检索结果-南通市图书馆

Yet another tutorial of disturbance observer： robust stabilization and recovery of nominal performance

在线全文

学校读者我要写书评

暂无评论

Control Theory and Technology 2016年第3期14卷 237-249页

作者： Hyungbo SHIM Gyunghoon PARK Youngjun joo Juhoon BACK Nam hoon JO ASRI Department of Electrical and Computer Engineering Seoul National University Korea Department of Electrical Engineering and Computer Science University of Central Florida U.S.A. School of Robotics Kwangwoon University Korea Department of Electrical Engineering Soongsil University Korea

This paper presents a tutorial-style review on the recent results about the disturbance observer （DOB） in view of robust stabilization and recovery of the nominal performance. The analysis is based on the case when the bandwidth of Q-filter is large, and it is explained in a pedagogical manner that, even in the presence of plant uncertainties and disturbances, the behavior of real uncertain plant can be made almost similar to that of disturbance-free nominal system both in the transient and in the steady-state. The conventional DOB is interpreted in a new perspective, and its restrictions and extensions are discussed.

关键词： Disturbance observer robust stabilization robust transient response disturbance rejection

The Influx of the Tsushima Current into the Central Ulleung Basin of East Sea (Sea of Japan), Korea

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2014年第6期88卷 1846-1851页

作者： Young-Suk BAK Seong-joo lee The Earth and Environmental System Research Center Chonbuk National University Department of Geology Kyungpook National University

A total of 85 samples, collected from the UBGH1-9 core taken from the Ulleung Basin, East Sea, Korea, were analyzed using diatom assemblages. 111 diatom species belonging to 46 genera were identified, and three diatom assemblage zones were established on the basis of occurrence and distribution pattern of diatoms. Diatom assemblage zone I（134.10–174 m） is characterized by a relatively high abundance of marine species, while the increased number of the brackish species is recorded in diatom assemblage zone II（75–125 m）. The assemblage zones IIIa became drastic drop of valve abundances and brackish planktons, whereas it became increase during the IIIb. High Td values which indicate an influence of warm current are recorded both in diatom assemblage zone I and III, and low Td values in diatom assemblage zone II. Analysis of diatom assemblages indicating that the depositional condition moved from oceanic to littoral-neritic environments and that paleotemperature underwent a shift from warm to cold condition at the middle interval, and from cold to warm condition in the upper interval of the UBGH1-9 core. This suggests that the lower（130–162 m） and upper intervals（0–20 m） of the UBGH1-9 core were deposited in the warm current condition（Tsushima Warm Current）.

关键词： assemblage depositional littoral drastic genera abundance oceanic Korea valve preservation

Recent updates of precision therapy for gastric cancer: Towards optimal tailored management

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第19期22卷 4638-4650页

作者： Moon Kyung joo Jong-Jae Park hoon Jai Chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) have been suggested as an important step in the formation of a microenvironment favorable for gastric cancer. Accomplishments in basic research have led to the development of novel agents targeting these signaling pathways. However, phase III studies of selective anti-HGF/c-MET antibodies and mTOR inhibitor failed to show significant benefits in terms of overall survival and progression-free survival. Few agents directly targeting STAT3 have been developed. However, this target is still critical issue in terms of chemoresistance, and SH2-containing protein tyrosine phosphatase 1 might be a significant link to effectively inhibit STAT3 activity. Inhibition of PD-1/PD-L1 showed durable efficacy in phase I studies, and phase III evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase II study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.

关键词： Gastric cancer Hepatocyte growth factor Mammalian target of rapamycin Signal transducer and activator of transcription 3 Programmed cell death ligand-1

Impact of homeobox genes in gastrointestinal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第37期22卷 8247-8256页

Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal(GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1(CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett's esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers. HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer. Thus, it is essential to examine the differential expression pattern of various homeobox genes in specific tumor types or cell lineages, and understand their underlying mechanisms. In this review, we summarize the available research on homeobox genes and present their potential value for the prediction of prognosis in GI cancers.

关键词： Homeobox genes HOX genes Caudalrelated homeobox transcription factor 2 Gastrointestinal cancers HOXB7

Proton pump inhibitor: The dual role in gastric cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： Moon Kyung joo Jong-Jae Park hoon Jai Chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3

Adaptive Model Predictive Control for Yaw System of Variable-speed Wind Turbines

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 219-224页

作者： Dongran Song Qing Chang Songyue Zheng Sheng Yang Jian Yang Young hoon joo the School of Automation Central South Universityand Hunan Provincial Key Laboratory of Power Electronics Equipment and GridChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 54150Korea

Due to varying characteristics of the wind condition, the performance of the wind turbines can be optimized by adapting the parameters of the control system. In this letter, an adaptive technique is proposed for the novel model predictive control(MPC) for the yaw system of the wind turbines. The control horizon is adapted to the one with the best predictive performance among multiple control horizons. The adaptive MPC is demonstrated by simulations using real wind data, and its performance is compared with the baseline MPC at fixed control horizon. Results show that the adaptive MPC provides better comprehensive performance than the baseline ones at different preview time of wind directions. Therefore, the proposed adaptive technique is potentially useful for the wind turbines in the future.

