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Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World Journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao Qian Xiao-Jing Lv Ying-Ying Cao Marcus J Daniels Zhong-Qiu Wang Li-na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACKGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

Significant enhancement of photoresponsive characteristics and mobility of MoS2-based transistors through hybridization with perovskite CsPbBr3 quantum dots

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nano Research 2019年第2期12卷 405-412页

作者： Taeho Noh Heung Seob Shin Changwon Seo Jun young Kim Jongwon Youn Jeongyong Kim Kwang-Sup Lee Jinsoo joo Department of Physics Korea University Seoul 02841 Republic of Korea Department of Advanced Materials and Chemical Engineering Hannatn University Daejeon 34430 Republic of Korea Department of Energy Science Sungkyunkwan University Suwon 16419 Republic of Korea

Inorganic perovskite CsPbBr3 quantum dots (QDs) are potential nanoscale photosensitizers;moreover,two-dimensional (2-D) molybdenum disulfide (MoS2) has been intensively studied for application in the active layers of optoelectronic *** this study,heterostructures of 2D-monolayered MoS2 with zero-dimensional functionalized CsPbBr3 QDs were prepared,and their nanoscale optical characteristics were *** effect of n-type doping on the MoS2 monolayer after hybridization with perovskite CsPbBr3 QDs was observed using laser confocal microscope photoluminescenca (PL) and Raman ***-effect transistors (FETs) using MoS2 and the MoS2-CsPbBr3 QDs hybrid were also fabricated,and their electrical and photoresponsive characteristics were investigated in terms of the charge transfer *** the MoS2-CsPbBr3 QDs-based FETs,the field effect mobility and photoresponsivity upon light irradiation were enhanced by ~ 4 times and a dramatic ~ 17 times,respectively,compared to the FET prepared without the parovskite QDs and without light *** is noteworthy that the photoresponsivity of the MoS-2-CsPbBr3 QDs-based FETs significantly increased with increasing light power,which is completely contrary to the behavior observed in previous studies of MoS2-based *** increased mobility and significant enhancement of the photoresponsivity can be attributed to the n-type doping effect and efficient energy transfer from CsPbBr3 QDs to *** results indicate that the optoelectronic characteristics of MoS2-based FETs can be significantly improved through hybridization with photosensitive parovskite CsPbBr3 QDs.

关键词： MoS2 perovskite quantum dot transistor photoresponsivity mobility charge transfer

Utilizing 3,4-ethylenedioxythiophene(EDOT)-bridged non-fullerene acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2022年第2期31卷 194-204页

作者： Sung Jae Jeon young Hoon Kim Ie na Kim nam Gyu Yang Ji Hee Yun Doo Kyung Moon nano and Information Materials(NIMs)Laboratory Department of Chemical EngineeringKonkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea Department of Academy of Applied Science and Technology Konkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea

A rational design of efficient low-band-gap non-fullerene acceptors(NFAs)for high-performance organic solar cells(OSCs)remains challenging;the main constraint being the decrease in the energy level of the lowest unoccupied molecular orbitals(LUMOs)as the bandgap of A-D-A-type NFAs ***,the short current density(J_(sc))and open-circuit voltage(V_(oc))result in a trade-off relationship,making it difficult to obtain efficient ***,three NFAs(IFL-ED-4 F,IDT-ED-4 F,and IDTT-ED-2 F)were synthesized to address the above-mentioned issue by introducing 3,4-ethylenedioxythiophene(EDOT)as aπ-*** NFAs exhibit relatively low bandgaps(1.67,1.42,and 1.49 eV,respectively)and upshifted LUMO levels(-3.88,-3.84,and-3.81 eV,respectively)compared with most reported low-band-gap ***,the photovoltaic devices based on IDT-ED-4 F blended with a PBDB-T donor polymer showed the best power conversion efficiency(PCE)of 10.4%with a high J_(sc) of 22.1 mA cm^(-2) and Voc of 0.884 V among the examined *** contrast,IDTT-ED-4 F,which was designed with an asymmetric structure of the D-p-A type,showed the lowest efficiency of 1.5%owing to the poor morphology and charge transport properties of the binary ***,when this was introduced as the third component of the PM6:BTP-BO-4 Cl,complementary absorption and cascade energy-level alignment between the two substances could be ***,the IDTT-ED-4 F-based ternary blend device not only improved the Jscand Voc,but also achieved a PCE of 15.2%,which is approximately 5.3%higher than that of the reference device with a minimized energy loss of 0.488 *** addition,the universality of IDTT-ED-2 F as a third component was effectively demonstrated in other photoactive systems,specifically,PM6:BTPe C9 and PTB7-Th:IEICO-4 *** work facilitates a better understanding of the structure–property relationship for utilizing efficient EDOT-bridged NFAs in high-performance OSC applications.

