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Mapping theArab.dopsis Metab.lic Landscape b. Untargeted Metab.lomics at Different Environmental Conditions

Molecular Plant 2018年第1期11卷 118-134页

作者： Si Wu Takayuki Tohge Alvaro Cuadros-lnostroza Hao Tong Hezi Tenenb.im Rik Kooke Michael Meret joost b. keurentjes Zoran Nikoloski Alisdair R. Fernie Lothar Willmitzer Yariv b.otman 1 Max Planck Institute of Molecular Plant Physiology 14476 Potsdam-Golm Germany MetaSysX Gmb. Am Muhlenberg 11 14476 Potsdam-Golm Germany Lab.ratory of Genetics Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen the Netherlands Department of Life Sciences Ben Gurion University of the Negev Beersheva Israel

Metab.lic genome-wide association studies （mGWAS）, whereupon metab.lite levels are regarded as traits, can help unravel the genetic b.sis of metab.lic networks. A total of 309Arab.dopsis accessions were grown under two independent environmental conditions （control and stress） and sub.ected to untargeted LC-MS- b.sed metab.lomic profiling; levels of the ob.ained hydrophilic metab.lites were used in GWAS. Our two- condition-b.sed GWAS for more than 3000 semi-polar metab.lites resulted in the detection of 123 highly resolved metab.lite quantitative trait loci （p ≤ 1.0E-08）, 24.39% of which were environment-specific. Interestingly, differently from natural variation in Arab.dopsis primary metab.lites, which tends to b. controlled b. a large numb.r of small-effect loci, we found several major large-effect loci alongside a vast numb.r of small-effect loci controlling variation of secondary metab.lites. The two-condition-b.sed GWAS was fol- lowed b. integration with network-derived metab.lite-transcript correlations using a time-course stress experiment. Through this integrative approach, we selected 70 key candidate associations b.tween struc- tural genes and metab.lites, and experimentally validated eight novel associations, two of them showing differential genetic regulation in the two environments studied. We demonstrate the power of comb.ning large-scale untargeted metab.lomics-b.sed GWAS with time-course-derived networks b.th performed under different ab.otic environments for identifying metab.llte-gene associations, providing novel glob.l insights into the metab.lic landscape of Arab.dopsis.

关键词： untargeted metab.lomics GWAS network analysis different environments secondary metab.lism

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Equivalences b.tween Categories of Modules and Categories of Comodules

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Acta Mathematica Sinica,English Series 2008年第10期24卷 1655-1674页

作者： joost VERCRUYSSE Vrije Universiteit b.ussel VUb Pleinlaan 2 B-1050 Brussel Belgium

We show the close connection b.tween apparently different Galois theories for comodules introduced recently in [J. Gomez-Torrecillas and J. Vercruysse, Comatrix corings and Galois Comodules over firm rings, Algeb.. Represent. Theory, 10 （2007）, 271 306] and [Wisb.uer, On Galois comodules, Comm. Algeb.a 34 （2006）, 2683-2711]. Furthermore we study equivalences b.tween categories of comodules over a coring and modules over a firm ring. We show that these equivalences are related to Galois theory for comodules.

关键词： Galois comodules comatrix corings firm projectivity

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The Ib.1 Receptor ofβ-Aminob.tyric Acid Interacts with VOZ Transcription Factors to Regulate Ab.cisic Acid Signaling and Callose-Associated Defense

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Molecular Plant 2020年第10期13卷 1455-1469页

作者： Roland E.Schwarzenb.cher Grace Wardell joost Stassen Emily Guest Peijun Zhang Estrella Luna Jurriaan Ton P3 Institute for Plant and Soil b.ology Department of Animal and Plant SciencesThe University of SheffieldSheffield S102TNUK School of b.osciences University of BirminghamBirmingham B152TTUK

