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Phosphorylated p70S6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder： correlation with

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Asian Journal of Andrology 2014年第4期16卷 611-617页

作者： Soon-Ja Kim Jung hoon Kim Hui Seok Jung Tae-Jin Lee Kyung Mee Lee In Ho Chang Department of Convergence Medicine and Pharmaceutical Biosciences Chung-Ang University Graduate School Seoul Department of Urology Department of Pathology Chung-Ang University College of Medicine Seoul Korea.

We investigated whether inhibiting phosphorylated p70S6K （p-p70S6K） suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma （LG-URCa） in vitro and whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray （TMA） for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70S6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group （P 〈 0.05; hazard ratio （HR）, 2.415） and the high p-p70S6K staining group （P 〈 0.05; HR, 2.249） were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70S6K siRNA and rapamycin, respectively （P 〈 0.05）. Transfection of p70S6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70S6K phosphorylation is important to prevent recurrence and that p70S6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder.

关键词： bladder cancer p7OS6K

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Does intraoperative frozen section really predict significant positive surgical margins after robot-assisted laparoscopic prostatectomy?A retrospective study

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Asian Journal of Andrology 2021年第1期23卷 74-79页

作者： Se Young Choi Byung hoon Chi Tae-Hyoung Kim Bumjin Lim Wonchul Lee Dalsan You Choung-Soo Kim Department of Urology Chung-Ang University HospitalChung-Ang University College of MedicineDongjak-guSeoul 06973Korea Department of Urology Asan Medical CenterUniversity of Ulsan College of MedicineSongpa-guSeoul 05505Korea

We investigated the relationship between positive surgical margin(PSM)-related factors and biochemical recurrence(BCR)and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate *** study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral *** frozen sections of the periurethra,dorsal vein,and bladder neck were *** ability of PSM-related factors to predict BCR and significant PSM was assessed by logistic *** 271 patients,108(39.9%)had PSM and 163(60.1%)had negative *** Gleason score^8(18.9%vs 7.5%,P=0.015)and T stage≥T3a(51.9%vs 24.6%,P<0.001)were significantly more frequent in the PSM *** analysis showed that Gleason pattern≥4(vs<4;hazard ratio:4.386;P=0.0004)was the only significant predictor of BCR in the PSM *** frozen sections had a sensitivity of 83.3%and a specificity of 84.2%in detecting PSM with Gleason pattern≥*** analysis showed that membranous urethra length(odds ratio[OR]:0.79,P=0.0376)and extracapsular extension of the apex(OR:4.58,P=0.0226)on magnetic resonance imaging(MRI)and positive periurethral tissue(OR:17.85,P<0.0001)were associated with PSM of the *** with Gleason pattern≥4 is significantly predictive of *** frozen sections of periurethral tissue can independently predict PSM,whereas sections of the bladder neck and dorsal vein could *** examination of these samples may help predict significant PSM in patients undergoing robot-assisted laparoscopic prostatectomy with preservation of functional outcomes.

关键词： biochemical recurrence frozen section positive surgical margin robotic-assisted prostatectomy

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Assembled Sb2Te3 Nanoparticles by Vapor Transport growth with Enhanced Thermoelectric Properties

Assembled Sb2Te3 Nanoparticles by Vapor Transport growth wit...

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中国化学会第27届学术年会

作者： Huey hoon Hng Freddy Yin Chang Boey 颜清宇 Majid Kabiri Samani George chung Kit School of Materials Science and Engineering Nanyang Technological University (NTU) 50 Nanyang Avenue School of Electrical and Electronic Engineering Nanyang Technological University

＜正＞Nanostructured thermoelectric semiconductors represent a promising new direction that can further increase energy conversion efficiency, which requires the realization of thermoelectric nanocrystals with size

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IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells

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World Journal of Gastroenterology 2006年第5期12卷 716-722页

作者： Tai Sang Lee Hyun Ju Song Ji hoon Jeong Young Sil Min Chang Yell Shin Uy Dong Sohn Department of Pharmacology College of PharmacyChung-Ang UniversitySeoul 156-756Republic of Korea Research Laboratory Dong-A Pharmaceuticals Co.LtdKyunggidoRepublic of Korea

