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Gut microbiota as a potential key to modulating humoral immunogenicity of new platform COVID-19 vaccines

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2447-2450页

作者： Hye Seong Bo Kyu Choi Young-Hee Han Jun Hyoung kim Jeong-An Gim Sooyeon Lim Ji Yun Noh Hee Jin Cheong Woo Joo kim joon Young Song Department of Internal Medicine Korea University College of MedicineSeoulRepublic of Korea Asia Pacific Influenza Institute Korea University College of MedicineSeoulRepublic of Korea Vaccine Innovation Center Korea University College of MedicineSeoulRepublic of Korea Department of Biomedical Systems Informatics Yonsei University College of MedicineSeoulRepublic of Korea Department of Food and Nutrition Chungbuk National UniversityCheongjuRepublic of Korea Department of Internal Medicine Chungbuk National University HospitalCheongjuRepublic of Korea Medical Science Research Center Korea University College of MedicineSeoulRepublic of Korea

Dear Editor,Coronavirus disease 2019(COVID-19)is a novel respiratory infectious disease,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which led to a global *** vaccination is the best measure to overcome a pandemic,the immunogenicity of vaccines can be influenced by diverse factors,including intrinsic(age,sex,genetics,and comorbidities),extrinsic(diet,nutrition,and behavior),and vaccine-associated characteristics.

关键词： vaccines respiratory acute

Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

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世界临床病例杂志 2023年第24期11卷 5789-5796页

作者： Jong-Hun Seo Su-Yeon Cho Ji-Hwan Park Jin-Young Seo Hyun-Young Lee Dong-joon kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.Adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion Adenosine Diltiazem Case Report

Anti-C4d chimeric antigen receptor regulatory T cells suppressed allograft rejection in ABO-incompatible heart transplantation

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Genes & Diseases 2022年第1期9卷 1-4页

作者： Sun-Kyung Lee Jerome Han Honglin Piao Nara Shin joon Young Jang Ji-Jing Yan Hyori kim Junho Chung Jaeseok Yang Biomedical Research Institute Seoul National University HospitalSeoul 03080Republic of Korea Department of Medicine Graduate SchoolSeoul National University College of MedicineSeoul 03080Republic of Korea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Biomedical Science Seoul National University College of MedicineSeoul 03080Republic of Korea Cancer Research Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Division of Nephrology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Republic of Korea Convergence Medicine Research Center Asan Medical CenterSeoul 05505Republic of Korea

ABO blood group-incompatible(ABOi)transplantation has been developed to overcome the serious problem of donor organ ***,antibody-mediated rejection(ABMR)remains as the main limitation to successful ABOi *** of desensitization treatment improved the outcomes of ABOi transplantation by suppressing ABMR;however,this strong,nonspecific immunosuppression also increases infectious ***,chimeric antigen receptor regulatory T cells(CAR Tregs)were developed to improve the antigen specificity,viability,and suppressive activity of Tregs.C4d deposition is a marker of ABMR and is also found in most ABOi allograft *** on these findings,we developed anti-C4d CAR Tregs to suppress ABMR in ABOi allografts.

关键词： C4d ABO allograft

DYNAMIC PROPERTIES OF AL-ALLOY FOAM BEAM DAMAGED BY COMPRESSIVE FATIGUE

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Acta Mechanica Solida Sinica 2008年第3期21卷 241-246页

作者： Sung-Gaun kim Ilhyun kim Amkee kim Seung-joon kim Junhong Park Division of Mechanical and Automotive Engineering Kongju National University 275 Budae-dongCheonan Chungnam 330-717 Korea Department of Mechanical Engineering Hanyang University Seongdong-Gu Seoul 133-791 Korea

The permanent residual strain in aluminum （Al） alloy foams induced by compressive fatigue gradually increases with the increasing number of loading cycles. Consequently, the progressive shortening of Al-alloy foam degrades the dynamic material performance by the failure and ratcheting of multi-cells in the foam. In this paper, the dynamic properties of Al-alloy foams damaged by compressive fatigue were studied. The beam specimens with various residual strains were made by cyclic compression-compression stress. The dynamic bending modulus and loss factor were evaluated by using a beam transfer function method. As a result, the dynamic bending stiffness of Al-alloy foam turned out to be decreased due to damage while the loss factor was improved because of the increasing energy dissipation of such factors as cracked cell walls formed during the shortening process of the foam. The loss factor shows a manifest dependence on the fatigue residual strain.

