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High scored thyroid storm after stomach cancer perforation: A case report

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World Journal of Clinical Cases 2022年第24期10卷 8768-8774页

作者： Seung Min baik Yejune Pae Jae-Myeong Lee Department of Surgery Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoul 07985South Korea Department of Surgery College of MedicineGraduate School of Korea UniversitySeoul 02841South Korea Department of Acute Care Surgery Korea University Anam HospitalSeoul 02841South Korea

BACKGROUND Thyroid storm is a life-threatening ***,the prevalence of thyroid storm is 1%-2%among patients admitted to the hospital for *** and Wartofsky(1993)introduced a scoring system using precise clinical criteria to identify thyroid *** 17 cases of thyroid storm with a score>70 points have been *** thyroid storms are uncommon,their clinical findings resemble those of *** SUMMARY A 48-year-old man was referred to the emergency room from a local clinic owing to suspicion of gastric ulcer perforation;medications for hypertension,diabetes mellitus,and hyperthyroidism had been suspended 1 year prior to this *** performed an emergency distal gastrectomy with Billroth II anastomosis for gastric cardia cancer perforation,and the patient was referred to the surgical intensive care unit(ICU).On the 2nd d in the ICU,his body temperature(BT)increased to 41.3℃ at 19:00,with the thyroid storm score(90 points)peaking at 18:00(BT;41.2℃,pulse rate;138/min,irritable status).The patient was administered propylthiouracil,intravenous glucocorticoids,acetaminophen,and Lugol’s solution ***,we performed bladder irrigation with cold saline using a Foley catheter and applied a hypothermic blanket to decrease the patient's *** vital signs were stable on the 8th day in the *** Thyroid storms are uncommon,with few reports in the literature;however,their clinical findings resemble those of sepsis and require further *** an untreated thyroid storm results in a high mortality rate,it should be investigated when managing sepsis.

关键词： Thyroid storm Stomach cancer Severity score Sepsis Case report

Alcoholic liver disease: Treatment

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World Journal of Gastroenterology 2014年第36期20卷 12934-12944页

作者： Ki Tae Suk Moon Young Kim Soon Koo baik Department of Internal Medicine Hallym University College of Medicine Chuncheon 200-704 South Korea Department of Internal Medicine Wonju College of Medicine Wonju Severance Christian Hospital Yonsei University Wonju 220-701 South Korea

The excess consumption of alcohol is associated with alcoholic liver diseases(ALD). ALD is a major healthcare problem, personal and social burden, and significant reason for economic loss worldwide. The ALD spectrum includes alcoholic fatty liver, alcoholic hepatitis, cirrhosis, and the development of hepatocellular carcinoma. The diagnosis of ALD is based on a combination of clinical features, including a history of significant alcohol intake, evidence of liver disease, and laboratory findings. Abstinence is the most important treatment for ALD and the treatment plan varies according to the stage of the disease. Various treatments including abstinence, nutritional therapy, pharmacological therapy, psychotherapy, and surgery are currently available. For severe alcoholic hepatitis, corticosteroid or pentoxifylline are recommended based on the guidelines. In addition, new therapeutic targets are being under investigation.

关键词： Liver disease Alcoholic Treatment

Oxygen insufflation via working channel in a fiberscope is a useful method: A case report and review of literature

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World Journal of Clinical Cases 2018年第16期6卷 1194-1198页

作者： Dowon Lee Jiseok baik Giyoung Yun Eunsoo Kim Department of Anesthesia and Pain Medicine School of Medicine Pusan National University Biomedical Research Institute Pusan National University Hospital

BACKGROUND Fiberoptic bronchoscopic intubation is the gold standard for endotracheal intubation in difficult or compromised airway situations. However, oxygen insufflation through the working channel of a fiberscope is a controversial method because of the possibility of gastric distention and rupture during an awake fiberoptic bronchoscopic intubation, despite the advantages of preventing fogging of the fiberoptic bronchoscopic lens, blowing oral secretions away, and oxygenation of *** SUMMARY Here, we describe a case of cervical instability where we rapidly performed fiberoptic bronchoscopic intubation using oxygen insufflation through working channel of the broncoscopy to administer general anesthesia after two previous failures due to low visibility. A 50-year-old man with a non-specific medical history underwent emergency cervical spine surgery for posterior fusion of the C2 and C3 vertebrae. After two unsuccessful attempts at intubation using the fiberoptic broncoscopy, we performed it successfully using the oxygen insufflation via the working channel, instead of using suction to remove the secretion from the *** Oxygen insufflation via the working channel of thebroncoscopy is a useful method for assisting with difficult intubation cases.

