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Acquisition of pluripotency in the chick embryo occurs during intrauterine embryonic development via a unique transcriptional network

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Journal of Animal Science and Biotechnology 2018年第3期9卷 574-584页

作者： Jae Yong Han Hyo Gun Lee Young Hyun Park Young Sun Hwang Sang Kyung Kim Deivendran Rengaraj Byung wook Cho Jeong Mook Lim Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Institute for Biomedical Sciences Shinshu University Department of Animal Science and Technology Chung-Ang University Department of Animal Science College of Natural Resources and Life Sciences Pusan National University

Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency. In avian species, however, the core transcriptional network that governs the acquisition of pluripotency during early embryonic development is not well ***: We found that chicken NANOG(c NANOG) was expressed in the stages between the pre-ovulatory follicle and oocyte and was continuously detected in Eyal-Giladi and Kochav stage I(EGK.I) to X. However, c POUV was not expressed during fol iculogenesis, but began to be detectable between EGK.V and VI. Unexpectedly, c SOX2 could not be detected during fol iculogenesis and intrauterine embryonic development. Instead of c SOX2, c SOX3 was maternally inherited and continuously expressed during chicken intrauterine development. In addition, we found that the pluripotency-related genes such as c ENS-1, c KIT, c LIN28 A, c MYC, c PRDM14, and c SALL4 began to be dramatical y upregulated between *** and ***: These results suggest that chickens have a unique pluripotent circuitry since maternally inherited c NANOG and c SOX3 may play an important role in the initial acquisition of pluripotency. Moreover, the acquisition of pluripotency in chicken embryos occurs at around *** to VI I.

关键词： Avian Embryonic development NANOG Pluripotency Transcriptional factor

Simultaneous intrahepatic and subgaleal hemorrhage in antiphospholipid syndrome following anticoagulation therapy

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World Journal of Gastroenterology 2013年第38期19卷 6494-6499页

作者： In-Chul Park Yang-Hyun Baek Sang-Young Han Sung-wook Lee Won-Tae chung Sung-Won Lee Sang-Hyeon Kang Duk-Song Cho Division of Gastroenterology and Hepatology Department of Internal MedicineCollege of MedicineDong-A University

Warfarin is a widely used *** differences in drug response,a narrow therapeutic range and the risk of bleeding render warfarin difficult to use *** 18-year-old woman with antiphospholipid syndrome received long-term warfarin therapy for a recurrent deep vein *** years later,she developed right flank *** diagnosed intrahepatic and subgaleal hemorrhages secondary to anticoagulation *** stopping oral anticoagulation,a follow-up computed tomography showed improvement in the *** restarting warfarin because of a recurrent thrombosis,the intrahepatic hemorrhage *** decided to start clopidogrel and hydroxychloroquine instead of *** patient has not developed further recurrent thrombotic or bleeding *** hemorrhage is a very rare complication of warfarin,and our patient experienced intrahepatic and subgaleal hemorrhage although she did not have any risk factors for bleeding or instability of the international normalized ratio control.

关键词： Warfarin Liver Subgaleal Hemorrhage Antiphospholipid syndrome

Second-look Arthroscopic Findings at least One-year after ACL Reconstruction:Comparison between Achilles Allograft and BPTB Autograft

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Second-look Arthroscopic Findings at least One-year after AC...

2002年第9届全国运动医学学术会议

作者： Sung-Ho Hahn Bo-Kyu Yang Seung-Rim Yi Shun-wook chung Dong-Ho Lee Se-Jin Oh Yong-Beom Yeo Department of Orthopedic Surgery National Police Hospital SeoulKorea M.D. Department of Orthopedic Surgery National Police Hospital SeoulKorea M.D． Department of Orthopedic Surgery National Police Hospital SeoulKorea M．D．

purpose The purpose of this study was to compare the arthroscopic findings between autograft group and allograft group minimal 1 year after anterior cruciate ligament reconstruction. materials and methods

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Safety and efficacy of transradial coronary angiography and intervention in patients older than 80 years： from the Korean Transradial Intervention Prospective Registry

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Journal of Geriatric Cardiology 2017年第2期14卷 81-86页

作者： Hoyoun Won Wang Soo Lee Sang-wook Kim Byung Ryul Cho Young Jin Youn Young-Hyo Lim Min-Ho Lee Jae-Hwan Lee Seung-Woon Rha Cardiovascular & Arrhythmia Center Chung-Ang University Hospital Chung-Ang University College of Medieine Seoul South Korea Division of Cardiology Kangwon National University Hospital Chuncheon South Korea Division of Cardiology Yonsei University Wonju College of Medicine Wonju South Korea Division of Cardiology College of Medicine Hanyang University Seoul South Korea Department of Cardiology Soonchunhyang University College of Medicine Seoul South Korea Department of Cardiology Chungnam National University Hospital Daejeon South Korea Department of Cardiology Korea University Guro Hospital Seoul South Korea

