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SUMS OF DUAL TOEPLITZ PRODUCTS ON THE ORTHOGONAL COMPLEMENTS OF FOCK-SOBOLEV SPACES

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Acta Mathematica Scientia 2024年第3期44卷 810-822页

作者：陈泳 young joo lee Department of Mathematics Hangzhou Normal UniversityHangzhou311121China Department of Mathematics Chonnam National UniversityGwangju61186Korea

We consider dual Toeplitz operators on the orthogonal complements of the FockSobolev spaces of all nonnegative real ***,for symbols in a certain class containing all bounded functions,we study the problem of when an operator which is finite sums of the dual Toeplitz products is compact or ***,for bounded symbols,we construct a symbol map and exhibit a short exact sequence associated with the C^(*)-algebra generated by all dual Toeplitz operators with bounded symbols.

关键词： dual Toeplitz operators Fock-Sobolev spaces symbol map

Cryptogenic organizing pneumonia associated with pregnancy:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1946-1951页

作者： young joo lee young Sun Kim Department of Obstetrics and Gynecology Kyung Hee University Medical CenterSeoul 02447South Korea

BACKGROUND Cryptogenic organizing pneumonia(COP),formerly known as bronchiolitis obliterans organizing pneumonia,is an extremely rare disease in *** this case,we report on COP diagnosed in recurrent pneumonia that does not respond to antibiotics in pregnant *** SUMMARY A 35-year-old woman with no prior lung disease presented with concerns of chest pain with cough,sputum,dyspnea,and mild fever at 11 wk’*** was diagnosed with community-acquired pneumonia and treated with antibiotics;her symptoms improved *** weeks after discharge,she was readmitted with aggravated *** computed tomography demonstrated multifocal patchy airspace consolidation and ground-glass opacities at the basal segments of the right lower lobe,at the lateral basal segment of the lower lobe,and at the lingular segment of the left upper *** lavage revealed an increased lymphocyte count and a decreased CD4/CD8 ***(0.5 mg/kg/d)was administered for 10 d after the second *** improved after 3 d of steroid treatment and other symptoms improved on the 5th day of steroid ***-delivery transbronchial lung biopsy further revealed the presence of granulation tissue with fibroblasts in smallbronchiole *** This case suggests that it is important to differentiate COP from atypical pneumonia in the deteriorated condition despite antibiotic treatment.

关键词： Antibiotics Bronchiolitis obliterans organizing pneumonia Corticosteroid Cryptogenic organizing pneumonia Pregnancy Case report

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

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Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： Ju-Hee Oh joo Hyun lee young-joo lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

SEQUENCES OF POWERS OF TOEPLITZ OPERATORS ON THE BERGMAN SPACE

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Acta Mathematica Scientia 2021年第3期41卷 657-669页

作者： Yong CHEN Kei Ji IZUCHI Kou Hei IZUCHI young joo lee Department of Mathematics Hangzhou Normal UniversityHangzhou 311121China Department of Mathematics Niigata UniversityNiigata 950-2181Japan Department of Mathematics Faculty of EducationYamaguchi UniversityYamaguchi 753-8511Japan Department of Mathematics Chonnam National UniversityGwangju 61186Korea

We consider Toeplitz operators Tu with symbol u on the Bergman space of the unit ball,and then study the convergences and summability for the sequences of powers of Toeplitz *** first charactreize analytic symbolsφfor which the sequence Tφ*kf or Tφkf converges to 0 or∞as k→∞in norm for every nonzero Bergman function ***,we characterize analytic symbolsφfor which the norm of such a sequence is summable or not *** also study the corresponding problems on an infinite direct sum of Bergman spaces as a generalization of our result.

关键词： Bergman space Toeplitz operator

Genomic change in hepatitis B virus associated with development of hepatocellular carcinoma

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World Journal of Gastroenterology 2016年第23期22卷 5393-5399页

作者： Danbi lee Heather Lyu young-Hwa Chung Jeong A Kim Priya Mathews Elizabeth Jaffee Lei Zheng Eunsil Yu young joo lee Soo Hyung Ryu Department of Internal Medicine University of Ulsan College of MedicineAsan Medical Center Sidney Kimmel Comprehensive Cancer Center Johns Hopkins University School of MedicineBaltimore Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Hepatobiliary Surgery University of Ulsan College of MedicineAsan Medical Center Department of Internal Medicine Inje Uni-versity College of MedicineSeoul Paik Hospital

AIM: To determine the genomic changes in hepatitis B virus(HBV) and evaluate their role in the development of hepatocellular carcinoma(HCC) in patients chronically infected with genotype C ***: Two hundred and forty chronic hepatitis B(CHB) patients were subjected and followed for a median of 105 mo. HCC was diagnosed in accordance with AASLD guidelines. The whole X, S, basal core promoter(BCP), and precore regions of HBV were sequenced using the direct sequencing ***: All of the subjects were infected with genotype C HBV. Out of 240 CHB patients, 25(10%) had C1653 T and 33(14%) had T1753 V mutation in X region; 157(65%) had A1762T/G1764 A mutations in BCP region, 50(21%) had G1896 A mutation in precore region and 67(28%) had pre-S deletions. HCC occurred in 6 patients(3%). The prevalence of T1753 V mutation was significantly higher in patients who developed HCC than in those without HCC. The cumulative occurrence rates of HCC were 5% and 19% at 10 and 15 years, respectively, in patients with T1753 V mutant, which were significantly higher than 1% and 1% in those with wild type HBV(P < 0.001).CONCLUSION: The presence of T1753 V mutation in HBV X-gene significantly increases the risk of HCC development in patients chronically infected with genotype C HBV.

