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体外循环下冠状动脉搭桥术中经颅多谱勒高强度短信号与术后神经心理学功能变化的关系(英文)

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中华急诊医学杂志 2005年第5期14卷 357-361页

作者：严敏戴安卢 Andreas Boning Sven Carstensen jorg kampen Peter H.Tonner Jens Scholz Berthold Bein 浙江大学医学院附属第二医院麻醉科杭州310009 德国基尔大学医学院麻醉科德国基尔大学医学院心胸外科

目的　评估经颅多谱勒超声(TCD) 监测术中高强度短信号(HITS) 数目能否预测术后神经心理功能变化的程度。方法　20例体外循环下行冠状动脉搭桥术的患者, 术中采用TCD监测HITS的数值, 神经心理学成套测验用于评定术后神经心理学功能的变... 详细信息

目的　评估经颅多谱勒超声(TCD) 监测术中高强度短信号(HITS) 数目能否预测术后神经心理功能变化的程度。方法　20例体外循环下行冠状动脉搭桥术的患者, 术中采用TCD监测HITS的数值, 神经心理学成套测验用于评定术后神经心理学功能的变化。结果　术中HITS的数值与术后神经心理学功能的是否有变化无关。成套测验与HITS的数值的多因素相关分析中发现RW Dg1 DG5 与HITS的数值有微弱相关。结论　体外循环过程中HITS数值的变化与术后神经心理学功能变化无关。

关键词：功能变化体外循环术后术中信号强度神经心理学功能经颅多谱勒超声冠状动脉搭桥术多因素相关分析 HITS TCD监测成套测验数值

鄂尔多斯盆地西缘李105井奥陶系乌拉力克组笔石生物地层研究

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地球学报 2024年

作者：王传尚胡勇 jorg Maletz 危凯古生物与地质环境演化湖北省重点实验室中国地质调查局武汉地质调查中心长江大学资源与环境学院柏林自由大学地质研究所

本文通过对鄂尔多斯盆地西缘李105井奥陶系乌拉力克组的笔石化石的研究,划分出两个笔石生物带,即Nemagraptus gracilis带和Cilmacograptus bicornis带,其时限为桑比期。根据乌拉力克组的沉积学特征,结合最新的岩相古地理研究进展,认为... 详细信息

本文通过对鄂尔多斯盆地西缘李105井奥陶系乌拉力克组的笔石化石的研究,划分出两个笔石生物带,即Nemagraptus gracilis带和Cilmacograptus bicornis带,其时限为桑比期。根据乌拉力克组的沉积学特征,结合最新的岩相古地理研究进展,认为原乌拉力克组的底界以一套特征的砾屑灰岩为标志欠妥,建议将克里摩里组上段的以黑色含笔石页岩为主的地层划归乌拉力克组,新厘定的乌拉力克组在盆地西缘北部露头区内蒙古乌海桌子山一带至少包含了Pterograptus elegans、Didymograptus murchisoni和Nemagraptus gracilis带等三个笔石带,其时限跨越中奥陶世达瑞威尔期晚期到晚奥陶世桑比期早期。可见,乌拉力克组在鄂尔多斯盆地西缘,其顶、底界线均存在明显的穿时。这一发现不仅为乌拉力克组的时限及其相变穿时提供了准确的生物地层约束,也为这一地区岩相古地理的重建及页岩气勘探有利相带的优选提供了依据。

关键词：鄂尔多斯盆地西缘乌拉力克组笔石带穿时李105井

Disease networks. Uncovering disease-disease relationships through the incomplete interactome

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四川生理科学杂志 2024年第4期46卷 199-199页

作者： jorg Menche Center for Complex Networks Research and Department of Physics Northeastern University 110 Forsyth Street 111 Dana Research Center Boston MA 02115 USA. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology Dana-Farber Cancer Institute 450 Brookline Avenue Boston MA 02215 USA. Center for Network Science Central European University Nador u. 9 1051 Budapest Hungary. Center for Complex Networks Research and Department of Physics Northeastern University 110 Forsyth Street 111 Dana Research Center Boston MA 02115 USA. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology Dana-Farber Cancer Institute 450 Brookline Avenue Boston MA 02215 USA. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology Dana-Farber Cancer Institute 450 Brookline Avenue Boston MA 02215 USA. Department of Genetics Harvard Medical School 77 Avenue Louis Pasteur Boston MA 02115 USA. Department of Medicine Brigham and Women's Hospital Harvard Medical School 75 Francis Street Boston MA 02115 USA. Center for Complex Networks Research and Department of Physics Northeastern University 110 Forsyth Street 111 Dana Research Center Boston MA 02115 USA. Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology Dana-Farber Cancer Institute 450 Brookline Avenue Boston MA 02215 USA. Center for Network Science Central European University Nador u. 9 1051 Budapest Hungary. Department of Medicine Brigham and Women's Hospital Harvard Medical School 75 Francis Street Boston MA 02115 USA. alb@neu.edu.

