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Frontiers in Biology 2016年第3期11卷 246-255页

作者： Charlotte M. Ermine jordan L. wright Clare L. Parish Davor Stanic Lachlan H. Thompson The Florey Institute for Neuroscience and Mental Health The University of Melbourne Parkville Victoria 3010 Australia Current address Wolfson Institute for Biomedical Research University College London Gower Street London WC1E 6BT UK

Although the functional neuroanatomy of the midbrain dopamine （mDA） system has been well characterized, the literature regarding its capacity to innervate the hippocampal formation has been inconsistent. The lack of expression of definitive markers for dopaminergic fibers, such as the dopamine transporter, in the hippocampus has complicated studies in this area. Here we have used immunohistochemical techniques to characterize the tyrosine hydroxylase expressing fiber network in the rat hippocampus, combined with retrograde tracing from the dentate gyrus to assess the capacity for afferent innervation by mDA neurons. The results indicate that virtually all tyrosine hydroxylase fibers throughout the hippocampus are of a noradrenergic phenotype, while the overlying cortex contains both dopaminergic and noradrenergic fiber networks. Furthermore, retrograde tracing from the dentate gyrus robustly labels tyrosine hydroxylase-immunoreactive noradrenergic neurons in the locus coeruleus but not mDA neurons.

关键词： noradrenaline hippocampus connectivity DAT neurogenesis

Oxidative dissolution of Cr(OH)_(3) and mixed Fe-Cr(Ⅲ)phases by aqueous Mn(Ⅲ)-pyrophosphate complex

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Journal of Environmental Sciences 2024年第5期139卷 105-113页

作者： Mismel Ruiz-Garcia jordan Stanberry Giovanna Ballerini Ribeiro Vasileios Anagnostopoulos Department of Chemistry University of Central FloridaOrlando FL 32816USA

The key role of manganese(Mn)in the biogeochemical cycle of trace elements has been of great interest in recent ***,the redox properties of aqueous Mn(Ⅲ)have been studied to a lesser ***(Ⅲ)is not stable in solution by ***,when complexed with inorganic ligands,it has shown potential to oxidize and reduce trace *** the present study,we are exploring the redox characteristics of the complex Mn(Ⅲ)-Pyrophosphate(Mn(Ⅲ)-PP).This complex is stable over a wide range of pH values but requires the ratio of Mn:PP to be less than 1:***,the redox reaction of chromium(Cr(Ⅲ))and Mn(Ⅲ)-PP is investigated.A solid,Cr(OH)_(3),is used as a source of Cr(Ⅲ).For this reaction,environmentally relevant parameters,such as pH,ionic strength,ratio Mn(Ⅲ)/Cr(Ⅲ),and excess of ligand,were *** showed that Mn(Ⅲ)can effectively oxidize Cr(Ⅲ)to Cr(Ⅵ),taking about 15 days for the reaction to *** reaction occurs only under acidic conditions(pH4),and with a low excess of *** initial Mn(Ⅲ)concentration decreases as the Cr(Ⅵ)is produced,and Cr(Ⅵ)can be adsorbed back into the Cr(OH)_(3)surface,limiting the mobility of this toxic *** this adsorption,significant amounts of Cr(VI)are release in the aqueous *** study shows the importance of a mobile species(Mn-PP complex)in the oxidation of Cr(Ⅲ)and the release of Cr(Ⅵ)to the environment.

关键词： Chromium Manganese Pyrophosphate complex Sorption Ionic strength Redox

Rapid production of new oligodendrocytes is required in the earliest stages of motor skill learning

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Rapid production of new oligodendrocytes is required in the ...

