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COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Signal Transduction and Targeted Therapy 2020年第1期5卷 910-920页

作者： Wonhwa Lee June Hong Ahn Hee Ho Park Hong Nam Kim Hyelim Kim Youngbum Yoo Hyosoo Shin Kyung Soo Hong jong Geol jang Chun Gwon Park Eun Young Choi jong-Sup Bae Young-Kyo Seo Aging Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Republic of Korea Division of Pulmonology and Allergy Department of Internal MedicineCollege of MedicineYeungnam University and Regional Center for Respiratory DiseasesYeungnam University Medical CenterDaegu 42415Republic of Korea Department of Biotechnology and Bioengineering Kangwon National UniversityChuncheonGangwon-do 24341Republic of Korea Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Department of Biomedical Engineering SKKU Institute for ConvergenceSungkyunkwan University(SKKU)SuwonRepublic of Korea Biomedical Institute for Convergence at SKKU(BICS) Sungkyunkwan University2066 Seobu-roJangan-guSuwon 16419Republic of Korea College of Pharmacy CMRIResearch Institute of Pharmaceutical SciencesBK21 Plus KNU Multi-Omics based Creative Drug Research TeamKyungpook National UniversityDaegu 41566Republic of Korea

Sterol regulatory element binding protein-2(SREBP-2)is activated by cytokines or pathogen,such as virus or bacteria,but its association with diminished cholesterol levels in COVID-19 patients is ***,we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in ***,we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients’blood and propose SREBP-2 C-terminal fragment as an indicator for determining *** confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression,while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU *** an infectious disease mouse model,inhibitors of SREBP-2 and NF-κB suppressed cytokine storms caused by viral infection and prevented pulmonary *** results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients.

关键词： cytokine diagnosis damage

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Shape Optimization of a Regenerative Blower Used for Building Fuel Cell System

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Open Journal of Fluid Dynamics 2012年第4期2卷 208-214页

作者： Choon-Man jang jong-Sung Lee Environmental Engineering Research Division Korea Institute of Construction Technology Goyang-Si Korea

This paper describes the optimal design of a Cathode blower used for a building fuel cell system. The Cathode air blower has a regenerative blower type. Two design variables, extension angle and number of impeller blade are introduced to enhance the blower performance. Pressure and efficiency of the blower are selected as an object function, and the optimal design is performed by a response surface method. Three-dimensional Navier-Stokes equations are introduced to analyze the performance and internal flow of the blower and to find the value of object function for the training data. Throughout the design optimization, it is found that an extension angle is effective to increase blower efficiency in the blower. The pressure rise for the optimal blower is successfully increased up to 3.17% compared with that of reference one at the design flow rate. It is noted that low velocity region disturbs to make strong recirculation flow in the each blade passage, thus increases local pressure loss. Detailed flow field inside a regenerative blower is also analyzed and compared.

关键词： Regenerative Blower Optimization Response Surface Method Efficiency Pressure

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Performance of Block Space-Time Code in Wireless Channel Dynamics

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International Journal of Communications, Network and System Sciences 2009年第6期2卷 461-468页

作者： Won Mee jang jong Hak JUNG 不详

In this work, we observe the behavior of block space-time code in wireless channel dynamics. The block space-time code is optimally constructed in slow fading. The block code in quasistatic fading channels provides affordable complexity in design and construction. Our results show that the performance of the block space-time code may not be as good as conventionally convolutional coding with serial transmission for some channel features. As channel approaches fast fading, a coded single antenna scheme can collect as much diversity as desired by correctly choosing the free distance of code. The results also point to the need for robust space-time code in dynamic wireless fading channels. We expect that self-encoded spread spec-trum with block space-time code will provide a robust performance in dynamic wireless fading channels.

关键词： Space-Time Codes Diversity Multiple Transmit Antennas Self-Encoded Spread Spectrum

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Recent advances in electronic devices for monitoring and modulation of brain

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Nano Research 2021年第9期14卷 3070-3095页

作者： Yong Won Kwon Yoon Sun Jun Young-Geun Park Jiuk jang jang-Ung Park Nano Science Technology Institute Department of Materials Science and EngineeringYonsei UniversitySeoul 03722Republic of Korea Center for Nanomedicine Institute for Basic Science(IBS)Seoul 03722Republic of Korea Graduate Program of Nano Biomedical Engineering(NanoBME) Advanced Science InstituteYonsei UniversitySeoul 03722Republic of Korea

The brain is actuated by billions of neurons with trillions of interconnections that regulate human *** the mechanisms of these systems that induce sensory reactions and respond to disease remains one of the greatest challenges in science,engineering,and *** advances in nanomaterials and nanotechnologies have led to the extensive research of electronic devices for brain interfaces to better understand the neural activities of the brains complex nervous *** development of sensor devices for monitoring the physiological signals of the brain related to traumatic injury status has accompanied by the progress of electronic neural probes in *** addition,these neurological and stereotactic surgical revolutions hold immense potential for clinical analysis of pharmacological systems within cerebral ***,we review the progress of electronic devices interfacing with brain in terms of the materials,fabrication technologies,and device *** activity can be measured and modulated by brain probes based on newly developed nanofabrication ***,in vivo pathological monitoring of the brain and pharmacological assessment has been developed in miniaturized and wireless *** also consider the key challenges and prospects for further development,and explore the future directions emerging in the latest research.