AIM： To examine the pathway related to the IL-1β induced activation of mitogen-activated protein （MAP） kinases in cat esophageal smooth muscle cells. METHODS： Culture of the esophageal smooth muscle cells from cat was prepared. Specific inhibitors were treated before applying the IL-β3. Western blot analysis was performed to detect the expressions of COX, iNOS and MAP kinases. RESULTS： In the primary cultured cells, although IL-β3 failed to upregulate the COX and iNOS levels, the levels of the phosphorylated forms of 1344142 HAP kinase and p38 MAP kinase increased in both concentration- and time-dependent manner, of which the level of activation reached a maximum within 3 and 18 h, respectively. The pertussis toxin reduced the level of p44/42 MAP kinase phosphorylation. Tyrphostin 51 and genistein also inhibited this activation. Neomycin decreased the density of the p44/42 HAP kinase band to the basal level. Phosphokinase C （PKC） was found to play a mediating role in the IL-1β-induced p44/42 MAP kinase activity. In contrast, the activation of p38 MAP kinase was inhibited only by a pretreatment with forskolin, and was unaffected by the other compounds. CONCLUSION： Based on these results, IL-1β-induced p44/42 MAP kinase activation is mediated by the Gi protein, tyrosine kinase, phospholipase C （PLC） and PKC. The pathway for p38 MAP kinase phosphorylation is different from that of p44/42 MAP kinase, suggesting that it plays a different role in the cellular response to IL- 1β.

关键词： IL-1β MAP kinase Esophageal smoothmuscle cells

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Proxy-Based Hierarchical Distributed Mobility Management for Tactical Networks

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Computers, Materials & Continua 2022年第2期70卷 2381-2399页

作者： Myoung-hun Han Bong-Soo Roh Kyungwoo Kim Dae-hoon Kwon Jae-Hyun Ham KyungHyun Yoon Sanghyun Seo Agency for Defense Development Daejeon34186Korea Department of Computer Science and Engineering Chung-Ang UniversitySeoul06974Korea College of Art&Technology Chung-Ang UniversityAnseong17546Korea

An important requirement in a military domain is a highly reliable mobility management method,especially when components of the networks aremoving in tactical network *** increase reliability,themobility management technology of the tactical network should be able to reflect the characteristics of the tactical network,such as a limited environment,failure,and hierarchical unit *** this paper,we propose a proxy-based hierarchical distributedmobilitymanagement scheme,which is highly focused on tactical *** the characteristics of tactical networks,the proposed scheme is composed of the following:1)a proxy-based method,2)a distributed mobility management method that synchronizes a mobility database between entities,and 3)a method of managing mobility by dividing the tactical network into upper and lower *** analysis and modeling and simulation results demonstrate that the method outperforms the existing state-of-the-art method in overcoming entity failure,handover cost,and delay in tactical environments.

关键词： Mobility management tactical networks PMIP DMM

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Clinical significance of the leptin and leptin receptor expressions in prostate tissues

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Asian Journal of Andrology 2008年第6期10卷 923-928页

作者： Jung hoon Kim Shin Young Lee Soon Chul Myung Young Sun Kim Tae-Hyoung Kim Mi Kyung Kim Departments of Urology College of Medicine Chung-Ang University Seoul 140-757 Korea Departments of Pathology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim： To evaluate the expression of leptin and leptin receptor in benign prostatic hyperplasia （BPH） and prostate cancer （PCa）, and to investigate whether they are associated with the development and progression of PCa. Methods： hnmunohistochemical staining was performed to examine the expression of leptin and leptin receptor in BPH and PCa. PCa was divided into three groups： localized PCa, locally advanced PCa and metastatic PCa. The positive staining was identified and the percentage of the positive staining was graded. We also assessed the relationship between both the Gleason score and body mass index （BMI） and PCa. Results： The percentage of the leptin expression in PCa was significantly higher than that in BPH （P 〈 0.01）. For the PCa group, the expressed levels of leptin showed a considerable correlation with localized PCa and metastatic PCa （P 〈 0.05）. Leptin receptor, however, did not reveal a definite difference between BPH and PCa. The expression of leptin indicated a significant difference between well-differentiated PCa （Gleason score ≤6） and poorly differentiated PCa （Gleason score 8-10）（P 〈 0.05）. The relation between the leptin expression level in PCa and the BMI was not remarkable （P = 0.447）. Conclusion： Our results suggest that leptin might have a promoting effect on the carcinogenesis and progression of PCa.