CDISC针刺治疗领域标准用户指南的应用解读

中国神经科学学会第十二届全国学术会议

作者： Lin XIAO David Ohayon Ian A.McKenzie Alexander Sinclair-Wilson jordan wright Alexander Fudge Ben Emery Hui-Liang LI William D Richardson Wolfson Institute for Biomedical Research University College London Institute of Neuroscience Second Military Medical University Centre de Biologie du Développement University Paul Sabatier Jungers Center for Neurosciences Research Oregon Health and Science University

Objective To investigate the possible role of oligodendrocyte in learning. Methods By searching published expression databases, we identified a novel marker of newly-forming oligodendrocytes – the ecto-enzyme Enpp6 – and used this to track oligodendrocyte differentiation in adult mice as they learned a motor skill(running on a complex wheel with unevenly spaced rungs). Results Production of Enpp6-expressing immature oligodendrocytes was accelerated within just 2.5 hours exposure to the complex wheel in subcortical white matter and within 4 hours in motor cortex. Conditional deletion of Myelin regulatory factor(Myrf) in oligodendrocyte precursors blocked formation of new Enpp6+ oligodendrocytes and impaired learning within the same -3 hour time frame. This very early requirement for oligodendrocytes suggests a direct and active role in learning, closely linked to synaptic strengthening. Running performance of normal mice continued to improve over the following week accompanied by secondary waves of oligodendrocyte precursor proliferation and differentiation. Conclusion We conclude that new oligodendrocytes contribute to both early and late stages of motor skill learning.

关键词： motor learning motor performance skill learning glia oligodendrocyte precursor cell NG2 cell myelin white matter mouse

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中国针灸 2024年

作者：李庚 jordan Li 温泽淮广州中医药大学第二附属医院省部共建中医湿证国家重点实验室广东省中医院美国国家癌症研究所企业词汇服务中心广州中医药大学科技创新中心

提高研究数据质量是高质量针灸临床研究的重要环节之一。临床数据交换标准协会（CDISC）开发了一系列标准，用以支持临床研究数据的采集、制表和分析。为更好地提高针刺临床研究效率和质量，同时促进多个同类研究数据的整合、共享和二... 详细信息

提高研究数据质量是高质量针灸临床研究的重要环节之一。临床数据交换标准协会（CDISC）开发了一系列标准，用以支持临床研究数据的采集、制表和分析。为更好地提高针刺临床研究效率和质量，同时促进多个同类研究数据的整合、共享和二次分析，CDISC制定并发布了针刺治疗领域标准用户指南。本文主要介绍针刺治疗领域标准用户指南，包括相关概念、主要内容及其如何在针刺临床研究中应用，并示例说明。

关键词：临床数据交换标准协会针灸数据标准化临床研究治疗领域标准

Changes in the adult sex ratio of six duck species breeding populations over two decades

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Avian Research 2024年第2期15卷 202-210页

作者： Monika Homolkova Petr Musil Diego Pavon-jordan Dorota Gajdosova Zuzana Musilova Sarka Neuzilova Jan Zouhar Department of Ecology Faculty of Environmental SciencesCzech University of Life Sciences PragueKamýcka 129CZ-16521Prague–SuchdolCzech Republic Department of Terrestrial Ecology Norwegian Institute for Nature Research(NINA)PO Box 5685 TorgardenTrondheimN-7485Norway Department of Econometrics Faculty of Informatics and StatisticsUniversity of Economicsnam.W.Churchilla 4CZ-13067Prague 3Czech Republic

Despite all efforts,long-term changes in the adult sex ratios of breeding duck populations are still unclear;this uncertainty is especially true for male-bias populations,which are often under the scrutiny of researchers lacking convenient results for the active protection of endangered *** with male-bias populations are usually strongly affected by a decline in population size that leads to a higher extinction *** this study,we examined our long-term data of the abundance of breeding populations in six duck species(Mallard Anas platyrhynchos,Gadwall Mareca strepera,Red-crested Pochard Netta rufina,Common Pochard Aythya ferina,Tufted Duck Aythya fuligula,and Common Goldeneye Bucephala clangula)from fishponds in South Bohemia,Czechia,between 2004 and *** evidence was used to assess long-term changes in the adult sex ratio in these breeding populations and investigate the possible effects of the NAO index(North Atlantic Oscillation index)on them,indicating climate conditions in *** determined a long-term decrease of the proportion of females in the breeding season in two of the six examined species:Common Pochard and Red-crested Pochard,which is driven by the long-term increase in the number of males in contrast to the decreasing or stable number of females likely caused by different migration behaviours between females and *** the case of Common Pochard,in breeding populations,we estimated 60-65%of males in the early 2000s rising to 75-80%in the early ***,we establish no significant effects linked to climate conditions of the previous winter in these species as a crucial cause of the changes of the proportion of females in the breeding population.