关键词： neural interfaces neural recording neuromodulation intracranial pressure monitoring microfluidic drug delivery

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Construction of tantalum/poly(ether imide)coatings on magnesium implants with both corrosion protection and osseointegration properties

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Bioactive Materials 2021年第4期6卷 1189-1200页

作者： Kwang-Hee Cheon Cheonil Park Min-Ho Kang In-Gu Kang Min-Kyu Lee Hyun Lee Hyoun-Ee Kim Hyun-Do Jung Tae-sik jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Biomedical-Chemical Engineering Catholic University of KoreaBucheonGyeonggi-doRepublic of Korea Institute of Health Science Research Korea UniversitySeoul02841Republic of Korea Department of Materials Science and Engineering Chosun UniversityGwangjuRepublic of Korea

Poly(ether imide)(PEI)has shown satisfactory corrosion protection capability with good adhesion strength as a coating for magnesium(Mg),a potential candidate of biodegradable orthopedic implant ***,its innate hydrophobic property causes insufficient osteoblast affinity and a lack of ***,we modify the physical and chemical properties of a PEI-coated Mg implant.A plasma immersion ion implantation technique is combined with direct current(DC)magnetron sputtering to introduce biologically compatible tantalum(Ta)onto the surface of the PEI *** PEI-coating layer is not damaged during this process owing to the extremely short processing time(30 s),retaining its high corrosion protection property and adhesion *** Ta-implanted layer(roughly 10-nm-thick)on the topmost PEI surface generates long-term surface hydrophilicity and favorable surface conditions for pre-osteoblasts to adhere,proliferate,and ***,in a rabbit femur study,the Ta/PEI-coated Mg implant demonstrates significantly enhanced bone tissue affinity and osseointegration *** results indicate that Ta/PEI-coated Mg is promising for achieving early mechanical fixation and long-term success in biodegradable orthopedic implant applications.

关键词： Magnesium Tantalum Poly(ether imide) Bio-functionalized coating Biodegradable orthopedic implants

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A case of rapidly progressing leiomyosarcoma combined with squamous cell carcinoma in the esophagus

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World Journal of Gastroenterology 2013年第32期19卷 5385-5388页

作者： Su Sun jang Woo Tae Kim Bong Suk Ko Eun Hae Kim jong Ok Kim Kuhn Park Seung Woo Lee Division of Gastroenterology Department of Internal MedicineDaejeon St. Mary’s HospitalCatholic University of Korea Department of Pathology Catholic University of KoreaDaejeon St. Mary’s Hospital Department of Thoracic and Cardiovascular Surgery Catholic University of KoreaDaejeon St. Mary’s Hospital

Esophageal leiomyosarcoma is a rare tumor that accounts for less than 1%of all malignant esophageal *** leiomyosarcoma combined with squamous cell carcinoma is even rarer than solitary *** experienced a case of leiomy... 详细信息

关键词： Leiomyosarcoma Carcinoma Squamous cell Esophagus Sarcoma

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A Note on the Universal Factorization Property of Groups

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Algebra Colloquium 2021年第4期28卷 635-644页

作者： Injo Hur jang Hyun Jo Department of Mathematics Education Chonnam National University Gwangju 61186Korea Department of Mathematics Sogang UniversitySeoul 04107Korea

We give criteria when a full subcategory D of the category of groups has C-universal factorization property(C-UFP)or C-strong universal factorization property(C-SUFP)for a certain category of groups *** a byproduct,we give affirmative answers to three unsettled questions in[***,***,Universal factorization property of certain polycyclic groups,*** *** 204(2006)555-567].

