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Wireless sequential dual light delivery for programmed PDT in vivo

Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-joon Kim Shu Uin Gan John S.ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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Radiotherapy for 65 patients with advanced unresectable hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第15期14卷 2394-2400页

作者： Yeon Seok Seo Jin Nam Kim Bora keum Sanghoon Park Yong Dae Kwon Yong Sik Kim Yoon Tae Jeen hoon Jai Chun Chul Yong Kim Chang Duck Kim ho Sang Ryu Soon ho Um Department of Internal Medicine Korea University College of Medicine Seoul 136-705 Korea Department of Radiation Oncology Korea University College of Medicine Seoul 136-705 Korea

AIM: To evaluate the efficacy of radiotherapy (RT) in patients with advanced unresectable hepatocellular carcinoma (HCC). METhoDS: A total of 65 patients were treated with RT in the Korea University Medical Center. The median age of the patients was 60 years, and 86.2% were men. 18.5% and 81.5% of the patients were diagnosed as TNM stage Ⅲ and Ⅳ-A, respectively. Treatment response was assessed 4 mo after initiation of RT. Tumor regression rate 1 mo after initiation of RT (TRR1m) was also assessed. Duration of survival was calculated from the initiation of RT. RESULTS: The objective treatment response was 56.9%. The 12 mo survival rate was 34.7%. Predictive factors for survival were Child-Pugh grade, α-fetoprotein level and treatment response. An objective response was achieved more frequently in patients with TRR1m ≥ 20% than in those with TRR1m < 20% (P < 0.001). CONCLUSION: RT is effective in treating advanced HCC with a tumor response rate of 56.9%.

关键词： Hepatocellular carcinoma Radiotherapy Treatment response Survival

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Extended lymph node dissection in robot-assisted radical prostatectomy： lymph node yield and distribution of metastases

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Asian Journal of Andrology 2014年第6期16卷 824-828页

作者： Kwang Hyun Kim Sey Kiat Lim Kyo Chul Koo Woong Kyu Han Sung joon hong Koon ho Rha Department of Urology Urological Science Institute Yonsei University College of Medicine Seoul Korea Department of Urology Ewha Womans University School ot Medicine Seoul Korea.

In this study, we reported our experience performing robotic extended lymph node dissection （eLND） in patients with prostate cancer. A total of 147 patients with intermediate and high-risk prostate cancer who underwent robotic eLND from May 2008 to December 2011 were included in this analysis. The dissection template extended to the ureter crossing the iliac vessels. We assessed lymph node yield, lymph node positivity, and perioperative outcomes. Lymph node positivity was also evaluated according to the number of lymph nodes （LNs） removed （〈22 vs 〉22）. The median number of LNs removed was 22 （11-51）, and 97 positive LNs were found in 24 patients （16.3%）. While the obturator fossa was the most common site for LN metastases （42.3%, 41/97）, the internal iliac area was the most common area for a single positive LN packet （20.8%, 5/24）. Eight patients （33.3%, 8/24） had positive LNs at the common iliac area. The incidence of positive LNs did not differ according to the number of LNs removed. Complications associated with eLND occurred in 21 patients （14.3%） and symptomatic lymphocele was found in five patients （3.4%）. In conclusion, robotic eLND can be performed with minimal morbidity. Furthermore, LN yield and the node positive rate achieved using this robotic technique are comparable to those of open series. In addition, the extent of dissection is more important than the absolute number of LNs removed in eLND, and the robotic technique is not a prohibitive factor for performing eLND.