关键词： Hepatocellular carcinoma Chronic hepatitis B Genomic change Hepatitis B virus Genotype C

Seroepidemiology of echovirus 30 in Korean children

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World Journal of Pediatrics 2017年第6期13卷 611-614页

作者： joo young lee Yumi Seo Ui Yoon Choi Jong-Hyun Kim Jin Han Kang Department of Pediatrics College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

Background:Although aseptic meningitis associated with echovirus type 30 has emerged as a global public health concern,no data have been reported on children's immune status against echovirus type *** current study aimed to investigate the seropositivity among Korean children for antibodies against echovirus ***:Two hundred and fifty residual serum samples were collected at ***'s *** were categorized by age into four groups:group 1 (3 months-2 years),group 2 (3-6 years),group 3 (7-10 years) and group 4 (11-15 years).Neutralizing antibodies against echovirus 30 were ***:Seroprotective neutralizing antibodies against echovirus 30 were detected in 129 (49%) *** rates were 23%,48%,55% and 73% in groups 1-4,*** antibody titers,1:256-1:512 was the highest neutralizing antibody titer range in group 2,while 1:1024-1:2048 in group 3 and *** the seropositive individuals in group 3 and 4,6% and 12% had neutralizing antibody titers of 1:2048,***:The seropositivity rate increased significantly with age..The distribution of neutralizing antibody titers varied by age group,and higher ranges of neutralizing antibody titers were observed in higher age *** findings suggest high susceptibility to echovirus 30 infection in children younger than 2 years *** 30 infection in childhood may have contributed to increased neutralizing antibody titers with age.

关键词： echovirus 30 Korea seroepidemiology

Erythropoietin decreases carbon tetrachloride-induced hepatic fibrosis by inhibiting transforming growth factor-beta

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Chinese Medical Journal 2012年第17期125卷 3098-3103页

作者： Soo young Park joo young lee Won young Tak young Oh Kweon Mi Suk lee Department of Internal Medicine Liver Research Institute Graduate School of Medicine Kyungpook National University Daegu Korea

Background In addition to hematopoietic effect, the erythropoietin is known as a multifunctional cytokine with anti-fibrosis and organ-protective activities. The purpose of this study was to evaluate the effect of recombinant human erythropoietin （rhEPO） on hepatic fibrosis and hepatic stellate cells （HSCs）. Methods Carbon tetrachloride （CCI4） induced hepatic fibrosis mice models were used for in vivo study and HSCs line for in vitro study. CCI4 and rhEPO （0,200 or 1000 U/kg） was injected intraperitoneally in BALB/c mice three times a week for 4 weeks. Immunohistochemistry and immunoblotting were performed to evaluate expressions of transforming growth factor-β1 （TGF-β1）, α-smooth muscle actin （α-SMA）, and fibronectin in explanted liver. Immunoblotting of α-SMA, phophorylated Smad-2 and Smad-2/3 was performed in HSCs treated with TGF-β1 and/or rhEPO. Results Expressions of TGF-β1, α-SMA, and fibronectin were increased in CCI4 injected mice livers, but significantly attenuated by co-treatment with CCI4 and rhEPO. Co-treatment of rhEPO markedly suppressed fibrosis in Masson＇s trichrome compared with treatment of only CCI4. TGF-β1 increased phosphorylated α-SMA, Smad-2 expressions in HSCs, which were decreased by rhEPO co-treatment. Conclusions Treatment of rhEPO effectively suppressed fibrosis in CCI4-induced liver fibrosis mice models. Anti-fibrosis effect of rhEPO could be related to inhibition of TGF-β1 induced activation of HSCs.

关键词： fibrosis erythropoietin transforming growth factor-beta hepatic stellate cell animal model

Sigmoid-sigmoid colon fistula caused by diverticulitis

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Chinese Medical Journal 2022年第4期135卷 491-492页

作者： Jeonghun lee young joo lee youngsun Kim Department of Internal Medicine Ye HospitalAnyangRepublic of Korea Department of Obstetrics and Gynecology Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea

To the Editor:Diverticular disease is common worldwide and the incidence of this disease increases with *** diverticulitis is serious and includes abscess,fistula,obstruction,and ***,surgical treatment is recommended to the patients with symptomatic *** these,colocolic fistula caused by diverticulitis is rare findings and especially,sigmoid-sigmoid fistula is an extremely rare *** present report describes a case of sigmoid-sigmoid colon fistula caused by *** results of this case may help physicians to recognize that multidisciplinary management and surgery are needed for the treatment of complicated diverticulitis with fistula.

关键词： fistula colon obstruction

Pseudomembranous conjunctivitis in a patient with DRESS syndrome

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 309-311页

作者： young joo lee youngsub Eom Seo Yeon Park Jung Jin Shin young Choi Jong Suk Song Hyo Myung Kim Department of Ophthalmology Korea University Ansan HospitalGyeonggi-do 15535Republic of Korea Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea Department of Ophthalmology Emory University School of MedicineAtlantaGA 30322USA BGN Jamsil Lotte Tower Eye Clinic Seoul 05551Republic of Korea Department of Dermatology Korea University Ansan HospitalGyeonggi-do 15355Republic of Korea Shin’s Eye Clinic Chungcheongnam-do 31513Republic of Korea

Dear Editor,Drug rash with eosinophilia and systemic symptoms(DRESS)syndrome is a drug reaction featuring high fever,eosinophilia,skin rashes,and multi-organ involvement that may be *** manifestations,including cicatrizing conjunctivitis,corneal infiltration,and anterior uveitis,are rarely reported[1-6]but may cause serious complications if ***,it is important to diagnose DRESS syndrome in patients with ocular features promptly with appropriate *** article reports a case diagnosed with DRESS syndrome associated with pseudomembranous conjunctivitis secondary to carfilzomib.

关键词： membranous conjunctivitis involvement