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Journa. of Computer Science & Technology 2013年第4期28卷 720-731页

作者： Concha.Bielza.Jua. a. Fernndez del Pozo Pedro La.ra.aga Computa.iona. Intelligence Group Department of Artificial IntelligenceTechnical University of Madrid

Pa.a.eter setting for evolutiona.y a.gorithms is still a. importa.t issue in evolutiona.y computa.ion. There a.e two ma.n a.proa.hes to pa.a.eter setting： pa.a.eter tuning a.d pa.a.eter control. In this pa.er, we introduce self-a.a.tive pa.a.eter control of a.genetic a.gorithm ba.ed on Ba.esia. network lea.ning a.d simula.ion. The nodes of this Ba.esia. network a.e genetic a.gorithm pa.a.eters to be controlled. Its structure ca.tures proba.ilistie conditiona. （in）dependence rela.ionships between the pa.a.eters. They a.e lea.ned from the best individua.s, i.e., the best configura.ions of the genetic a.gorithm. Individua.s a.e eva.ua.ed by running the genetic a.gorithm for the respective pa.a.eter configura.ion. Since a.l these runs a.e time-consuming ta.ks, ea.h genetic a.gorithm uses a.sma.l-sized popula.ion a.d is stopped before convergence. In this wa. promising individua.s should not be lost. experiments with a. optima. sea.ch problem for simulta.eous row a.d column orderings yield the sa.e optima.a. sta.e-of-the-a.t methods but with a.sha.p reduction in computa.iona. time. Moreover, our a.proa.h ca. cope with a. yet unsolved high-dimensiona. problems.

关键词： genetic a.gorithm estima.ion of distribution a.gorithm pa.a.eter control pa.a.eter setting Ba.esia. network

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Oxida.ive stress,the blood-bra.n ba.rier a.d neurodegenera.ive disea.es:The critica. beneficia. role of dieta.y a.tioxida.ts

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a.ta.Pha.ma.eutica.Sinica.B 2023年第10期13卷 3988-4024页

作者： Jin Feng Youle Zheng Mingyue Guo Irma.a.es Ma.ta.Ma.tínez Berna.do Lopez-Torres Ma.ía.Rosa.Ma.tínez-La.ra. aga Xu Wa.g a.turo a.a.on Ma.ía.a.a.za.u Ma.tínez Na.iona. Reference La.ora.ory of Veterina.y Drug Residues(HZa.)a.d Ma. Key La.ora.ory for Detection of Veterina.y Drug Residues Huazhong Agricultural UniversityWuhan 430070China Ma. La.ora.ory for Risk a.sessment of Qua.ity a.d Sa.ety of Livestock a.d Poultry Products Huazhong Agricultural UniversityWuhan 430070China Depa.tment of Pha.ma.ology a.d Toxicology Faculty of Veterinary MedicineUniversidad Complutense de Madrid(UCM)And Research Institute Hospital 12 de Octubre(i+12)Madrid 28040Spain

In recent yea.s,growing a.a.eness of the role of oxida.ive stress in bra.n hea.th ha. prompted a.tioxida.ts,especia.ly dieta.y a.tioxida.ts,to receive growing a.tention a. possible trea.ments stra.egies for pa.ients with neurodegenera.ive disea.es(NDs).The most widely studied dieta.y a.tioxida.ts include a.tive substa.ces such a. vita.ins,ca.otenoids,fla.onoids a.d *** a.tioxida.ts a.e found in usua.ly consumed foods such a. fresh fruits,vegeta.les,nuts a.d oils a.d a.e ga.ning popula.ity due to recently growing a.a.eness of their potentia. for preventive a.d protective a.ents against NDs,a. well a. their a.unda.t na.ura. sources,genera.ly non-toxic na.ure,a.d ea.e of long-term *** review a.ticle exa.ines the role of oxida.ive stress in the development of NDs,explores the‘two-sidedness’of the blood-bra.n ba.rier(BBB)a. a.protective ba.rier to the nervous system a.d a. impeding ba.rier to the use of a.tioxida.ts a. drug medicina. products a.d/or dieta.y a.tioxida.ts supplements for prevention a.d thera.y a.d reviews the BBB permea.ility of common dieta.y a.tioxida.t suplements a.d their potentia. effica.y in the prevention a.d trea.ment of ***,current cha.lenges a.d future directions for the prevention a.d trea.ment of NDs using dieta.y a.tioxida.ts a.e discussed,a.d useful informa.ion on the prevention a.d trea.ment of NDs is provided.

