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Aging impairs the osteocytic regulation of collagen integrity and bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha Dole Nadja M.Maldonado Luna Natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina D.King jordan B.Burton Birgit Schilling Simon Melov Simon tang Eric Schaible Tamara Alliston Department of Orthopaedic Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Graduate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in elderly *** molecular mechanisms that establish and maintain bone quality,independent of bone mass,are unknown but are thought to be primarily determined by *** hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling(PLR),which maintains bone material *** examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged bone displayed decreased TGFβsignaling and PLR,but aging did not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted the behavior of collagen material at the nanoscale and tissue scale in macromechanical *** effects of age on bone mass,density,and mineral material behavior were independent of osteocytic TGFβ.We determined that the decline in bone quality with age arises from the loss of osteocyte function and the loss of TGFβ-dependent maintenance of collagen integrity.

关键词： maintain primarily integrity

氢取代石墨单炔的机械化学合成及其电催化特性

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物理化学学报 2018年第9期34卷 1080-1087页

作者：李乔丹李永唐佳宁崔晓莉复旦大学材料科学系上海200433 上海空间电源研究所上海200245 帝国理工学院先进材料科学与工程系

氢取代石墨单炔是一种仅由苯环上的sp^2杂化碳和氢与乙炔基上的sp杂化碳组成具有与石墨炔相似平面网状结构的二维富碳材料。本文以碳化钙和三溴苯为原料,通过机械化学方法合成了氢取代石墨单炔,并通过X射线电子能谱、拉曼光谱、固体核... 详细信息

氢取代石墨单炔是一种仅由苯环上的sp^2杂化碳和氢与乙炔基上的sp杂化碳组成具有与石墨炔相似平面网状结构的二维富碳材料。本文以碳化钙和三溴苯为原料,通过机械化学方法合成了氢取代石墨单炔,并通过X射线电子能谱、拉曼光谱、固体核磁共振成像~1H谱和透射电子显微镜加以证实。紫外可见漫反射吸收光谱和电化学测试表明样品为p型半导体,带隙为2.30 eV,在硫酸钠溶液(pH=7)中的析氧起始过电位为0.04 V,在催化产氧和光催化方面具有应用潜力。

关键词：氢取代石墨单炔机械化学半导体析氧

Clean coal geology in China:Research advance and its future

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International Journal of Coal Science & Technology 2020年第2期7卷 299-310页

作者： Xiaoshuai Wang Yuegang tang Shaoqing Wang Harold HSchobert College of Geoscience and Surveying Engineering China University of Mining and Technology(Beijing)Beijing100083China The EMS Energy Institute The Pennsylvania State UniversityUniversity ParkPennsylvania16802United States Schobert International LLCJordanMinnesota55352United States

In China,the connection between coal utilization and environmental pollution has been increasingly evident due to the rapid growth in energy *** coal technology(CCT)is one of the effective methods to address coal-associated ***,CCT needs the practical and theoretical support of clean coal geology(CCG).In this paper,a new definition of CCG is proposed,based on the definitions of coal,coal geology,and CCT,combined with the development of national *** is the discipline comprehensively researching the genesis,nature,distribution,cleaning potential,clean utilization and environmental effects of resources(coal,coal bed methane,and other coal-associated resources)that can be cleaned by *** research content of CCG is discussed from different aspects,such as cleaning potential evaluation,geological guarantee for coal mining,ash yields and sulfur contents,trace elements,pollution caused by coal,and mine *** progress of CCG in China is also briefly divided into four stages and ***,scientific problems in CCG are summarized and an outlook for CCG is given.

关键词： Clean coal Clean coal geology Research content Progress China

Afteruse development of former landfll sites in Hong Kong

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第6期5卷 443-451页

作者： C.T.Wong M.K.Leung M.K.Wong W.C.tang Architectural Services Department HKSAR Government

Landfll is one of the major methods in disposing of municipal solid waste(MSW) in Hong Kong. There are now 13 closed landfll sites in Hong Kong, and a restoration program has been launched since 1999 to transform the closed landfll sites back into recreational area. The MSW underneath these closed landfll sites will biodegrade slowly and gradually, releasing toxic gases and leachate. As there have only been a few afteruse development ever completed in Hong Kong, this paper describes the consideration in planning and design of two former landfll sites in Hong Kong–Ngau Chi Wan(NCW) and jordan Valley(JV) landflls, in particular a discussion on the MSW settlement. Various models in predicting the longterm MSW settlement have been available. This paper reviews the applicability of these models to predict MSW settlement. However, as the predicted settlements can be signifcantly in error, they need sitespecifc calibration and validation. This paper therefore presents the settlement monitoring data in these former landfll sites over the last 30 years, and suggests modifying the Bjarngard and Edgers’ method for estimating this long-term settlement as well as the effect of additional surcharge due to afteruse development. Based on the regression of these data, compression indices Cce and C at different stages of the settlement in the modifed method have been calibrated and validated.