关键词： Wind turbine yaw system wind direction adaptive model predictive control

Fossil-Winged Fruits of Fraxinus(Oleaceae) and Liriodendron(Magnoliaceae) from the Duho Formation,Pohang Basin,Korea

在线全文

学校读者我要写书评

暂无评论

Acta Geologica Sinica(English Edition) 2009年第5期83卷 845-852页

作者： Seung-Ho JUNG Seong-joo lee Department of Geology Kyungpook National UniversityDaegu 702-701Korea

A total of 16 specimens of fossil-winged fruits were found from the Middle Miocene marine deposits, Duho Formation, Pohang Basin, Korea. They were identified into two structurally different groups： 15 specimens into a winged fruit of Fraxinus, and one specimen of Liriodendron. The most samaras （13 specimens） were identified as Fraxinus oishii, which is characterized by narrowly ovate or ovate-elliptic shapes that are 2.7-3.6 cm in length and 0.7-1 cm in width （i/w ratio=3.4-4）. The apexes of the Fraxinus oishii samara are round or slightly emarginated, and a seed of the samara is always located at the base, of which the general shape is narrow rhombic-ellipsoidal. The seed is 1.2-2 cm long and 0.5-0.7 cm wide. Two specimens are different from the samara of Fraxinus oishii. They have a 6.6 length/width ratio （3.3 cm long and 0.5 cm wide）, and thus, are temporarily classified into the Fraxinus sp. One specimen was recognized as a winged seed of Liriodendron meisenense. The wing is broadly lanceolate to elliptic in shape, has a smooth, acute apex, and is approximately 3 cm long and 0.7 cm wide. Samaras of Fraxinus oishii and Liriodendron meisenense were early reported from the Middle Miocene deposits from North Korea, but these specimens are the first discovery in South Korea. Further study of the Duho Formation may connect flora relationships between North and South Korea.

关键词： winged fruits Fraxinus Liriodendron Middle Miocene Pohang Basin Korea

A global multiplicity result for two-point boundary value problems of p-Laplacian systems

在线全文

学校读者我要写书评

暂无评论

Science China Mathematics 2010年第4期53卷 967-984页

作者： lee Eun Kyoung lee Yong-hoon Department of Mathematics Pusan National University

In this paper,we consider the existence,nonexistence and multiplicity of positive solutions for two-point boundary value problems of p-Laplacian systems which have a singular indefinite weight and real *** proofs,we mainly make use of the upper and lower solution method and the fixed point index *** obtain a global multiplicity result,we construct a weighted space to benefit richer topology of the solution space than C 0-space.

关键词： p-Laplacian system singular indefinite weight multiparameters upper solution and lower solution fixed point index theorem weighted space

Three-dimensional imaging of spatio-temporal dynamics of small blood capillary network in the cortex based on optical coherence tomography:A review

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2020年第1期3卷 97-112页

作者： Fangjian Xing Jang-hoon lee Collin Polucha Jonghwan lee Jiangsu Key Laboratory for Opto-Electronic Technology School of Physics and Technology Nanjing Normal University Nanjing 210023P.R.China Center for Biomedical Engineering School of Engineering Brown University ProvidenceRhode IslandUSA Carney Institute for Brain Science Brown University ProvidenceRI 02906USA

Optical coherence tomography angiography(OCTA)has emerged as an advanced in vivo im-aging modality,which is widely used for the clinic ophthalmology and neuroscience research in the rodent brain cortex among *** on the high numerical aperture(NA)probing lens and the motion-corrected algorithms,a high-resolution imaging technique called OCT micro-angiography is applied to resolve the small blood capillary vessels ranging from 5μm to 10μm in *** OCT-based techniques are recently evolving further from the structural imaging of capillaries toward spatio-temporal dynamic imaging of blood flow in capillaries,here we present a review on the latest techniques for the dynamic flow *** on capillary blood flow using these techniques will help us better understand the roles of capillary blood flow for normal functioning of the brain as well as how it malfunctions in diseases.

关键词： Capillary vessel dynamics blood flow OCT angiography brain cortex micro-angiogram