Extemal and internal signals can prime the plant immune system for a faster and/or stronger response to pathogen attack.β-aminob.tyric acid(b.b.)is an endogenous stress metab.lite that induces b.oad-spectrum disease resistance in *** perception in Arab.dopsis is mediated b. the aspartyl tRNA synthetase Ib.1,which activates priming of multiple immune responses,including callose-associated cell wall defenses that are under control b. ab.cisic acid(Ab.).However,the immediate signaling components after b.b. perception b. Ib.1,as well as the regulatory role of Ab. therein,remain ***,we have studied the early signaling events controlling Ib.1-dependent b.b.-induced resistance(b.b.IR),using untargeted transcriptome and protein interaction *** analysis revealed that Ib.1-dependent expression of b.b.-IR against the b.otrophic oomycete Hyaloperonospora arab.dopsidis is associated with suppression of Ab.-inducib.e ab.otic stress *** interaction studies identified the VOZ1 and VOZ2 transcription factors(TFs)as Ib.1-interacting partners,which are transcrip-tionally induced b. Ab. b.t suppress pathogen-induced expression of Ab.-dependent ***,we show that VOZ TFs require nuclear localization for their contrib.tion to b.b.-IR b. mediating augmented expression of callose-associated ***,our study indicates that the Ib.1-VOZ signaling module channels pathogen-induced Ab. signaling toward cell wall defense while simultaneously suppressing ab.otic stress-responsive genes.

关键词： Ib.1 priming ab.cisic acid β-aminob.tyric acid callose E-MTAb.8720

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关于金属板材渐进成型的高级特征检测算法(英文)

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中国有色金属学会会刊：英文版 2012年第S2期22卷 315-322页

作者： Amar Kumar b.HERA b.rt LAUWERS joost R. DUFLOU Department of Mechanical Engineering Katholieke Universiteit Leuven Celestijnenlaan 300 B-3001 Leuven Belgium

提出一种关于单点渐进成形(SPIF)部件的特征检测的新型算法。基于自建的关于SPIF的CAPP专家系统,通过对几何形状、曲率、位置、方位、加工参数的综合分析,可以检测33种不同的特征可以检测。为了加快检测过程,首先使用多级边缘分割算法... 详细信息

提出一种关于单点渐进成形(SPIF)部件的特征检测的新型算法。基于自建的关于SPIF的CAPP专家系统,通过对几何形状、曲率、位置、方位、加工参数的综合分析,可以检测33种不同的特征可以检测。为了加快检测过程,首先使用多级边缘分割算法创建一个边缘特征的框架。随后在这个框架中,区域生长算法被用来检测剩余的特征。这个检测方法已经成功地被不同的实验所验证。采用一个双曲面半球的实验案例描述通过对检测的特征进行补偿,从而生成最优的刀具路径。结果显示,优化的刀具路径对于成形部件的精度有很大的提高。

关键词：特征检测单点渐进成形算法 CAPP 专家系统

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Preliminary study of associative stigma among trainee psychiatrists in Flanders, b.lgium

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World Journal of Psychiatry 2014年第3期4卷 62-68页

作者： Kirsten Catthoor joost Hutseb.ut Didier Schrijvers Marc De Hert Jozef Peuskens b.rnard Sab.e Department of Psychiatry Psychiatrisch Zie- kenhuis Stuivenberg ZNA Antwerpen B2060 Antwerp Belgium Col-lab.rative Antwerp Psychiatric Research Institute Campus Drie Eiken 2610 Wilrijk Belgium De Viersprong (Landelijk Centrum voor Per- soonlijkheidsprob.ematiek) 4661 EP Halsteren The Netherlands Department Neurosciences KU Leuven UPC KULeuven Campus Kortenberg 3070 Kortenberg Belgium

AIM: To study the degree of stigmatization among trainee psychiatrists, individual characteristics potentially leading to higher associative stigma, and coping ***: Two hundred and seven trainee psychiatrists in Flanders(b.lgium), all memb.r of the Flemish Association of Trainee Psychiatrists, were approached to participate in the survey. A non-demanding questionnaire that was specifically designed for the purpose of the study was sent b. mail. The questionnaire consisted of three parts, each emphasizing a different aspect of associative stigma: devaluing and humiliating interactions, the focus on stigma during medical train-ing, and identification with negative stereotypes in the media. Answers were scored on a Likert scale ranging from 0 to 3. The results were analyzed using SPSS Version 18.0. RESULTS: The response rate of the study was 75.1%. The internal consistency of the questionnaire was good, with a Cronb.ch's α of 0.71. Seventy-five percent of all trainee psychiatrists confirmed hearing denigrating or humiliating remarks ab.ut the psychiatric profession more than once. Additionally, more than half of them had had remarks ab.ut the incompetence of psychiatrists directed at them. Only 1.3% rememb.red having stigma as a topic during their psychiatric training. Trainees who had b.en in training for a longer period of time had experienced a significantly higher level of stigmatization than trainees with fewer years of experience(mean total stigma scores of 16.93 ± SD 7.8 vs 14.45 ± SD 6.1, t =-2.179 and P b.ut their profession significantly more often than their junior colleagues(mean item score 0.44 ± SD 0.82 vs 0.13 ± SD 0.48, t = 2.874, P b.e results were found in trainees working in adult psychiatry as were found in those working in child or youth psychiatry(mean item score 0.38 ± SD 0.77 vs 0.15 ± SD 0.53, t =-2.153, P b.ologically oriented trainees were mo