关键词： Non-fullerene acceptor 3,4-ethylenedioxythiophene Organic solar cell π-bridge π-spacer

Weekend and nighttime effect on the prognosis of peptic ulcer bleeding

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World Journal of Gastroenterology 2012年第27期18卷 3578-3584页

作者： young Hoon Youn Yong Jin Park Jae Hak Kim Tae joo Jeon Jae Hee Cho Hyojin Park Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 135-720South Korea Department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGyeonggi-do 410-773South Korea Department of Internal Medicine Inje University Sanggye Paik HospitalInje University College of MedicineSeoul 139-707South Korea Department of Internal Medicine Kwandong University Myungji HospitalKwandong University College of MedicineGyeonggi-do 412-270South Korea

AIM:To evaluate whether weekend or nighttime admission affects prognosis of peptic ulcer bleeding despite early ***:Retrospective data collection from four referral centers,all of which had a formal out-of-hours emergency endoscopy service,even at weekends.A total of 388 patients with bleeding peptic ulcers who were admitted via the emergency room between January 2007 and December 2009 were *** parameters included time from patients' arrival until endoscopy,mortality,rebleeding,need for surgery and length of hospital ***:The weekday and weekend admission groups comprised 326 and 62 patients,*** were no significant differences in baseline characteristics between the two groups,except for younger age in the weekend *** patients (97%) had undergone early endoscopy,which resulted in a low mortality rate regardless of point of presentation (1.8% overall vs 1.6% on the weekend).The only outcome that was worse in the weekend group was a higher rate of rebleeding (12% vs 21%,P = 0.030).However,multivariate analysis revealed nighttime admission and a high Rockall score (≥ 6) as significant independent risk factors for rebleeding,rather than weekend ***:Early endoscopy for peptic ulcer bleeding can prevent the weekend effect,and nighttime admission was identified as a novel risk factor for rebleeding,namely the nighttime effect.

关键词： Early endoscopy Nighttime effect Pepticulcer bleeding Rebleeding Weekend effect

Identifying Driver Genes Mutations with Clinical Significance in Thyroid Cancer

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Computers, Materials & Continua 2021年第4期67卷 1241-1251页

作者： Hyeong Won Yu Muhammad Afzal Maqbool Hussain Hyungju Kwon young joo Park June young Choi Kyu Eun Lee Department of Surgery Seoul National University Bundang HospitalSeongnam-siKorea Department of Software Sejong UniversitySeoulKorea Department of Surgery College of MedicineEwha Womans UniversitySeoulKorea Department of Internal Medicine Seoul National University Hospital and College of MedicineSeoulKorea Department of Surgery Seoul National University Hospital and College of MedicineSeoulKorea

