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Suppression of laser-induced choroidal neovascularization by intravitreal injection of tristetraprolin

International Journal of Ophthalmology(English edition) 2014年第6期7卷 952-958页

作者： Yong Wun Cho Yong Seop Han In Young chung Seong Jae Kim Seong wook Seo Ji Myong Yoo jong Moon Park Department of Ophthalmology Gyeongsang National University School of Medicine Gyeongsang Institute of Health Science Gyeongsang National University

AIM: To examine the effect of intravitreal adenoviral vector-mediated tristetraprolin(Ad-TTP) on VEGF m RNA expression in a rat model of laser-induced choroidal ***: Ad-TTP was prepared using a commercial kit. Retinal laser-induced photocoagulation(10 spots per eye) was performed on rats in this experimental choroidal neovascularization(CNV) model. Rats were divided into four groups: control(single intravitreal injection of balanced salt solution, n =10), laser-induced CNV(photocoagulation only, n =20), laser-induced CNV plus Ad-TTP injection(photocoagulation plus a single intravitreal Ad-TTP injection, n =20) and Ad-TTP injection only(n =10). Changes in choroidal morphology were evaluated in ten rats in the laser only and the laser plus Ad-TTP groups. Two weeks after laser injury, the size of CNV was calculated by perfusion with high-molecular-weight fluorescein isothiocyanate(FITC)-dextran. VEGF m RNA expression in retina-choroid tissue from ten rats in each group was measured by reverse transcription polymerase chain reaction(RT-PCR). RESULTS: Two weeks after treatment, the area of laser-induced CNV was reduced by approximately 60% in the rats given the Ad-TTP injection compared with that in the laser-only group. There was a tendency toward decreased VEGF m RNA expression in the Ad-TTP injection ***: A single intravitreal injection of Ad-TTP significantly suppressed CNV size in this experimental laser-induced CNV model. Ad-TTP injection also decreased VEGF m RNA expression compared with that inthe laser-induced CNV group. The present study is meaningful as the first study to investigate the effect of tristetraprolin delivered via intravitreal injection.

关键词： laser-induced choroidal neovascularization tristetraprolin adenoviral vectors

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Generation of tumor spheroids using a droplet-based microfluidic device for photothermal therapy

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Microsystems & Nanoengineering 2020年第1期6卷 796-805页

作者： jong Min Lee Ji wook Choi Christian D.Ahrberg Hyung Woo Choi Jang Ho Ha Seok Gyu Mun Sung Joon Mo Bong Geun chung Department of Mechanical Engineering Sogang UniversitySeoulKorea Division of Chemical Industry Yeungnam University CollegeDaeguRepublic of Korea Research Center Sogang UniversitySeoulKorea Department of Biomedical Engineering Sogang UniversitySeoulKorea

Despite their simplicity,monolayer cell cultures are not able to accurately predict drug behavior in vivo due to their inability to accurately mimic cell-cell and cell-matrix *** contrast,cell spheroids are able to reproduce these interactions and thus would be a viable tool for testing drug ***,the generation of homogenous and reproducible cell spheroids on a large scale is a labor intensive and slow process compared to monolayer cell ***,we present a droplet-based microfluidic device for the automated,large-scale generation of homogenous cell spheroids in a uniform *** the microfluidic system,the size of the spheroids can be tuned to between 100 and 130μm with generation frequencies of 70 *** demonstrated the photothermal therapy(PTT)application of brain tumor spheroids generated by the microfluidic device using a reduced graphene oxide-branched polyethyleneimine-polyethylene glycol(rGO-BPEI-PEG)nanocomposite as the PTT ***,we generated uniformly sized neural stem cell(NSC)-derived neurospheres in the droplet-based microfluidic *** also confirmed that the neurites were regulated by ***,this droplet-based microfluidic device could be a powerful tool for photothermal therapy and drug screening applications.