关键词： Aluminum foam fatigue dynamic stiffness loss factor

Exploring anharmonic lattice dynamics and dielectric relations in niobate perovskites from first-principles self-consistent phonon calculations

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npj Computational Materials 2023年第1期9卷 757-766页

作者： Kwangrae kim Woohyun Hwang Seung-Hyun Victor Oh Aloysius soon Department of Materials Science&Engineering Yonsei UniversitySeoul 03722Republic of Korea

Group I niobates(KNbO_(3) and NaNbO_(3))are promising lead-free alternatives for high-performance energy storage *** their potential,their complex phase transitions arising from temperature-dependent phonon softening and anharmonic effects on dielectric properties remain poorly *** this study,we employ density-functional theory(DFT)and self-consistent phonon(SCP)calculations to investigate finite-temperature phonons in cubic niobate *** include explicit anharmonic vibrational effects,SCP frequencies are shifted by the bubble self-energy correction within the quasiparticle(QP)approximation,providing precise descriptions of phonon softening in these strongly anharmonic *** further calculate the static dielectric constant of KNbO_(3) and NaNbO_(3) as a function of temperature using the Lyddane-Sachs-Teller(LST)relation and QP-corrected phonon *** theoretical results align with experimental data,offering reliable temperature-dependent phonon dispersions while considering anharmonic self-energies and thermal expansion effects,enhancing our understanding of the complex relations between lattice vibrations and phase transitions in these anharmonic oxides.

关键词： harmonic phonon dielectric

Adhesion and Suction Functions of the Tip Region of a Nectar-drinking Butterfly Proboscis

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Journal of Bionic Engineering 2017年第4期14卷 600-606页

作者： Seung Chul Lee Jun Ho kim Sang joon Lee Department of Mechanical Engineering Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea Center for Biofluid and Biomimic Research Pohang University of Science and Technology Pohang 37673 Gyeongbuk Republic of Korea

In this study, we investigated the dynamic functions of the tip region of the butterfly proboscis through which liquid is sucked during liquid feeding. The microstructures and flow patterns in the tip region of the proboscis were in vivo analyzed. The tip region can be divided into two functional sections： namely adhesion and suction sections. The liquid adheres to the adhesion section during liquid suction. Although the tip region has numerous slits connected to food canal of the proboscis, liquid is mainly sucked through the suction section, which section is submerged in the fluid pulled by the adhesion section and then successfully imbibes liquid. To check the dynamic functions of the tip region, we fabricated a suction tip model having adhesion and suction parts. The in vitro model experiments show that the hydrophilicity of the adhesion part and the existence of the suction inlet improve the liquid uptake driven by a suction pump. This study may provide insights for the biomimetic design of nectar-feeding butterflies.

关键词： butterfly proboscis nectar-feeding strategy suction

Ultra-low concentration of total organic carbon in ultrapure water using ion-exchange resin embedding silanized magnetic nanoparticles

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Journal of Environmental Sciences 2020年第6期32卷 11-17页

作者： Jung joon Lee Jihyeon Park Bo-Hyun kim Sunjong Lee Department of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419South Korea Korea Institute of Industrial Technology 89 Yangdaegiro-gilIpjang-myeonCheonan-si 31056South Korea

Regeneration of pure water is an important issue not only for the healthy life but also for the fine control of precise processes in various *** important issue in ultrahigh purified water is to reduce the amount of total organic carbon(TOC).Herein,we introduce a new approach to reduce the TOC using the surface silanized nanoparticles,in which the magnetic nanoparticles(mNPs)are silanized and then complexed with ion exchange resin(IER)*** Fe3O4 mNPs are surface modified by using high concentrated vinyltrimethoxysilane(VTMS)and then adhered on the surface of IER *** surface modified mNPs have a thick-shell of polysiloxane layer varying from 5 to 22 nm depending on the amount of VTMS used,which leads the significant increase of specific surface *** IER beads embedding VTMS-silanized mNPs achieves about 7μg/L of the TOC level in ultrapure water system,which is two orders less than 228μg/L of the feeding water and one order less than 96μg/L from the system using pristine IER *** result is mainly attributed to the polysiloxane layer forming broccoli-like surface structure and some part by the vinyl group of VTMS exposed to the amines in the water.