Background Radial artery access for coronary procedures is a safe and beneficial technique. However, elderly patients have been considered as a higher risk group of access site related complications compared to younger patients. This study was conducted to investigate the feasibility and safety oftransradial coronary angiography or intervention in the elderly. Methods A total of 6132 patients from Korean Transradial Intervention Prospective Registry at 20 centers were analyzed. Patients were divided into the non-elderly group （n = 5667） and the elderly （_〉 80 years） group （n = 465）. Using propensity score matching, the elderly group （n = 465） was compared with one-to-one matched the non-elderly group （n = 465）. Results After propensity score matching, mean age was 64.3 ＋ 10.3 years in the non-elderly group and 83.5 -4- 3.3 years in the elderly group. There was no difference of procedural characteristics, procedural and fluoroscopic times. Access site cross-over rate was not different between the non-elderly group and elderly group （7.5% vs. 6.2%, P = 0.074）. Bleeding compli- cations occurred similarly in two groups （2.6% of the non-elderly group vs. 1.9% of the elderly group, P -~ 0.660）. Access site complications were 1.9% of the non-elderly group and 0.9% of the elderly group （P = 0.263）. Both of in hospital death and cardiovascular death for one year were also similar between two groups. Conclusions Transradial angiography or intervention was safe and feasible in elderly patients. Complication rates and clinical outcomes in elderly patients were comparable with those in non-elderly patients.

关键词： The elderly patients Transmdial coronary angiography Transradial coronary intervention

Concomitant therapy achieved the best eradication rate for Helicobacter pylori among various treatment strategies

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World Journal of Gastroenterology 2015年第1期21卷 351-359页

作者： Hyun Jeong Lee Jin Il Kim Jin Soo Lee Eun Jung Jun Jung-Hwan Oh Dae Young Cheung Woo Chul chung Byung-wook Kim Sung Soo Kim Division of Gastroenterology Department of Internal MedicineCollege of MedicineThe Catholic University of KoreaSeoul 150-713South Korea

AIM: To compare the Helicobacter pylori(***) eradication rate of clarithromycin-based triple therapy,metronidazole-based triple therapy,sequential therapy and concomitant ***: A total of 680 patients infected with *** were divided into 4 groups and each group was treated with a different eradication ***-based triple therapy was applied to the first group [rabeprazole,amoxicillin and clarithromycin(PAC) group: proton pump inhibitor(PPI),amoxicillin,clarithromycin],whereas the second group was treated with metronidazole-based triple therapy [rabeprazole,amoxicillin and metronidazole(PAM) group: PPI,amoxicillin,metronidazole].The third group was treated with rabeprazole and amoxicillin,followed by rabeprazole,clarithromycin and metronidazole(sequential group).The final group was simultaneously treated with rabeprazole,amoxicillin clarithromycin and metronidazole(concomitant therapy group).In the case of a failure to eradicate ***,second-line quadruple and third-line eradication therapies were ***: The per protocol(PP) analysis was performed on 143,139,141 and 143 patients in the PAC,PAM,sequential and concomitant groups,*** excluded patients who did not receive a C13-urea breath test(22,20,23 and 22 patients,respectively) and patients with less than an 80% compliance level(5,11,6 and 5 patients,respectively).The eradication rates were 76.2%(109/143) in the PAC group,84.2%(117/139) in the PAM group,84.4%(119/141) in the sequential group and 94.4%(135/143) in the concomitant group(P = 0.0002).All 14 patients who failed second-line therapy were treated with thirdline eradication *** these 14 patients,6 infections were successfully eradicated with the thirdline *** PP and intention-to-treat analysis showed an eradication rate of 42.9%(6/14).In the PAC group,3 of 4 patients were successfully cured(3/4,75%); 2 of 2 patients in the PAM group(2/2,100%) and 1 of 5 patients in the seque

关键词： Helicobacter pylori Eradication Drug resistance Co

Percutaneous closure of congenital Gerbode defect using Nit-Occlud^®LêVSD coil

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World Journal of Cardiology 2017年第7期9卷 634-639页

作者： Quang T Phan Sang-wook Kim Hieu L Nguyen Cardiovascular Intervention Department Quang Nam Central General Hospital chung-Ang University Hospital Cardiovas-cular Intervention Center

We present a case report about percutaneous closure of a congenital Gerbode defect using Nit-Occlud~? Lê VSD coil. The patient was referred to our hospital with a diagnosis of ventricular septal defect(VSD) and severe pulmonary arterial hypertension. But transthoracic echocardiography revealed a communication between the left ventricle(LV) and the right atrial(RA), called Gerbode defect. Catheterization confirmed the shunt from the LV to the RA. We successfully closed the defect with a VSD coil. After uneventful 6 mo follow-up, the patient was out of dyspnea, the symptom urged him to have medical attention. This case report is to discuss the diagnosis and percutaneous treatment approach for this rare congenital heart disease.

