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Diffusion-free valve for preprogrammed immunoassay with capillary microfluidics

Microsystems & Nanoengineering 2023年第4期9卷 197-209页

作者： Pooya Azizian Jasmina Casals-Terré jordi ricart Joan M.Cabot Energy and Engineering Department Leitat Technological CenterTerrassaBarcelonaSpain Mechanical Engineering Department Technical University of CataloniaTerrassaBarcelonaSpain

By manipulating the geometry and surface chemistry of microfluidic channels,capillary-driven microfluidics can move and stop fluids spontaneously without external ***,complex microfluidic circuits can be preprogrammed by synchronizing the capillary pressures and encoding the surface tensions of microfluidic chips.A key component of these systems is the capillary ***,the main concern for these valves is the presence of unwanted diffusion during the valve loading and activation steps that can cause *** this study,we design and validate a novel diffusion-free capillary valve:theπ-*** valve consists of a 3D structure and a void *** void acts as a spacer between two fluids to avoid direct *** the valve is triggered,the air trapped within the void is displaced by pneumatic suction induced from the capillary flow downstream without introducing a gas bubble into the *** proposed design eliminates diffusive mixing before valve *** simulation is used to study the function and optimize the dimensions of theπ-valve,and 3D printing is used to fabricate either the mould or the microfluidic chip.A comparison with a conventional valve(based on a constrictionexpansion valve)demonstrates that theπ-valve eliminates possible backflow into the valve and reduces the mixing and diffusion during the loading and trigger *** a proof-of-concept,this valve is successfully implemented in a capillary-driven circuit for the determination of benzodiazepine,achieving the successive release of 3 solutions in a 3Dprinted microfluidic chip without external *** results show a 40%increase in the fluorescence intensity using theπ-valve relative to the conventional ***,theπ-valve prevents cross-contamination,minimizes sample use,and facilitates a sophisticated preprogrammed release of fluids,offering a promising tool for conducting automated immunoassays applicable at point-of-

关键词： capillary steps eliminate

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Predictors of bowel damage in the long-term progression of Crohn’s disease

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World Journal of Clinical Cases 2022年第33期10卷 12208-12220页

作者： Agnes Fernández-Clotet Julian Panés Elena ricart Jesús Castro-Poceiro Maria Carme Masamunt Sonia Rodríguez Berta Caballol Ingrid Ordás jordi Rimola Department of Gastroenterology Hospital ClinicBarcelona 08036Spain Universitat de Barcelona Institut d'Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)Barcelona 08036Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDMadrid 28029Spain Department of Radiology Hospital ClinicBarcelona 08036Spain

BACKGROUND Crohn’s disease(CD)is a chronic inflammatory bowel disorder that progresses to bowel damage(BD)over *** image-based index,the Lémann index(LI),has been developed to measure cumulative *** To characterize the long-term progression of BD in CD based on changes in the LI and to determine risk factors for long-term *** This was a single-center longitudinal cohort *** who had participated in prospective studies on the accuracy of magnetic resonance imaging using endoscopy as a gold standard and who had a follow-up of at least 5 years were reevaluated after 5-12 *** Seventy-two patients were *** increased in 38 patients(52.8%),remained unchanged in 9 patients(12.5%),and decreased in 25 patients(34.7%).The small bowel score and surgery subscale significantly increased(P=0.002 and P=0.001,respectively),whereas the fistulizing subscale significantly decreased(P=0.001).Baseline parameters associated with BD progression were ileal location(P=0.026),CD phenotype[stricturing,fistulizing,or both(P=0.007,P=0.006,and P=0.035,respectively)],disease duration>10 years(P=0.019),and baseline LI stricturing score(P=0.049).No correlation was observed between BD progression and baseline clinical activity,biological markers,or severity of endoscopic *** BD,as assessed by the LI,progressed in half of the patients with CD over a period of 5-12 *** main determinants of BD progression were ileal location,stricturing/fistulizing phenotype,and disease duration.

关键词： Crohn’s disease Lémann index Bowel damage Inflammatory bowel disease Magnetic resonance imaging

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Can ricart体育综合体

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建筑技艺 2010年第11期16卷 126-131页

作者： Pere Buil Castells jordi Fornells Castelló Manuel Arguijoy Asociados Carles Bima Puig Filipe Araújo Ricardo Borges Arnau Boronat Rubén Heras Sónia Bom Iigo Ribera Sónia Gaspar Adrià Goula 吴春花 vora arquitectura

Can ricart体育俱乐部综合体位于一个历史上曾经一度萧条的区域,但该区域近年来发生了很大的变化.因此综合体的建设将对周边建筑的再生起到非常重要的作用,而且通过体育活动的运营也有助于区域与整个社会层的整合.

关键词：建筑立面游泳池水池阳极电镀 Can ricart 建筑内部空间体育

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