关键词： lymph node excision prostatectomy prostatic neoplasm robotics

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Construction of random sheared fosmid library from Chinese cabbage and its use for Brassica rapa genome sequencing project

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Journal of Genetics and Genomics 2011年第1期38卷 47-53页

作者： Tae-ho Park Beom-Seok Park Jin-A Kim joon Ki hong Mina Jin Young-Joo Seol Jeong-Hwan Mun Genomics and Functional Bio-Material Division National Academy of Agricultural ScienceRural Development Administration The Department of horticultural Science Daegu University

As a part of the Multinational Genome Sequencing Project of Brassica rapa, linkage group R9 and R3 were sequenced using a bacterial artificial chromosome （BAC） by BAC strategy. The current physical contigs are expected to cover approximately 90% euchromatins of both chromosomes. As the project progresses, BAC selection for sequence extension becomes more limited because BAC libraries are restriction enzyme-specific. To support the project, a random sheared fosmid library was constructed. The library consists of 97536 clones with average insert size of approximately 40 kb corresponding to seven genome equivalents, assuming a Chinese cabbage genome size of 550 Mb. The library was screened with primers designed at the end of sequences of nine points of scaffold gaps where BAC clones cannot be selected to extend the physical contigs. The selected positive clones were end-sequenced to check the overlap between the fosmid clones and the adjacent BAC clones. Nine fosmid clones were selected and fully sequenced. The sequences revealed two completed gap filling and seven sequence extensions, which can be used for further selection of BAC clones confirming that the fosmid library will facilitate the sequence completion of B. rapa.

关键词： Brassica rapa Chinese cabbage Fosmid library Genome sequencing Physical contig

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Biochemical outcomes after robot-assisted radical prostatectomy in patients with follow-up more than 5-years

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Asian Journal of Andrology 2013年第3期15卷 404-408页

作者： Kwang Hyun Kim Sey Kiat Lim Tae-Young Shin Byung Ha Chung Sung joon hong Koon ho Rha Department of Urology Urological Science Institute Yonsei University College of Medicine Seoul Korea

In this study, we assessed biochemical outcomes after robot-assisted radical prostatectomy （RARP）. Between July 2005 and November 2007, one hundred and seventy-six consecutive patients treated by RARP without neoadjuvant treatment were included in this study. All procedures were performed by a single surgeon and the median follow-up period was 60 months （interquartile range （IQR）： 59-69）. The median prostate specific antigen was 7.50 ng ml-1 （IQR： 5.14-11.45） and 39.2% of the patients were classified as intermediate risk and 15.3% were classified as high risk; on final pathological examination, 35.2% of the patients had non-organ confined disease and 37.5% and 14.2% had Gleason scores of 7 and 8-10, respectively. The biochemical recurrence （BCR）-free survival rates at 3 and 5 years were 85.6% and 81.2%, respectively. The 5-year BCR-free survival rates stratified by pathologic Gleason scores were 93.1% in Gleason scores of 6 or less, 74.5% in a Gleason score of 7, and 58.1% in Gleason scores of 8 or greater, respectively （P〈0.001）. When stratified by pathologic stage, the BCR-free survival rates were 89.8% in pT2 patients, 66.2% in pT3a patients, and 39.3% in pT3b patients at 5 years following RARP, respectively （P〈0.001）. Preoperative prostate-specific antigen （PSA）, pathologic stage, postoperative Gleason score and surgical margin status were independently associated with BCR in multivariate analysis. In this study, we report biochemical outcomes after RARP with the longest follow-up periods to date in Asian men. We found that robotic surgery provided satisfactory biochemical outcomes, and that RARP is a safe and effective procedure in terms of oncologic outcomes.

