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Stipa tenacissima Does not Affect the Foliar δ^(13)C and δ^(15)N of Introduced Shrub Seedlings in a Mediterranean Semi-arid Steppe

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Journal of Integrative Plant Biology 2006年第8期48卷 897-905页

作者： Fernando T.Maestre Susana Bautista jordi Cortina Departamento de Ecologia Universidad de AlicanteApartado de correos 9903080 AlicanteSpain Department of Biology Duke UniversityPhytotron BuildingScience DriveBox 90340DurhamNorth Carolina 27708-0340USA Centro de Estudios Ambientales del Mediterraneo C/ Charles Darwin 1446980 PaternaSpain

Recent studies have shown that the tussock grass Stipa tenacissima L. facilitates the establishment of late-successional shrubs, in what constitutes the first documented case of facilitation of woody plants by grasses. With the aim of increasing our knowledge of this interaction, in the present study we investigated the effects of S. tenacissima on the foliar δ13C, δ15N, nitrogen concentration, and carbon ： nitrogen ratio of introduced seedlings of Pistacia lentiscus L., Quercus coccifera L., and Medicago arborea L. in a semi-arid Mediterranean steppe. Six months after planting, the values of δ13C ranged between -26.9‰ and -29.6‰, whereas those of δ15N ranged between -1.9‰ and 2.7‰. The foliar C ： N ratio ranged between 10.7 and 53.5, and the nitrogen concentration ranged between 1.0% and 4.4%. We found no significant effect of the microsite provided by S. tenacissima on these variables in any of the species evaluated. The values of δ13C were negatively correlated with predawn water potentials in M. arborea and were positively correlated with relative growth rate in Q. coccifera. The values of δ15N were positively correlated with the biomass allocation to roots in the latter species. The present results suggest that the modification of environmental conditions in the are surrounding S. tenacissima was not strong enough to modify the foliar isotopic and nitrogen concentration of shrubs during the early stages after planting.

关键词： facilitation Medicago arborea Pistacia lentiscus Quercus coccifera stable isotopes steppe Stipa tenacissima.

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Biological insights in non-small cell lung cancer

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Cancer Biology & Medicine 2023年第7期20卷 500-518页

作者： Rafael Rosell Anisha Jain jordi Codony-Servat Eloisa Jantus-Lewintre Blake Morrison jordi Barretina Ginesta María González-Cao Germans Trias i Pujol Research Institute Badalona 08028Spain IOR Hospital Quiron-DexeusBarcelona 08028Spain Department of Microbiology JSS Academy of Higher Education&ResearchMysuru 570015India Pangaea Oncology Hospital Quiron-DexeusBarcelona 08028Spain Department of Biotechnology Universitat Politècnica de ValenciaMixed Unit TRIAL(General University Hospital of Valencia Research Foundation and Príncipe Felipe Research Center)CIBERONCValencia 46014Spain Sumitomo Pharma Oncology Inc.CambridgeMA and LehiUT 84043USA

Lung oncogenesis relies on intracellular cysteine to overcome oxidative *** tumor types,including non-small cell lung cancer(NSCLC),upregulate the system x-c cystine/glutamate antiporter(xCT)through overexpression of the cystine transporter SLC7A11,thus sustaining intracellular cysteine levels to support glutathione *** factor erythroid 2-related factor 2(NRF2)serves as a master regulator of oxidative stress resistance by regulating SLC7A11,whereas Kelch-like ECH-associated protein(KEAP1)acts as a cytoplasmic repressor of the oxidative responsive transcription factor *** in KEAP1/NRF2 and p53 induce SLC7A11 activation in *** cystine is crucial in supplying the intracellular cysteine levels necessary to combat oxidative *** in cystine availability lead to iron-dependent lipid peroxidation,thus resulting in a type of cell death called *** inhibitors of xCT(either SLC7A11 or GPX4)induce ferroptosis of NSCLC cells and other tumor *** cystine uptake is impaired,the intracellular cysteine pool can be sustained by the transsulfuration pathway,which is catalyzed by cystathionine-B-synthase(CBS)and cystathionine g-lyase(CSE).The involvement of exogenous cysteine/cystine and the transsulfuration pathway in the cysteine pool and downstream metabolites results in compromised CD8^(+)T cell function and evasion of immunotherapy,diminishing immune response and potentially reducing the effectiveness of immunotherapeutic *** is a previously unrecognized form of regulated cell *** NSCLCs driven by EGFR,ALK,or KRAS,selective inhibitors induce pyroptotic cell death as well as *** targeted therapy,the mitochondrial intrinsic apoptotic pathway is activated,thus leading to the cleavage and activation of ***,gasdermin E is activated,thus leading to permeabilization of the cytoplasmic membrane and cell-lytic pyroptosis(indicated by characte