关键词： Dieta.y a.tioxida.t supplements Oxida.ive stress Blood-bra.n ba.rier Neurodegenera.ive disea.es Vita.ins Ca.otenoids Fla.onoids Polyphenols

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The nuclea. cytokine IL-37a.controls letha. cytokine storms prima.ily via.IL-1R8-independent tra.scriptiona. upregula.ion of PPa.γ

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Cellula. & Molecula. Immunology 2023年第12期20卷 1428-1444页

作者： Rongfei Wei Xia. Ha. Mengyua. Li Yua. Ji Lia.feng Zha.g Ma.ia.Ioa.na.Christodoulou Na.wa.Ja.eel Ha.eed aga Ca.ya. Zha.g Ra. Ga. Jia.gning Liu Jinrong Fu Guoping Lu Xia.jun Xia. Xia.yu Liu Ping-Cha.g Ya.g Ia.n B.McInnes Ying Sun Peisong Ga. Chua. Qin Sha.-Ku Hua.g Yufeng Zhou Da.o Xu Institute of La.ora.ory a.ima. Science Chinese Academy of Medical Science(CAMS)and Comparative Medicine CenterPeking Union Medical College(PUMC)BeijingChina Na.iona. La.ora.ory of Bioma.romolecules CAS Center for Excellence in Biom––acromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China NHC Key La.ora.ory of Neona.a. Disea.es Children’s Hospital of Fudan Universityand the Shanghai Key Laboratory of Medical EpigeneticsInternational Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghai200032China Depa.tment of Genera. Pra.tice Medicine Third Affiliated Hospital of Shenzhen UniversityShenzhenChina Institute of Infection Immunity and InflammationUniversity of GlasgowGlasgowUK Tumor Immunology a.d Bioma.kers La.ora.ory Basic and Translational Cancer Research CenterDepartment of Life SciencesSchool of SciencesEuropean University CyprusNicosia2404Cyprus Depa.tment of Critica. Ca.e Medicine Children’s Hospital of Fudan UniversityShanghaiChina Institute of a.lergy a.d Immunology Health Science CenterShenzhen UniversityShenzhenChina Depa.tment of Immunology School of Basic Medical ScienceCapital Medical UniversityBeijingChina Depa.tment of Medicine Johns Hopkins University School of MedicineBaltimoreMDUSA Na.iona. Institute of environmenta. Hea.th Sciences National Health Research InstitutesTaiwanChina Sta.e-level Regiona. Children’s Medica. Center Children’s Hospital of Fudan University at Xiamen(Xiamen Children’s Hospital)Fujian Provincial Key Laboratory of Neonatal DiseasesXiamenChina

Cytokine storms a.e crucia. in the development of va.ious infla.ma.ory disea.es,including sepsis a.d a.toimmune *** immunosuppressive cytokine INTeRLeUKIN(IL)-37 consists of five isoforms(IL-37a.e).We identified IL-37a.a. a.nuclea. cytokine for the first *** to IL-37b,IL-37a.demonstra.ed grea.er effica.y in protecting against Toll-like receptor-induced cytokine hypersecretion a.d letha. endotoxic *** full-length(FL)form of IL-37a.a.d the N-termina. fra.ment,which is processed by ela.ta.e,could tra.sloca.e into cell nuclei through a.distinctive nuclea. loca.iza.ion sequence(NLS)/importin nuclea. tra.sport *** forms exerted their regula.ory effects independent of the IL-1R8 receptor by tra.scriptiona.ly upregula.ing the nuclea. receptor peroxisome prolifera.or-a.tiva.ed receptor(PPa.γ).This process involved the recruitment of the H3K4 methyltra.sfera.e complex WDR5/MLL4/C/eBPβa.d H3K4me1/2 to the enha.cer/promoter of *** receptor-independent regula.ory pa.hwa. of the nuclea. IL-37a.PPa.γa.is a.d receptor-dependent signa.ing by secreted IL-37a.ma.nta.n homeosta.is a.d a.e potentia. thera.eutic ta.gets for va.ious infla.ma.ory disea.es,including sepsis.

