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Effect of hydro co-extrusion on microstructure of duo-cast Al3003/Al4004 clad materials

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Transactions of Nonferrous Metals Society of China 2014年第S1期24卷 75-80页

作者： In-Soo SON Sang-Pill lee Jin-Kyung lee Woo-Cheol KIM Ji-Seon MOON Sangmok lee jong-sup lee Yong-Bae KIM Geun-Ahn lee Dong-Su BAE Department of Mechanical Engineering Dong-Eui University Busan Korea Department of Advanced Materials Engineering Dong-Eui University Busan Korea Advanced Forming Tech. Center Korea Institute of Industrial Technology Incheon Korea

The effects of hydro co-extrusion on the microstructure changes of aluminum hybrid duo-cast Al 3003/Al 4004 clad materials were studied. The specimen of duo-cast Al 3003/Al 4004 clad materials was in circle shape, and was composed of Al 3003(outside) and Al 4004(inside) materials. The specimen was extruded by the hydro co-extrusion equipment. The manufacturing conditions of the specimen were 423 K in temperature and 5 in extrusion ratio. The dimensions of the specimen were 80 mm in diameter of the Al 4004 material and 35 mm in thickness of the Al 3003 material before the hydro co-extrusion process, and 30 mm in diameter and about 5 mm in thickness after the extrusion process, respectively. The microstructure and the hardness for two specimens were investigated. The hardness value of cross section in the duo-cast Al 3003/Al 4004 clad materials before the extrusion process was increased in form of the parabola toward the center. However, after the extrusion process, it was almost constant in the portion of Al 4004 material. Lots of big voids above 1 mm in diameter in the specimen existed in the interfacing region of Al 3003 and Al 4004 materials before the extrusion process. These big voids disappeared after the process of hydro co-extrusion.

关键词： clad materials hydro co-extrusion process duo-casting microstructure

Pain Efficacy of a Home-Based Low-Intensity Continuous Ultrasound Stimulator for Knee Arthritis: A Single-Arm, Open-Label, Prospective Clinical Trial

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Health 2024年第7期16卷 703-716页

作者： Md. Habibur Rahman Yeon-Gyu Jang Johny Bajgai Subham Sharma Kchorng Vira Abdul-Nasir Sofian Seong Hoon Goh Yundeok Kim Cheol-Su Kim Doo-sup Kim Kyu-Jae lee Department of Convergence Medicine Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Neurosurgery Wonju Severance Christian Hospital Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Global Medical Science Wonju College of Medicine Yonsei University Wonju Republic of Korea Department of Internal Medicine Division of Hematology-Oncology Wonju Severance Christian Hospital Wonju Republic of Korea Department of Orthopaedic Surgery Wonju College of Medicine Yonsei University Wonju Republic of Korea

1) Background: Osteoarthritis (OA) is defined as a degenerative joint disease that mainly affects the bone. This study aims to evaluate the effect of low-intensity continuous ultrasound (LICUS) treatment on the knee of osteoarthritis patients through home-based intervention using the LICUS medical device. 2) Methods: The clinical trials were designed in a single-arm, open-label, and intervention study. Thirty-five participants, including those who dropped out (12%), were screened and enrolled. The patients received LICUS (1.1 MHz, 1.5 W/cm2, collimated beams) on the knee by the instructions of the investigator at home (5 min/session, 3 times/day, for four-weeks). Outcome measures were assessed using the Visual Analog Scale (VAS) as a primary endpoint and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) as a secondary endpoint to evaluate pain relief and functional recovery of the knee between pre-treatment (baseline) and post-treatment (four-weeks). 3) Results: Knee pain scores measured using the VAS and WOMAC indices were significantly reduced after a four-week treatment with LICUS compared to baseline. Knee stiffness and functional capacity were significantly reduced after the LICUS application. In addition, there were no reports of adverse effects during the study period. 4) Conclusion: Long-term and home-based application of LICUS can be recommended as an alternative option for the treatment of OA patients, as evidenced by the effect of pain relief and knee function recovery.

关键词： Knee Osteoarthritis Low-Intensity Continuous Ultrasound Stimulator Clinical Trial Visual Analogue Scale Western Ontario and McMaster Universities Osteoarthritis Index

Endoscopic ultrasonography does not differentiate neoplastic from non-neoplastic small gallbladder polyps

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World Journal of Gastroenterology 2009年第19期15卷 2361-2366页

作者： Young Koog Cheon Won Young Cho Tae Hee lee Young Deok Cho jong Ho Moon Joon Seong lee Chan sup Shim Institute for Digestive Research and Digestive Disease Center Soon Chun Hyang University College of Medicine657 Hannam-DongYongsan-KuSeoul 140-743South Korea