关键词： Solute carrier family 7 member 11(SLC7A11) nuclear factor erythroid 2-related factor 2(NRF2) ferroptosis pyroptosis KRAS G12C allele-specific inhibitors non-small cell lung cancer(NSCLC)

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Light spectral filtering based on spatial adiabatic passage

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Light(Science & Applications) 2013年第1期2卷 90-97页

作者： Ricard Menchon-Enrich Andreu Llobera jordi Vila-Planas Victor J Cadarso jordi Mompart Veronica Ahufinger Department of Physics Universitat Auto`noma de BarcelonaE-08193 BellaterraBarcelonaSpain Chemical Transducers Group Institut de Microelectro`nica de Barcelona(IMBCNMCSIC)E-08193 BellaterraBarcelonaSpain Microsystems Laboratory(LMIS1) Ecole Polytechnique Federale de Lausanne(EPFL)CH-1015 LausanneSwitzerland

We present the first experimental realization of a light spectral filter based on the spatial adiabatic passage *** demonstrate that a fully integrable CMOS-compatible system of three coupled identical total internal reflection silicon oxide waveguides with variable separation along their propagation direction can be used simultaneously as a low-and high-pass spectral filter within the visible range of *** is injected into the right waveguide,and after propagating along the system,long wavelengths are transferred into the left output,whereas short wavelengths propagate to the right and central *** stopband reaches values up to 211 dB for the left output and approximately 220 dB for the right plus central *** passband values are close to 0 dB for both *** also demonstrate that the filtering characteristics of the device can be controlled by modifying the parameter values,which define the geometry of the triple-waveguide ***,the general filtering behavior of the system does not critically depend on technological ***,the spatial adiabatic passage filtering approach constitutes an alternative to other integrated filtering devices,such as interference or absorbance-based filters.

关键词： CMOS-compatible technology integrated optics devices spatial adiabatic passage wavelength filtering devices

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Does Greek Foot Predispose to Morton’s Neuroma?

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Open Journal of Orthopedics 2014年第7期4卷 176-182页

作者： Christopher Jump Michael Rice Daniel Gheorghiu jordi sanchez-Ballester Department of Orthopaedics and Trauma St. Helens and Knowsley NHS Trust Liverpool UK Liverpool Medical School University of Liverpool Liverpool UK

Background: Morton’s neuroma is the enlargement of an interdigital nerve most commonly located between the third and fourth metatarsals. Greek foot is a normal variant where the first metatarsal is shorter than the second metatarsal. To our knowledge, there is currently no reported association between Greek foot and Morton’s neuroma in the literature. Methods: Retrospective study of 184 patients. Two separate cohorts were recruited. Cohort A comprised of 100 randomly selected asymptomatic patients. Cohort B comprised of 84 patients with a history of foot pain and histologically confirmed Morton’s neuroma. Foot shape was determined by using a self-assessment tool and plain radiographs. Statistical analyses were performed using the Chi-square test on the association between Greek foot and Morton’s neuroma. A p-value of ﹣9). Conclusions: This study has shown a possible association between the presence of a Greek foot and the presence of Morton’s neuroma. Although our study design has limitations and does not allow full statistical analysis, we do believe that the shown association between Greek foot and Morton’s neuroma can help clinicians and other health care providers in establishing the diagnosis of Morton’s neuroma in patients with a painful foot.

关键词： Morton’s Neuroma Greek Foot Egyptian Foot Foot Pain

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Synthesis,structural study,thermal,optical properties and characterization of the new compound[C6H7N2O2]3TeCl5·2Cl

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Chinese Chemical Letters 2017年第8期28卷 1773-1779页

作者： Dhaou Maraii jordi Farjas Xavier Fontrodona Mohamed Dammak Laboratoire de Chimie Inorganique Facultédes Sciences de SfaxUniversity of SfaxBP 11713000 SfaxTunisia University of Girona Campus MontiliviEdif.PIIE17071 GironaCataloniaSpain

