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The haplotype-resolved T2T reference genome highlights structural variation underlying agronomic traits of melon

Horticulture Research 2023年第10期10卷 12-24页

作者： Guoli Li Lingli Tang Yuhua He Yongyang Xu Abdelhafid Bendahmane jordi Garcia-Mas Tao Lin Guangwei Zhao National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops Zhengzhou Fruit Research InstituteChinese Academy of Agricultural SciencesZhengzhouHenan 450009China China Agricultural University College of HorticultureBeijing 100193China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanyaHainan 572024China Zhongyuan Research Center Chinese Academy of Agricultural SciencesXinxiang 453400China Institute of Plant Sciences Paris-Saclay(IPS2) INRAECNRSUniversity of Paris-SaclayUniversity of EvryUniversity of Paris-DiderotGif sur Yvette 91192France Centre for Research in Agricultural Genomics(CRAG)CSIC-IRTA-UAB-UB Edifici CRAGCampus UABBellaterra08193 BarcelonaSpain Institut de Recerca i Tecnologia Agroalimentàries(IRTA) Edifici CRAGCampus UABBellaterra08193 BarcelonaSpain

Melon(Cucumis melo L.)is an important vegetable crop that has an extensive history of ***,the genome of wild and semi-wild melon types that can be used for the analysis of agronomic traits is not yet *** we report a chromosome-level T2T genome assembly for 821(*** *** ***),a semi-wild melon with two haplotypes of∼373 Mb and∼364 Mb,*** genome analysis discovered a significant number of structural variants(SVs)between melo(*** ***)and agrestis(*** ***)genomes,including a copy number variation located in the ToLCNDV resistance locus on chromosome ***-wide association studies detected a significant signal associated with climacteric ripening and identified one candidate gene CM_ac12g14720.1(CmABA2),encoding a cytoplasmic short chain dehydrogenase/reductase,which controls the biosynthesis of abscisic *** study provides valuable genetic resources for future research on melon breeding.

关键词： agronomic traits structural

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Seasonal metal fluxes derived by the interaction of surface water and groundwater in an aquaculture estuary

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Acta Oceanologica Sinica 2023年第8期42卷 113-124页

作者： Xiaoxiong Wang jordi Garcia-Orellana Xiaogang Chen Jianan Liu Fenfen Zhang Jianguo Qu Zhuoyi Zhu Jinzhou Du State Key Laboratory of Estuarine and Coastal Research East China Normal UniversityShanghai 200062China ICTA-UAB Institut de Ciència i Tecnologia AmbientalsUniversitat Autònoma de BarcelonaBarcelona E-08193Spain Departament de Física Universitat Autònoma de BarcelonaBarcelona E-08193Spain Key Laboratory of Coastal Environment and Resources of Zhejiang Province School of EngineeringWestlake UniversityHangzhou 310024China School of Oceanography Shanghai Jiao Tong UniversityShanghai 200030China

Submarine groundwater discharge(SGD)plays a major role as a conveyor of metals to coastal ***,the seasonal change of metal fluxes derived through SGD is ***,we evaluated the behaviours and fluxes of trace metals(Mn,Fe,Ba,Pb,U,Cr,Zn,Cu)in an estuary under different seasonal *** behaviours of trace metals revealed that SGD was the source of Mn(3.51 mmol/(m^(2)·d)),Fe(0.174 mmol/(m^(2)·d))and Ba(0.024 mmol/(m^(2)·d)),but the Cu sink(−0.55μmol/(m^(2)·d))and other metals exhibited a seasonal source‒sink *** seasonal variation of dissolved organic matter and the fresh groundwater proportion in subterranean estuaries may have an important effect on metals fluxes especially for the Fe,Mn and *** result shows that the single seasonal metal fluxes estimation applied to the annual scale will cause a large deviation,up to 3.6 times for Fe,5.5 times for Mn,and 15 times for ***,the influence of seasonal fluctuations on SGDderived metal fluxes cannot be ignored,and our findings will be important for comprehending the metal budget and cycle in nearshore environment.

