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Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF-β1/BMP-2 activity

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International Journal of Oral Science 2018年第4期10卷 203-211页

作者： Maria B.Asparuhova jordi caballé-serrano Daniel Buser Vivianne Chappuis Laboratory of Oral Cell Biology School of Dental MedicineUniversity of Bern Department of Oral Surgery and Stomatology School of Dental MedicineUniversity of Bern Department of Oral and Maxillofacial Surgery School of Dental MedicineUniversitat Internacional de Catalunya

Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (P <0.001) release of transforming growth factor-β1 (TGF-β1) from autologous bone within 10 min versus a delayed bone morphogenetic protein-2 (BMP-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMP-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMP-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMP-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMP-2-induced osteoblast differentiation due to prolonged BMP signaling and reduced expression of the BMP-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.

关键词： Bone-conditioned medium contributes to initiation and progression of osteogenesis by exhibiting synergistic TGF BMP-2 activity

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Analysis of an event study using the Fama–French five‑factor model:teaching approaches including spreadsheets and the R programming language

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Financial Innovation 2023年第1期9卷 2042-2075页

作者： Monica Martinez‑Blasco Vanessa serrano Francesc Prior jordi Cuadros IQS School of Management-Universitat Ramon Llull Via Augusta 39008017 BarcelonaSpain IQS School of Engineering-Universitat Ramon Llull Via Augusta 39008017 BarcelonaSpain

The current financial education framework has an increasing need to introduce tools that facilitate the application of theoretical models to real-world data and ***,only a limited number of free tools are available for this *** this lack of tools,the present study provides two approaches to facilitate the implementa-tion of an event *** first approach consists of a set of MS Excel files based on the Fama–French five-factor model,which allows the application of the event study methodology in a semi-automatic *** second approach is an open-source R-programmed tool through which results can be obtained in the context of an event study without the need for programming *** tool widens the calculus possibilities provided by the first approach and offers the option to apply not only the Fama–French five-factor model but also other models that are common in the finan-cial *** is a user-friendly tool that enables reproducibility of the analysis and ensures that the calculations are free of manipulation *** approaches are freely available and ready-to-use.

关键词： Event study Fama–French five-factor model Financial education Teaching innovation Spreadsheet R programming language

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Positive effect of spring advance on the diet quality of an alpine herbivore

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Integrative Zoology 2022年第1期17卷 78-92页

作者： Johan ESPUNYES Emmanuel serrano Sara CHAVES jordi BARTOLOMÉ Pierre MENAUT Elena ALBANELL Pascal MARCHAND Kévin FOULCHÉ Mathieu GAREL Wildlife Ecology and Health group(WE&H)i Servei d’Ecopatologia de la Fauna Salvatge(SEFaS) Department of Animal Medicine and SurgeryFaculty of Veterinary MedicineUniversitat Autònoma de BarcelonaBellaterraSpain Wildlife Conservation Medicine Research Group(WildCoM) Department of Animal Medicine and SurgeryFaculty of Veterinary MedicineUniversitat Autònoma de BarcelonaBellaterraSpain Research and Conservation Department Zoo de BarcelonaBarcelonaSpain Group of Ruminant Research(G2R) Department of Animal and Food ScienceFaculty of Veterinary MedicineUniversitat Autònoma de BarcelonaBellaterraSpain French Agency for Biodiversity Direction Régionale OccitanieService d’Appui aux Acteurs et Mobilisation du TerritoireVilleneuve de RivièreFrance French Agency for Biodiversity Direction de la Recherche et Appui ScientifiqueUnitéOngulés SauvagesGièresFrance

Changes in vegetation phenology related to global warming are having alarming effects on the life history traits of many herbivore *** changes are particularly critical in alpine ecosystems,where strong climate limitations on plant growth make seasonal synchronization imperative for the growth,reproduction and survival of ***,despite the pivotal role of resource-use strategies on the performances of such species,few studies have explicitly assessed the mechanistic impact of climate change on their *** aimed to fill this gap by studying the effect of spring onset on the dietary composition and quality of a medium-size alpine herbivore while considering density-dependent processes and age-and sex-specific differences in foraging *** an exceptional,long-term(24 years)direct individual-based dietary monitoring of a Pyrenean chamois population(Rupicapra pyrenaica pyrenaica),we showed that ongoing earlier onsets of spring are leading to an earlier access to high-quality forage and therefore a higher diet quality at a fixed date,without apparent changes in diet *** also showed that at high densities,intraspecific competition reduced diet quality by driving animals to feed more on woody plants and less on nutritious forbs and *** assessing the mechanistic effects of global warming on the dietary patterns of species at the center of trophic networks,this study is an essential step for predictive models aiming at understanding the ongoing ecosystem consequences of the global climatic crisis.