The new organic-inorganic compound, [C_6H_7N_2O_2]_3TeCl_5·2Cl was synthesized and its structure was determined at room temperature in the triclinic system （P^-1） with the following parameters： a = 10.5330（11）？, b = 10.6663（11）？, c = 15.9751（16）？, α = 82.090（2）°, β = 71.193（2）°, γ = 68.284（2）°and Z = 2. The final cycle of refinement led to R = 0.057 and Rw = 0.149. The crystal structure was stabilized by an extensive network of N--H···Cl and non-classical C--H···Cl hydrogen bonds between the cation and the anionic group. Several thermal analysis techniques such as thermogravimetric analysis, differential scanning calorimetric analysis and evolved gas analysis were used. We used isoconversional kinetics methods to determine the kinetics parameters. We observe that the decomposition of [C_6H_7N_2O_2]_3TeCl_5·2Cl entails the formation hydrochloric acid of nitroaniline as volatiles. The infrared spectra were recorded in the4000–400 cm^（-1）frequency region. The Raman spectra were recorded in the external region of the anionic sublattice vibration 50–1500 cm^（-1）. The optical band gap was calculated from the UV-Vis absorbance spectra using classical Tauc relation which was found to be 3.12 and 3.67 eV.

关键词： Thermal analysis Kinetics parameters Structural analysis FTIR Raman Optical absorption

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Potential of sea buckthorn-based ingredients for the food and feed industry-a review

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Food Production, Processing and Nutrition 2020年第1期2卷 162-178页

作者： Arnau Vilas-Franquesa jordi Saldo Bibiana Juan Centre d’Innovació Recerca i Transferència en Tecnologia dels Aliments(CIRTTA)XaRTATECNIOMALTA-ConsoliderDepartament de Ciència Animal i dels AlimentsFacultat de VeterinàriaUniversitat Autònoma de Barcelona(Cerdanyola del Vallès)BarcelonaSpain Instituto Politécnico Nacional(IPN) Centro de Desarrollo de Productos Bióticos(CEPROBI)YautepecMorelosMexico

Food industries seek to incorporate nutritious ingredients as they could bring added value to the final food *** of the most interesting options is that sea buckthorn contains high concentrations of vitamin C,carotenoids,tocopherols,and other bioactive compounds,in addition to the unique lipid profile in the berry pulp,seed,and *** review summarizes the state-of-the-art of potential applications of sea buckthorn within the food and feed industry based on previously described *** such as cheese,yoghurt or beverages already benefit from its ***,using sea buckthorn in feed products also derives into higher quality final products(*** quality,egg quality).Poultry,pig,and fish farming have been studied for that *** all the accumulated articles depicted in the present review,the use of this fruit in food product formulation is nowadays *** options for food product development with sea buckthorn are herein discussed.

关键词： Food science Feed additive Product development Health Bioactive compounds Added value Sea buckthorn

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Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation

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Neural Regeneration Research 2020年第12期15卷 2260-2261页

作者： Samuel Pena-Díaz jordi Pujols Salvador Ventura Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

Parkinson’s disease (PD) is a neurodegenerative disorder belonging to a group of human pathologies known as synucleinopathies,which includes multiple system atrophy or dementia with Lewy bodies (Spillantini et al.,1998).These diseases share a common neuropathological feature,the presence ofα-synuclein (α-Syn) deposits,although they differ in the cellular and anatomical compartment in whichα-Syn inclusions *** affects more than 1% of people over 60 years of age,thus being the second most prevalent neurodegenerative disease in the world and the most common synucleinopathy.

关键词： al. diseases atrophy

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Developing kNN forest data imputation for Catalonia

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Journal of Forestry Research 2024年第4期35卷 142-155页

作者： Timo Pukkala Núria Aquilué Ariadna Just jordi Corbera Antoni Trasobares Forest Science and Technology Centre of Catalonia(CTFC) Crta.de St.Llorençde MorunysKm 225280 SolsonaSpain Cartographic and Geological Institute of Catalonia(ICGC) 08038 BarcelonaSpain

