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How the physical inactivity is affected by social-, economic- and physical-environmental factors: an exploratory study using the machine learning approach

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International Journal of Digital Earth 2023年第1期16卷 2503-2521页

作者： Kangjae Lee Jue Wang joon heo Department of Location-Based Information System Kyungpook National UniversitySangju-siGyeongsangbukdoRepublic of Korea Department of Geography Geomatics and EnvironmentUniversity of Toronto MississaugaMississaugaCanada Department of Civil and Environmental Engineering Yonsei UniversitySeoulRepublic of Korea

Previous studies have utilized regression models to investigate the impact of environmental factors on physical ***,such approaches are inadequate for data-driven analysis seeking to identify robust associations from the intricate and multi-variable interactions between physical activity and environmental *** the emergence of the concept of the exposome,which encompasses the totality of exposures,this paper explores machine learning models for predicting the percentage of physical inactivity in ***,while considering 28 social-,economic-,and physical-environmental *** aim of this study is to address the research gap and gain insight into the complex associations between environmental exposures and physical *** machine learning models were tested,and the performances were compared to select the best classifier for further *** study used data from the Behavioral Risk Factor Surveillance System(BRFSS)of the Centers for Disease Control and *** mean population of all counties was 102,841,and the mean percentage of population below 18 years was 22.3%.The partial dependence plot analysis indicated that only one feature–bachelor’s degree–exhibited a close-to-linear relationship with physical ***-vehicle crash death rate and mean temperature showed nonlinear and non-monotonic relationships with the predicted percentage of physical inactivity.

关键词： Physical inactivity environmental effects machine learning GIS

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Acetylacetone-TiO_(2) Promoted Large Area Compatible Cascade Electron Transport Bilayer for Efficient Perovskite Solar Cells

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Energy & Environmental Materials 2024年第2期7卷 221-228页

作者： Hyong joon Lee Jin Kyoung Park Jin Hyuck heo Sang Hyuk Im Department of Chemical and Biological Engineering Korea University145 Anam-ro Seongbuk-guSeoul 17104Korea

In designing efficient perovskite solar cells(PSCs),the selection of suitable electron transport layers(ETLs)is critical to the final device performance as they determine the driving force for selective charge ***_(2)nanoparticles(NPs)based ETLs have been a popular choice for PSCs due to superior electron mobility,but their relatively deep-lying conduction band energy levels(ECB)result in substantial potential ***,TiO_(2)NPs establish favorable band alignment owing to shallower ECB,but their low intrinsic mobility and abundant surface trap sites impede the final *** this reason,constructing a cascaded bilayer ETL is highly desirable for efficient PSCs,as it can rearrange energy levels and exploit on advantages of an individual *** this study,we prepare SnO_(2)NPs and acetylacetone-modified TiO_(2)(Acac-TiO_(2))NPs and implement them as bilayer SnO_(2)/Acac-TiO_(2)(BST)ETL,to assemble cascaded energy band ***_(2)contributes to rapid charge carrier transport from high electron mobility while Acac-TiO_(2)minimizes band-offset and effectively suppresses interfacial ***,the optimized BST ETL generates synergistic influence and delivers power conversion efficiency(PCE)as high as 23.14%with open-circuit voltage(V_(oc))reaching 1.14 ***,the BST ETL is transferred to a large scale and the corresponding mini module demonstrates peak performance of 18.39%PCE from 25 cm^(2)aperture ***,the BST-based mini module exhibit excellent stability,maintaining 83.1%of its initial efficiency after 1000 h under simultaneous 1 Sun light-soaking and damp heat(85℃/RH 85%)environment.

关键词： acetylacetone large area perovskite solar cells TiO_(2)

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Ultrasonic Approach of Rayleigh Pitch-Catch Contact Ultrasound Waves on CFRP Laminated Composites

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Journal of Materials Science & Technology 2008年第3期24卷 407-409页

作者： In-Young Yang Kwang-Hee Im Uk heo David K Hsu Je-Woong Park Hak-joon Kim Sung-Jin Song School of Mechanical Eng. Chosun Univ Department of Automotive Eng. Woosuk Univers-ity Center for Nondestructive Evaluation Iowa State University Dept.of Naval Arch.and Ocean Eng. Chosun Univ School of Mechanical Eng. Sungkyunkwan University

CFRP （carbon fiber reinforced plastics） composite materials have wide applicability because of their inherent design flexibility and improved material properties. However, impacted composite structures have 50%-75% less strength than undamaged structures. In this work, a CFRP composite material was nondestructively characterized in order to ensure product quality and structural integrity of CFRP and one-sided pitch-catch technique was developed to measure impacted-damaged area by using an automated-data acquisition system in an immersion tank. A pitch-catch signal was found to be more sensitive than normal incidence backwall echo of longitudinal wave under defect conditions in the composite.

