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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina Kim joon-Tae Kim Ji Sung Lee Beom joon Kim Jong-Moo park Kyusik Kang Soo joo Lee Jae Guk Kim Jae-Kwan Cha Dae-Hyun Kim Tai Hwan park Sang-Soon park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog Kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-joo Kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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Multiple malignant extragastrointestinal stromal tumors of the greater omentum and results of immunohistochemistry and mutation analysis:A case report

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World Journal of Gastroenterology 2007年第24期13卷 3392-3395页

作者： Jong-Han Kim Yoon-Jung Boo Cheol-Woong Jung Sung-Soo park Seung-joo Kim young-Jae Mok Sang-Dae Kim Yang-Suk Chae Chong-Suk Kim Kim Korea University Hospital Seoul 136-705 Korea Deparment of Surgery Pathology KoreaUniversity College of medicine Seoul 136-705 Korea

To report an extragastrointestinal stromal tumor （EGIST） that occurs outside the gastrointestinal tract and shows unique clinicopathologic and immunohistochemical features. In our case, we experienced multiple soft tissue tumors that originate primarily in the greater omentum, and in immunohistochemical analysis, the tumors showed features that correspond to malignant EGIST. Two large omental masses measured 15 cm×10 cm and 5 cm×4 cm sized and several small ovoid fragments were attached to small intestine, mesentery and peritoneum. On histologic findings, the masses were separated from small bowel serosa and had high mitotic count （115/50 HPFs）. In the results of immunohistochemical stains, the tumor showed CDl17 （c-kit） positive reactivity and high Ki-67 labeling index. On mutation analysis, the c-kit gene mutation was found in the juxtamembrane domain （exon 11）and it was heterozygote. Platelet-derived growth factor receptor （PDGFR） gene mutation was also found in the juxtamemembrane （exon 12） and it was polymorphism. From above findings, we proposed that there may be several mutational pathways to malignant EGIST, so further investigations could be needed to approach this unfavorable disease entity.

关键词： Extragastrointestinal stromal tumor Greater omentum c-kit Platelet-derived growth factor receptor Mutation

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Cerebral and splenic infarctions after injection of N-butyl-2-cyanoacrylate in esophageal variceal bleeding

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World Journal of Gastroenterology 2013年第34期19卷 5759-5762页

作者： Dae-Seong Myung Cho-Yun Chung Hyung-Chul park Jong-Sun Kim Sung-Bum Cho Wan-Sik Lee Sung-Kyu Choi young-Eun joo Department of Internal Medicine Chonnam National University Medical School

Variceal bleeding is the most serious complication of portal hypertension,and it accounts for approximately one fifth to one third of all deaths in liver cirrhosis ***,endoscopic treatment remains the predominant method for the prevention and treatment of variceal *** treatments include band ligation and injection *** sclerotherapy with N-butyl-2-cyanoacrylate has been successfully used to treat variceal *** injection sclerotherapy with N-butyl-2-cyanoacrylate provides effective treatment for variceal bleeding,injection of N-butyl-2-cyanoacrylate is associated with a variety of complications,including systemic ***,we report a case of cerebral and splenic infarctions after the injection of N-butyl-2-cyanoacrylate to treat esophageal variceal bleeding.

关键词： Cerebrum Esophageal varix Infarction N-butyl-2-cyanoacrylate Spleen

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Active Fault-Tolerance Low Power Multiplier with OpenRISC Platform

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通讯和计算机（中英文版） 2010年第2期7卷 43-51页

作者： Han-Sam Jung joo-Yul park Ki-Seok Chung Department of Electronics Computer ＆ Communication Engineering Hanyang University Seoul 133-791 Korea

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Chemical and Biochemical Characterization of Doenjang （Korean Soy Paste） Supplemented with Glasswort （Salicornia herbacea L.） and Rice （Oryza sativa L.）

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Journal of Food Science and Engineering 2012年第5期2卷 283-292页

作者： Bo young Jeon Da Hye joo Doo Hyun park Department of Biological Engineering Seokyeong University Seou1136-704 Korea

Four types of Doenjang were prepared from 100% （w/w） defatted soybean （DFS）, a mixture of 80% （w/w） defatted soybean and 20% （w/w） glasswort （DFS-G）, a mixture of 80% （w/w） defatted soybean and 20% （w/w） rice （DFS-R）, or a mixture of 60% （w/w） defatted soybean, 20% （w/w） glasswort and 20% （w/w） rice （DFS-GR）. Maturity of the DFS-G doenjang was the highest, which was proportional to total amino acid content. Antioxidative compounds and total amino acids were relatively higher in the doenjang with glasswort （DFS-G, DFS-GR） than those in the other preparations （DFS, DFS-R）. Succinic and pyroglutamic acid were relatively higher but levulinic acid was relatively lower in the doenjang with glasswort compared to those in the others. Mn, Fe, Zn, and Al were relatively higher in the doenjang with glasswort compared to those in the others. Volatile organic compounds were differently produced depending on doenjang type and influenced definitely by addition of glasswort and rice. Some bacterial communities responsible for meju fermentation were changed during ripening for doenjang whereas others were conserved.

关键词： Doenjang (Korean soy paste) meju glasswort rice bacterial community.