关键词： Adult sex ratio Breeding population Population dynamics Red-listed species Waterfowl Winter weather conditions

Molecular mechanism of a coastal cyanobacterium Synechococcus *** 7002 adapting to changing phosphate concentrations

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Marine Life Science & Technology 2024年第3期6卷 562-575页

作者： Qiao-Wei Sun Yu Gao jordan Wang Fei-xue Fu Cheng-Wen Yong Shuang-Qing Li Hai-Long Huang Wei-Zhong Chen Xin-Wei Wang Hai-Bo Jiang School of Marine Sciences Ningbo UniversityNingbo 315211China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519080China School of Life Sciences Central China Normal UniversityWuhan 430079China Department of Biological Sciences University of Southern CaliforniaLos AngelesCA 90089USA

Phosphorus concentration on the surface of seawater varies greatly with different environments,especially in *** molecular mechanism by which cyanobacteria adapt to fluctuating phosphorus bioavailability is still *** this study,transcriptomes and gene knockouts were used to investigate the adaptive molecular mechanism of a model coastal cyanobacterium Synechococcus *** 7002 during periods of phosphorus starvation and phosphorus recovery(adding sufficient phosphorus after phosphorus starvation).The findings indicated that phosphorus deficiency affected the photosynthesis,ribosome synthesis,and bacterial motility pathways,which recommenced after phosphorus was *** more,most of the metabolic pathways of cyanobacteria were enhanced after phosphorus recovery compared to the control which was kept in continuous phosphorus replete *** on transcriptome,54 genes potentially related to phosphorusdeficiency adaptation were selected and knocked out individually or in *** was found that five mutants showed weak growth phenotype under phosphorus deficiency,indicating the importance of the genes(A0076,A0549-50,A1094,A1320,A1895)in the adaptation of phosphorus *** mutants were found to grow better than the wild type under phosphorus deficiency,suggesting that the products of these genes(A0079,A0340,A2284–86)might influence the adaptation to phosphorus *** analysis revealed that cyanobacteria exposed to highly fluctuating phosphorus concentrations have more sophisticated phosphorus acquisition *** results elucidated that Synechococcus *** 7002 have variable phosphorus response mechanisms to adapt to fluctuating phosphorus concentration,providing a novel perspective of how cyanobacteria may respond to the complex and dynamic environments.

关键词： Synechococcus sp PCC 7002 Phosphorus fluctuation Cyanobacteria ・Gene knockout Molecular mechanism

Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King jordan B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

在庙堂与江湖之间——苏轼和王守仁的仕途与文思

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孔学堂 2024年第1期11卷 59-69,168-177页

作者：徐圻 Liu Huawen(译) jordan B.Martin(校) 国际儒学联合会贵州省哲学学会贵州贵阳550525 孔学堂学术委员会 the Foreign Languages School at Shanghai Jiao Tong University Yuelu Academy at Hunan University

苏轼(苏东坡)和王守仁(王阳明),这是两个在中华文化史上具有顶级影响力的名字。他们各自所处的时代相差400余年,不可同日而语;他们一个是北宋文学家、思想家、政治家,一个是明代哲学家、政治家、军事家;他们的生活道路、政治生涯、文化... 详细信息

苏轼(苏东坡)和王守仁(王阳明),这是两个在中华文化史上具有顶级影响力的名字。他们各自所处的时代相差400余年,不可同日而语;他们一个是北宋文学家、思想家、政治家,一个是明代哲学家、政治家、军事家;他们的生活道路、政治生涯、文化贡献、历史影响都很不相同。但苏轼和王守仁,有许多相似或相近之处,比如他们的社会背景、政治抱负、人生遭遇、思想倾向、文化情怀等等。比较苏轼和王守仁的相同与不同,对于认识、反思中国古代的政治生态和文化走向是有启示意义的。