关键词： fluid viable simplicity

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Lithium plating-free 1 Ah-level high-voltage lithium-ion pouch battery via ambi-functional pentaerythritol disulfate

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能源化学:英文版 2023年第8期83卷 229-238,I0007页

作者： Dung Tien Tuan Vu Jinsol Im Jae-Hee Kim Jisoo Han Gyeong Jun chung Giang Thi Huong Nguyen Junhyeok Seo Minjae Kim Eui-Hyung Hwang Young-Gil Kwon Jae wook Shin Kuk Young Cho Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science&Chemical Engineering Hanyang UniversityAnsan 15588Republic of Korea Fine Chem Co.Ltd. Daejeon 34365Republic of Korea d CSIM Co.Ltd. Yesan 32400Republic of Korea Dongwha Electrolyte Nonsan 32925Republic of Korea

Elevating the charge cut-off voltage beyond traditional 4.2 V is a commonly accepted technology to increase the energy density of Li-ion batteries(LIBs) but the risk of Li-dendrites and fire hazard increases as well. The use of ambi-functional additive, which forms stable solid electrolyte interphase(SEI) simultaneously at both cathode and anode, is a key to enabling a dendrites-free and well-working high-voltage LIB. Herein, a novel ambi-functional additive, pentaerythritol disulfate(PEDS), at 1 wt% without any other additive is demonstrated. We show the feasibility and high impacts of PEDS in forming lithium sulfateincorporated robust SEI layers at NCM523 cathode and graphite anode in 1 Ah-level pouch cell under4.4 V, 25 °C and 0.1 C rate, which mitigates the high-voltage instability, metal-dissolution and cracks on NCM523 particles, and prevents Li-dendrites at graphite anode. Improved capacity retention of 83%after 300 cycles is thereby achieved, with respect to 69% with base electrolyte, offering a promising path toward the design of practical high-energy LIBs.

关键词： Lithium-ion pouch cell Lithium plating-free High-voltage Ambi-functional additive SEI layer

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Rationally designed graphene channels for real-time sodium ion detection for electronic tongue

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InfoMat 2023年第7期5卷 43-58页

作者： chung Won Lee Sang Eon Jun Seung Ju Kim Tae Hyung Lee Sol A.Lee Jin wook Yang Jin Hyuk Cho Shinyoung Choi Cheol-joo Kim Soo Young Kim Ho Won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoulRepublic of Korea Department of Materials Science and Engineering Korea UniversitySeoulRepublic of Korea Department of Chemical Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwonRepublic of Korea

Monitoring taste-inducing ions and molecules continuously in liquids or solutions is of great considerable matter for the realization of the electronic tongue(E-tongue).Particularly from the five major tastes,the highly selective,sensitive detection of Na^(+)in real-time is *** is due to the saltiness of food is the key ingredient in most ***,existing Na^(+)detecting devices have relatively low performances of selectivity,sensitivity,and lack of on–off ***,conventional devices significantly deteriorate in capac-ity due to repetitive usage or lifetime shortage by degradation of the sensing ***,a graphene-based channel was rationally designed by the facile decoration of Calix[4]arene and Nafion to address this *** act as a receptor and a molecular sieve,respectively,to enhance selectivity and sensitivity and elon-gate the life expectancy of the *** device was merged with a microfluidic channel to control the injection and withdrawal of solutions to fulfill dynamic on–off *** fabricated device has highly selective,sensitive Na^(+)detection properties compared to other 10 molecule/ionic *** on–off functions of the device were available,also possesses a long lifespan of at least 220 ***,it can precisely discriminate real beverages containing Na^(+),which can be observed by principal component analysis *** features offer the possibility of ascending to a platform for E-tongues in near future.

关键词： electronic tongue graphene microfluidic channels Na^(+)sensors solution-gated field-effect transistors

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The neuroprotective effects of human growth hormone as a potential treatment for amyotrophic lateral sclerosis

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Neural Regeneration Research 2015年第8期10卷 1201-1203页

作者： Jin-Young chung Jun-Sang Sunwoo Min-wook Kim Manho Kim Department of Veterinary Internal Medicine and Geriatrics Kangwon National University Department of Neurology Seoul National University Hospital Department of Rehabilitation Medicine College of Medicine The Catholic University of Korea Institute of Catholic Integrative Medicine (ICIM) Incheon St. Mary’s Hospital Protein Metabolism Medical Research Center Seoul National University College of Medicine

Human growth hormone（GH）is a single-chain polypeptide of 191 amino acids that is involved in the regulation of various physiological processes,such as growth and *** is synthesized and secreted by somatotropic cells in the anterior pituitary *** secretion is primarily regulated by a balance between growth hormone-releasing hormone and growth hormone-inhibiting hormone,

关键词： amyotrophic metabolism secretion physiological inhibiting secreted neuronal primarily pituitary polypeptide

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Effect of parallel resonance on the electron energy distribution function in a 60 MHz capacitively coupled plasma