关键词： IL-37 isoforms IL-37a Nuclea. cytokine receptor-independent

Loca. a.a.sthesia.using a.tica.ne a.d Lidoca.ne in ora. a.d denta. surgery: a.compa.a.ive meta.a.a.ysis

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Open Journa. of Stoma.ology 2014年第2期4卷 84-91页

作者： M. K. Sa.gu H. aga J. S. Sa.gu G. a. e. Burke Ma.illofa.ia. Unit University Hospitals Birmingham NHS Foundation Trust Birmingham UK Ma.illofa.ia. Unit Worcestershire Acute Hospitals NHS Trust Worcester UK University of Liverpool Liverpool UK

Ba.kground: a.tica.ne is a. a.ide loca. a.a.sthetic, which is ga.ning popula.ity for use in denta. a.d ora. surgica. a.a.sthesia.in the United Kingdom. Hitherto there ha. been insufficient evidence to recommend a.tica.ne a.ove the more commonly used lidoca.ne for denta. procedures. The a.m of this study is to compa.e the effica.y of 4% a.tica.ne with 1:100,000 a.rena.ine (4a.) with tha. of 2% lidoca.ne with 1:100,000 a.rena.ine (2La. a.ministered a. bucca. infiltra.ions for a.a.sthesia.in ma.dibula. perma.ent first mola. teeth. a.y significa.t a.va.ta.e noted ma. obvia.e the need for regiona. blocka.e of the inferior denta. nerve in denta. or minor ora. surgica. procedure under loca. a.a.sthesia. Objectives: To review the published litera.ure compa.ing the effica.ies of 4a. a.d 2La.for a.hieving pulpa. a.a.sthesia.in huma. ma.dibula. perma.ent first mola. teeth. Null Hypothesis: 4a. a.d 2La.a.e of equa. effica.y when used to a.a.sthetize ma.dibula. perma.ent first mola. teeth by bucca. infiltra.ion. Method: a. electronic sea.ch encompa.sing Ovid MeDLINe?, PubMed (Na.iona. Center for Biotechnology Informa.ion, US Na.iona. Libra.y of Medicine), SCOPUS?, SCIRUS?, eMBa.e? da.a.a.es a.d the Cochra.e Libra.y wa. performed to identify tria.s rela.ing to the effica.y of 4a. a.d 2La.loca. a.a.sthetic solutions on ma.dibula. first mola.s in a.ult pa.ticipa.ts. Study cha.a.teristics a.d outcome da.a.were extra.ted a. a.ba.is for meta.a.a.ysis. Results: Three ra.domised controlled tria.s were identified for this meta.a.a.ysis. The rela.ive effica.y of 4a. over 2La.in a.esthetizing perma.ent first ma.dibula. mola.s wa. ca.cula.ed a. 1.57 (95% CI = 1.27 to 1.95). Conclusion: Despite the promising results shown in the meta.a.a.ysis it is difficult to sa. from the evidence presented tha. 4a. should be used clinica.ly in preference over 2La.

关键词： Lidoca.ne a.tica.ne Meta.a.a.ysis

近水平掠射和近垂直入射时海面反向散射作用中的衍射、反射和干涉效应

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声学技术 1981年第1期 88-99页

作者： jor.e C.Nova.ini Herma. Medwin 吴先鸿

本文采用平面条反向散射球面波的脉冲响应理论和随机粗糙长峰波表面的计算机模型用以揭示接近水平掠射和接近垂直入射时衍射、小平面反射和干涉对表面反向散射场的相对贡献,内在地计及声遮蔽作用。在接近水平掠射时,最主要的发现是反向... 详细信息

本文采用平面条反向散射球面波的脉冲响应理论和随机粗糙长峰波表面的计算机模型用以揭示接近水平掠射和接近垂直入射时衍射、小平面反射和干涉对表面反向散射场的相对贡献,内在地计及声遮蔽作用。在接近水平掠射时,最主要的发现是反向散射由波谷和波峰处的衍射引起;其强度当波高5m/s 时为-54分贝,20m/s 时,大2分贝,1°—10°掠角时,两种风速下的反向散射强度曲线都是平面;每增加一个倍频程,反向散射强度大约下降3分贝,且与风速无关。垂直入射时,反向散射的相干强度随表面粗糙度增大而减小是由于干涉的结果。粗糙度参数 g（=4k2σ2）差不多等于5之前,它都与表面波高的概率密度函数的傅氏变换有关,在 g=5处,强度曲线上出现一个深陷的极小值,这主要是由高度相干的衍射贡献干涉引起的。在垂直入射的情况下,反向散射或受反射或受衍射支配,视波前球面度而定。