关键词： Afteruse development Closed landflls Municipal solid waste(MSW) settlement Modifed Bjarngard and Edgers' method

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四维Qi系统零平衡点的Hopf分岔反控制

物理学报 2008年第10期57卷 6162-6168页

作者：刘素华唐驾时上海工程技术大学高职学院上海200437 湖南大学力学与航空航天学院长沙410082

通过线性与非线性状态反馈,实现了对四维Qi系统零平衡点的Hopf分岔反控制.首先确定产生Hopf分岔的线性控制项,得到线性控制增益的选取原则.然后,利用稳定性分析,借助于对线性受控Qi系统的jordan标准型的直接控制以及适当的变换,确定影响... 详细信息

通过线性与非线性状态反馈,实现了对四维Qi系统零平衡点的Hopf分岔反控制.首先确定产生Hopf分岔的线性控制项,得到线性控制增益的选取原则.然后,利用稳定性分析,借助于对线性受控Qi系统的jordan标准型的直接控制以及适当的变换,确定影响Hopf分岔稳定性的非线性控制项,得到非线性控制增益的选取原则.针对所考虑分岔参数的不同,给出不同的控制方案.最后通过数值模拟验证了理论分析结果的正确性.

关键词： Qi系统 Hopf分岔反控制稳定性

基于谱聚类初始化非负矩阵分解的机械故障诊断

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仪器仪表学报 2013年第12期34卷 2806-2811页

作者：张焱汤宝平邓蕾重庆大学机械传动国家重点实验室重庆400030

针对非负矩阵分解(NMF)收敛性问题,提出使用谱聚类方法为NMF产生结构化初始值,研究基于谱聚类初始化NMF的机械故障诊断模型。首先利用NJW谱聚类算法求取振动信号聚类中心,再以聚类中心初始化信号特征空间基向量并以NMF算法迭代求取基向... 详细信息

针对非负矩阵分解(NMF)收敛性问题,提出使用谱聚类方法为NMF产生结构化初始值,研究基于谱聚类初始化NMF的机械故障诊断模型。首先利用NJW谱聚类算法求取振动信号聚类中心,再以聚类中心初始化信号特征空间基向量并以NMF算法迭代求取基向量,最后将各模式数据在特征空间映射所得投影系数作为特征矢量输入到最近邻分类器(KNNC)中进行故障识别。基于谱聚类初始化NMF的机械故障诊断模型实现了机械故障特征提取到故障识别的全程自动化,谱聚类初始化方法提升了NMF收敛效果与分解性能,并提高了诊断精度,滚动轴承诊断实例验证了模型的有效性。

关键词：特征空间非负矩阵分解谱聚类故障诊断

肾血管性高血压诱导代谢综合征猪的心肌线粒体损伤,导致心脏损伤和功能障碍

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中华高血压杂志 2022年第3期30卷 300-300页

作者： Nargesi AA Farah MC Zhu XY Zhang L tang H jordan KL Saadiq IM Lerman A Lerman LO Eirin A 袁源(翻译) 周卫(翻译) 不详

肾血管性高血压(renovascular hypertension,RVH)患者常常也并发代谢综合征(metabolic syn-drome,Met S)。Met S和高血压并存增加心血管病的发病率和死亡率,但是心脏损伤的潜在机制仍不清楚。本研究假设合并Met S可引发RVH猪心肌线粒体... 详细信息

肾血管性高血压(renovascular hypertension,RVH)患者常常也并发代谢综合征(metabolic syn-drome,Met S)。Met S和高血压并存增加心血管病的发病率和死亡率,但是心脏损伤的潜在机制仍不清楚。本研究假设合并Met S可引发RVH猪心肌线粒体损伤,导致心脏损伤和功能障碍。方法:经过16周喂食诱导合并或不合并RVH(单侧肾动脉狭窄)的实验猪患MetS,瘦猪(Lean)作为对照组,每组6只。

关键词：肾血管性高血压心脏损伤肾动脉狭窄心肌线粒体损伤功能障碍心血管病代谢综合征 hypertension

从个案规范到民法法典化--以“乔丹案”对司法解释及民法典草案的影响为例

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现代法学 2020年第3期42卷 195-209页

作者：汤文平暨南大学法学院/知识产权学院广州510632

从本土判例中提取个案规范并融入法典体系,是我国民法典编纂及适用的一大课题。对"乔丹案"这样一个"确定性判例"之个案规范,在融入法典之前,应重启法政策考量,并在各考量主题之下挖掘事理,联通内外体系、"大小传统",再由个案裁判通往法... 详细信息

从本土判例中提取个案规范并融入法典体系,是我国民法典编纂及适用的一大课题。对"乔丹案"这样一个"确定性判例"之个案规范,在融入法典之前,应重启法政策考量,并在各考量主题之下挖掘事理,联通内外体系、"大小传统",再由个案裁判通往法条取舍以及后法典的法教义学体系构建。而后可知,就本案所涉权利碰撞不能慑于名人光环,不能片面理解诚信原则,而应辩证看待"搭便车"行为,避开概念法学"颠倒法论"的陷阱。应看到与商标权相碰撞的"姓名"及"姓名权"的特殊性,体察姓名权人长期放任公然占用带来的失权可能。基此建构评价框架,预估待决个案的走向,并观照法典编纂厘定人格利益财产化的正当性限度。这项研究虽着力于具体制度,却又是法学实证主义道路一次完整的"实验"。

关键词：指导案例113号名人姓名权驰名商标权利失效法学实证主义

Banach空间中的jordan-von Neumann型常数和正规结构

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数学学报（中文版） 2017年第3期60卷 383-388页

作者：左占飞唐春雷重庆三峡学院数学与统计学院万州404100 西南大学数学与统计学院重庆400715

首先利用James常数J(X)给出了jordan-von Neumann型常数C_(-∞)(X)的一个估计式,然后由此式说明确实存在C_(-∞)(X) 详细信息

首先利用James常数J(X)给出了jordan-von Neumann型常数C_(-∞)(X)的一个估计式,然后由此式说明确实存在C_(-∞)(X)

关键词： jordan-von Neumann型常数 James常数正规结构