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World Journal of Gastroenterology 2009年第18期15卷 2258-2264页

作者： Dongho Choi Hyo Won Lee Kyung Yul Hur Jae joon Kim Gyeong-Sin park Si-Hyong Jang Young Soo Song Ki-seok Jang Seung Sam Paik Department of Surgery College of MedicineSoonchunhyang University140-743 SeoulSouth Korea Department of Surgery Chi Hang Hospital140-741 SeoulSouth Korea Department of Pathology College of MedicineCatholic University137-040 SeoulSouth Korea Department of Pathology College of MedicineHanyang University133-790 SeoulSouth Korea

AIM:To verify that CD markers are available for detecting cancer stem cell populations and to evaluate their clinical significance in colon ***:Immunohistochemistry for CD133,CD24 and CD44 was performed on the tissue microarray of 523 colorectal *** records were reviewed and clinicopathological analysis was ***:In colorectal adenocarcinoma,128 of 523 cases(24.5%) were positive and 395 cases(75.5%) were negative for CD133 *** hundred and sixty-four of 523 cases(50.5%) were positive and 259 cases(49.5%) were negative for CD24 *** hundred and two of 523 cases(96%) were negative and 21 cases(4%) were positive for CD44 *** clinicopathological analysis,CD133 expression was present more in male patients(P = 0.002) and in advanced T stage cancer(P = 0.024).Correlation between CD24 expression and clinicopathological factors was seen in the degree of differentiation(P = 0.006).Correlation between CD44 expression and clinicopathological factors was seen in the tumor size(P = 0.001).Survival was not significantly related to CD133,CD24 and CD44 ***:CD markers were related to invasiveness and differentiation of colorectal ***,CD expression was not closely related to survival.

关键词： CD133 CD24 CD44 Colon cancer stemcells Colorectal adenocarcinoma

Hopping-Aware Cluster Header Capability for Sensor Relocation in Mobile IoT Networks

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Intelligent Automation & Soft Computing 2023年第5期36卷 1613-1625页

作者： Moonseong Kim Jaeyoung park Young-joon Kim Woochan Lee Department of IT Convergence Software Seoul Theological UniversityBucheon14754Korea Department of Computer Engineering Hongik UniversitySeoul04066Korea Department of Electronic Engineering Gachon UniversitySeongnam13120Korea Department of Electrical Engineering Incheon National UniversityIncheon22012Korea

Mobile sensor nodes such as hopping sensors are of critical importance in data ***,the occurrence of sensing holes is unavoidable due to the energy limitation of the ***,it is evident that the relocation of mobile sensors is the most desirable method to recover the sensing *** previous research conducted by the authors so far demonstrated the most realistic hopping sensor relocation scheme,which is suitable for the distributed *** previous studies,the cluster header plays an essential role in detecting the sensing hole and requesting the neighboring cluster to recover the sensing hole that occurred in the sensor ***,the limitations of the cluster header in the previously proposed relocation protocol are not fully *** the cluster header jumps more frequently than non-header nodes,its energy con-sumption is relatively high compared to other ***,it is most likely to lead to header node failure and can lead to data loss on the *** this paper,the jumping ability and energy consumption of the cluster header are seriously *** ability to replace cluster headers in case of failure is also *** results show that the data collection time can be further increased,which demonstrates the validity of the proposed algorithms.

关键词： Hopping sensor mobileinternetofthings relocationprotocol header node numericalsimulation

Improved formaldehyde gas sensing properties of well-controlled Au nanoparticle-decorated In2O3 nanofibers integrated on low power MEMS platform

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Journal of Materials Science & Technology 2020年第3期38卷 56-63页

作者： Dongha Im Donghyun Kim Dasol Jeong Woon Ik park Myoungpyo Chun joon-Shik park Hyunjung Kim Hyunsung Jung Nano Materials&Nano Technology Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Department of Mineral Resources and Energy Engineering Chonbuk National UniversityJeonju 54896Republic of Korea Smart Sensor Research Center Korea Electronic Technology InstituteSeongnam 13509Republic of Korea