The combined use of LiDAR(Light Detection And Ranging)scanning and field inventories can provide spatially continuous wall-to-wall information on forest *** information can be used in many ways in forest mapping,scenario analyses,and forest manage-ment *** study aimed to find the optimal way to obtain continuous forest data for Catalonia when using kNN imputation(kNN stands for“k nearest neighbors”).In this method,data are imputed to a certain location from k field-measured sample plots,which are the most similar to the location in terms of LiDAR metrics and topographic *** multidimensional Euclidean distance was used as the similarity *** study tested two different methods to optimize the distance *** first method optimized,in the first step,the set of LiDAR and topographic variables used in the measure,as well as the transformations of these *** weights of the selected variables were optimized in the second *** other method optimized the variable set as well as their transformations and weights in one single *** two-step method that first finds the variables and their transfor-mations and subsequently optimizes their weights resulted in the best imputation *** the study area,the use of three to five nearest neighbors was *** and latitude turned out to be the most important variables when assessing the similarity of two locations of Catalan forests in the context of kNN data *** optimal distance measure always included both LiDAR metrics and topographic *** study showed that the optimal similarity measure may be different for different ***,it was suggested that kNN data imputation should always be started with the optimization of the measure that is used to select the k nearest neighbors.

关键词： Forest inventory Differential evolution Simulated annealing LiDAR

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Regeneration patterns in Mexican pine-oak forests

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Forest Ecosystems 2019年第4期6卷 384-395页

作者： Teresa Alfaro Reyna jordi Martínez-Vilalta Javier Retana CREAF E-08193 Cerdanyola del VallèsBarcelonaSpain Universitat Autònoma de Barcelona E-08193 Cerdanyola del VallèsBarcelonaSpain

Background: Global change is causing an increase in the incidence of natural and anthropogenic disturbances on forests, which frequently interact synergistically and promote changes in forest structure, composition and functioning. In this study we evaluate the regeneration of Pinaceae and Fagaceae species in pure and mixed stands in Mexico to determine if current regeneration patterns are indicative of changes in the relative dominance of these two tree families, as observed in other temperate regions. We also identify the environmental factors that determine the regeneration patterns of Pinaceae and Fagaceae species in these ***: We use data from two consecutive surveys of the National Inventory of Forests and Soils of Mexico(INFyS),obtained in 2004–2009 and 2009–2014. Our results show that the spatial patterns of regeneration are affected by forest structure, by climate, by the type and intensity of disturbances and by land tenure. Importantly, the presence and abundance of Fagaceae regeneration is generally higher than that of Pinaceae, and tends to be favoured(relative to Pinaceae) under warmer climates and by the presence of ***: The higher regeneration of Fagaceae relative to Pinaceae under warmer and fire-prone conditions could have important impacts on the composition and functioning of Mexican temperate forests under ongoing climate change, as well as affect their resilience to future disturbances.

关键词： Fagaceae Forest dynamics Forest inventory Mexico Pinaceae Regeneration Temperate forests

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Diffusion-free valve for preprogrammed immunoassay with capillary microfluidics

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Microsystems & Nanoengineering 2023年第4期9卷 197-209页

作者： Pooya Azizian Jasmina Casals-Terré jordi Ricart Joan M.Cabot Energy and Engineering Department Leitat Technological CenterTerrassaBarcelonaSpain Mechanical Engineering Department Technical University of CataloniaTerrassaBarcelonaSpain

By manipulating the geometry and surface chemistry of microfluidic channels,capillary-driven microfluidics can move and stop fluids spontaneously without external ***,complex microfluidic circuits can be preprogrammed by synchronizing the capillary pressures and encoding the surface tensions of microfluidic chips.A key component of these systems is the capillary ***,the main concern for these valves is the presence of unwanted diffusion during the valve loading and activation steps that can cause *** this study,we design and validate a novel diffusion-free capillary valve:theπ-*** valve consists of a 3D structure and a void *** void acts as a spacer between two fluids to avoid direct *** the valve is triggered,the air trapped within the void is displaced by pneumatic suction induced from the capillary flow downstream without introducing a gas bubble into the *** proposed design eliminates diffusive mixing before valve *** simulation is used to study the function and optimize the dimensions of theπ-valve,and 3D printing is used to fabricate either the mould or the microfluidic chip.A comparison with a conventional valve(based on a constrictionexpansion valve)demonstrates that theπ-valve eliminates possible backflow into the valve and reduces the mixing and diffusion during the loading and trigger *** a proof-of-concept,this valve is successfully implemented in a capillary-driven circuit for the determination of benzodiazepine,achieving the successive release of 3 solutions in a 3Dprinted microfluidic chip without external *** results show a 40%increase in the fluorescence intensity using theπ-valve relative to the conventional ***,theπ-valve prevents cross-contamination,minimizes sample use,and facilitates a sophisticated preprogrammed release of fluids,offering a promising tool for conducting automated immunoassays applicable at point-of-

关键词： capillary steps eliminate

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