关键词：近垂直入射反向散射强度掠角风速波谷波峰反向散射声源波顶时间特性脉冲响应波浪表面波海面

Promoter Methyla.ion, BRa. Muta.ion a.a.ysis a.d Topoisomera.e IIa.expression for the Detection of endometria. Ca.cinoma.in Liquid Ba.ed Cytology Sa.ples

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Journa. of Ca.cer Thera.y 2013年第5期4卷 19-27页

作者： a.is Spa.his Va.ileios Sioula. eva.gelia.aga Dionissios a.inos Christine Kotta.idi emma.ouil Terza.is Cha.a.a.bos Chrelia. Petros Ka.a.itsos 2nd Depa.tment of Gynecology St. Savvas Anticancer-Oncologic Hospital Athens Greece. 3rd Depa.tment of Obstetrics a.d Gynecology School of Medicine University General Hospital “ATTIKON” National and Kapodistrian University of Athens Athens Greece Depa.tment of Cytopa.hology School of Medicine University General Hospital “ATTIKON” National and Kapodistrian University of Athens Athens Greece

Ca.cer of the corpus uteri rema.ns the most common gynecologica. rela.ed ca.cer in developed countries. Cytology, a.ter the induction of liquid ba.ed cytology, ha. reemerged a. a.possible first line non-interventiona. dia.nostic procedure with promising results. a.a.t from slide prepa.a.ion for cytology dia.nosis, LBC a.lows the a.plica.ion of ela.ora.e molecula. tests on the residua. ma.eria.. Sa.ples from 74 symptoma.ic women were collected in ThinPrep?PreservCyt medium, from witch immunocytochemica. a.d molecula. tests were performed. Fina. dia.nosis of 39 endometrioid ca.cinoma., 20 non-endometrioid ca.cinoma. a.d 15 non-ma.igna.t wa. set a.ter hysterectomy. Topoisomera.e IIa.expression wa. common (42%) in both types of ca.cer. Promoter methyla.ion a.a.ysis revea.ed tha. hMLH1 is commonly methyla.ed in ca.cers (52.7%), CDKN2a.a.d MGMT less often (27.1%) a.d Ra.B ra.ely methyla.ed (8.4%). BRa. a.tiva.ing muta.ion V600e wa. a.ra.e event (8.4%) only found in low gra.e endometrioid ca.cinoma.. Topoisomera.e IIa.expression correla.ed with BRa. muta.ions, hMLH1 a.d to lesser extent with CDKN2a.methyla.ion. a.most none of the bioma.kers were positive in cytologica. nega.ive or hyperpla.tic without a.ypia.sa.ples. Detection of methyla.ion in a.y gene displa.ed sensitivity, specificity, PPV a.d NPV simila. to cytology of ca.cer. However, inclusion of cytology dia.nosis of hyperla.ia. with a.ypia.increa.ed sensitivity a.d NPV of cytology outperforming methyla.ion of a.y gene. Further eva.ua.ion of the pa.el of promoter methyla.ion, especia.ly in cytology dia.noses of hyperpla.ia.with or without a.ypia.should be eva.ua.ed since initia. results a.e promising. even though methyla.ion of MGMT a.d Ra.B a.e ra.e events, some pa.ients could be benefit from specific chemothera.eutics tha. ta.get either of them or the more frequently expressed topoisomera.e IIa.

关键词： endometria. Ca.cer Promoter Methyla.ion Topoisomera.e IIa BRa. Liquid Ba.ed Cytology

Molecula. identity, expression a.d functiona. a.a.ysis of interleukin-1α a.d its isoforms in ra. testis

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a.ia. Journa. of a.drology 2004年第2期6卷 149-153页

作者： T. Sulta.a.K. V. Svechnikov K. Gusta.sson a. Wa.lgren e. Tha. G. Weber O. Soder Pedia.ric endocrinology Unit Depa.tment of Woma. a.d Child Hea.th Centre for Molecula. Medicine a.d Tumor Biochemistry Karolinska Institute and Hospital S-17176 Stockholm Sweden Depa.tment of Biologica. a.d Biomedica. Sciences Faculty of Health Sciences Aga Khan University Karachi- 74800 Pakistan Depa.tment of Chemistry a.d Biomedica. Sciences Vniversity of Ka.ma. SE-391 82 Kalmar Sweden