Approaches for the fabrication of a low power-operable formaldehyde(HCHO)gas sensor with high sensitivity and selectivity were performed by the utilization of an effective micro-structured platform with a micro-heater to reach high temperature with low heating power as well as by the integration of indium oxide(In2O3)nanofibers decorated with well-dispersed Au nanoparticles as a sensing *** In2O3 nanofibers with the large specific surface area were prepared by the electrospinning following by calcination *** nanoparticles with the well-controlled size as a catalyst were synthesized on the surface of In2O3 *** Au-decorated In2O3 nanofibers were reliably integrated as sensing materials on the bridge-type micro-platform including micro-heaters and *** micro-platform designed to maintain high temperature with low power consumption was fabricated by a microelectromechanical system(MEMS)*** micro-platform gas sensor consisting with Au-In2O3 nanofibers were fabricated effectively to detect HCHO gases with high sensitivity and *** HCHO gas sensing behaviors were schematically studied as a function of the gas concentration,the size of the adsorbed Au nanoparticles,the applied power to raise the temperature of a sensing part and the kind of target gases.

关键词： Gold nanoparticle In2O3 nanofiber Formaldehyde Gas sensor Low power Micro-platform

Small bowel ulcer bleeding due to suspected clopidogrel use in a patient with clopidogrel resistance:A case report

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World Journal of Clinical Cases 2021年第15期9卷 3689-3695页

作者： Sang Hoon Lee Dong Ryeol Ryu Sung joon Lee Sung Chul park Byung Ryul Cho Seung Koo Lee Sang Ji Choi Hyun seok Cho Division of Gastroenterology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Division of Cardiology Department of Internal MedicineKangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Anatomic Pathology Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Surgery Kangwon National University HospitalKangwon National University School of MedicineChuncheon-si 24289South Korea Department of Hospital Medicine Kangwon National University HospitalChuncheon-si 24289South Korea

BACKGROUND Clopidogrel is a platelet aggregation inhibitor used for the management of cardiovascular *** antiplatelet therapy decreases cardiovascular events after successful coronary drug-eluting stenting,it increases the risk of gastrointestinal(GI)*** 20%of the patients who take clopidogrel exhibit resistance to the *** SUMMARY We report the first case of a small bowel bleeding ulcer in an 86-year-old man with clopidogrel *** had a history of taking clopidogrel due to unstable *** was no evidence of bleeding in the stomach,duodenum,or colon through upper and lower GI *** abdominal computed tomography showed the extravasation of radiocontrast media at the *** of unstable vital signs,emergency surgery was *** ulcers with inflammation were found in the *** pathologic findings revealed simple *** VerifyNow P2Y12 test showed clopidogrel *** year after changing to aspirin,capsule endoscopy was performed and the small bowel ulcers were *** Small bowel ulcers and bleeding due to clopidogrel are not very common,but the prevalence is expected to increase in older age patients with risk factors despite clopidogrel resistance.

关键词： Clopidogrel Resistance Small bowel Multiple ulcers Hematochezia Surgery Case report

Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo

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Nano Research 2017年第2期10卷 503-519页

作者： Seongchan Kim Yuri Choi Ginam park Cheolhee Won Young-joon park Younghoon Lee Byeong-Su Kim DaI-Hee Min Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry Seoul National University Seou108826 Republic of Korea Department of Energy Engineering and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Institute of Nanobio Convergence Technology Lemonex Inc. Seou108826 Republic of Korea College of Pharmacy Ajou University Worldcuplo 206 Yeongtong-gu Suwon 16499 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot （CD）, and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles （NPs） enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein （GFP） expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy.