关键词： leptin leptin receptor prostatic neoplasms

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Chemoresistive materials for electronic nose:Progress,perspectives,and challenges

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InfoMat 2019年第3期1卷 289-316页

作者： Seo Yun Park Yeonhoo Kim Taehoon Kim Tae hoon Eom Soo Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Center for Integrated Nanotechnologies Los Alamos National LaboratoryLos AlamosNew Mexico School of Chemical Engineering and Materials Science Chung-Ang UniversitySeoulRepublic of Korea

An electronic nose(e-nose)is a device that can detect and recognize odors and flavors using a sensor *** has received considerable interest in the past decade because it is required in several areas such as health care,environmental monitoring,industrial applications,automobile,food storage,and ***,there are still obstacles in developing a portable e-nose that can be used for a wide variety of *** practical applications of an e-nose,it is necessary to collect a massive amount of data from various sensing materials that can transduce interactions with molecules reliably and analyze them via pattern *** addition,the possibility of miniaturizing the e-nose and operating it with low power consumption should be ***,it should work efficiently over a long period of *** satisfy these requirements,several different chemoresistive material platforms including metal oxides,organics such as polymers and carbonbased materials,and two-dimensional materials were investigated as sensor elements for an *** an individual material has limited selectivity,there is a continuing effort to improve the selectivity and gas sensing properties through surface decoration and compositional and structural *** produce a reliable e-nose,which can be used for practical applications,researches in various fields have to be *** paper reviews the progress of research on e-noses based on a chemoresistive gas sensor array and discusses the inherent challenges and potential solutions.

关键词： chemoresistive materials electronic nose metal oxides polymers two-dimensional materials

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Incremental age-related one-year MACCE after acute myocardial infarction in the drug-eluting stent era （from KAMIR-NIH registry）

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Journal of Geriatric Cardiology 2018年第9期15卷 574-584页

作者： Dae-Won Kim Sung-Ho Her Ha Wook Park Kiyuk Chang Wook Sung chung Ki Bae Seung Myung Ho Jeong Hyo-Soo Kim Hyeon Cheoi Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae Kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae Ji-hoon Jung Division of Cardiology Daejeon St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Division of Cardiology Seoul St. Mary's Hospital College of Medicine the Catholic University of Korea Seoul South Korea Chonnam National University Hospital Gwangju South Korea Seoul National University Hospital Seoul South Korea Sungkyunkwan Universtiy Samsung Medical Center Seoul South Korea chungnam National University Hospital Daejeon South Korea chungbuk National University Hospital Cheongju South Korea Kyungpook National University Hospital Daegu South Korea Keimyung University Dongsan Medical Center Daegu South Korea Yeungnam University Hospital Daegu South Korea Pusan National University Hospital Busan South Korea Wonkwang University Hospital Iksan South Korea Chonbuk National University Hospital Jeonju South Korea Statistical Manager Institute of Toxicology Daejeon South Korea

Objectives To evaluate the age-related one-year major adverse cardiocerebrovascular events （MACCE） after percutaneous coronary intervention （PCI） in acute myocardial infarction （AMI）. We analyzed the association between age and one-year MACCE after AMI. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institue of Health （KAMIR-NIH） between November 2011 and December 2015 were classified into four groups according to age （Group I, 〈 60 years, n = 4199; Group II, 60-70 years, n = 2577; Group III; 70-80 years, n = 2774; Group IV, ≥ 80 years, n = 1018）. Patients were analyzed for one-year composite of MACCE （cardiac death, myocardial infarction, target vessel revascularization, cerebrovascular events） after AMI. Results The one-year MACCE in AMI were 3.5% （Group I）, 6.3% （Group II）, 9.6% （Group III） and 17.6% （Group IV）. After adjustment for confounding para- meters, the analysis results showed that patients with AMI had incremental risk of one-year MACCE [Group II, adjusted hazard ratios （aHR） = 1.224, 95% CI： 0.965-1.525, P = 0.096; Group III, aHR = 1.316, 95% CI： 1.037-1.671, P= 0.024; Group IV, aHR = 1.975, 95% CI： 1.500-62.601, P〈 0.001） compared to Group I. Especially, cardiac death in the composite of primary end point played a major role in this effect （Group II, aHR = 1.335, 95% CI： 0.941-1.895, P= 0.106; Group III, aHR = 1.575, 95% CI： 1.122-2.210, P= 0.009; Group IV, aHR = 2.803, 95% CI： 1.937-4.054, P 〈 0.001）. Conclusions Despite advanced techniques and medications for PCI in AMI, age still exerts a powerful influence in clinical outcomes. Careful approaches, even in the modem era of developed cardiology are needed for aged-population in AMI intervention.