关键词： subterranean estuary seawater intrusion heavy metals seasonal changes coastal management

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Strain-induced spatially indirect exciton recombination in zinc-blende/wurtzite CdS heterostructures

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Nano Research 2015年第9期8卷 3035-3044页

作者： Dehui Li Yang Liu Maria de la Mata Cesar Magen jordi Arbiol Yuanping Feng Qihua Xiong Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Institut de Ciencia de Materials de Barcelona ICMAB-CSIC Campus de la UAB 08193 Bellaterra Catalonia Spain Laboratofio de Microscopias Avanzadas (LMA) Instituto de Nanociencia de Aragon (INA) ARAID and Departamento de Fisica de la Materia condensada Universidad de Zaragoza 50018 Zaragoza Spain Institucio Catalana de Recerca i Estudis Avancats (ICREA) 08010 Barcelona Catalonia Spain Institut Catala de Nanociencia i Nanotecnologia (ICN2) Campus UAB 08193 Bellaterra Catalonia Spain Department of Physics National University of Singapore 2 Science Drive 3 Singapore 117542 Singapore Division of Microelectronics School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798Singapore

Strain engineering provides an effective mean of tuning the fundamental properties of semiconductors for electric and optoelectronic applications. Here we report on how the applied strain changes the emission properties of hetero- structures consisting of different crystalline phases in the same CdS nanobelts. The strained portion was found to produce an additional emission peak on the low-energy side that was blueshifted with increasing strain. Furthermore, the additional emission peak obeyed the Varshni equation with temperature and exhibited the band-filling effect at high excitation power. This new emission peak may be attributed to spatially indirect exciton recombination between different crystalline phases of CdS. First-principles calculations were performed based on the spatially indirect exciton recombination, and the calculated and experimental results agreed with one another. Strain proved to be capable of enhancing the anti-Stokes emission, suggesting that the efficiency of laser cooling may be improved by strain engineering.

关键词： strain,CdS nanobelts,photoluminescence,spatially indirect excitonrecombination,inter-crystalline phasetransition

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Environment-driven intraspecific variation shows coordination of functional traits of deciduous oaks among and within different biological levels

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Journal of Forestry Research 2024年第6期35卷 95-109页

作者： Yutong Lin Yuan Lai Songbo Tang Jeannine Cavender-Bares Josep Peñuelas jordi Sardans Jianfeng Liu Lingling Zhang Yuanwen Kuang Key Laboratory of Vegetation Restoration and Management of Degraded Ecosystems South China Botanical GardenChinese Academy of SciencesGuangzhou 510650People’s Republic of China Yulin Normal University Yulin 537000People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of SciencesGuangzhou 510650People’s Republic of China Department of Ecology Evolution and Behavior University of MinnesotaSt.PaulMN 55108USA CSIC Global Ecology Unit CREAF-CSIC-UAB08193 BellaterraBarcelonaCataloniaSpain CREAF Cerdanyola del Vallès08193 BarcelonaCataloniaSpain Research Institute of Forestry Chinese Academy of ForestryBeijing 100091People’s Republic of China

Deciduous oaks(Quercus spp.)are distributed from subalpine to tropical regions in the northern hemi-sphere and have important roles as carbon sinks and in climate change *** variations in plant functional traits at multiple biological levels and linking them to environmental variables across geographical ranges is important for forecasting range-shifts of broadly-distrib-uted species under climate *** sampled leaves of five deciduous Quercus *** approximately 20°of latitude(~21°N-41°N)and 20 longitude(~99°E-119°E)across China and measured 12 plant functional traits at different biological *** traits varied distinctively,either within each biological level or among different levels driven by climatic and edaphic *** at the organ level were significantly correlated with those at the cellular and tissue levels,while traits at the whole-plant level only correlated with those at the tissue *** Quercus species responded to changing environments by regulating stomatal size,leaf thickness and the palisade mesophyll thickness to leaf thickness ratios with contrasting degree of effect to adjust the whole-plant functioning,i.e.,intrinsic water use efficiency(iWUE),carbon supply and nitrogen *** results suggest that these deciduous Quercus *** maintain vigour by increasing iWUE when subjected to large temperature changes and insufficient moisture,and by accu-mulating leaf non-structural carbohydrates under drought *** findings provide new insights into the inher-ent variation and trait coordination of widely distributed tree species in the context of climate change.