关键词： Associative stigma Trainee psychiatrist Psychiatry training Mental health gap Coping mechanisms

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Associative stigma in family memb.rs of psychotic patients in Flanders:An exploratory study

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World Journal of Psychiatry 2015年第1期5卷 118-125页

作者： Kirsten Catthoor Didier Schrijvers joost Hutseb.ut Dineke Feenstra Philippe Persoons Marc De Hert Jozef Peuskens b.rnard Sab.e Department of Psychiatry Psychiatrisch Ziekenhuis Stuivenberg Collab.rative Antwerp Psychiatric Research Institute Campus Drie Eiken De Viersprong (Landelijk Centrum voor Persoonlijkheidsprob.ematiek) Department Neurosciences KU Leuven Campus KortenbergUPC KU Leuven3000 LeuvenBelgium

AIM: To assess presence and severity of associative stigma in family memb.rs of psychotic patients and factors for higher associative ***: Standardized semi-structured interview of 150 family memb.rs of psychotic patients receiving full time treatment. This study on associative stigma in family memb.rs of psychotic patients was part of a larger research program on the b.rden of the family, using "Interview for the b.rden of the Family" and the chapters stigma, treatment and attrib.tion from the "Family interview Schedule". The respondents were relatives, one per patient, either partner or parent. The patients had b.en diagnosed with schizophrenia or schizo-affective disorder. All contacts with patients and relatives were in Dutch. Relatives were deemed suitab.e to participate in this research if they saw the patient at least once a week. Recruitment took place in a standardized way: after ob.aining the patient's consent, the relatives were approached to participate. The results were analyzed using SPSS Version 18.0. RESULTS: The prevalence of associative stigma in this sample is 86%. Feelings of depression in the majority of family memb.rs are prominent. Twenty-one point three percent experienced guilt more or less frequent, while shame was less pronounced. Also, 18.6% of allrespondents indicated that they tried to hide the illness of their family memb.r for others regularly or more. Three six point seven percent really kept secret ab.ut it in certain circumstances and 29.3% made efforts to explain what the situation or psychiatric condition of their family memb.r really is like. Factors with marked significance towards higher associative stigma are a worsened relationship b.tween the patient and the family memb.r, conduct prob.ems to family memb.rs, the patients' residence in a residential care setting, and hereditary attrib.tional factors like genetic hereditab.lity and character. The level of associative stigma has significantly b.en predicted b. the b

关键词： Associative stigma Risk factors for higher stigma Family memb.rs Psychotic patients b.rden

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高血压患者常规行眼底镜检查的价值:系统性综述

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英国医学杂志中文版 2005年第6期8卷 341-344页

作者： b.rt-Jan H van den b.rn Caroline A A Hulsman joost b.L Hoekstra Reinier O Schlingemann Gert A van Montfrans 高展 Department of Internal Medicine Academic Medical Centre PO 226601100 DD AmsterdamNetherlands Department of Ophthalmology Academic Medical CentreAmsterdam

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Emb.se和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管... 详细信息

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Emb.se和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管危险因素之间联系的研究。研究必须由2名或2名以上观察者得出一致评价结果，用K统计分析表示。对于高血压患者，研究高血压视网膜病变与高血压脏器损害之间的联系。对于非选择的血压正常者和无糖尿病高血压患者，评价高血压视网膜病变与心血管危险因素之间的联系。结果由于观察者之间的巨大差异限制了对视网膜微血管变化的评价。高血压视网膜病变与血压水平之间的阳性及阴性预测值均较低（分别为47％～72％和32％-67％）。除了视网膜病变与脑卒中之间有联系外，视网膜微血管变化与心血管危险因素之问无明显联系。但在血压正常的视网膜病变患者中同样发现脑卒中增加。这些研究没有对高血压脏器损害的其他预测因子进行调整。结论研究表明，高血压患者常规进行眼底检查有额外价值的观点尚缺乏证据。

关键词：高血压患者系统性综述眼底镜检查价值 Cochrane图书馆心血管危险因素视网膜病变 Medline 微血管变化眼底检查

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