关键词： cuticle microhistological analysis diet composition near-infrared spectroscopy Rupicapra pyrenaica

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Management of hypoxemia in SARS-CoV-2 infection:Lessons learned from one year of experience,with a special focus on silent hypoxemia

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Journal of Intensive Medicine 2021年第1期1卷 26-30页

作者： Ricardo serrano Xavier Corbella jordi Rello Critical Care Department.Hospital de Hellín.Gerencia Atención Integrada de Hellín Albacete 02400Spain Interna Medicine Department Hospital Universitari de Bellvitge-IDIBELLL’Hospitalet de LlobregatBarcelona 08907Spain School of Medicine Universitat Internacional de CatalunyaBarcelona 08017Spain Vall d’Hebron Institute of Research Barcelona 08035Spain Research in Critical Care CHU CaremeauNîmes 30900France Centro de Investigación Biomédica en Red de Enfermedades Respiratorias(CIBERES) Instituto de Salud Carlos IIIMadrid 28029Spain

Silent hypoxemia is common in patients with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)*** this article,the possible pathophysiological mechanisms underlying respiratory symptoms have been reviewed,and the presence of hypoxemia without hypoxia is also *** experience we have gained since the start of the Coronavirus disease 19(COVID-19)pandemic has changed our point of view about which patients with respiratory involvement should be admitted to the intensive care unit/high-dependency unit for mechan-ical ventilation and *** patients with clinically well-tolerated mild to moderate hypoxemia(silent hypoxemia),regardless of the extent of pulmonary opacities found in radiological studies,the administration of supplemental oxygen therapy may increase the risk of endothelial *** risk of sudden respiratory arrest during emergency intubation,which could expose healthcare workers to infection,should be considered along with the risks of premature *** for intubation need to be revisited based on updated evidence showing that many patients with severe hypoxemia do not show increased work of *** has implica-tions in patient management and may explain in part reports of broad differences in outcomes among intubated patients.

关键词： COVID-19 Acute respiratory distress syndrome(ARDS) Pandemic Critical care

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西班牙Dom建筑事务所办公室

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中国建筑装饰装修 2011年第8期 174-179页

作者： Pablo serrano Elorduy Blanca Elorduy jordi Anguera Dom建筑事务所

在被Dom事务所当成办公室之前．这个空间是一个仓库，完全和外界是隔绝的。所以Dom要做的第一步就是将室内空间向户外的街道和花园打开。于是，他们把办公室设计成了一个铁皮木盒．并利用大面积的玻璃开窗引进室外光线。所有铁皮都被漆... 详细信息

在被Dom事务所当成办公室之前．这个空间是一个仓库，完全和外界是隔绝的。所以Dom要做的第一步就是将室内空间向户外的街道和花园打开。于是，他们把办公室设计成了一个铁皮木盒．并利用大面积的玻璃开窗引进室外光线。所有铁皮都被漆成深灰的石墨色．与室内的家具同一色调。玻璃窗内侧安置了深灰色幕布，可以调节空间的隐私度。

关键词：办公室设计建筑事务所 Dom 西班牙室内空间玻璃窗铁皮仓库

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田园慢生活

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现代装饰（家居） 2015年第2期 154-159页

作者： Pablo serrano Elorduy Blanca Elorduy jordi Anguera 范嘉苑西班牙Dom Arquitectura

本案位于西班牙莱里达的一个小镇上,坐拥青翠葱郁的山林美景和美不胜收的田园景色。业主为了腾出更多的住宅空间来款待客人,所以决定将原有的几个牲口棚、仓库等空间改造成住宅。设计师保留了建筑原有的体量,翻新了建筑立面及屋顶,并对... 详细信息

本案位于西班牙莱里达的一个小镇上,坐拥青翠葱郁的山林美景和美不胜收的田园景色。业主为了腾出更多的住宅空间来款待客人,所以决定将原有的几个牲口棚、仓库等空间改造成住宅。设计师保留了建筑原有的体量,翻新了建筑立面及屋顶,并对室内空间进行了全面的改造。为了契合周遭的乡村景色,房子内部多采用木材及石材元素,以打造出粗犷自然的田园风格。家具及配饰的选择上以简约大方的风格为主,没有过多的配饰,以突出建筑本身的结构美。

关键词：住宅空间莱里达田园风格结构美建筑立面体量照明效果色系

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Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant

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World Journal of Transplantation 2015年第1期5卷 19-25页

作者： José M álamo Claudia Olivares Lydia Barrera Luis M Marín Gonzalo Suarez Carmen Bernal Juan serrano jordi Muntané Francisco J Padillo Miguel A Gómez Unit of Liver Transplantation Department of Surgery University of Seville41013 Seville Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 08036 Barcelona Spain Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla Seville 41013 Spain