According to the disease module hypothesis,the cellular components associated with a disease segregate in the same neighborhood of the human interactome,the map of biologically relevant molecular ***,given the incompleteness of the interactome and the limited knowledge of disease-associated genes,it is not obvious if the available data have sufficient coverage to map out modules associated with each disease.

关键词： incomplete interactions. networks.

Common interacting genetic variation shapes susceptibility to type 1 diabetes in a Colombian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gloria Garavito-De Egea Alex Dominguez-Vargas jorg e l.Velez Gustavo Aroca Luis Fagng Elkin Navarro-Quiroz Zilac Espitaleta Kenny Del Toro-Camargo Leticia Martinez-Ariza Tatiana Gonzalez-Vargas Susana Garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bolivar Facultad de Ciencias de la SaludBarranquillaColombia Clinica de la Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of loci across the human genome conferring susceptibility to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibility diseases diabetes

Bringing epigenetics into the diagnostics of the andrology laboratory： challenges and perspectives

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Asian Journal of Andrology 2014年第5期16卷 669-674,I0006页

作者： Ruth Klaver jorg Gromoll Centre of Reproductive Medicine and Andrology University Clinics of MOnster MOnster Germany

Recent studies have shown significant associations of aberrant DNA methylation in spermatozoa with idiopathic male infertility, increased frequency of spontaneous abortions and imprinting disorders. Thus, the analysis of DNA methylation of specific genes in spermatozoa has the potential to become a new valuable diagnostic marker in clinical andrology. This perspective article discusses the current state and value of DNA methylation analysis in the diagnostic setup of infertile men and outlines challenges and perspectives. It highlights the potential of DNA methylation in andrological diagnostics and its putative benefit in the examination of hitherto idiopathic infertile patients is described.

关键词： DNA methylation male infertility spermatogenesis

Transfer of CrylAc and Cry2Ab proteins from genetically engineered Bt cotton to herbivores and predators

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Insect Science 2018年第5期25卷 823-832页

作者： Michael Meissle jorg Romeis Agroscope Research Division Agroecology and Environment Zurich Switzerland

With the cukivation of Bt cotton, the produced insecticidal Cry proteins are ingested by herbivores and potentially transferred along the food chain to natural enemies, such as predators. In laboratory experiments with Bollgard II cotton, concentrations of CrylAc and Cry2Ab were measured in Lepidoptera larvae （Spodoptera littoralis, Hello- this virescens）, plant bugs （Euschistus heros）, aphids （Aphis gossypii）, whiteflies （Bemisia tabaci）, thrips （ Thrips tabaci, Frankliniella occidentalis）, and spider mites （Tetranychus urticae）. Tritrophic experiments were conducted with caterpillars ofS. littoralis as prey and larvae of ladybird beetles （Harmonia axyridis, Adalia bipunctata） and lacewings （Chrysop- erla carnea） as predators. Immunological measurements （ELISA） indicated that herbivores feeding on Bt cotton contained 5%-50% of the Bt protein concentrations in leaves except whiteflies and aphids, which contained no or only traces of Bt protein, and spider mites, which contained 7 times more Cry 1Ac than leaves. Similarly, predators contained 1%-30% of the Cry protein concentration in prey. For the nontarget risk assessment, this indicates that Bt protein concentrations decrease considerably from one trophic level to the next in the food web, except for spider mites that contain Bt protein concentrations higher than those measured in the leaves. Exposure of phloem sucking hemipterans is negligible.

