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Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

World Journal of Gastroenterology 2010年第31期16卷 3897-3904页

作者： Jung Myun Kwak Hyun joo Lee Seon Hahn Kim Han Kyeom Kim young Jae Mok young Tae Park Jong Sang Choi Hong young Moon Department of Surgery Korea University Anam Hospital Department of Pathology Korea University Guro Hospital Department of Surgery Korea University Guro Hospital Department of Gastroenterology Korea Uni-versity Guro Hospital

AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraff inembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraff in array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer.

关键词： S100A4 E-cadherin p53 Prognostic factor Colorectal cancer

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Interleukin-24 is correlated with differentiation and lymph node numbers in rectal cancer

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World Journal of Gastroenterology 2011年第9期17卷 1167-1173页

作者： youngmin Choi Mee-Sook Roh young-Seoub Hong Hyung-Sik Lee Won-joo Hur Department of Radiation Oncology Dong-A University School of Medicine Department of Pathology Dong-A University School of Medicine Department of Preventive Medicine Dong-A University School of Medicine

AIM:To assess the significance of interleukin(IL)-24 and vascular endothelial growth factor(VEGF)expression in lymph-node-positive rectal cancer. METHODS:Between 1998 and 2005,90 rectal adenocarcinoma patients with lymph node involvement were *** patients received radical surgery and postoperative pelvic chemoradiotherapy of 50.4-54.0 *** of 5-fluorouracil and leucovorin or levamisole was given intravenously during the first and last week of radiotherapy,and then monthly for about 6 *** of IL-24 and VEGF was evaluated by immunohistochemical staining of surgical specimens, and their relations with patient characteristics and survival were *** median follow-up of surviving patients was 73 mo(range:52-122 mo). RESULTS:IL-24 expression was found in 81 out of 90 patients;31 showed weak intensity and 50 showedstrong *** expression was found in 64 out of 90 *** and weak intensities of IL-24 expression were classified as negative expression for ***-24 expression was significantly reduced in poorly differentiated tumors in comparison with well or moderately differentiated tumors(P=0.004),N2b to earlier N stages(P=0.016),and stageⅢc to stageⅢ a orⅢb(P=0.028).The number of involved lymph nodes was also significantly reduced in IL-24-positive patients in comparison with IL-24-negative ones. There was no correlation between VEGF expression and patient *** of IL-24 and VEGF was not correlated with survival,but N stage and stages were significantly correlated with survival. CONCLUSION:IL-24 expression was significantly correlated with histological differentiation,and inversely correlated with the degree of lymph node involvement in stageⅢrectal cancer.

关键词： Interleukin-24 Rectal cancer Lymph node Histological differentiation Vascular endothelial growth factor

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幼儿园自制教玩具与游戏化教学的融合分析

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玩具世界 2024年第3期 245-247页

作者：杨娜酒泉职业技术学院附属幼儿园

幼儿园教育旨在促进幼儿的身心发展，教玩具和游戏化教学都是幼儿园教学非常重要的组成部分。在当前的幼儿园教育中，教玩具和游戏教学往往存在孤立运用的问题，未能充分发挥两者的合力。基于此，研究如何将自制教玩具与游戏化教学融合... 详细信息

幼儿园教育旨在促进幼儿的身心发展，教玩具和游戏化教学都是幼儿园教学非常重要的组成部分。在当前的幼儿园教育中，教玩具和游戏教学往往存在孤立运用的问题，未能充分发挥两者的合力。基于此，研究如何将自制教玩具与游戏化教学融合运用，对提高幼儿园教育质量具有重要意义。文章分别阐述幼儿园自制教玩具的概念、意义、分类及制作方法，以及游戏化教学的概念及意义、原则及方法等，并探讨自制教玩具与游戏化教学的具体融合路径。

关键词：游戏化教学自制教玩具幼儿园融合策略

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Comparison of the Bright Band Characteristics Measured by Micro Rain Radar (MRR) at a Mountain and a Coastal Site in South Korea

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Advances in Atmospheric Sciences 2009年第2期26卷 211-221页

作者： joo-Wan CHA Ki-Ho CHANG Seong Soo YUM young-Jean CHOI Department of Atmospheric Sciences Yonsei University Global Environment System Research Laboratory NIMR/KMA