关键词： prostatectomy prostatic neoplasm recurrence robotics

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Grasper type scissors for endoscopic submucosal dissection of gastric epithelial neoplasia

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World Journal of Gastroenterology 2013年第37期19卷 6221-6227页

作者： Woo-Chul Chung Byung-Wook Kim Chul-Hyun Lim Tae-ho Kim Jae-Myung Park joon-Sung Kim Division of Gastroenterology Department of Internal MedicineSuwon St.Vincent’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineIncheon St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of Korea Division of Gastroenterology Department of Internal MedicineBucheon St.Mary’s HospitalThe Catholic University of Korea

AIM:To evaluate the efficacy and safety of grasper type scissors(GTS)for endoscopic submucosal dissection(ESD)of gastric epithelial ***:The study was performed by 4 endoscopists in 4 institutions affiliated to The Catholic University of *** was performed in 76 consecutive patients with gastric epithelial neoplasia by using the GTS(37 patients)or the hook knife plus coagrasper(HKC)(39 patients).The complete resection rate,complication rate,total time elapsed and elapsed time per square centimeter of the dissected specimen were analyzed between the GTS and HKC ***:The mean age of the GTS group was 62.3±11.4 years and mean age of the HKC group was 65.6±10.1 *** adenocarcinoma was found in32.4%in the GTS group and 33.3%in the HKC *** procedures were performed without interruption in every case in both *** en bloc resection rates of both groups were 100%.The total time elapsed during the procedure was 44.54±21.72 min in the GTS group and 43.77±21.84 min in the HKC group(P=0.88)and the time elapsed per square centimeter of the resected lesion was 7.53±6.35 min/cm2in the GTS group and 6.92±5.93 min/cm2in the HKC group(P=0.66).The overall complication rate was not significantly different between the two ***:GTS is a safe and effective device for ESD compared with *** can be performed with GTS alone,which can reduce the costs for ESD.

关键词： Gastric epithelial neoplasia Endoscopic submucosal dissection Grasper type scissors hook knife Coagrasper

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Unilateral pulmonary hemorrhage caused by negative pressure pulmonary edema:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1408-1415页

作者： Hyung joon Park Seung ho Park Un Tak Woo Sang Yun Cho Woo Jae Jeon Woo Jong Shin Department of Anesthesia and Pain Medicine Hanyang UniversityGuri HospitalGuri 11923Gyeonggi-doSouth Korea

BACKGROUND Unilateral pulmonary hemorrhage is typically reported in young and healthy men with upper respiratory tract obstruction during anesthesia in special *** pressure in the lungs is created,resulting in negative pressure pulmonary edema(NPPE).CASE SUMMARY A 78-year-old male patient diagnosed with spinal stenosis was admitted to receive a unilateral laminectomy with bilateral *** patient had been diagnosed with hypertension four years earlier and asthma more than 70 years *** experienced a unilateral alveolar hemorrhage associated with NPPE that occurred in a longstanding asthma patient who bit the intubated endotracheal tube for a short period during posture change at the end of *** diffuse alveolar hemorrhage accompanied by NPPE was caused in this case by airway obstruction in an older patient with asthma without known risk factors,anesthesiologists should be careful not to induce airway irritation during anesthesia awakening in asthma *** Because diffuse alveolar hemorrhage accompanied by NPPE can occur,anesthesiologists should take care not to induce airway irritation.

关键词： Airway Anesthesia Asthma Hemorrhage Pulmonary edema Case report Surgery

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Negative oncologic impact of poor postoperative pain control in left-sided pancreatic cancer

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World Journal of Gastroenterology 2017年第4期23卷 676-686页

作者： Eun-Ki Min Jae Uk Chong ho Kyoung Hwang Sang joon Pae Chang Moo Kang Woo Jung Lee Yonsei University College of Medicine Seoul 03722 Department of Hepatobiliary and Pancreatic Surgery Yonsei University College of Medicine Pancreaticobiliary Cancer Clinic Yonsei Cancer CenterSeverance Hospital National Health Insurance Corporation Ilsan hospital