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Plasma Science and Technology 2023年第4期25卷 69-78页

作者： You HE Yeong-Min LIM Jun-Ho LEE Ju-Ho KIM Moo-Young LEE Chin-wook chung Department of Electrical Engineering Hanyang University17 Haengdang-dongSeongdong-guSeoul 133-791Republic of Korea Department of Nanoscale Semiconductor Engineering Hanyang University17 Haengdang-dongSeongdong-guSeoul 133-791Republic of Korea

In general,as the radio frequency(RF)power increases in a capacitively coupled plasma(CCP),the power transfer efficiency decreases because the resistance of the CCP *** this work,a parallel resonance circuit is applied to improve the power transfer efficiency at high RF power,and the effect of the parallel resonance on the electron energy distribution function(EEDF)is investigated in a 60 MHz *** CCP consists of a power feed line,the electrodes,and *** reactance of the CCP is positive at 60 MHz and acts like an inductive load.A vacuum variable capacitor(VVC)is connected in parallel with the inductive load,and then the parallel resonance between the VVC and the inductive load can be *** the capacitance of the VVC approaches the parallel resonance condition,the equivalent resistance of the parallel circuit is considerably larger than that without the VVC,and the current flowing through the matching network is greatly ***,the power transfer efficiency of the discharge is improved from 76%,70%,and 68%to 81%,77%,and 76%at RF powers of 100 W,150 W,and 200 W,*** parallel resonance conditions,the electron heating in bulk plasma is enhanced,which cannot be achieved without the VVC even at the higher RF *** enhancement of electron heating results in the evolution of the shape of the EEDF from a biMaxwellian distribution to a distribution with the smaller temperature difference between high-energy electrons and low-energy *** to the parallel resonance effect,the electron density increases by approximately 4%,18%,and 21%at RF powers of 100 W,150 W,and 200 W,respectively.

关键词： capacitively coupled plasma parallel resonance electron energy distribution function

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Single omental metastasis of renal cell carcinoma after radical nephrectomy:A case report

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世界临床病例杂志 2023年第25期11卷 5994-5999页

作者： Jae-wook chung Jun-Koo Kang Eun Hye Lee So Young Chun Yun-Sok Ha Jun Nyung Lee Tae-Hwan Kim Tae Gyun Kwon Ghil Suk Yoon Department of Urology Kyungpook National University HospitalDaegu 41404South Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41404South Korea Biomedical Research Institute Kyungpook National UniversityDaegu 41404South Korea Joint Institute for Regenerative Medicine Kyungpook National UniversityDaegu 41404South Korea Department of Pathology Kyungpook National University HospitalDaegu 41404South Korea Department of Pathology School of MedicineKyungpook National UniversityDaegu 41404South Korea

BACKGROUND Renal cell carcinoma(RCC)is the third most common malignancy in the genitourinary *** lungs,bone,lymph nodes,liver,and brain are common metastatic sites of ***,there is limited literature on single omental metastasis of *** SUMMARY We present the case of a 44-year-old man with single omental metastasis of RCC after laparoscopic radical *** diagnosis of the resected left kidney revealed pT3a clear cell RCC(Fuhrman grade III).At 6 mo postoperatively,abdominal computed tomography revealed a 12-mm enhancing nodule in the left lower *** 7 mo after initial operation,laparoscopic removal of the left omental nodule was *** pathological results indicated metastatic clear cell ***,the patient is being treated with adjuvant *** Omental metastasis of RCC owing to laparoscopic radical nephrectomy is *** should be aware of the diverse nature of RCC.

关键词： Metastasis Omentum Renal cell carcinoma Radical nephrectomy Case report

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Risk factors for rebleeding after angiographically negative acute gastrointestinal bleeding

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World Journal of Gastroenterology 2009年第32期15卷 4023-4027页

作者： Ijin Joo Hyo-Cheol Kim Jin wook chung Hwan Jun Jae Jae Hyung Park Department of Radiology Seoul National University College of Medicine Institute of Radiation Medicine Seoul National University Medical Research Center Clinical Research Institute Seoul National University HospitalSeoul 110-744South Korea

AIM:To identify possible predictive factors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal ***: From January 2000 to July 2007, 128 patients with acute non-variceal gastrointestinal bleeding had negative f indings after initial angiography. Clinical and laboratory parameters were analyzed ***: Among 128 patients, 62 had no recurrent gastrointestinal bleeding and 66 had recurrent gastrointestinal bleeding within 30 d. As determined by the use of multivariate analysis, an underlying malignancy, liver cirrhosis and hematemesis were significant factors related to recurrent gastrointestinal ***: Clinical factors including underlying malignancy, liver cirrhosis, and hematemesis are important predictors for rebleeding after angiographically negative findings in patients with acute non-variceal gastrointestinal bleeding.