Data from a long term measurement of Micro Rain Radar （MRR） at a mountain site （Daegwallyeong, DG, one year period of 2005） and a coastal site （Haenam, HN, three years 2004-2006） in South Korea were analyzed to compare the MRR measured bright band characteristics of stratiform precipitation at the two sites. On average, the bright band was somewhat thicker and the sharpness （average gradient of reflectivity above and below the reflectivity peak） was slightly weaker at DG, compared to those values at HN. The peak reflectivity itself was twice as strong and the relative location of the peak reflectivity within the bright band was higher at HN than at DG. Importantly, the variability of these values was much larger at HN than at DG. The key parameter to cause these differences is suggested to be the difference of the snow particle densities at the two sites, which is related to the degree of riming. Therefore, it is speculated that the cloud microphysical processes at HN may have varied significantly from un-rimed snow growth, producing low density snow particles, to the riming of higher density particles, while snow particle growth at DG was more consistently affected by the riming process, and therefore high density snow particles. Forced uplifting of cloudy air over the mountain area around DG might have resulted in an orographic supercooling effect that led to the enhanced riming of supercooled cloud drops.

关键词： Micro Rain Radar bright band thickness and sharpness cloud microphysical processes local characteristics

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Evolution of microstructure and tensile properties of cold-drawn hyper-eutectoid steel wires during post-deformation annealing

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Journal of Materials Science & Technology 2020年第6期41卷 1-11页

作者： Majid Jafari Chan-Woo Bang Jong-Chan Han Kyeong-Min Kim Seon-Hyeong na Chan-Gyung Park Byeong-joo Lee Department of Materials Science and Engineering POSTECH Pohang 37673 South Korea

Manufacturing temperatures of severely cold-drawn hyper-eutectoid steel wires are sufficiently high to influence the mobility of dislocations and alloy elements,thereby affecting the materials’mechanical ***,we describe the evolution of microstructure and tensile strength of the as-drawn 3.45 GPa steel wire during post-deformation annealing for 30 min at 150-450℃.Annealing at 150℃raised the strength to 3.77 GPa by age-hardening through activation of dislocations pinning by carbon,while further temperature rising up to 450℃caused a severe loss of *** was proved that annealing at 300 and 450℃destabilizes the lamellar microstructure,promoting the formation of carbon-deficient(Fe,Mn,Cr)3 C-type cementite particles with preferentially rounded and partially faceted *** at 450℃yielded the accumulation of Mn and Cr at the ferrite/particle interfaces,and their concentrations at the interfaces were dependent on the interface structure;i.e.,lower concentrations at rounded interfaces(formed through capillarity–driven coarsening of the spheroidized cementite),and higher concentrations at faceted interfaces(that are initially existing in the as-drawn state).Our proof-of-principle observations,supported by thermodynamic calculations and kinetic assessments,provide a pathway for understanding the changes in microstructural and tensile properties during manufacturing of the hyper-eutectoid steel wires.

关键词： Three-dimensional atom probe(3DAP) High resolution transmission electron microscopy(HRTEM) nano-grained low-carbon steel Annealing Tensile behavior

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地方应用型高校艺术类大学生思想政治教育途径探究

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济宁学院学报 2024年第1期45卷 103-107页

作者：岳娜济宁学院音乐学院山东曲阜273155

艺术类大学生既具有高校青年大学生的普遍共性,又具有艺术类特长生的个性化特点,存在着艺术素养与文化素养不平衡、个体观念较为突出、学习能力参差不齐等方面的问题。鉴于此,地方应用型高校围绕艺术类大学生开展思想政治教育工作时,需... 详细信息

艺术类大学生既具有高校青年大学生的普遍共性,又具有艺术类特长生的个性化特点,存在着艺术素养与文化素养不平衡、个体观念较为突出、学习能力参差不齐等方面的问题。鉴于此,地方应用型高校围绕艺术类大学生开展思想政治教育工作时,需要全面客观把握和评价、因势利导才能进行有效的思想政治教育;要充分把握思想政治教育基本规律和艺术类大学生成长成才规律,探索出具有专业特色的、有力量有温度的艺术类大学生思想政治教育实践途径,通过有针对性的教育、引导和帮助,使艺术类大学生在追求德艺双馨中成就人生价值。