AIMTo investigate the association between postoperative pain control and oncologic outcomes in resected pancreatic ductal adenocarcinoma (PDAC).METhoDSFrom January 2009 to December 2014, 221 patients were diagnosed with PDAC and underwent resection with curative intent. Retrospective review of the patients was performed based on electronic medical records system. One patient without records of numerical rating scale (NRS) pain intensity scores was excluded and eight patients who underwent total pancreatectomy were also excluded. NRS scores during 7 postoperative days following resection of PDAC were reviewed along with clinicopathologic characteristics. Patients were stratified into a good pain control group and a poor pain control group according to the difference in average pain intensity between the early (POD 1, 2, 3) and late (POD 5, 7) postoperative periods. Cox-proportional hazards multivariate analysis was performed to determine association between postoperative pain control and oncologic *** total of 212 patients were dichotomized into good pain control group (n = 162) and poor pain control group (n = 66). Median follow-up period was 17 mo. A negative impact of poor postoperative pain control on overall survival (OS) was observed in the group of patients receiving distal pancreatectomy (DP group; 42.0 mo vs 5.0 mo, P = 0.001). Poor postoperative pain control was also associated with poor disease-free survival (DFS) in the DP group (18.0 mo vs 8.0 mo, P = 0.001). Patients undergoing pancreaticoduodenectomy or pylorus-preserving pancreaticoduodenectomy (PD group) did not show associations between postoperative pain control and oncologic outcomes. Poor patients’ perceived pain control was revealed as an independent risk factor of both DFS (HR = 4.157; 95%CI: 1.938-8.915; P < 0.001) and OS (HR = 4.741; 95%CI: 2.214-10.153; P < 0.001) in resected left-sided pancreatic *** postoperative pain relief durin

关键词： Pancreatic cancer Pancreatectomy Survival Postoperative pain Recurrence

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Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance

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World Journal of Gastroenterology 2014年第33期20卷 11753-11761页

作者： ho Hyun Nam Dae Won Jun Hye joon Jeon Jai Sun Lee Waqar Khalid Saeed Eun Kyung Kim Department of Translational Medicine Hanyang University Graduate School of Biomedical Science and Engineering Seoul 133-791 South Korea Department of Internal Medicine Hanyang University School of Medicine Seoul 133-791 South Korea Department of Pathology Eulji University College of Medicine Seoul 139-872 South Korea

AIM: To evaluate the effects of osthol on intrahepatic fat synthesis, β-oxidation, inflammation, and insulin resistance by multifaceted analysis.

关键词： Osthol Non-alcoholic fatty liver disease Ste-rol regulatory element binding protein

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Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps

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World Journal of Gastroenterology 2009年第19期15卷 2361-2366页

作者： Young Koog Cheon Won Young Cho Tae Hee Lee Young Deok Cho Jong ho Moon joon Seong Lee Chan Sup Shim Institute for Digestive Research and Digestive Disease Center Soon Chun Hyang University College of Medicine657 Hannam-DongYongsan-KuSeoul 140-743South Korea

AIM： To assess the ability of endoscopic ultrasonography （EUS） to differentiate neoplastic from non- neoplastic polypoid lesions of the gallbladder （PLGs）.METhoDS： The uses of EUS and transabdominal ultrasonography （US） were retrospectively analyzed in 94 surgical cases of gallbladder polyps less than 20 mm in ***： The prevalence of neoplastic lesions with a diameter of 5-20 mm was 27.2% （10/58）; 22-15 mm, 25.4% （4/26）, and 16-20 mm, 50% （5/20）. The overall diagnostic accuracies of EUS and US for small PLGs were 80.9% and 63.9% （P 〈 0.05）, respectively. EUS correctly distinguished 12 （63.2%） of 19 neoplastic PLGs but was less accurate for polyps less than 1.0 cm （4/10, 40%） than for polyps greater than 1.0 cm （8/9, 88.9%）（P = 0.02）.CONCLUSION： Although EUS was more accurate than US, its accuracy for differentiating neoplastic from non-neoplastic PLGs less than 1.0 cm was low. Thus, EUS alone is not sufficient for determining a treatment strategy for PLGs of less than 1.0 cm.

关键词： Endoscopic ultrasonography Neoplasticlesion Polypoid gallbladder lesion

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