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Transplantation of human adipose tissue-derived stem cells for repair of injured spiral ganglion neurons in deaf guinea pigs

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Neural Regeneration Research 2016年第6期11卷 994-1000页

作者： Sujeong jang Hyong-Ho Cho Song-Hee Kim Kyung-Hwa Lee Yong-Bum Cho jong-Seong Park Han-Seong Jeong Department of Physiology Chonnam National University Medical School Department of Otolaryngology Chonnam National University Medical School Department of Pathology Chonnam National University Medical School

Excessive noise, ototoxic drugs, infections, autoimmune diseases, and aging can cause loss of spiral ganglion neurons, leading to permanent sensorineural hearing loss in mammals. Stem cells have been confirmed to be able to differentiate into spiral ganglion neurons. Little has been reported on adipose tissue-derived stem cells（ADSCs） for repair of injured spiral ganglion neurons. In this study, we hypothesized that transplantation of neural induced-human ADSCs（NI-h ADSCs） can repair the injured spiral ganglion neurons in guinea pigs with neomycin-induced sensorineural hearing loss. NI-h ADSCs were induced with culture medium containing basic fibroblast growth factor and forskolin and then injected to the injured cochleae. Guinea pigs that received injection of Hanks＇ balanced salt solution into the cochleae were used as controls. Hematoxylin-eosin staining showed that at 8 weeks after cell transplantation, the number of surviving spiral ganglion neurons in the cell transplantation group was significantly increased than that in the control group. Also at 8 weeks after cell transplantation, immunohistochemical staining showed that a greater number of NI-h ADSCs in the spiral ganglions were detected in the cell transplantation group than in the control group, and these NI-h ADSCs expressed neuronal markers neurofilament protein and microtubule-associated protein 2. Within 8 weeks after cell transplantation, the guinea pigs in the cell transplantation group had a gradually decreased auditory brainstem response threshold, while those in the control group had almost no response to 80 d B of clicks or pure tone burst. These findings suggest that a large amount of NI-h ADSCs migrated to the spiral ganglions, survived for a period of time, repaired the injured spiral ganglion cells, and thereby contributed to the recovery of sensorineural hearing loss in guinea pigs.

关键词： guinea ganglion repair hearing adipose injured brainstem auditory neuronal cochlear

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Predictive value of ^(18)F-fluorodeoxyglucose PET/CT for transarterial chemolipiodolization of hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第25期18卷 3215-3222页

作者： Myeong Jun Song Si Hyun Bae Ie Ryung Yoo Chung-Hwa Park Jeong Won jang Ho jong Chun Byung Gil Choi Hae Giu Lee jong Young Choi Seung Kew Yoon Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Nuclear Medicine College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea Department of Radiology College of MedicineThe Catholic University of KoreaSeoul 137-040South Korea

AIM： To investigate the correlation of 18F-fluorodeoxy- glucose （18F-FDG） positron emission tomography （PET） with clinical features and the prediction of treatment response. METHODS： A total of 83 hepatocellular carcinoma （HCC） patients undergoing 18F-FDG PET before transar- terial chemolipiodolization with systemic chemo-infusion between October, 2006 and May, 2009 were retrospec-tively enrolled. The patients included 68 men and 15 women （mean age, 60 ~ 10.7 years）. The effect of 18F- FDG-monitored PET uptake on clinical features and on the evaluated treatment response was ascertained with modified Response Evaluation Criteria in Solid Tumors. The PET parameters of maximal standardized uptake value of the tumor （Tsuvmax）, the ratio of the tumor maximal standardized uptake value （SUV） to the liver maximal SUV （Tsuvmax/Lsuwax） and the ratio of tumor maximal SUV to the liver mean SUV （msuvmax/LSUVrnean） were tested as predictive factors. RESULTS： Among the 3 SUV parameters, the TSUV- =maxdLsuvmean ratio （cutoff value of 1.90） was significantly associated with tumor burden including tumor size, tu- mor number, α-fetoprotein levels and tumor stage （P 〈 0.001, P = 0.008, P = 0.011, P 〈 0.001, respectively）. The objective response rates in patients with a high SUV ratio （≥ 1.90） were significantly better than those with a low SUV ratio （〈 1.90）（P = 0.020）. The overall survival rates of patients exhibiting a low Tsuvmax/Lsu- Vmean ratio （〈 1.90） and those with a high SUV ratio （≥1.90） was 38.2 and 10.3 mo, respectively （P 〈 0.01）. However, the time to progression showed no significant difference between the groups （P = 0.15）. CONCLUSION： 18F-FDG PET can be an important predictor of HCC treatment. In particular, the Tsuvmax/ Lsuwean ratio （cutoff value of 1.90） can provide useful information in treatment prognosis for HCC patients treated with Iocoregional therapy.