关键词： Acute myocardial infarction Aged-population Major adverse cardiocerebrovascular events

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CAD/CAM for scalable nanomanufacturing:A network-based system for hybrid 3D printing

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Microsystems & Nanoengineering 2017年第1期3卷 135-145页

作者： Hae-Sung Yoon Hyun-Taek Lee Ki-Hwan Jang chung-Soo Kim Hyunseo Park Dae-Wook Kim Kunwoo Lee Sangkee Min Sung-hoon Ahn BK21 Plus Transformative Training Program for Creative Mechanical and Aerospace Engineers Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical Engineering University of Wisconsin-MadisonMadisonWI 53706USA Institute of Advanced Machines and Design Seoul National UniversitySeoul 08826Republic of Korea

Micro-and nano-structuring have been highlighted over several decades in both science and engineering *** addition to continuous efforts in fabrication techniques,investigations in scalable nanomanufacturing have been pursued to achieve reduced feature size,fewer constraints in terms of materials and dimensional complexity,as well as improved process *** this study,based on recent micro-/nanoscale fabrication processes,characteristics and key requirements for computer-aided design and manufacturing(CAD/CAM)systems for scalable nanomanufacturing were *** include a process knowledge database,standardized processing,active communication,adaptive interpolation,a consistent coordinate system,and management of peripheral *** scalable nanomanufacturing,it is important to consider the flexibility and expandability of each process,because hybrid and bridging processes represent effective ways to expand process *** an example,we describe a novel CAD/CAM system for hybrid three-dimensional(3D)printing at the *** novel hybrid process was developed by bridging aerodynamically focused nanoparticle printing,focused ion beam milling,micromachining,and spincoating *** system developed can print a full 3D structure using various inorganic materials,with a minimum process scale of 50 *** most obvious difference versus CAD/CAM at‘conventional’scales is that our system was developed based on a network to promote communication between users and process *** the network-based system,it is also possible to narrow the gap among different processes/*** anticipate that this approach can contribute to the development of CAD/CAM for scalable nanomanufacturing and a wide range of hybrid processes.

关键词： Computer-aided design and manufacturing(CAD/CAM) nanomanufacturing network-based 3D printing

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Perforated duodenal ulcer presenting with massive hematochezia in a 30-month-old child

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World Journal of Gastroenterology 2009年第38期15卷 4853-4855页

作者： Na Mi Lee Sin Weon Yun Soo Ahn Chae Byoung hoon Yoo Seong Jae Cha Byung Kook Kwak Department of Pediatrics College of MedicineChung-Ang University Department of General Surgery College of MedicineChung-Ang University Department of Radiology College of MedicineChung-Ang University

Peptic ulcer disease is uncommon in children and rarely suspected as a cause of abdominal complaints in this age group; the diagnosis is therefore made almost exclusively when complications develop. Peptic ulcer disease is usually not considered in the differential diagnosis of pediatric patients. We present the case of a 30-month-old boy with duodenal perforation due to a peptic ulcer without a known etiology. The patient was admitted through the emergency department due to severe hematochezia and ongoing anemia; he presented with neither abdominal pain nor abdominal distension. There were no medical problems, and no drugs, such as corticosteroids or nonsteroidal anti-inflammatory drugs, had been prescribed or administered recently. We tried to control the active bleeding by medical treatment including arterial embolization, but the active bleeding was not controlled. Finally, an exploratory laparotomy was performed. A discrete anterior perforation with active bleeding of the duodenal wall was found. After the operation, there were no complications and the patient recovered fully.

关键词： Duodenal ulcer Peptic ulcer perforation Children Hematochezia Hemorrhage

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