Advances in technology are enabling gene mutations in papillary thyroid carcinoma(PTC)to be analyzed and clinical outcomes,such as recurrence,to be *** date,the most common genetic mutation in PTC is in BRAF kinase(BRAF).However,whether mutations in other genes coincide with those in BRAF remains to be *** aim of this study was to find mutations in other genes that co-exist with mutated BRAF,and to analyze their frequency and clinical relevance in *** and genetic data were collected from 213 PTC patients with a total of 36,572 mutation sites in 735 *** matching with genes from PTC entries in a global database(NCBI Gene),69 genes with mutations in coding regions were chosen for further *** frequency-based analysis,we identified commonly mutated genes co-existing with mutated BRAF and,using the mutation count correlation matrix(MCCM)method,analyzed their incidence according to age and *** designed Chord diagrams to reveal gene relationships concerning age and gender,and found that mutations in ALK,ATM,COL1A1,MSTIR,PRKCA,and WNK1 most commonly coincide with mutated BRAF,followed by APC,AURKA,and *** findings provide further insight into the genetic profile of PTC.

关键词： Medical informatics papillary thyroid carcinoma cancer gene mutation analysis BRAF clinical significance

Polymyxin B hemoperfusion as a feasible therapy after source control in abdominal septic shock

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World Journal of Gastrointestinal Surgery 2019年第12期11卷 422-432页

作者： Jin joo Kim young Jun Park Ki Yoon Moon Jin Hyeong Park Yong Ki Jeong Eun young Kim Division of Trauma and Surgical Critical Care Department of Surgery Seoul St. Mary’s Hospital College of Medicine The Catholic University of Korea

BACKGROUND Polymyxin B hemoperfusion(PMX-HP)has been used as a treatment for intraabdominal septic shock by absorbing and removing endotoxins of gram-negative *** To investigate the clinical efficacy of PMX-HP in patients with gram-negative septic shock who underwent abdominal *** From January 2012 to December 2018,patients who had septic shock secondary to peritonitis were *** were classified into PMX-HP treated and control groups based on postopreative intervention using *** clinical outcomes were compared using 1:1 propensity score matching methods to balance the overall distribution between the two *** After propensity score matching,40 patients were analyzed(20 patients in the PMX group and 20 patients in the control group).The scores of total Sequential Organ Failure Assessment(SOFA)score,renal SOFA and coagulation SOFA were significantly improved in the PMX group but not in the control group.(from 11.2±5.8 to 4.7±3.5 in PMX group vs 10.0±4.0 to 8.7±7.3 in control group,P=0.047 from 2.6±1.0 to 0.7±1.0 in PMX group vs 2.6±1.5 to 2.8±1.6 in control group,P=0.000,from 1.6±1.5 to 1.3±1.3 in PMX group vs 1.2±1.2 to 2.8±1.8 in control group,P=0.014,respectively).Further,the length of intensive care unit(ICU)stay was significantly shorter in PMX ***,no statistically significant difference was found in ICU mortality(50%in PMX group vs 50%in control group).CONCLUSION PMX-HP is a feasible adjunct treatment for peritonitis in ICU patients with peritonitis for improved organ impairment and to stabilize *** would be helpful to enhance clinical outcomes especially in patients with complete elimination of the source of gram-negative bacilli infection by surgical procedure accompanied with conventional treatment of sepsis.

关键词： Intraabdominal septic shock Panperitonitis Polymyxin B hemoperfusion Sepsis Toraymyxin

Modulatory effects of the fruits of Tribulus terrestris L. on the function of atopic dermatitis-related calcium channels,Orai1 and TRPV3

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Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 580-585页

作者： joo Hyun nam Hyo Won Jung young-Won Chin Woo Kyung Kim Hyo Sang Bae Department of Physiology College of MedicineChannelopathy Research Center(CRC)Dongguk University Department of Herbology College of Korean MedicineDongguk University College of Pharmacy Dongguk University Department of Internal Medicine Graduate School of MedicineChannelopathy Research Center(CRC)Dongguk University Department of Sasang Constitutional Medicine College of Korean MedicineDongguk University

