地理研究进展,认为... 详细信息

本文通过对鄂尔多斯盆地西缘李105井奥陶系乌拉力克组的笔石化石的研究,划分出两个笔石生物带,即Nemagraptus gracilis带和Cilmacograptus bicornis带,其时限为桑比期。根据乌拉力克组的沉积学特征,结合最新的岩相古地理研究进展,认为原乌拉力克组的底界以一套特征的砾屑灰岩为标志欠妥,建议将克里摩里组上段的以黑色含笔石页岩为主的地层划归乌拉力克组,新厘定的乌拉力克组在盆地西缘北部露头区内蒙古乌海桌子山一带至少包含了Pterograptus elegans、Didymograptus murchisoni和Nemagraptus gracilis带等三个笔石带,其时限跨越中奥陶世达瑞威尔期晚期到晚奥陶世桑比期早期。可见,乌拉力克组在鄂尔多斯盆地西缘,其顶、底界线均存在明显的穿时。这一发现不仅为乌拉力克组的时限及其相变穿时提供了准确的生物地层约束,也为这一地区岩相古地理的重建及页岩气勘探有利相带的优选提供了依据。

关键词：鄂尔多斯盆地西缘乌拉力克组笔石带穿时李105井