关键词： Impact damages C-scanner Carbon fiber reinforced plastics (CFRP) Pitchcatch mode

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Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation

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World Journal of Stem Cells 2022年第3期14卷 245-263页

作者： Min-Jung Kim Won Moon Jeonghoon heo Sangwook Lim Seung-Hyun Lee Jee-Yeong Jeong Sang joon Lee Department of Biochemistry Cancer Research Institute Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Internal Medicine Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Molecular Biology and Immunology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of Radiation Oncology Kosin University College of MedicineSeo-gu 49267BusanSouth Korea Department of General Surgery Kosin University College of MedicineSeogu 49267BusanSouth Korea Department of Ophthalmology Gospel HospitalKosin University College of MedicineSeo-gu 49267BusanSouth Korea

BACKGROUND Bone marrow(BM)suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to *** concerted efforts,there is no definitive treatment method *** studies have reported using mesenchymal stromal cells(MSCs),but their therapeutic effects are *** We administered and examined the effects of various amounts of adipose-derived MSCs(ADSCs)in mice with radiation-induced BM *** Mice were divided into three groups:Normal control group,irradiated(RT)group,and stem cell-treated group following whole-body irradiation(WBI).Mouse ADSCs(mADSCs)were transplanted into the peritoneal cavity either once or three times at 5×10^(5) cells/200μ*** white blood cell count and the levels of,plasma cytokines,BM mRNA,and BM surface markers were compared between the three *** BM-derived CD34+hematopoietic progenitor cells were co-cultured with human ADSCs(hADSCs)or incubated in the presence of hADSCs conditioned media to investigate the effect on human cells in *** The survival rate of mice that received one transplant of mADSCs was higher than that of mice that received three *** transplantations of ADSCs delayed the repopulation of BM hematopoietic stem ***-inflammatory effects and M2 polarization by intraperitoneal ADSCs might suppress erythropoiesis and induce myelopoiesis in sub-lethally RT *** The results suggested that an optimal amount of MSCs could improve survival rates post-WBI.

关键词： Adipose tissue-derived stem cells Bone marrow suppression Mesenchymal stromal cells Radiation Cell therapy

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Ceramic-metal package for high power LED lighting

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Frontiers of Optoelectronics 2012年第2期5卷 133-137页

作者： Yu Jin heo Hyo Tae KIM Sahn NAHM Jihoon KIM Young joon YOON Jonghee KIM Korea Institute of Ceramic Engineering and Technology Seoul 153-801 Korea Department of Materials Science and Engineering Korea University Seoul 136 701 Korea

High power light-emitting diodes （LEDs） lighting has drawn a great interest in the field of street light system in recent years. Key parameters for successful launching of LED street light in the commercial market are price and light efficiency, respectively, and they are greatly influenced by the materials and design factors used in high power LED package. This article presents a new design and materials processing technology to realize the solution of LED packaging with advantageous in price and performance. Cost effective materials and processing technology can be realized via thick film glass-ceramic insulating layer and silver conductor. Highly effective thermal design using direct heat dissipation to heat sink in LED package is demonstrated.

关键词： light-emitting diodes (LEDs) package high-power thick film heat dissipation thermal resistance

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Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

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World Journal of Gastroenterology 2021年第23期27卷 3342-3356页

作者： Seunghun Lee Jeonghoon heo Eun-Kyung Ahn Jae Hyun Kim Young-Ho Kim Hee-Kyung Chang Sang-joon Lee Jongsik Kim Seun-Ja Park Department of Colorectal Surgery Kosin University College of MedicineBusan 49267South Korea Department of Molecular Biology and Immunology Kosin University College of MedicineBusan 49267South Korea Department of Gastroenterology Kosin University College of MedicineBusan 49267South Korea Department of Pathology Kosin University College of MedicineBusan 49267South Korea Department of Ophthalmology Kosin University College of MedicineBusan 49267South Korea Department of Anatomy Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune ***,there is no successful treatment for significant improvement in *** cells display their therapeutic effects through their repopulating capacity or secreting *** To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced *** mADSCs were isolated from adipose tissue of C57BL/6 *** mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 *** colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 *** mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were *** mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were *** The isolated mADSCs maintained the mADSCs specific gene expression profiles during *** conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory *** loss of body weight and reduction in colon length were ameliorated in the CM *** conditioned mADSCs secretome reduced the histological score in colon *** expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,*** elevation of serum IL-6 levels was also ameliorated in the CM *** results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be

关键词： Adipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regeneration

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Production of Transgenic Korean Native Cattle Expressing Enhanced Green Fluorescent Protein Using a FIV-Based Lentiviral Vector Injected into MII Oocytes

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Journal of Genetics and Genomics 2013年第1期40卷 37-43页

作者： Yong-Nan Xu Sang-Jun Uhm Bon-Chul Koo Mo-Sun Kwon Ji-Yeol Roh Jung-Seok Yang Hyun-Yong Choi Young-Tae heo Xiang-Shun Cui joon-Ho Yoon Dae-Hwan Ko Teoan Kim Nam-Hyung Kim Department of Animal Sciences Chungbuk National University361-763Republic of Korea Department of Animal Science and Biotechnology Sangji Youngseo College220-713Republic of Korea Department of Physiology Catholic University of Daegu School of Medicine712-702Republic of Korea Department of Animal Resources Community KongJu National University340-702Republic of Korea