AIM: To investigate if conversion to the mammalian target of rapamycin inhibitors(mTORi) improves renal function in diabetic and/or hypertensive liver transplant patients immunosuppressed with tacrolimus or ***: The study included 86 liver graft recipients immunosuppressed with mTORi treatment after orthotopic liver transplantation(OLT), including all liver recipients with worsening renal function before conversion to mTORi(n = 55 patients) and recipients with normal renal function who converted to m TORi for other reasons(n = 31 patients). We identified patients with diabetes mellitus(n = 28), arterial hypertension(n = 27), proteinuria(n = 27) and all three factors(n = 8)(some patients have hypertension and diabetes and no proteinuria). The primary endpoint was evolution in renal function defined as the development in plasma creatinine as a function of diabetes mellitus(DM), hypertension(HT) or proteinuria. We required elevated serum creatinine for at least two weeks to define renal ***: Only patients that converted because of renal failure with plasma creatinine levels > 1.5 mg/dL showed an improvement of renal function(2.14 to 1.77 mg/dL)(P = 0.02). Patients with DM showed no improvement of serum creatinine levels(1.31 mg/dL to 1.37 mg/dL) compared with non DM patients(1.31 mg/dL to 1.15 mg/dL)(P = 0.01), HT patients(1.48 mg/dL to 1.5 mg/dL) with non HT patients(1.21mg/d L to 1.08 mg/dL) and patients with proteinuria(1.44 mg/dL to 1.41 mg/dL) and no proteinuria(1.31 mg/dL to 1.11 mg/dL). CONCLUSION: In OLT recipients with diabetes or hypertensive nephropathy, conversion to m TORi does not improve renal function but stabilizes plasma levels of creatinine. Proteinuria is not a contraindication to conversion to m TORi; it also stabilizes renal function. Conversion to m TORi should only be avoided in patients with diabetes, hypertension and proteinuria.

关键词： Mammalian target of rapamycin inhibitors Liver transplant Renal dysfunction Hypertension Diabetes

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Improving outcomes in pancreatic cancer: Key points in perioperative management

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World Journal of Gastroenterology 2014年第39期20卷 14237-14245页

作者： José M álamo Luis M Marín Gonzalo Suarez Carmen Bernal Juan serrano Lydia Barrera Miguel A Gómez jordi Muntané Francisco J Padillo Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREH o Ciberehd) Instituto de Salud Carlos Ⅲ 28029 Madrid Spain Francisco J Padillo Department of General Surgery Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla 41013 Seville Spain

This review focused in the perioperative management of patients with pancreatic cancer in order to improve the outcome of the disease. We consider that the most controversial points in pancreatic cancer management are jaundice management, vascular resection and neoadjuvant therapy. Preoperative biliary drainage is recommended only in patients with severe jaundice, as it can lead to infectious cholangitis, pancreatitis and delay in resection, which can lead to tumor progression. The development of a phase Ⅲ clinical trial is mandatory to clarify the role of neo-adjuvant radiochemotherapy in pancreatic adenocarcinoma. Venous resection does not adversely affect postoperative mortality and morbidity, therefore, the need for venous resection should not be a contraindication to surgical resection in selected patients. The data on arterial resection alone, or combined with vascular resection at the time of pancreatectomy are more heterogeneous, thus, patient age and comorbidity should be evaluated before a decision on operability is made. In patients undergoing R0 resection, arterial resection can also be performed.

关键词： Pancreatic cancer Obstructive jaundice Preoperativ

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气管内肺泡Ⅱ型细胞移植逆转博来霉素诱导的肺纤维化

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中华结核和呼吸杂志 2008年第4期31卷 249-249页

作者： serrano-Mollar A NacherM Gay-jordi G 金建敏孙永昌

背景和目的：干细胞移植被认为是能够修复肺纤维化的治疗途径，但因研究结果不尽一致，限制了干细胞作为一种有效治疗方法的应用。肺泡Ⅱ型细胞是肺上皮的前体细胞，上皮细胞损伤后能够快速增殖、分化成肺泡Ⅰ型细胞。在肺纤维化过程中... 详细信息

背景和目的：干细胞移植被认为是能够修复肺纤维化的治疗途径，但因研究结果不尽一致，限制了干细胞作为一种有效治疗方法的应用。肺泡Ⅱ型细胞是肺上皮的前体细胞，上皮细胞损伤后能够快速增殖、分化成肺泡Ⅰ型细胞。在肺纤维化过程中，肺泡Ⅱ型和Ⅰ型细胞消亡，代之以大量的纤维母细胞增生，提示肺泡Ⅱ型细胞的消失损害了修复机制，在肺纤维化的发生发展中起重要作用。本研究旨在探讨气管内肺泡Ⅱ型细胞移植能否中止和逆转博来霉素诱导的大鼠肺纤维化。

关键词：肺泡Ⅱ型细胞肺纤维化博来霉素细胞移植气管内逆转上皮细胞损伤纤维母细胞增生

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基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小鼠新的代谢通路的探索工具

基于LC-Q-TOF的多组织代谢组学:一种确认受富含多元酚食物影响小...

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作者： Mariona Jove Jose C.E.serrano Nadia Ortega Victoria Ayala Neus Angles jordi Reguant Jose R.Morello Maria Paz Romero Maria Jose Motilva Joan Prat Reinald Pamplona Manuel Portero-Otin 王茂清

现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明...

现在有关膳食对机体影响的代谢组学研究仅仅是研究膳食对血样和尿样的影响,而忽略了其他生物样本,例如盲肠内容物,就等于遗漏了消化系统的作用和忽略了肠道微生物菌群在代谢中的重要作用和其在生物利用率方面的影响。许多研究已经证明多组织样本代谢组学在评估营养物质在机体内的代谢影响方面的重要性。然而这些研究都是以核磁共振技术为分析手段的,由于核磁共振技术的低灵敏度,限制了

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