关键词： Climate gradient Intraspecific variation Plant functional traits Deciduous Quercus species Whole-plant function

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Automated Synthesis of Wideband Bandpass Filters Based on Slow-Wave EBG Structures

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Computers, Materials & Continua 2016年第6期52卷 159-174页

作者： Marco Orellana jordi Selga Paris Vélez Marc Sans Ana Rodríguez Vicente Boria Ferran Martín GEMMA/CIMITEC Departament d’Enginyeria ElectrònicaUniversitat Autònoma de Barcelona08193 Bellaterra(Barcelona)Spain Departamento de Comunicaciones-iTEAM Universitat Politècnica de València46022 ValenciaSpain

This paper is focused on the automated synthesis of wideband bandpass filters operating at microwave frequencies and based on electromagnetic bandgap(EBG)*** classical counterpart of such filter consists of a combination of transmission line sections and shunt-connected grounded stubs placed at equidistant *** replacing the transmission line sections with capacitively-loaded lines(a kind of EBG-based lines)exhibiting the same phase shift at the lower cutoff frequency and the same characteristic(actually Bloch)impedance,filter size is reduced and the spurious pass bands can be efficiently *** practice,the loading capacitances are implemented by means of patches,in order to achieve a fully planar filter *** presence of the patches reduces the effective phase velocity of the capacitively-loaded lines,thus providing a slow-wave effect useful for filter ***,due to periodicity,such EBG-based lines exhibit wide stop bands,which are used for spurious *** though such EBGbased filters were previously reported by some of the authors,a systematic synthesis method was not applied for filter *** this paper,the main aim is to demonstrate the potential of aggressive space mapping(ASM)for that purpose,and it will be shown that such filters can be automatically synthesized.

关键词： Electromagnetic bandgaps(EBG) microwave filters slow-wave transmission lines space mapping.

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Intermittent chaos for ergodic light trapping in a photonic fiber plate

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Light(Science & Applications) 2016年第1期5卷 209-215页

作者： Marina Mariano Gregory Kozyreff Luis G Gerling Pablo Romero-Gomez Joaquim Puigdollers Jorge Bravo-Abad jordi Martorell ICFO-Institut de Ciencies Fotoniques The Barcelona Institute of Science and TechnologyCastelldefels(Barcelona)08860Spain Département de Physique UniversitéLibre de Bruxelles(ULB)Campus de la PlaineBruxelles B-1050Belgium Departament Enginyeria Electrònica Universitat Politècnica de CatalunyaBarcelona 08034Spain Departamento de Física Teórica de la Materia condensada and condensed Matter Physics Center(IFIMAC) Universidad Autónoma de MadridMadrid 28049Spain Departament de Física Universitat Politècnica de CatalunyaTerrassa 08222Spain

Extracting the light trapped in a waveguide,or the opposite effect of trapping light in a thin region and guiding it perpendicular to its incident propagation direction,is essential for optimal energetic performance in illumination,display or light harvesting *** we demonstrate that the paradoxical goal of letting as much light in or out while maintaining the wave effectively trapped can be achieved with a periodic array of interpenetrated fibers forming a photonic fiber *** entering perpendicular to that plate may be trapped in an intermittent chaotic trajectory,leading to an optically ergodic *** fabricated such a photonic fiber plate and showed that for a solar cell incorporated on one of the plate surfaces,light absorption is greatly *** this,we found the unexpected result that a more chaotic photon trajectory reduces the production of photon scattering entropy.

关键词： chaos ergodicity fiber light-guiding plate light harvesting light trapping

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Late Miocene/Early Pliocene vertebrate fauna from Mallorca(Balearic Islands,Western Mediterranean):an update

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Integrative Zoology 2014年第2期9卷 183-196页

作者： Pere BOVER Juan ROFES Salvador BAILON jordi AGUSTÍ Gloria CUENCA-BESCÓS Enric TORRES Josep Antoni ALCOVER IMEDEA(CSIC-UIB) Mediterranean Institute for Advanced StudiesDepartment of Biodiversity and ConservationBalearic IslandsSpain Research Associate Division of Vertebrate Zoology/Mammalogy Department American Museum of Natural HistoryNew YorkNYUSA Department of Stratigraphy and Paleontology University of the Basque CountryLeioaSpain Grupo Aragosaurus-IUCA Area of PaleontologíaEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain UMR 7209-7194 of CNRS Department of Ecology and Biodiversity ManagementNational Museum of Natural HistoryParisFrance ICREA Institut Catalàde Paleoecologia Humana i EvolucióSocial(IPHES)Universitat Rovira i VirgiliTarragonaSpain