关键词：艺术类大学生思想政治教育

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跨学科视角下的汉语言文学互动教育模式探究

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教育教学论坛 2024年第35期 161-164页

作者：李娜四川工业科技学院教育学院四川德阳618500

随着汉语言文学专业开放性与跨学科性的日益凸显,相关专业探讨进入新议程,引发了更多的关注。高校迫切须要深入挖掘专业要求,探寻跨学科思想资源,培养兼具大国担当与人文关怀的青少年,深化汉语言文学教育改革。为此,以互动教育模式概述... 详细信息

随着汉语言文学专业开放性与跨学科性的日益凸显,相关专业探讨进入新议程,引发了更多的关注。高校迫切须要深入挖掘专业要求,探寻跨学科思想资源,培养兼具大国担当与人文关怀的青少年,深化汉语言文学教育改革。为此,以互动教育模式概述为切入点,简要阐述了跨学科视角下汉语言文学互动教育模式面临的目标定位不准、教学内容混乱、考核形式陈旧、教师队伍不足等挑战;再以此为基础,提出了互动教育,以期为相关教育者提供参考,培养更多的优秀人才。

关键词：跨学科汉语言文学互动教育

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拔尖创新人才培养实践的思考——基于优化博士后培育的讨论

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吉林省教育学院学报 2024年第9期40卷 164-168页

作者：高娜吉林大学

拔尖创新人才培养是一个现实且紧迫的问题,博士后制度是全球范围内培养、吸引创新型青年人才的重要制度,本文旨在以优化博士后培养为出发点和落脚点,进行拔尖创新人才培养的实践思考。首先阐明博士后制度在拔尖创新人才培养中的关键性贡... 详细信息

拔尖创新人才培养是一个现实且紧迫的问题,博士后制度是全球范围内培养、吸引创新型青年人才的重要制度,本文旨在以优化博士后培养为出发点和落脚点,进行拔尖创新人才培养的实践思考。首先阐明博士后制度在拔尖创新人才培养中的关键性贡献,其次比较国际上的发展情况和经验做法,剖析我国博士后人才培养所面临的问题,最后提出开发个体价值以释放博士后潜力、构建合作共享空间以打破学术交流壁垒、优化科研经费资助渠道和力度以驱动创新、建立灵活聘任机制提升博士后合作意愿、构筑科研效能激励机制助推创新成果产出等优化建议。

关键词：拔尖创新人才培养博士后培育优化实践思考

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Microforming of superplastic 5083 aluminum alloy

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中国有色金属学会会刊：英文版 2012年第S3期22卷 656-660页

作者： Md.Abu Mowazzem HOSSAIN Sung-Tae HONG Kyu-Yeol PARK young-Sang na School of Mechanical Engineering University of Ulsan Korea Institute of Materials Science

The mechanical behavior of superplastic 5083 aluminum alloy during microforming process was investigated by finite element analysis.A micro V-groove die was modeled to analyze the effects of forming time,load and temperature on the microformability of the 5083 aluminum ***,the microformability of the 5083 aluminum alloy was estimated using a microformability *** simulation results show that the microformability increases with the forming load,time and temperature *** of the 5083 aluminum alloy during microforming using the V-groove die was also investigated in terms of the effective strain *** results show that the superplasticity of the 5083 aluminum alloy occurs in a specific part of the material for a specific period during the microforming process depending on the forming conditions and the microformability index.

关键词： microforming superplasticity 5083 aluminum alloy

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过有德性的生活:南开大学幼儿园公能根基德育实践

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陕西学前师范学院学报 2024年第6期40卷 112-113页

作者：张娜南开大学幼儿园天津300071

南开大学幼儿园公能根基德育秉持大德育观,聚焦爱国品德教育、传统节日教育、儿童戏剧教育和家园社协同教育,坚持引导幼儿过一种有德性的生活,大力支持其开展“知行合一”的躬身实践,并在长期潜移默化之中,塑造幼儿公能品德,淬炼幼儿至... 详细信息

南开大学幼儿园公能根基德育秉持大德育观,聚焦爱国品德教育、传统节日教育、儿童戏剧教育和家园社协同教育,坚持引导幼儿过一种有德性的生活,大力支持其开展“知行合一”的躬身实践,并在长期潜移默化之中,塑造幼儿公能品德,淬炼幼儿至善良知,觉解南开精神,陶冶幼儿完满心灵,最终实现幼儿德性教育的价值旨归。

关键词：幼儿园德育公能根基德育德性教育

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