AIM： To assess the ability of endoscopic ultrasonography （EUS） to differentiate neoplastic from non- neoplastic polypoid lesions of the gallbladder （PLGs）.METHODS： The uses of EUS and transabdominal ultrasonography （US） were retrospectively analyzed in 94 surgical cases of gallbladder polyps less than 20 mm in ***： The prevalence of neoplastic lesions with a diameter of 5-20 mm was 27.2% （10/58）; 22-15 mm, 25.4% （4/26）, and 16-20 mm, 50% （5/20）. The overall diagnostic accuracies of EUS and US for small PLGs were 80.9% and 63.9% （P 〈 0.05）, respectively. EUS correctly distinguished 12 （63.2%） of 19 neoplastic PLGs but was less accurate for polyps less than 1.0 cm （4/10, 40%） than for polyps greater than 1.0 cm （8/9, 88.9%）（P = 0.02）.CONCLUSION： Although EUS was more accurate than US, its accuracy for differentiating neoplastic from non-neoplastic PLGs less than 1.0 cm was low. Thus, EUS alone is not sufficient for determining a treatment strategy for PLGs of less than 1.0 cm.

关键词： Endoscopic ultrasonography Neoplasticlesion Polypoid gallbladder lesion

BIOCOMPATIBILITY OF A PDMS-COATED MICRO-DEVICE:BLADDER VOLUME MONITORING SENSOR

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Chinese Journal of Polymer Science 2012年第2期30卷 242-249页

作者： Dong sup lee Su Jin Kim Jun Ho Sohn In Gul Kim Sae Woong Kim Dong Wan Sohn jong Hyun Kim Bumkyoo Choi Department of Urology St.Vincent's HospitalCollege of Medicinethe Catholic University of KoreaSuwonKorea Department of Urology Seoul St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Urology Yeouido St.Mary's HospitalCollege of Medicinethe Catholic University of KoreaSeoulKorea Department of Mechanical Engineering Sogang UniversitySeoulKorea

We evaluated the biocompatibility of a dimethylpolysiloxane-coated micro-device which had been designed for monitoring real-time bladder volume in previous studies. The extract assay with dimethylpolysiloxane which had been used for coating the micro-device to measure the bladder volume was performed as an in vitro cytotoxicity test. For in vivo biocompatibility testing, the inflammatory responses around the implantation site of the micro-device in subcutaneous tissue of rat were assessed by light microscope with H＆E stain and fluorescence microscope with ED1 stain and von Willebrand factor stain. The averages of cell viability in dimethylpolysiloxane group were 84.6% and 82.3% at 24 h and 72 h incubation, respectively. The qualitative evaluations with light and fluorescence microscope revealed that the inflammatory changes peaked during 2 weeks but almost disappeared at 4 weeks after implantation of devices. The quantitative evaluations for granulation layer formation and neovascularization showed that the thickness of the layer in dimethylpolysiloxane group peaked during 2 weeks but it came to be stabilized at 4 weeks as thin as at 2 weeks in control group, and the frequency of neovascularization was higher in dimethylpolysiloxane group than in control group but it was not increased with time. The dimethylpolysiloxane-coated micro-device is thought be a reliable bio-medical device.

关键词： Dimethylpolysiloxane Devices Biocompatibility testing.

Novel Time-dependent Multi-omics Integration in Sepsis-associated Liver Dysfunction

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1101-1116页

作者： Ann-Yae Na Hyojin lee Eun Ki Min Sanjita Paudel So Young Choi HyunChae Sim Kwang-Hyeon Liu Ki-Tae Kim jong-sup Bae Sangkyu lee Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 41566Republic of Korea Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of PharmacyKyungpook National UniversityDaegu 41566Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease ***,it remains challenging to specify the study design for the subsequent integration strategies that can associate sepsis pathophysiology and clinical ***,we conducted a time-dependent multi-omics integration(TDMI)in a sepsis-associated liver dysfunction(SALD)*** successfully deduced the relation of the Toll-like receptor 4(TLR4)pathway with *** TLR4 is a critical factor in sepsis progression,it is not specified in single-omics analyses but only in the TDMI *** finding indicates that the TDMI-based approach is more advantageous than single-omics analyses in terms of exploring the underlying pathophysiological mechanism of ***,TDMI-based approach can be an ideal paradigm for insightful biological interpretations of multi-omics datasets that will potentially reveal novel insights into basic biology,health,and diseases,thus allowing the identification of promising candidates for therapeutic strategies.

关键词： Multi-omics Omics technology Sepsis-associated liver dysfunction Single omics Time-dependent integration

Effect of production process on performance properties of warm rubberized binders

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 589-597页

作者： Hyun Hwan Kim Mithil Mazumder Soon-Jae lee Moon-sup lee Department of Engineering Technology Texas State UniversitySan MarcosTX 78666USA Korea Institute of Civil Engineering and Building Technology Gyeonggi 411-712South Korea

The study presents an experimental evaluation of performance properties of two different production processes of warm rubberized *** types of rubberized binder were produced through dry process and wet process and two of the available wax additives were added into the rubberized binders(i.e.,LEADCAP and Sasobit).Rubberized binders with wax additives were artificially short-term and long-term aged using the rolling thin film oven(RTFO) and pressure aging vessel(PAV) *** binder tests were carried out on the binders through the rotational viscometer(RV),the dynamic shear rheometer(DSR),and the bending beam rheometer(BBR).In general,the results of this study indicated that(1) the viscosity properties have been found to be similar between dry and wet processes,(2) the rubberized binders manufactured by wet process were observed to have the higher rutting resistance than those by dry process,(3) the wet process resulted in better performance in the fatigue cracking test than the dry process,and(4) the blending method was found to have little influence of stiffness properties.

