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superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi

BioDesign Research 2022年第1期2022卷 151-165页

作者： Ryan R.Cochrane Arina shrestha Mariana M.severo de Almeida Michelle Agyare-Tabbi stephanie L.Brumwell samir Hamadache jordyn s.meaney Daniel P.Nucifora Henry Heng say Jehoshua sharma Maximillian P.M.soltysiak Cheryl Tong Katherine Van Belois Emma J.L.Walker Marc-AndréLachance Gregory B.Gloor David R.Edgell Rebecca s.shapiro Bogumil J.Karas Department of Biochemistry Schulich School of Medicine and DentistryThe University of Western OntarioLondonONCanada N6A 5C1 Department of Molecular and Cellular Biology University of GuelphGuelphONCanada N1G 2W1 Department of Biology The University of Western OntarioLondonOntarioCanada N6A 5B7

Fungi are nature’s recyclers,allowing for ecological nutrient cycling and,in turn,the continuation of life on *** fungi inhabit the human microbiome where they can provide health benefits,while others are opportunistic pathogens that can cause ***,members of the fungal kingdom,have been domesticated by humans for the production of beer,bread,and,recently,medicine and ***,the great untapped potential exists within the diverse fungal ***,many yeasts are intractable,preventing their use in biotechnology or in the development of novel treatments for pathogenic ***,as a first step for the domestication of new fungi,an efficient DNA delivery method needs to be ***,we report the creation of superior conjugative plasmids and demonstrate their transfer via conjugation from bacteria to 7 diverse yeast species including the emerging pathogen Candida *** create our superior plasmids,derivatives of the 57 kb conjugative plasmid pTA-Mob 2.0 were built using designed gene deletions and insertions,as well as some unintentional ***,a cluster mutation in the promoter of the conjugative gene traJ had the most significant effect on improving conjugation to *** addition,we created Golden Gate assembly-compatible plasmid derivatives that allow for the generation of custom plasmids to enable the rapid insertion of designer genetic ***,we demonstrated that designer conjugative plasmids harboring engineered restriction endonucleases can be used as a novel antifungal agent,with important applications for the development of next-generation antifungal therapeutics.

关键词： insertion continuation harbor

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Bietti’s crystalline dystrophy in an African American patient: an unusual racial demographic for a condition more common in individuals of East Asian descent

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1291-1292页

作者： Virang Kumar Vikram Brar jordyn Prell Ann Jewell Natario Couser Virginia Commonwealth University school of Medicine RichmondVA 23298USA Department of Ophthalmology Virginia Commonwealth University School of MedicineRichmondVA 23298USA Department of Human and Molecular Genetics Virginia Commonwealth University School of MedicineRichmondVA 23298USA Department of Pediatrics Virginia Commonwealth University School of MedicineRichmondVA 23298USA

Dear Editor,The study outlining the manifestations of Bietti’s crystalline dystrophy(BCD)in five Chinese patients offered insights into common disease-causing variants associated with Chinese patients as well as a novel mutation[1].This genetic condition is commonly reported among East Asian populations and to some extent Mediterranean populations[2].

关键词： dystrophy crystalline condition

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All Eyes on Hangzhou

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Beijing Review 2016年第14期59卷 38-39页

作者： jordyn Dahl

When China hosts the Group of 20 （G20） summit in Hangzhou,capital of Zhejiang Province,this coming september,the world will be watching not just the country＇s leaders for signs of how its economy is performing,but also what steps the G20 countries are taking to maintain order in an increasingly fraught period of economic and social unrest.

关键词：杭州眼睛浙江省领导人经济

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Off to a Good start

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ChinAfrica 2016年第5期8卷 38-39页

作者： jordyn Dahl

REsEARCHERs at the Guangzhou Medical University in south China＇s Guangdong Province made headlines in April when they conducted an experiment to modify genes in human embryos - that would not have grown into human ba... 详细信息

关键词： Off to a Good start

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searching for China’s Next Unicorn

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Beijing Review 2015年第44期58卷 38-39页

作者： jordyn Dahl

startup conference underscores China＇s push for innovation to spur economic growth

关键词：中国独角兽经济增长

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An Encouraging Upturn

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Beijing Review 2016年第16期59卷 34-35页

作者： jordyn Dahl

Aslew of positive economic indicator results in March suggested China＇s economic stimulus may be having its desired impact. The manufacturing activity rebounded in March for the first time in nine months, industrial companies＇ profits grew at their fastest rate in more than 18 months, and the service sector also saw healthy growth.

关键词：中国经济经济指标工业企业制造业服务业

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