关键词： 18F-fluorodeoxyglucose positron emissiontomography Transarterial chemolipiodolization withsystemic chemo-infusion Treatment response Predic-tive factor, Overall survival

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Studies on Mycelial Growth of Some Basidiomycetes and Decomposition of Media

Studies on Mycelial Growth of Some Basidiomycetes and Decomp...

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The 7th Korea-China Joint Symposium for Mycology

作者： jong-CHUN CHEONG KAB-YEUL jang CHANG-SUNG JHUNE JEONG-sik PARK Applied Microbiology Division National Institute of Agricultural Science and Technology R.D.A. Applied Microbiology Division National Institute of Agricultural Science and Technology R.D.A. Applied Microbiology Division National Institute of Agricultural Science and Technology R.D.A. Applied Microbiology Division National Institute of Agricultural Science and Technology R.D.A.

＜正＞In order to develop the environmentally friendly bio-materials for mycelial growth condition of some basidiomycetes and decomposition of media were studied. Sparassis crispa grew well at HBA （Honey Banana extra...

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基于动态邻域指标重构的风电机组故障检测方法

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太阳能学报 2024年第9期45卷 557-563页

作者：钱小毅孙天贺姜兴宇王宝石沈阳工程学院辽宁省电网节能与控制重点实验室沈阳110136

复杂多变的运行工况是造成风电机组故障检测中误报和漏报现象的主要原因之一,为此,提出一种邻域规模与阈值动态协同的风电机组故障检测方法。定义阶梯近邻和状态分离度两种重构指标,以评估模型的故障分离能力,据此构建邻域规模的迭代修... 详细信息

复杂多变的运行工况是造成风电机组故障检测中误报和漏报现象的主要原因之一,为此,提出一种邻域规模与阈值动态协同的风电机组故障检测方法。定义阶梯近邻和状态分离度两种重构指标,以评估模型的故障分离能力,据此构建邻域规模的迭代修正策略。提出阈值静态分量与动态分量的融合方法,通过动态邻域规模和动态阈值减少由状态突变引起的误报和漏报。利用兆瓦级风电机组常见的10种故障进行仿真实验,验证所提方法可更有效分离正常状态与异常状态,进而降低误报率和漏报率。

关键词：风电机组故障检测重构复杂工况动态邻域规模动态阈值

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Effects of precipitation strengthening heat treatment for Al-Mg alloy

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Transactions of Nonferrous Metals Society of China 2011年第6期21卷 1218-1224页

作者： Seong-jong KIM Seok-Ki jang Min-Su HAN Seong-Kwon KIM jong-Sin KIM Division of Marine System Engineering Mokpo Maritime University Mokpo City Jeonnam 530-729 Korea Media Engineering Seoul National University of Technology Seoul 139-743 Korea Korean Register of Shipping Tokyo Branch Office 3rd F Sanko BLDG＇ 4-11 Nohonbashi Kodenma-cho Cho-ku 103-0001 Tokyo Japan

The corrosions resulting from defects in painting layers frequently occur in Al alloys, so the application of corrosion preventing systems is also very important. Optimum conditions in terms of electrochemistry in relation to solution treatment, quenching and artificial aging treatment were established in order to optimize precipitation strengthening conditions intended to enhance the strength of Al alloys. Slow strain rate tests （SSRT） at various applied potentials were conducted in potential range from -1.8 to 0.5 V. The results show that the maximum tensile strengths, elongations and time-to-fracture are shown to be high values. After precipitation strengthening heat treatment, a tendency appear that time-to-fracture increases as elongation increases. In the potential range from -1.3 V to -0.7 V, the specimens show excellent mechanical properties, and thus this range is considered to be a corrosion prevention range.