关键词： hereditary productive universal factorization property

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Utilizing hybrid faradaic mechanism via catalytic and surface interactions for high-performance flexible energy storage system

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Journal of Energy Chemistry 2023年第8期83卷 541-548,I0013页

作者： Dong-Gyu Lee Hyeonggeun Choi Yeonsu Park Min-Cheol Kim jong Bae Park Suok Lee Younghyun Cho Wook Ahn A-Rang jang Jung Inn Sohn John Hong Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Republic of Korea Division of Physics and Semiconductor Science Dongguk University-SeoulSeoul 04620Republic of Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Republic of Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Republic of Korea School of Materials Science and Engineering Kookmin UniversitySeoul 02707Republic of Korea

Improving the capacitance and energy density is a significant challenge while developing practical and flexible energy storage system(ESS).Redox mediators(RMs),as redox-active electrolyte additives,can provide additional energy storing capability via electrochemical faradaic contribution on electrodes for high-performance flexible ***,determining effective material combinations between electrodes and RMs is essential for maximizing surface faradaic redox reactions for energy-storage *** this study,an electrode-RM system comprising heterostructured hybrid(carbon fiber(CF)/MnO_(2)) faradaic electrodes and iodine RMs(I-RMs) in a redox-active electrolyte is *** CF/MnO_(2)with the 1-RMs(CF/MnO_(2)-I) induces dominant catalytic faradaic interaction with the I-RMs,significantly enhancing the surface faradaic kinetics and increasing the overall energy-storage *** CF/MnO_(2)-I ESSs show a 12.6-fold(or higher) increased volumetric energy density of 793.81 mWh L^(-1)at a current of 10 μA relative to ESSs using CF/MnO_(2)without I-RMs(CF/MnO_(2)).Moreover,the CF/MnO_(2)-I retains 93.1% of its initial capacitance after 10,000 cycles,validating the excellent ***,the flexibility of the ESSs is tested at different bending angles(180° to 0°),demonstrating its feasibility for flexible and high-wear ***,CF/MnO_(2)electrodes present a practical material combination for high-performance flexible energy-storage devices owing to the catalytic faradaic interaction with I-RMs.

关键词： Energy storage system Redox mediators Faradaic electrodes Catalytic interactions Mechanical stability

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Preparation and investigation of Pd doped Cu catalysts for selective hydrogenation of acetylene

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Frontiers of Chemical Science and Engineering 2020年第4期14卷 522-533页

作者： Xinxiang Cao Tengteng Lyu Wentao Xie Arash Mirjalili Adelaide Bradicich Ricky Huitema Ben W.-L.jang jong K.Keum Karren More Changjun Liu Xiaoliang Yan Department of Chemistry Texas A&M University-CommerceCommerceTX 75429-3011.USA Laboratory for Development&Application of Cold Plasma Technology College of Chemistry and Chemical EngineeringLuoyang Normnal UniversityLuoyang 471022China Collaborative Innovation Center of Chemical Science and Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Center for Nanophase Materials Sciences and Chemical Science Division Oak Ridge National LaboratoryOak RidgeTN 37831USA College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China

A series of PdCu bimetallic catalysts with low Cu and Pd loadings and different Cu:Pd atomic ratios were prepared by conventionally sequential impregnation(CSD)and modified sequential impregnation(MSI)of Cu and Pd for selective hydrogenation of *** indicates that the supported copper(I)nitrate in the PdCu bimetallic catalysts prepared by MSI can be directly reduced to Cu metal particles due to the hydrogen spillover from Pd to Cu(NO3)2 *** addition,for the catalysts prepared by MSI,Pd atoms can form PdCu alloy on the surface of metal particles,however,for the catalysts prepared by CSI,Pd tends to migrate and exist below the surface layer of *** results indicate that compared with CSI,the MSI method enables samples to possess preferable stability as well as comparable reaction *** should be due to the MSI method in favor of the formation of PdCu alloy on the surface of metal ***,even Pd loading is super low,<0.045 wt-%in this study,by through adjusting Cu loading to an appropriate value,attractive reactivity and selectivity still can be achieved.

关键词： copper palladium catalysts acetylene selec-tive hydrogenation

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Thermal Conductivity Measurement of Zr-ZrO<sub>2</sub>Simulated Inert Matrix Nuclear Fuel Pellet

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World Journal of Nuclear Science and Technology 2013年第2期3卷 46-50页

作者： Dong-Joo Kim Young Woo Rhee jong Hun Kim jang Soo Oh Keon sik Kim Jae Ho Yang LWR Fuel Technology Division Korea Atomic Energy Research Institute Daejeon South Korea

For an evaluation of a thermal conductivity of Zr + 30 vol% ZrO2 simulated inert matrix nuclear fuel pellet, a simulated fuel pellet was fabricated using a hot-pressing method at 800°C in a vacuum and at a 20 MPa load. And several thermophysical properties of the simulated inert matrix fuel pellet were measured and calculated. The thermal diffusivity and linear thermal expansion as a function of temperature of the simulated fuel pellet were measured using a laser flash method and a dilatometry, respectively. Finally, based on the experimental data, the thermal conductivity of the simulated inert matrix fuel pellet was calculated and evaluated.

关键词： Inert Matrix Nuclear Fuel Dispersion Fuel Thermal Conductivity Thermal Expansion Specific Heat

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