The potential benefits of generating and using transgenic cattle range from improvements in agriculture to the production of large quantities of pharmaceutically relevant proteins. Previous studies have attempted to produce transgenic cattle and other livestock by pronuclear injection and somatic cell nuclear transfer, but these approaches have been largely ineffective; however, a third approach, lentivirus-mediated transgenesis, has successfully produced transgenic livestock. In this study, we generated transgenic （TG） Korean native cattle using perivitelline space injection of viral vectors, which expressed enhanced green fluorescent protein （EGFP） systemically. Two different types of lentiviral vectors derived from feline immunodeficiency virus （FIV） and human immunodeficiency virus （HIV） carrying EGFP were injected into the perivitelline space of MII oocytes. EGFP expression at 8-cell stage was significantly higher in the FIV group compared to the HIV group （47.5% ± 2.2% v.s. 22.9% 4± 2.9%）. Eight-cell embryos that expressed EGFP were cultured into blastocysts and then transferred into 40 heifers. Ten heifers were successfully impregnated and delivered 10 healthy calves. All of these calves expressed EGFP as detected by in vivo imaging, PCR and Southern blotting. In addition, we established an EGFP-expressing cell line from TG calves, which was followed by nuclear transfer （NT）. Recloned 8-cell embryos also expressed EGFP, and there were no differences in the rates of fusion, cleavage and development between cells derived from TG and non-TG calves, which were subsequently used for NT. These results illustrate that FIV-based lentiviruses are useful for the production of TG cattle. Moreover, our established EGFP cell line can be used for additional studies that involve induced pluripotent stem cells.

关键词： Transgenic cattle Lentiviral vector Perivitelline space injection Enhanced green fluorescent protein

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Clinical validation of scoring systems of postoperative pancreatic fistula after pancreatoduodenectomy: applicability to Eastern cohorts?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 211-218页

作者： Jae Seung Kang Taesung Park Youngmin Han Seungyeon Lee Jae Ri Kim Hongbeom Kim Wooil Kwon Sun-Whe Kim Jin Seok heo Seong Ho Choi Dong Wook Choi Song Cheol Kim Tae Ho Hong Dong Sup Yoon joon Seong Park Sang Jae Park Sung-Sik Han Sae-Byeol Choi Joo Seop Kim Chang-Sup Lim Jin-Young Jang Department of Surgery and Cancer Research Institute Seoul National University College of MedicineSeoulRepublic of Korea Department of Statistics and Interdisciplinary Program in Biostatistics Seoul National UniversitySeoulRepublic of Korea Department of Mathematics and Statistics Sejung UniversitySeoulRepublic of Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryUlsan University College of Medicine and Asan Medical CenterSeoulRepublic of Korea Department of Surgery Seoul St.Mary’s HospitalThe Catholic University of KoreaCollege of MedicineSeoulRepublic of Korea Pancreatobiliary Cancer Clinic Department of SurgeryGangnam Severance HospitalYonsei University College of MedicineSeoulRepublic of Korea Center for Liver Cancer National Cancer CenterGyeonggidoRepublic of Korea Department of Surgery Korea University Guro HospitalKorea University College of MedicineSeoulRepublic of Korea Department of Surgery Kangdong Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Surgery Seoul Metropolitan Government-Seoul National University Boramae Medical CenterSeoul National University College of MedicineSeoulRepublic of Korea

Background:Although several prediction models for the occurrence of postoperative pancreatic fistula(POPF)after pancreatoduodenectomy(PD)exist,all were established using Western ***-scale external validation studies in Eastern cohorts that consider demographic variables including lower body mass index(BMI)are *** purpose of this study was to externally validate POPF prediction models using nationwide large-scale Korean ***:Nine tertiary university hospitals in the Republic of Korea ***'preoperative characteristics,intraoperative factors,and pathologic findings were *** grades were determined according to the 2016 International Study Group on Pancreatic Surgery *** POPF risk models(Callery,Roberts,and Mungroop)were selected for external ***:A total of 1,898 PD patients were enrolled.A non-pancreatic disease diagnosis[hazard ratio(HR),1.856;95%confidence interval(CI),1.223–2.817;P=0.004),higher preoperative BMI(HR,1.069;95%CI,1.019–1.121;P=0.006),and soft pancreatic texture(HR,1.859;95%CI,1.264–2.735;P=0.002)were independent risk factors for clinically relevant POPF(CR-POPF).The area under the receiver operating characteristic curve(AUC)values were 0.61,0.64,and 0.63 on the Callery,Roberts,and Mungroop models,respectively;all were lower than those published in each external validation ***:Western POPF prediction models performed less well when applied to Korean ***,a large-scale Eastern-specific and externally validated POPF prediction model is needed.

关键词： Pancreatic fistula pancreatoduodenectomy(PD) predictive score

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