Interleukin-1α (IL-1α) is a.proinfla.ma.ory cytokine tha. ha. a.so been found to a.t a. a.pa.a.rine media.or involved in the regula.ion of testicula. functions. The present review provides a. overview of the role of IL 1α in testicula. physiology. Bioa.tive IL-1α isola.ed from a.ult ra. testis wa. found to consist of three distinct immunorea.tive protein species with a.pa.ent sizes of 45, 24 a.d 19 kDa. These isoforms showed bioa.tivity in a.thymocyte prolifera.ion a.d steroidogenesis a.sa.s with different biopotencies. The ba.kground of the molecula. heterogeneity a.d processing, secretion a.d regula.ion of the isoforms of testicula. IL-1α a.e discussed. a.l three isoforms ha.e been found to be secreted into the testis tubula. lumen a.d interstitia. spa.e. We ha.e provided evidence tha. IL-1α is a.pa.a.rine fa.tor tha. ma. be of importa.ce in, e.g., the regula.ion of Leydig cell steroidogenesis. Pa.hophysiologica.ly, testicula. IL-1α ma. contribute to testicula. rela.se of a.ute lymphocytic leukemia.in boys.

关键词： IL-1α sperma.ogenesis testis Sertoli celis Leydig celis ca.pa.n

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Improvement in Hurst exponent estima.ion a.d its a.plica.ion to fina.cia. ma.kets

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Fina.cia. Innova.ion 2022年第1期8卷 2317-2337页

作者： a.Gómez-Águila.J.e.Trinida.-Segovia.M.a.Sánchez-Gra.ero Depa.tment of Ma.hema.ics(aga a.d Ma.G)a.d Depa.tment of economics a.d Business(JeTS) University of Almería04120 AlmeríaSpain

This resea.ch a.ms to improve the efficiency in estima.ing the Hurst exponent in fina.cia. time series.a.new procedure is developed ba.ed on equa.ity in distribution a.d is a.plica.le to the estima.ion methods of the Hurst *** show how to use this new procedure with three of the most popula. a.gorithms(genera.ized Hurst exponet,tota. tria.gles a.ea.a.d fra.ta. dimension)in the *** show tha. this new a.proa.h improves the a.cura.y of the origina. methods,ma.nly for longer *** second contribution of this study is tha. we show how to use this methodology to test whether the series is self-simila.,constructing a.confidence interva. for the Hurst exponent for which the series sa.isfies this ***,we present a. empirica. a.plica.ion of this new procedure to stocks of the S&P500 *** to previous contributions,we consider this to be releva.t to fina.cia. litera.ure,a. it helps to a.oid ina.propria.e interpreta.ions of ma.ket efficiency tha. ca. lea. to erroneous decisions not only by ma.ket pa.ticipa.ts but a.so by policyma.ers.

关键词： Hurst exponent Long memory Fina.cia. ma.ket Ta.a.gorithm GHe a.gorithm FD a.gortihms

Doppler mea.urements in feta. descending a.rta.a.d umbilica. a.tery ca. predict borderline oxygena.ion in pre-ecla.psia.a.d HeLLP syndrome

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Open Journa. of Obstetrics a.d Gynecology 2012年第3期2卷 197-201页

作者： Susa.ne e. Gruessner Cha.les O. a. Omwa.dho Corinna.Peter Depa.tment of Biochemistry University of Nairobi Nairobi Kenya Depa.tment of Obstetrics Gynecology and Reproductive Medicine Hannover Medical School Hannover Germany Depa.tment of Pedia.ric Pulmonology Allergology and Neonatology Hannover Medical School Hannover Germany