关键词： bioimaging carbon dot gene delivery RNA interference targeted cancer therapy

Scolopendra subspinipes mutilans protected the ceruleininduced acute pancreatitis by inhibiting high-mobility group box protein-1

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World Journal of Gastroenterology 2013年第10期19卷 1551-1562页

作者： Il-Joo Jo Gi-Sang Bae Kyoung-Chel park Sun Bok Choi Won-seok Jung Su-Young Jung Jung-Hee Cho Mee-Ok Choi Ho-joon Song Sung-Joo park Department of Herbology School of Oriental MedicineWonkwang UniversityIksanJeonbuk 540-749South Korea Department of Beauty Science Kwangju women's UniversityKwangju 506-713South Korea Hanbang Body-fluid Research Center Wonkwang UniversityIksanJeonbuk 540-749South Korea Jeollanamdo Development Institute for Korean Traditional Medicine JangheungJeollanamdo 529-851South Korea

AIM:To evaluate the inhibitory effects of Scolopendra subspinipes mutilans(SSM) on cerulein-induced acute pancreatitis(AP) in a mouse ***:SSM water extract(0.1,0.5,or 1 g/kg) was administrated intraperitoneally 1 h prior to the first injection of *** AP developed,the stable cholecystokinin analogue,cerulein was injected hourly,over a 6 h *** samples were taken 6 h later to determine serum amylase,lipase,and cytokine *** pancreas and lungs were rapidly removed for morphological examination,myeloperoxidase assay,and real-time reverse transcription polymerase chain *** specify the role of SSM in pancreatitis,the pancreatic acinar cells were isolated using collagenase *** the cells were pre-treated with SSM,then stimulated with *** cell viability,cytokine productions and high-mobility group box protein-1(HMGB-1) were ***,the regulating mechanisms of SSM action were ***:The administration of SSM significantly attenuated the severity of pancreatitis and pancreatitis associated lung injury,as was shown by the reduction in pancreatic edema,neutrophil infiltration,vacuolization and *** treatment also reduced pancreatic weight/body weight ratio,serum amylase,lipase and cytokine levels,and mRNA expression of multiple inflammatory mediators such as tumor necrosis factor-α and interleukin-1β.In addition,treatment with SSM inhibited HMGB-1 expression in the pancreas during *** accordance with in vivo data,SSM inhibited the cerulein-induced acinar cell death,cytokine,and HMGB-1 *** also inhibited the activation of c-Jun NH2-terminal kinase,p38 and nuclear factor(NF)-κ***:These results suggest that SSM plays a protective role during the development of AP and pancreatitis associated lung injury via deactivating c-Jun NH2-terminal kinase,p38 and NF-κB.

关键词： Scolopendra subspinipes mutilans Cytokines Acute pancreatitis High-mobility group box protein-1

High-performance colorful semitransparent perovskite solar cells with phase-compensated microcavities

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Nano Research 2018年第5期11卷 2553-2561页

作者： Kyu-Tae Lee Ji-Yun Jang Na Young Ha Soonil Lee Hui joon park Department of Materials Science and Engineering University of Illinois Urbana Illinois 61801 USA Department of EnergySystems Research Ajou University Suwon 16499 Republic of Korea Department of Electrical and Computer Engineering Ajou University Suwon 16499 Republic of Korea

We demonstrate highly efficient multi-colored semitransparent perovskite solar cells that can create high angular tolerant controllable transmissive colors up to 60~, based on phase-compensated microcavities. The efficiency of the semitransparent colors was improved by impedance matching, which was enabled by placing a dielectric functional layer on top of traditional optical microcavities, with negligible influence on color pureness. The vast majority of the visible part of solar radiation is efficiently utilized for solar energy harvesting, achieving 10.47%, 10.66%, and 11.18% of efficiency for red, green, and blue （RGB） colored solar cells, respective136 while a very small proportion of the visible solar spectrum is used for structural coloration that can be readily tuned by altering the cavity medium thickness. The approach described herein can be suitable for a variety of applications such as display systems with ultra-low power consumption, highly efficient colorful solar panels, low-power wearable electronics, and energy-efficient optoelectronics.