关键词： Al alloy slow strain rate test electrochemistry precipitation strengthening heat treatment mechanical property

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Schottky barrier modulation of bottom contact SnO_(2) thin-film transistors via chloride-based combustion synthesis

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Journal of Materials Science & Technology 2023年第17期148卷 199-208页

作者： Bongho jang Junhee Lee Hongki Kang Jaewon jang Hyuk-Jun Kwon Department of Electrical Engineering and Computer Science DGISTDaegu 42988South Korea School of Electronic and Electrical Engineering Kyungpook National UniversityDaegu 41566South Korea School of Electronics Engineering Kyungpook National UniversityDaegu 41566South Korea Convergence Research Advanced Centre for Olfaction DGISTDaegu 42988South Korea

The enhanced carrier flow at the interface between Au and SnO_(2)semiconductors,which initially form Schottky contacts,is realized using chloride-based combustion ***-based combustion sys-tems can achieve chlorine(Cl)doping effects as well as conversion to crystalline SnO_(2)films at clearly lower temperatures(∼250℃)than conventional *** to the Cl doping effect,the high carrier concentration can induce thin potential barriers at the metal/semiconductor(MS)junctions,resulting in carrier injection by *** a result,compared to conventional SnO_(2)thin-film transistors,the de-vices fabricated by combustion synthesis exhibit significantly improved electrical performance with field-effect mobility of 6.52 cm 2/Vs(∼13 times),subthreshold swing of 0.74 V/dec,and on/offratio of∼10^(7)below 300℃.Furthermore,because of the enhanced tunneling carriers induced by the narrowed barrier width,the Schottky barriers are significantly reduced from 0.83 to 0.29 eV(65%decrease)at 250℃and from 0.42 to 0.17 eV(60%decrease)at 400℃.Therefore,chloride-based combustion synthesis can con-tribute to developing SnO_(2)-based electronics and flexible devices by achieving both high-quality oxide films and improved current flow at the MS interface with low-temperature annealing.

关键词： SnO_(2) Combustion Sol-gel Schottky contact Thin-film transistors

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Graphene and MXene-based porous structures for multifunctional electromagnetic interference shielding

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Nano Research 2023年第1期16卷 1387-1413页

作者： Xi Shen jang-Kyo Kim Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China School of Mechanical and Manufacturing Engineering University of New South WalesSydneyNSW 2052Australia The Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHung HomHong Kong 999077China

Electrically conductive porous structures are ideal candidates for lightweight and absorption-dominant electromagnetic interference(EMI)*** this review,we summarize the recent progress in developing porous composites and structures from emerging two-dimensional(2D)graphene and MXene nanosheets for EMI shielding *** properties contributing to various energy loss mechanisms are probed with a critical discussion on their correlations with EMI shielding *** approaches to constructing bulk porous structures,such as 2D porous films,three-dimensional(3D)aerogels and foams,and hydrogels,are compared to highlight important material and processing parameters required to achieve optimal microstructures.A comprehensive comparison of EMI shielding performance is also carried out to elucidate the effects of different assembly techniques and *** multifunctional applications in adaptive EMI shielding,mechanical force attenuation,thermal management,and wearable devices are introduced,underlining the importance of unique compositions and microstructures of porous *** process–structure–property relationships established in this review would offer valuable guidance and insights into the design of lightweight EMI shielding materials.