关键词： Congenital Gerbode defect Nit-Occlud^®LêVSD coil Congenital heart disease Transcatheter device closure Device embolization

An Integrated Growth Model of Software Reliability Based on the Non-Homogeneous Poisson Process

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An Integrated Growth Model of Software Reliability Based on ...

The Sixth International Conference on Information and Management Sciences

作者： Sei Kwon Park Sang wook Park Department of Information Systems chung Ang University South Korea Kuang-Wei Wen and Kyung Hoon Yang Department of Information SystemsUniversity of Wisconsin-La CrosseU.S.A Telecommunications Technology Association Gyeonggi-do South Korea

＜正＞In this paper,we propose an integrated growth model of software reliability based on the non-homogeneous Poisson *** model shows the relationship between several distinctively developed *** also demonstrates not only each of the major attributes of the previous models but also the combined hidden attributes of those models. In addition,we derived estimates of the parameters of the integrated growth model and subsequently,tested the model with real world *** found that our growth model is better than previous models in its flexibility to explain the reliability of software attributes and ability to apply to various situations in the real world.

关键词： Software Reliability Non-Homogeneous Poisson Process Software Reliability Growth Model

Large-scale and high-quality Ⅲ-nitride membranes through microcavity-assisted crack propagation by engineering tensile-stressed Ni layers

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Opto-Electronic Science 2022年第10期 45-55页

作者： Jung-Hong Min Kwangjae Lee Tae-Hoon chung Jung-wook Min Kuang-Hui Li Chun Hong Kang Hoe-Min Kwak Tae-Hyeon Kim Youyou Yuan Kyoung-Kook Kim Dong-Seon Lee Tien Khee Ng Boon S.Ooi Photonics Laboratory Computer Electrical and Mathematical Sciences and Engineering Division (CEMSE) King Abdullah University of Science and Technology (KAUST) Department of Electrical Engineering Stanford University Light Source Research Division Korea Photonics Technology Institute (KOPTI) School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology Department of Advanced Convergence Technology Research Institute of Advanced Convergence Technology Korea Polytechnic University King Abdullah University of Science and Technology (KAUST)

Epitaxially grown Ⅲ-nitride alloys are tightly bonded materials with mixed covalent-ionic bonds. This tight bonding presents tremendous challenges in developing Ⅲ-nitride membranes, even though semiconductor membranes can provide numerous advantages by removing thick, inflexible, and costly substrates. Herein, cavities with various sizes were introduced by overgrowing target layers, such as undoped GaN and green LEDs, on nanoporous templates prepared by electrochemical etching of n-type GaN. The large primary interfacial toughness was effectively reduced according to the design of the cavity density, and the overgrown target layers were then conveniently exfoliated by engineering tensile-stressed Ni layers. The resulting Ⅲ-nitride membranes maintained high crystal quality even after exfoliation due to the use of GaN-based nanoporous templates with the same lattice constant. The microcavity-assisted crack propagation process developed for the current Ⅲ-nitride membranes forms a universal process for developing various kinds of largescale and high-quality semiconductor membranes.

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Development of Web Camera of CMOS sensor using VHDL and Embedded Linux

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Development of Web Camera of CMOS sensor using VHDL and Embe...

第二十三届中国控制会议

作者： Byoung-wook Choi Eun-Cheol Shin Kyoung-Chul Koh Department of Control and Measurement Sunmoon UniversityChung-NamKorea Department of Control and Measurement Sunmoon UniversityChung-NamKorea Department of Control and Measurement Sunmoon UniversityChung-NamKorea

＜正＞ In this paper, we developed a network-based image capture board of CMOS sensor. The design, implementation details including Embedded Linux porting and CPLD logics, and performance of capture board are described. The image capture board consists of SoC（S3C4530A）, CPLD and CMOS image sensor. In order to capture image data of sensor we designed capture logics on CPLD by using VHDL program. Embedded Linux such as uClinux is performed on the image capture board to utilize development environment and TCP/IP protocol stacks. The applications are based on socket communication between GUI on PC and Embedded Linux based capture board. The embedded web camera is applicable for developing the web-based vision system such as a mobile robot and device monitoring.

关键词： Embedded system CMOS image sensor uClinux VHDL sensor inspection