关键词： Rubberized binder Dry process Wet process Viscosity Rutting Fatigue cracking

Gost effectiveness of crack treatment methods:A field study

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第6期6卷 598-607页

作者： Mithil Mazumder Hyun Hwan Kim Soon-Jae lee Moon-sup lee Materials Science Engineeringand Commercialization ProgramTexas State UniversitySan MarcosTX 78666USA Department of Engineering Technology Texas State UniversitySan MarcosTX 78666USA Korea Institute of Civil Engineering and Building Technology Gyeonggi-do 10223South Korea

In the United States,more than 94%highways are paved with asphalt materials and placing crack sealant materials has been a common pavement maintenance for *** sealing treatment includes the use of a router to create a reservoir on the intended cracks whereas crack filling is given without doing any modification to the crack *** the initial cost of crack sealing is higher,it is expected to have a longer service period compared to crack *** is little research on comparison of short and long term cost effectiveness between these two treatments using the real field cost data *** this study four test sites in Texas were treated with crack filling and sealing using the same sealant material and finishing *** effectiveness of both treatments was measured in terms of initial,annual average and life cycle cost based on the cost inputs during *** general,the results of this study indicated that(1)on an average approximately 45%initial cost increase was estimated with the two routing configurations of crack sealing;(2)material and labor cost is found to have the most significant effect on the higher initial cost of crack sealing compared to other associated costs;(3)annual average and life cycle costs have shown that crack sealing is more cost effective pavement maintenance compared to crack filling over a long period of time;(4)agency cost is observed to be reduced by approximately 24%with crack sealing treatment based on the35 year analysis period.

关键词： Crack sealing Crack filling Initial cost Annual average cost Life cycle cost

Unusual case of emphysematous cystitis mimicking intestinal perforation:A case report

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世界临床病例杂志 2023年第28期11卷 6943-6948页

作者： Hye Yoon Kang Dae-sup lee Donghyoun lee Department of Surgery Samsung Medical CenterSeoul 06338South Korea Department of Emergency Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Jeju National University HospitalJeju National University College of MedicineJeju 63241South Korea

BACKGROUND Emphysematous cystitis(EC)is a bladder condition commonly caused by gasgenerating bacterial *** that increase the risk for developing this condition include female gender,age≥60 years,and diabetes mellitus,glycosuria,and urinary *** symptoms of EC often lack specificity,making diagnostic imaging techniques crucial for accurate identification of the *** SUMMARY This report presents an unusual case of EC that mimicked intestinal *** it was initially challenging to differentiate between intestinal perforation and EC on admission,the patient managed to avoid unnecessary surgery and made a good recovery solely through antibiotic *** Successful treatment of the patient described herein highlights the importance of accurately diagnosing EC,which can be difficult to differentiate from intestinal perforation.

关键词： Emphysematous cystitis Intestinal Bowel Perforation Bladder Case report

The influence of thermohaline fronts on chlorophyll a concentrations during spring and summer in the southeastern Yellow Sea

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Acta Oceanologica Sinica 2013年第9期32卷 82-90页

作者： JANG Pung-Guk lee Tong sup KANG Jung-Hoon SHIN Kyoungsoon Korea Institute of Ocean Science and Technology/South Sea Institute Department of Oceanography College of Natural SciencesPusan National University

A spatial and temporal variation in physiochemical parameters in the southeastern Yellow Sea （YS） is in- vestigated in the spring and summer of 2009 to 2011. Nutrient show a strong negative relationship with chlorophyll a （Chl a） concentration in spring, and the subsurface chlorophyll a maxima （SCM） layer was associated with the nitracline in summer. In summer, the SCM was usually found within or above the pyc- nocline and at the depths of shoals from the open sea to the coastal sea due to tidal and/or topographical fronts in the southernmost study area. High Chl a concentrations were found in the central southern YS, where the YS cold water layer expanded under the pycnocline and encountered water masses during spring and summer. After a typhoon in the summer of2011, Chl a concentration increased, especially in the central southern YS, where cold waters occurred below the pycnocline. The results suggest that the development of thermohaline fronts may play an important role in the growth and accumulation of phytoplankton biomass in the upper layer of the southeastern YS during spring and summer.

关键词： Yellow Sea Cold Water nutrient chorophyll a thermohaline front