关键词： porous composite graphene MXene electrical conductivity electromagnetic interference(EMI)shielding

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Difference in cortical activation during use of volar and dorsal hand splints:a functional magnetic resonance imaging study

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Neural Regeneration Research 2016年第8期11卷 1274-1277页

作者： Sung Ho jang Woo Hyuk jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

There have been no studies reported on the difference in cortical activation during use of volar and dorsal hand *** attempted to investigate the difference in cortical activation in the somatosensory cortical area during use of volar and dorsal hand splints by functional magnetic resonance imaging（f MRI）.We recruited eight healthy volunteers.f MRI was performed while subjects who were fitted with volar or dorsal hand splints performed grasp-release *** of interest were placed on the primary motor cortex（M1）,primary somatosensory cortex（S1）,posterior parietal cortex（PPC）,and secondary somatosensory cortex（S2）.Results of group analysis of f MRI data showed that the total numbers of activated voxels in all ROIs were significantly higher during use of volar hand splint（3,376） compared with that（1,416） during use of dorsal hand *** each ROI,use of volar hand splint induced greater activation in all ROIs（M1：1,748,S1 ：1,455,PPC：23,and S2：150） compared with use of dorsal hand splint（M1：783,S1：625,PPC：0,and S2：8）.The peak activated value was also higher during use of volar hand splint（t-value：17.29） compared with that during use of dorsal hand splint（t-value：13.11）.Taken together,use of volar hand splint induced greater cortical activation relevant to somatosensory function than use of dorsal hand *** result would be important for the physiatrist and therapist to apply appropriate somatosensory input in patients with brain injury.

关键词： nerve regeneration functional MRI hand splint somatosensory function dorsal hand splint volar hand splint neural regeneration

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Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies

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Neuroscience Bulletin 2013年第3期29卷 366-372页

作者： Sung Ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. However, relatively little is known about the mechanisms of recovery of somatosensory function. Based on the previous human studies, a review of 11 relevant studies on the mecha- nisms underlying the recovery of somatosensory function in stroke patients was conducted based on the fol- lowing topics：（1） recovery of an injured somatosensory pathway, （2） peri-lesional reorganization, （3） contribu- tion of the unaffected somatosensory cortex, （4） contribution of the secondary somatosensory cortex, and （5） mechanisms of recovery in patients with thalamic lesions. We believe that further studies in this field using combinations of diffusion tensor imaging, functional neuroimaging, and magnetoencephalography are needed. In addition, the clinical significance, critical period, and facilitatory strategies for each recovery mechanism should be clarified.

关键词： stroke somatosensory recovery brain mapping brain plasticity

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锌诱导对香菇菌丝生长速度及金属硫蛋白含量的影响

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中国无机分析化学 2024年第1期14卷 18-25页

作者：姜海云孙振英刘贵巧邯郸市食品药品检验中心河北邯郸056002 河北工程大学生命科学与食品工程学院河北邯郸056038

金属硫蛋白(Metallothionein)对镉、铜和锌等多种元素有高度亲和性,具有重金属解毒的功能。选取食用菌中的香菇(Mushrooms)作为代表菌种,在固体培养基中添加了不同浓度梯度的元素锌盐溶液,每天测定不同锌浓度作用下香菇的生长速度;培养... 详细信息

金属硫蛋白(Metallothionein)对镉、铜和锌等多种元素有高度亲和性,具有重金属解毒的功能。选取食用菌中的香菇(Mushrooms)作为代表菌种,在固体培养基中添加了不同浓度梯度的元素锌盐溶液,每天测定不同锌浓度作用下香菇的生长速度;培养结束,测定菌丝体内锌含量和金属硫蛋白含量。结果表明,培养环境中锌浓度越高,菌丝体内富锌量越多。通过一系列元素吸附和金属硫蛋白含量相关性分析,发现元素锌含量与香菇中金属硫蛋白含量呈正相关性,锌含量越高,金属硫蛋白含量也越高。实验结果为香菇及其他食用菌富集元素锌机理提供参考,还为食用菌安全问题的解决提供一定参考依据。

关键词：香菇菌丝金属锌吸附金属硫蛋白

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