The vertebrate fossil record from the Balearic Islands(western Mediterranean)has improved considerably over the past decade,especially in Mallorca and *** Menorca,the Pliocene terrestrial fauna was updated by the discovery and description of the large-sized leporid Nuralagus,several reptiles and an *** Mal-lorca,paleontological exploration yielded 2 deposits with a Late Miocene/Early Pliocene chronology,Calóden Rafelino(CdR)and Na Burguesa-1(NB-1).So far,4 new mammalian taxa and 2 new reptiles have been iden-tified for the CdR deposit,whereas the faunal assemblage from the recently discovered deposit(Apr 2012)of NB-1 is currently composed of,at least,6 terrestrial mammals,8 reptiles and an *** faunal composi-tion and some primitive characteristics of the obtained taxa suggest that the chronology of this deposit is slight-ly earlier than the *** terrestrial vertebrates recorded in these 2 Mallorcan deposits are changing the view of the paleofaunal assemblage previously known for the Plio-Pleistocene of the *** charac-teristics displayed by some of the taxa suggest that these faunas would be at the beginning of an isolated *** this paper we present a preliminary report on the fossils recovered from the NB-1 deposit,as well as some unpublished data from CdR,and we analyze the whole fauna from both Mallorcan deposits,focusing on taxonomical and paleobiogeographical aspects.

关键词： Early Pliocene Late Miocene Mallorca new fauna paleobiogeography

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Diagnosing heart failure in centenarians

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Journal of Geriatric Cardiology 2019年第1期16卷 1-11页

作者： Signe Hoi Rasmussen Karen Andersen-Ranberg jordi Sanchez Dahl Mads Nybo Bernard Jeune Kaare Christensen Sabine Gill Danish Aging Research Center Department of Public HealthUniversity of Southern DenmarkOdenseDenmark Department of Geriatrics Odense University HospitalOdenseDenmark Department of Cardiology Odense University HospitalOdenseDenmark Department of Clinical Biochemistry and Pharmacology Odense University'HospitalOdenseDenmark Max-Planck Odense Center on the Biodemography of Aging University of Southern DenmarkOdenseDenmark

Background As a consequence of the demographic development with increasing proportion of older people,the prevalence of heart failure(HF)is expected to rise with considerable economic and societal ***,knowledge on cardiac structure and function among population-based samples of the exceptional old is *** Population-based study of all persons(no exclusion criteria)living in the western part of Denmark and turning 100 years in the year ***-home face-to-face interviews were conducted,and echocardiography and blood sampling for plasma Brain Natriuretic Peptide(BNP)were offered to those who were able to give *** Out of 303 eligible,238(79%)participated,of which 125(53%)accepted *** ventricular(LV)dysfunction was present in 68(54%)of the participants of whom less than half had HF *** hypertension was present in 31(42%)with no correlation to LV *** well-known association between increased level of BNP and the prevalence of LV dysfunction could not be *** This in-home echocardiographic study shows that more than half of the participants had LV dysfunction,although mostly *** was no association between heart failure symptoms and LV ***,BNP seems to have lost its biomarker potential to rule out heart failure in *** to the latter,and the questionable symptom validity among centenarians,the current criteria to diagnose HF might be less valid in a centenarian population than in younger olds.