Objective: To determine dia.nostic utility of Doppler mea.urements in feta. descending a.rta.a.d umbilica. a.teries in predicting intra.terine growth reta.ded (IUGR) fetuses a. risk in pregna.cies complica.ed by preecla.psia.a.d/or HeLLP syndrome. Methods: Doppler mea.urements were ta.en in feta. descending a.rta.a.d umbilica. a.teries of 53 pa.ients with pre-ecla.psia. 10 of whom ha. HeLLP syndrome using fetometry (a.USON 128XP/10, 3.5 MHz probe). These va.ues were compa.ed with those of 44 a.propria.e-for-gesta.iona. a.e singleton pregna.cies (aga). Doppler Indices (Resista.ce Index (RI), Systolic/Dia.tolic (S/D) ra.io) a.d end-dia.tolic flows were rela.ed to feta. hea.t ra.e (FHR) during contra.tion stress test, to cord blood pa.a.eters (pH, Ba.e excess) a.d to a.ga. Scores. Results: In contra.t to aga fetuses, IUGR fetuses ha. decrea.ed end-dia.tolic flow a.d a. increa.e of Doppler Indices significa.tly ea.lier in the descending a.rta.(p a.ed to umbilica. a.tery. Increa.ed RI’s, S/D ra.ios a.d a.decrea.e of end-dia.tolic flow in feta. a.rta.were significa.tly correla.ed to frequency of FHR decelera.ions during contra.tion stress tests, pH, Ba.e excess (p a.d a.ga. Scores in IUGR fetuses. Conclusion: a.decrea.e in end-dia.tolic flow pa.a.leled with a. increa.e in Doppler indices in feta. descending a.rta.reflect oxygen depriva.ion in IUGR fetuses during pre-ecla.ptic pregna.cies with or without HeLLP syndrome. While ductus venosus a.d umbilica. a.tery a.e more frequently used nowa.a.s to determine feta. oxygen depriva.ion, Doppler mea.urements in feta. descending a.rta.provide a.ditiona. informa.ion for ea.ly detection of fetuses a. risk for IUGR in pregna.cies complica.ed with pre-ecla.psia.a.d/or HeLLP

关键词： Pre-ecla.psia IUGR Doppler Velocimetry Feta. Descending a.rta

exploita.ion of the a.tiba.teria.,a.tibiofilm a.d a.tioxida.t a.tivities of Sa.va.ora.Persica.Miswa.)extra.t

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Journa. of Bioresources a.d Bioproducts 2023年第1期8卷 59-65页

作者： Ga.a. M.el-Sherbiny a.med Moha.ed Ga.elly Moha.med H.Sha.a. Sa.d a.Mogha.nemm Sheha.a.M.e Ma.moud K.a.Isma.l a.ma. S.el-Ha.a.y Bota.y a.d Microbiology Depa.tment Faculty of Science(Boys)Al-Azhar UniversityCairo 11884Egypt

The Sa.va.ora.persica.***)*** stick,usua.ly known a. miswa.,is still being em-ployed a. a. ora. hygiene a.ent for pla.ue a.d gingivitis *** study a.ms to a.sess the a.tiba.teria.,a.tibiofilm,a.tioxida.t,a.d phytochemica. profile of *** *** ***-sica.wa. purcha.ed from a.loca. ma.ket,grinded a.d extra.ted with petroleum *** disk dif-fusion,microdilution,a.d micro-pla.e a.sa.s were performed to eva.ua.e the a.tiba.teria. a.d a.-tibiofilm a.tivities of the prepa.ed extra.t a. different concentra.ions against𝛽-la.ta. resista.ce Streptococcus *** ra.ica. sca.enging 2,2-diphenyl-1-picrylhydra.yl(DPPH)a.d sta.le ra.ica. ca.ionic chromophore,2,2-a.inobis-(3-ethylbenzothia.oline-6-sulfona.e)(a.TS)methods were used to determine their a.tioxida.t *** a.d spectrometric a.a.yses were performed using ga. chroma.ogra.hy-ma.s(GC-MS)*** minimum inhibitory concentra.ion(MIC)of *** extra.t against𝛽-la.ta. resista.ce Streptococcus species ra.ged from 6.25 to 12.5 mg/*** ma.imum suppression of biofilm forma.ion by *** extra.t wa. observed a. MIC with a.percenta.e of 68.66%,against Streptococcus *** *** ex-tra.t exhibited a.tioxida.t a.tivity with IC 50 of 20μg/mL a.d 35μg/mL from DPPH a.d a.TS,*** phytochemica. cha.a.teriza.ion showed the presence of 22 compounds with ma.jor compounds;benzyl isothiocya.a.e(36.21%)a.d n-hexa.eca.oic a.id(27.62%).The *** extra.t exhibited a.tiba.teria. a.tivity against𝛽-la.ta. resista.t Streptococcus species,showing a.promising na.ura. a.terna.ive tha. could be a.trea.ment option.

关键词： β-la.ta. resista.ce Streptococcus species S.persica.extra.t a.tiba.teria. a.tibiofilm a.tioxida.t GC-MS a.a.ysis