关键词：消化道出血血管造影急性危险因素恶性肿瘤调查结果多元分析肝硬化

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Double layered self-expanding metal stents for malignant esophageal obstruction, especially across the gastroesophageal junction

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World Journal of Gastroenterology 2012年第28期18卷 3732-3737页

作者： Min Dae Kim Su Bum Park Dae Hwan Kang Jae Hyung Lee Cheol Woong Choi Hyung wook Kim chung Uk chung Young Il Jeong Department of Internal Medicine Bongseng Memorial Hospital Busan 601-723 South Korea Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 626-770 South Korea

AIM: To evaluate the clinical outcomes of double-layered self-expanding metal stents (SEMS) for treatment of malignant esophageal obstruction according to whether SEMS crosses the gastroesophageal junction (GEJ). METHODS: Forty eight patients who underwent the SEMS insertion for malignant esophageal obstruction were enrolled. Patients were classified as GEJ group (SEMS across GEJ, 18 patients) and non-GEJ group (SEMS above GEJ, 30 patients) according to SEMS position. Double layered (outer uncovered and inner covered stent) esophageal stents were placed. RESULTS: The SEMS insertion and the clinical improvement were achieved in all patients in both groups. Stent malfunction occurred in seven patients in the GEJ group and nine patients in the non-GEJ group. Tumor overgrowth occurred in five and eight patients, respectively, food impaction occurred in one patient in each group, and stent migration occurred in one and no patient, respectively. There were no significant differences between the two groups. Reflux esophagitis occurred more frequently in the GEJ group (eight vs five patients, P = 0.036) and was controlled by proton pump inhibitor. Aspiration pneumonia occurred in zero and five patients, respectively, and tracheoesophageal fistula occurred in zero and two patients, respectively. CONCLUSION: Double-layered SEMS are a feasible and effective treatment when placed across the GEJ for malignant esophageal obstruction. Double-layered SEMS provide acceptable complications, especially migration, although reflux esophagitis is more common in the GEJ group.

关键词：金属支架交界处食管梗阻恶性治疗 SEMS 质子泵抑制剂

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Effect of music on colonoscopy performance: A propensity scorematched analysis

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 397-406页

作者： Eun Jeong Choi Sam Ryong Jee Sang Heon Lee Jun Sik Yoon Seung Jung Yu jong Hyun Lee Han Byul Lee Sang wook Yi Myeong Pyo Kim Byung Cheol chung Hong Sub Lee Department of Internal Medicine Inje University College of MedicineBusan Paik HospitalBusan 47392South Korea Department of Public Health Ajou University Graduate School of Public HealthSuwon 16499South Korea Department of Preventive Medicine and Public Health Catholic Kwandong University College of MedicineGangneung 25601South Korea

BACKGROUND Music has been used to reduce stress and improve task performance during medical *** To assess the effects of music on colonoscopy performance *** We retrospectively reviewed patients who underwent colonoscopy performed by four endoscopists with popular *** performance outcomes,such as insertion time,adenoma detection rate(ADR),and polyp detection rate(PDR),were compared between the music and non-music *** reduce selection bias,propensity score matching was *** After one-to-one propensity score matching,169 colonoscopies were selected from each *** significant differences in insertion time(4.97 vs 5.17 min,P=0.795)and ADR(39.1%vs 46.2%,P=0.226)were found between the two *** analysis showed that the insertion time(3.6 vs 3.8 min,P=0.852)and ADR(51.1%vs 44.7%,P=0.488)did not significantly differ between the two groups in ***,in trainees,PDR(46.9%vs 66.7%,P=0.016)and ADR(25.9%vs 47.6%,P=0.006)were significantly lower in the music than in the nonmusic *** The current study found that listening to music during colonoscopy did not affect procedure ***,it suggested that music may distract trainees from appropriately detecting adenomas and polyps.

关键词： Music Colonoscopy Performance Adenoma Colonic polyps Cecal insertion time

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