关键词： Brain Natriuretic Peptide Centenarian Heart failure In-home echocardiography Left ventricular dysfunction

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PIM-1 inhibition with AZD1208 to prevent osimertinib- induced resistance in EGFR-mutation positive non-small cell lung cancer

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Journal of Cancer Metastasis and Treatment 2019年第3期4卷 80-89页

作者： Jillian Wilhelmina Paulina Bracht Niki Karachaliou jordi Berenguer Manuel Fernandez-Bruno Martyna Filipska Carlos Pedraz-Valdunciel Carles Codony-Servat jordi Codony-Servat RafaelRosell Pangaea Oncology Laboratory of Molecular BiologyQuirón-Dexeus University InstituteBarcelona 08028Spain Instituto Oncológico Dr Rosell(IOR) University Hospital Sagrat CorQuironSalud GroupBarcelona 08029Spain Institut d’Investigacióen Ciències Germans Trias i Pujol Badalona 08916Spain Institut Catalàd’Oncologia Hospital Germans Trias i PujolBadalona 08916Spain Instituto Oncológico Dr Rosell(IOR) Quirón-Dexeus University InstituteBarcelona 08028Spain

Aim: The progression free survival of non-small cell lung cancer (NSCLC) patients has been doubled over the last years, but still single epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) lead to incomplete responses. Compensatory signaling pathways are activated upon single EGFR TKIs. We have shown that compounds, which inhibit these pathways, are synergistic with EGFR TKIs. Proviral integration site for Moloney murine leukemia virus (PIM) has been connected to cancer therapy resistance, being involved in receptor tyrosine kinase, signal transducer and activator of transcription 3 (STAT3) and interleukin-6 signaling. We hypothesized that combined PIM and EGFR inhibition may improve the upfront therapy of EGFR-mutation positive NSCLC. Methods: We reviewed the literature on PIM kinases, and performed cell viability assays, gene expression analyses, and immunoblotting experiments to reveal the mechanisms of action of the PIM inhibitor (AZD1208) alone and combined with osimertinib in five EGFR-mutation positive NSCLC cell lines. Results: Osimertinib alone induced the activation of signal transducer and activator of transcription 3 (STAT3) as well as other signaling nodes. Combined osimertinib and AZD1208 yielded moderate synergistic effects in all ;NSCLC cell lines investigated. Among the EGFR-mutation positive cell lines examined, the H1975 and PC9 cell lines had the highest PIM1 and STAT3 mRNA expression. The combination decreased the osimertinib-induced STAT3 phosphorylation. Conclusion: This study provides a short review on PIM kinases, and shows our results of combined PIM and EGFR inhibition in EGFR-mutation positive NSCLC cell lines. The combination was moderately synergistic but decreased STAT3 phosphorylation, an important signaling node in therapy resistance.

关键词： Non-small cell lung cancer EGFR PIM-1 AZD1208 tyrosine kinase inhibitors

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Wheat ear carbon assimilation and nitrogen remobilization contribute significantly to grain yield

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Journal of Integrative Plant Biology 2016年第11期58卷 914-926页

作者： Bangwei Zhou Maria Dolores Serret Abdelhalim Elazab jordi Bort Pie José Luis Araus Iker Aranjuelo álvaro Sanz-Sáez Key Laboratory of Vegetation Ecology Ministry of EducationInstitute of Grassland ScienceNortheast Normal University Unit of Plant Physiology Faculty of BiologyUniversity of Barcelona Agrobiotechnology Institute Public University of Navarra-CSIC-Navarra GovernmentArrosadia Campus Department of Plant Biology University of the Basque Country Pharmacy Faculty

The role of wheat ears as a source of nitrogen （N） and carbon （C） in the grain filling process has barely been studied. To resolve this question, five wheat genotypes were labeled with 15N-enriched nutrient solution. N remobilization and absorption were estimated via the nitrogen isotope composition of total organic matter and Rubisco. Gas exchange analyses showed that ear photosynthesis contributed substantially to grain filling in spite of the great loss of C due to respiration. Of the total kernel N, 64.7% was derived from the N acquired between sowing and anthesis, while the remaining 35.3% was derived from the N acquired between anthesis and maturity. In addition, 1.87 times more N was remobilized to the developing kernel from the ear than from the flag leaf. The higher yielding genotypes showed an increased N remobflization to the kernel compared to the lower yielding genotypes. In addition, the higher yielding genotypes remobilized more N from the ears to the kernel than the lower yielding genotypes, while the lower yielding genotypes remobilized more N from the flag leaf to the kernel. Therefore, the ears contribute significantly toward fulfilling C and N demands during grain filling.

关键词： Carbon accumulation ear grain yield nitrogenaccumulation Rubisco

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