Objective: To examine the effects of Tribulus terrestris L.(T. terrestris) extract on the modulation of calcium channels to evaluate its use in topical agents for treatment of atopic ***: The 70% methanol extract of T. terrestris was prepared. Human HEK293 T cells with over-expressed calcium release-activated calcium channel protein 1(Orai1),transient receptor potential vanilloid 1, or transient receptor potential vanilloid 3(TRPV3)were treated with T. terrestris extract. Modulation of ion channels was measured using a conventional whole-cell patch-clamp ***: T. terrestris extract(100 mg/m L) significantly inhibited Orai1 activity in Orai1-stromal interaction molecule 1 co-overexpressed HEK293 T cells. In addition, T. terrestris extract significantly increased the TRPV3 activity compared with 2-Aminoethyl diphenylborinate(100 mmol/L), which induces the full activation of ***: Our results suggest that T. terrestris extract may have a therapeutic potential for recovery of abnormal skin barrier pathologies in atopic dermatitis through modulating the activities of calcium ion channels, Orai1 and TRPV3. This is the first study to report the modulatory effect of a medicinal plant on the function of ion channels in skin barrier.

关键词： Tribulus terrestris L. Atopic dermatitis Ion channels ORAI1 TRPV3

Clinical characteristics of peptic ulcer perforation in Korea

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World Journal of Gastroenterology 2017年第14期23卷 2566-2574页

作者： young joo Yang Chang Seok Bang Suk Pyo Shin Tae young Park Ki Tae Suk Gwang Ho Baik Dong joon Kim Department of Internal Medicine Hallym University College of Medicine Chuncheon Sacred Heart Hospital

AIM To elucidate the epidemiological characteristics and associated risk factors of perforated peptic ulcer(PPU).METHODS We retrospectively reviewed medical records of patients who were diagnosed with benign PPU from 2010 through 2015 at 6 Hallym university-affiliated *** A total of 396 patients were identified with postoperative complication rate of 9.1% and mortality rate of 0.8%. Among 174(43.9%) patients who were examined for Helicobacter pylori(H. pylori) infection, 78(44.8%) patients were positive for H. pylori infection, 21(12.1%) were on non-steroidal anti-inflammatory drugs(NSAIDs) therapy, and 80(46%) patients were neither infected of H. pylori nor treated by any kinds of NSAIDs. Multivariate analysis indicated that older age(OR = 1.09, 95%CI: 1.04-1.16) and comorbidity(OR = 4.11, 95%CI: 1.03-16.48) were risk factors for NSAID-associated PPU compared with non-H. pylori, non-NSAID associated PPU and older age(OR = 1.04, 95%CI: 1.02-1.07) and alcohol consumption(OR = 2.08, 95%CI: 1.05-4.13) were risk factors for non-H. pylori, non-NSAID associated PPU compared with solely H. pylori positive *** Elderly patients with comorbidities are associated with NSAIDs-associated PPU. Non-H. pylori, non-NSAID peptic ulcer is important etiology of PPU and alcohol consumption is associated risk factor.

关键词： Helicobacter pylori Non-steroidal anti-inflammatory drugs Peptic ulcer perforation Stomach ulcer Duodenal ulcer

Effects of Signal Spectrum Bandwidth on Different PMD Compensation Feedback Methods

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光学学报 2003年第S1期23卷 581-582页

作者： na young Kim Duckey Lee Sangin Kim namkyoo Park Seoul national University Rm 301-1101 School of EECS Shilim Kwanak Seoul KoreaSeoul National University Rm 301-1101 School of EECS Shilim Kwanak Seoul KoreaDepartment of Electrical Engineering Ajou University San5 Wonchun-Dong Paldal-Gu Suwon KoreaSeoul National University Rm 301-1101 School of EECS Shilim Kwanak Seoul Korea

We compared efficiencies of different PMD compensation feedback methods against transmission signal bandwidth, including NRZ, RZ, CRZ format under various duty cycles. We found that the critical factor determining the efficiency of PMD compensation is not the modulation format, but the spectral bandwidth of the transmission signal.

关键词： PMD PMDC Effects of Signal Spectrum Bandwidth on Different PMD Compensation Feedback Methods of DOP on