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Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung joo Cho Hye Jung park Hye Won Lee Beom Kyung Kim Jun Yong park Do young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

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Clinicopathologic factors influencing the accuracy of EUS for superficial esophageal carcinoma

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World Journal of Gastroenterology 2014年第20期20卷 6322-6328页

作者： Jung Im Jung Gwang Ha Kim Hoseok I Do youn park Tae Kyun Kim young Hwa Cho Yong Wan Sung Mun Ki Choi Bong Eun Lee Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research Institute Pusan National University Hospital Busan 602-739 South Korea Department of Chest Surgery Pusan National University School of Medicine Busan 602-739 South Korea Department of Pathology Pusan National University School of Medicine Busan 602-739 South Korea

AIM: To identify clinicopathologic factors influencing the accuracy of a high-frequency catheter probe endoscopic ultrasonography (EUS) for superficial esophageal carcinomas (SECs).

关键词： Esophageal cancer Endoscopic ultrasonography Accuracy

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Predictive factors associated with malignancy of intraductal papillary mucinous pancreatic neoplasms

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World Journal of Gastroenterology 2010年第42期16卷 5353-5358页

作者： Jin Hee Lee Kyu Taek Lee Jongwook park Sun youn Bae Kwang Hyuck Lee Jong Kyun Lee Kee-Taek Jang Jin Seok Heo Seong Ho Choi Dong Wook Choi Jong Chul Rhee Department of Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea Department of Pathology Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 135710South Korea

AIM:To identify preoperative predictive factors associated with malignancy of intraductal papillary mucinous neoplasms(IPMNs) of the ***:Between April 1995 and April 2010,129 patients underwent surgical resection for IPMNs at our institute and had confirmed pathologic *** medical records were retrospectively reviewed and immunohistochemical staining for mucin(MUC) in pancreatic tissues was ***:Univariate analysis showed that the following five variables were closely associated with malignant IPMNs preoperatively:absence of extrapancreatic malignancy;symptoms;tumor size > 4 cm;main pancreaticduct(MPD) size > 7 mm;and lymph node enlargement on preoperative computed tomography(CT).Multivariate analysis revealed that the following two factors were significantly associated with malignant IPMNs preoperatively:MPD size > 7 mm [odds ratio(OR) = 2.50];and lymph node enlargement on preoperative CT(OR = 3.57).No significant differences in the expression of MUC1,MUC2 and MUC5AC were observed between benign and malignant ***:MPD size > 7 mm and preoperative lymph node enlargement on CT are useful predictive factors associated with malignancy of IPMNs.

关键词： Intraductal papillary mucinous neoplasms Malignancy Predictive factors Pancreatic neoplasms

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Correlations between endoscopic and clinical disease activity indices in intestinal Behcet's disease

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World Journal of Gastroenterology 2012年第40期18卷 5771-5778页

作者： Hyun Jung Lee youn Nam Kim Hui Won Jang Han Ho Jeon Eun Suk Jung Soo Jung park Sung Pil Hong Tae Il Kim Won Ho Kim Chung Mo Nam Jae Hee Cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Department of Biostatistics Yonsei University College of MedicineSeoul 120-752South Korea Department of Preventive Medicine Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April *** also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with *** endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was *** determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were ***:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the *** endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ***,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD *** with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the ***:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD ***,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.

关键词： Intestinal Behcet's disease Disease activityindex Colonoscopy Ulcer Endoscopic severity

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Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study

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World Journal of Gastroenterology 2020年第4期26卷 404-415页

作者： Jung Min Moon Eun Ae Kang Kyungdo Han Seung Wook Hong Hosim Soh Seona park jooyoung Lee Hyun Jung Lee Jong Pil Im joo Sung Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND The incidence of inflammatory bowel disease(IBD)is increasing in *** risk factors associated with IBD development have been *** To investigate trends and environmental risk factors of Crohn’s disease(CD)diagnosed in persons aged≥40 years in South *** Using the National Health Insurance Service database,a total of 14060821 persons aged>40 years who underwent national health screening in 2009 were followed up until December *** with newly diagnosed CD were enrolled and compared with non-CD *** was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration program codes from the National Health Insurance Service *** mean follow-up periods was 7.39 ***,sex,diabetes,hypertension,smoking,alcohol consumption,regular exercise,body mass index,anemia,chronic kidney disease(CKD)and dyslipidemia were adjusted for in the multivariate analysis *** During the follow-up,1337(1.33/100000)patients developed *** in the middle-aged group(40-64 years)had a higher risk than women[adjusted hazard ratio(aHR)1.46,95%confidence interval(CI):1.29-1.66];however,this difference tended to disappear as the age of onset *** the middle-aged group,patients with a history of smoking[(aHR 1.46,95%CI:1.19-1.79)and anemia(aHR 1.85,95%CI:1.55-2.20)]had a significantly higher CD *** the elderly group(age,≥65 years),ex-smoking and anemia also increased the CD risk(aHR 1.68,95%CI:1.22-2.30)and 1.84(95%CI:1.47-2.30,respectively).Especially in the middle-aged group,those with CKD had a statistically elevated CD risk(aHR 1.37,95%CI:1.05-1.79).Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups.[Middle-aged:aHR 0.77(95%CI:0.66-0.89)and aHR 0.73(95% CI:0.63-0.84),respectively][Elderly-group:aHR 0.57(95% CI:0.42-0.78)and aHR 0.84(95%CI 0.67-1.04),respectively].For regular p

关键词： Crohn’s disease Aged Environmental Risk factors Epidemiology Nationwide cohort

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