关键词： perovskite solar cells semitransparency color filters optical cavities

DYNAMIC PROPERTIES OF AL-ALLOY FOAM BEAM DAMAGED BY COMPRESSIVE FATIGUE

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Acta Mechanica Solida Sinica 2008年第3期21卷 241-246页

作者： Sung-Gaun Kim Ilhyun Kim Amkee Kim Seung-joon Kim Junhong park Division of Mechanical and Automotive Engineering Kongju National University 275 Budae-dongCheonan Chungnam 330-717 Korea Department of Mechanical Engineering Hanyang University Seongdong-Gu Seoul 133-791 Korea

The permanent residual strain in aluminum （Al） alloy foams induced by compressive fatigue gradually increases with the increasing number of loading cycles. Consequently, the progressive shortening of Al-alloy foam degrades the dynamic material performance by the failure and ratcheting of multi-cells in the foam. In this paper, the dynamic properties of Al-alloy foams damaged by compressive fatigue were studied. The beam specimens with various residual strains were made by cyclic compression-compression stress. The dynamic bending modulus and loss factor were evaluated by using a beam transfer function method. As a result, the dynamic bending stiffness of Al-alloy foam turned out to be decreased due to damage while the loss factor was improved because of the increasing energy dissipation of such factors as cracked cell walls formed during the shortening process of the foam. The loss factor shows a manifest dependence on the fatigue residual strain.

关键词： Aluminum foam fatigue dynamic stiffness loss factor

Design of Authoring Tool for Static and Dynamic Projection Mapping

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Computers, Materials & Continua 2021年第1期66卷 1-16页

作者： Sang-joon Kim Nammee Moon Min Hong Gooman park Yoo-Joo Choi Seoul National University of Science and Technology 172 Gongneung-dongNowon-guSeoulKorea Hoseo University 165 Sechul-ri Baebang-eupAsan-siChungcheongnam-doKorea Soonchunhyang University 336-745Asan-siChungcheongnam-doKorea Seoul Media Institute Technology 661 Deungchon-dongGangseo-guSeoulKorea

This study introduces the design details of a tool to create interactive projection-mapping content in a convenient *** the proposed tool design,a homography-based camera–projector calibration method was applied with the use of red–green–blue-depth images from a Kinect V2 sensor that did not require accurate camera calibration *** addition,the proposed tool simultaneously achieved static projection mapping that projected the image content onto a fixed object,and dynamic projection mapping that projected the image content onto a user’s body,by tracing the moving *** verify the effectiveness of the proposed content-creation tool,users with no programming capabilities were employed to create contents that were projected onto various objects in fixed positions and a user’s body in various poses,thereby analyzing the tool’s ***,the projection accuracy was analyzed at different depth positions,and the projection-mapping accuracy was verified with the use of the proposed method.

关键词： Dynamic projection mapping camera-projector calibration Kinect projection mapping content authoring tool

S/S+ Band Tunable Thulium Doped Fiber Laser Anchored on 50 GHz ITU-T Grid

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光学学报 2003年第S1期23卷 381-382页

作者： Jonghan park Seong joon Ahn Hoseong Seo Namkyoo park Seoul National University Rm 301-1101 School of EECS Shilim Kwanak Seoul KoreaDivision of Electronics Sunmoon University.Korean Research Institute of Standards and ScienceSeoul National University Rm 301-1101 School of EECS Shilim Kwanak Seoul Korea

We demonstrate a S/S+ band tunable thulium doped fiber laser (TTDFL) anchored on 50GHz ITU-T Grid. Over 57nm of tuning range (1454.9 ~ 1512.0 nm) covering most of the Thulium bandwidth and more than 8dBm output power ... 详细信息

关键词： ITU Band Tunable Thulium Doped Fiber Laser Anchored on 50 GHz ITU-T Grid nm FFP S/S TDF on been FSR for mode GHz than