关键词： arthropod food web Bacillus thuringiensis Bt cotton Cry protein ELISA transgenic plants

Fundamental influences of particles on stirred and unstirred venting processes of foaming systems

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 141-148页

作者： Henrik LEIMEISTER jorg STEINBACH Department of Process Engineering Technische Universitat Berlin Strage des 17. Juni 135 10623 Berlin Germany

Venting is the common safety measure to protect plant equipment against excessive overpressure. So far, scenarios in which particles were part of the system and should have been accounted for did ignore their presence; the scenarios were treated like a two-phase system. Current research shows that particles can have a major influence on the venting behaviour. Experimental results indicate that particles affect level swell and relief flow especially of foamy systems. Based on those results four different layers of influence of the particle have been identified and are presented in a first model. Based on this model recommendations for the development of new and more complex models are given.

关键词： venting multi-phase

The contribution of small leaks in a baghouse filter to dust emission in the PM2.s range-A system approach

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Particuology 2017年第1期15卷 40-52页

作者： Oliver Kurtz jorg Meyer Gerhard Kasper Institut for Mechanische Verfahrenstechnik und Mechanik Karlsruhe Institute of Technology 76131 Karlsruhe Germany Freudenberg Filtration Technologies 69465 WeinheimGermany.

The contribution of leakage in a baghouse filter （defined as a short circuit between the upstream and downstream sides of the filter） to the emission of fine particles is quantified in comparison to other dust emission sources, and the influence of key operating variables on overall system response is analyzed. The study was conducted on a well-maintained pilot-scale filter unit （9 bags of 500 g/m^2 calendered polyester needle felt; total surface area 4.2 m^2） operated in Ap-controlled mode over a range of pulsing intensities, with two types of test dust （one free-flowing and the other cohesive） at inlet concentrations of 10 and 30 g/m^3. Leaks included single holes between 0.5 and 4 mm diameter, intentionally placed in either the plenum plate or one of the filter bags, as well as seamlines from bag confectioning. Emissions were sep- arated by source into a transient contribution due to dust penetration through the filter bags after each cleaning pulse, and a continuous contribution from leaks. This separation was based on a novel method of data processing that relies on time-resolved concentration measurements with a specially calibrated optical particle counter. Tiny leaks on the order of 1 mm generated the same emission level as all the bags combined, and dominated continuous emissions. The equivalent leak cross section （leakage = media emission） was about 1 ppm of the total installed filter surface, independent of upstream dust concentra- tion. Leakage through open seamlines amounted to 75% of media emissions in case of free-flowing test dust. Leakage was restricted to aerodynamic diameters less than ~5 μm （roughly the PM2.s mass frac- tion）. For comparison, time-averaged mass penetration through conventional needle-felt media ranged from about 10^-5 to 10^-6, depending on cohesiveness of the particle material and pulse cleaning intensity, giving emission levels between about 0.02 and 0.2 mg/m^3 at the reference concentration of 10 R/m^2.

关键词： Air filtration Baghouse Pulse-cleaned filters Leaks PM2.5 Dust emission

Numerical analysis of hydroabrasion in a hydrocyclone

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Petroleum Science 2016年第2期13卷 304-319页

作者： Mehdi Azimian Hans-jorg Bart Department of Mechanical and Process Engineering University of Kaiserslautern 67663 Kaiserslautern Germany

The velocity profiles and separation efficiency curves of a hydrocyclone were predicted by an Euler-Euler approach using a computational fluid dynamics tool ANSYS-CFX 14.5. The Euler-Euler approach is capable of considering the particle-particle interactions and is appropriate for highly laden liquid-solid mixtures. Pre- dicted results were compared and validated with experi- mental results and showed a considerably good agreement. An increase in the particle cut size with increasing solid concentration of the inlet mixture flow was observed and discussed. In addition to this, the erosion on hydrocyclone walls constructed from stainless steel 410, eroded by sand particles （mainly SiOz）, was predicted with the Euler-La- grange approach. In this approach, the abrasive solid particles were traced in a Lagrangian reference frame as discrete particles. The increases in the input flow velocity, solid concentration, and the particle size have increased the erosion at the upper part of the cylindrical body of the hydrocyclone, where the tangential inlet flow enters the hydrocyclone. The erosion density in the area between the cylindrical to conical body area, in comparison to other parts of the hydrocyclone, also increased considerably. Moreover, it was observed that an increase in the particle shape factor from 0.1 to 1.0 leads to a decrease of almost 70 % in the average erosion density of the hydrocyclone wall surfaces.

关键词： Hydrocyclone Computational fluiddynamicS (CFD) Separation efficiency - Erosion rateErosion impact parameters