关键词： Total organic carbon Ultrapure water Magnetic nanoparticle Ion-exchange resin Hybrid structure

Critical factors to inhibit water-splitting side reaction in carbon-based electrode materials for zinc metal anodes

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Carbon Energy 2022年第6期4卷 1080-1092页

作者： Dong Hyuk Kang Eunji Lee Beom Sik Youn Son Ha Jong Chan Hyun Juhee Yoon Dawon Jang Kyoung Sun kim Hyungsub kim Sang Moon Lee Sungho Lee Hyoung-joon Jin Hyung-Kyu Lim Young Soo Yun KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSeongbuk-guSouth Korea Division of Chemical Engineering and Bioengineering Kangwon National UniversityChuncheonGangwon-doSouth Korea Department of Eco-Polymer Science and Engineering Inha UniversityIncheonMichuhol-guSouth Korea Carbon Composite Materials Research Center Institute of Advanced Composite MaterialsKorea Institute of Science and Technology(KIST)Jeollabuk-doSouth Korea Department of Chemical and Biological Engineering Korea UniversitySeoulSeongbuk-guSouth Korea Neutron Science Division Korea Atomic Energy Research Institute(KAERI)DaejeonYuseong-guSouth Korea Research Center for Materials Analysis Korea Basic Science Institute(KBSI)DaejeonYuseong-guSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSeongbuk-guSouth Korea

Zinc metal anodes(ZMA)have high theoretical capacities(820 mAh g−1 and 5855 mAh cm−3)and redox potential(−0.76 V *** hydrogen electrode),similar to the electrochemical voltage window of the hydrogen evolution reaction(HER)in a mild acidic electrolyte system,facilitating aqueous zinc batteries competitive in next-generation energy storage ***,the HER and byproduct formation effectuated by water-splitting deteriorate the electrochemical performance of ZMA,limiting their *** this study,a key factor in promoting the HER in carbon-based electrode materials(CEMs),which can provide a larger active surface area and guide uniform zinc metal deposition,was investigated using a series of threedimensional structured templating carbon electrodes(3D-TCEs)with different local graphitic orderings,pore structures,and surface *** ultramicropores of CEMs are the determining critical factors in initiating HER and clogging active surfaces by Zn(OH)2 byproduct formation,through a systematic comparative study based on the 3D-TCE series *** the 3D-TCEs had a proper graphitic structure with few ultramicropores,they showed highly stable cycling performances over 2000 cycles with average Coulombic efficiencies of≥99%.These results suggest that a well-designed CEM can lead to high-performance ZMA in aqueous zinc batteries.

关键词： aqueous batteries carbon electrode hydrogen evolution reaction multivalent ion zinc metal anode

Microstructure and Tensile Behavior of a Nano-Structured Al-Fe Based Alloy

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Journal of Rare Earths 2004年第Z2期22卷 65-68页

作者： Won-Yong kim Jae-Sung Park Mok-soon kim Tae-Yeub Ra Advanced Materials R&D Center Korea Institute of Industrial Technology # 472Kajwa-dongSuh-guIncheon 404-254Korea School of Materials Science and EngineeringInha University # 253Yonghyun-dongNam-guIncheon 402-751Korea School of Materials Science and EngineeringInha University # 253Yonghyun-dongNam-guIncheon 402-751Korea Advanced Materials R&D CenterKorea Institute of Industrial Technology # 472Kajwa-dongSuh-guIncheon 404-254Korea

Room temperature deformation behavior of A1-8Fe-2Mo-2V-1Zr alloy produced by spray forming and subsequent warm-extrusion at 693 K and/or rolling at 423 K was investigated in terms of tensile test and microstructural *** the specimen processed by spray forming and warm extrusion, the microstructure consisting of equiaxed grains with the average grain size of 500 nm in the matrix phase and uniformly dispersed fine intermetallic A13(Fe, Mo, V, Zr) and A16(Fe, Mo, V, Zr) phases less than 100 nm was characterized. It was revealed that subsequent warm rolling after warm extrusion promotes precipitation of a fine dispersoid from the supersaturated matrix phase. Warm rolling was found to be effective to increase the yield and tensile strength in the high strain rate regime. Elongation of the warm rolled specimen showed highe r value than extruded specimen over the whole strain rate region studied.

关键词： microstructure tensile deformation A1-Fe based alloy spray forming extrusion warm rolling precipitation strain rate sensitivity