关键词：苏轼和王守仁政治境遇文学高峰哲学宗师历史回声

Maternal Group B Streptococcus Infection Correlates Inversely With Preeclampsia in Pregnant African American Women

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Maternal-Fetal Medicine 2024年第1期6卷 23-28页

作者： Keun Soo Kwon Tzu Hsuan Cheng Simone A。Reynolds jordan Zhou Huchong Cai Sharon Lee Ivan Velickovic Mudar Dalloul David Wlody Ming Zhang Department of Anesthesiology State University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Epidemiology and Biostatistics School of Public HealthState University of New York-Downstate Health Sciences UniversityNew York 11203USA Department of Obstetrics and Gynecology State University of New York-Downstate Health Sciences UniversityNew York 11203USA

Objective:To determine whether an association exists between group B Streptococcus(GBS)colonization and preeclampsia among pregnant Black ***:This retrospective cross-sectional study involved Black women who gave birth at State University of New York Downstate Hospital between January 2010 and December *** were collected from the Obstetric Department,including delivery date,time,mode of delivery,age of the mother,weeks of gestation at delivery,and antepartum *** GBS test results were originally determined using the eSwab transport *** was defined based on the American College of Obstetricians and Gynecologists criteria for the periods 2010–2012 and 2013–*** primary outcome was whether GBS was associated with the outcome of preeclampsia in the population of Black ***,including smoking status,gestational age,parity,body mass index,maternal age,and presence of herpes simplex virus(HSV)and human immunodeficiency virus(HIV)were examined as potential ***-squared test and logistic regression model were used,presenting odds ratios with 95%confidence intervals(P<0.050),analyzed with SAS on Demand for Academics(SAS Institute,Inc.,NY).Results:Among the 8,019 Black women included in this study,GBS-positive women(n=977)had a 53%reduction in the likelihood of being diagnosed with preeclampsia compared to GBS-negative women(adjusted odds ratio,0.47;95%confidence interval,0.32–0.70).We did not find evidence of differences in the distribution of smoking habits(P=0.783)or maternal age(P=0.107)between GBS-positive and GBS-negative ***,the GBS-positive women tended to be less likely to have a preterm delivery(9.62%(94/977)vs.24.24%(1707/7042),P<0.001),less likely to be nulliparous(33.37%(326/977)vs.37.87%(2667/7042),P=0.006),and less likely to be obese(51.38%(502/977)vs.55.30%(3894/7042),P<0.001)compared with GBS-negative *** contrast,GBS-positive women were more likely to have a comorbid infecti

关键词： Pregnancy outcome Preeclampsia GBS colonization African American Afro-Caribbean

一种历时性的、尺度灵活的、关系性的、视角化的运作:捍卫(一直变革的)媒介特异性

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世界电影 2024年第3期 47-69页

作者： [美国]乔丹·斯约尔柏愔(译) 不详南京师范大学金陵女子学院

至少从弗里德里希·基特勒(Friedrich Kittler)宣称光纤电缆是“媒介的终结”以来,电影和媒介研究领域就有了这样一种观点:随着所有的媒介变成数字化,媒介特异性的概念就逐渐变得越来越没有意义。与此同时,随着媒介学者将注意力转向诸... 详细信息

至少从弗里德里希·基特勒(Friedrich Kittler)宣称光纤电缆是“媒介的终结”以来,电影和媒介研究领域就有了这样一种观点:随着所有的媒介变成数字化,媒介特异性的概念就逐渐变得越来越没有意义。与此同时,随着媒介学者将注意力转向诸如尘埃、城市和鲸鱼,很多人都质疑我们的领域是否具有一致性。我认为尽管表述方式有所变化,但数字融合使媒介特异性变得更为重要,而不是无足轻重。虽然我们的研究对象广泛,无法凝聚我们的学科,但将媒介特异性的使用作为一种历时性的、尺度灵活的、关系性的、视角化的运作却可以做到。

关键词：媒介研究弗里德里希数字融合光纤电缆历时性数字化基特勒特异性