关键词： Fiberscope Fiberoptic intubation Oxygen insufflation Difficulty airway Cervical instability Case report

Invasive and non-invasive diagnosis of cirrhosis and portal hypertension

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World Journal of Gastroenterology 2014年第15期20卷 4300-4315页

作者： Moon Young Kim Woo Kyoung Jeong Soon Koo baik Department of Internal Medicine Yonsei University Wonju College of MedcineWonju Severance Christan HospitalWonju 220-701South Korea Department of Radiology and Center for Imaging Science Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 440-746South Korea

With advances in the management and treatment of advanced liver disease,including the use of antiviral therapy,a simple,one stage description for advanced fibrotic liver disease has become *** refining the diagnosis of cirrhosis to reflect disease heterogeneity is essential,current diagnostic tests have not kept pace with the progression of this new *** biopsy and hepatic venous pressure gradient measurement are the gold standards for the estimation of hepatic fibrosis and portal hypertension(PHT),respectively,and they have diagnostic and prognostic ***,they are invasive and,as such,cannot be used repeatedly in clinical *** ideal noninvasive test should be safe,easy to perform,inexpensive,reproducible as well as to give numerical and accurate results in real *** should be predictive of long term outcomes related with fibrosis and PHT to allow prognostic ***,many types of noninvasive alternative tests have been developed and are under *** particular,imaging and ultrasound based tests,such as transient elastography,have shown promising *** most of these noninvasive tests effectively identify severe fibrosis and PHT,the methods available for diagnosing moderate disease status are still insufficient,and further investigation is essential to predict outcomes and individualize therapy in this field.

关键词： Hepatic fibrosis Portal hypertension Liver biopsy Hepatic venous pressure gradient Non-invasive test Transient elastography

Flexible thermocouple using a thermoelectric graphene fiber with a seamless junction

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Journal of Materials Science & Technology 2024年第5期172卷 15-22页

作者： Seungwon Kim Soomook Lim Myeong Hee Jeong Wonjoon Kim Seunghyun baik Ji Won Suk School of Mechanical Engineering Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea Department of Smart Fab.Technology Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan UniversitySuwonGyeonggi-do 16419Republic of Korea

Temperature is an important physical variable that indicates the condition of the human body and artificial *** wearable applications require the development of temperature sensors with different form *** this study,a fiber-shaped thermoelectric temperature sensor is fabricated using a continuous graphene fiber whose two halves possess different reduction states.A seamless junction is formed by partially reducing a wet-spun graphene oxide fiber with hydroiodic acid(HI)solutions of different ***-half of the fiber is mildly reduced with 0.97 wt%HI,while the other half is highly reduced with 30.6 wt%*** different reduction states of the graphene composite fiber result in different Seebeck coefficients,allowing for the fabrication of a fiber-shaped graphene thermocou-ple without any laborious *** flexible graphene thermocouple exhibits high sensitivity with a thermopower of 12.5μV K^(-1)in the temperature range of room temperature to∼70℃.Furthermore,it exhibits high linearity with a correlation coefficient exceeding 0.995 and fast response with a time constant of 0.24 *** to its mechanical robustness and flexibility,the stand-alone graphene ther-mocouple can be knitted into a cotton fabric glove,which presents a fast response to environmental changes without any external power *** work offers a unique fabrication method for producing a high-performance,flexible thermocouple that features a seamless and clear junction without the use of additional *** alternative method eliminates the complicated assembly processes typically required for conventional thermocouples.

关键词： Graphene fiber Thermocouple Reduced graphene oxide Flexible temperature sensor Seebeck coefficient

Switching-on of serotonergic calcium signaling in activated hepatic stellate cells

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World Journal of Gastroenterology 2011年第2期17卷 164-173页

作者： Kyu-Sang Park Pyo-jin Sin Dong Hyeon Lee Seung-Kuy Cha Min-Jeong Kim Na-Hyun Kim Soon-Koo baik Seong-Woo Jeong In Deok Kong Department of Physiology and Institute of Lifelong Health Yonsei University Wonju College of Medicine Department of Physiology College of MedicinePochon CHA University Department of Basic Nursing Science Keimyung University College of Nursing Department of Internal Medicine Yonsei University Wonju College of Medicine

AIM:To investigate serotonergic Ca 2+ signaling and the expression of 5-hydroxytryptamine(5-HT) receptors,as well as Ca 2+ transporting proteins,in hepatic stellate cells(HSCs) . METHODS:The intracellular Ca 2+ concentration([Ca 2+ ]i) of isolated rat HSCs was measured with a fluorescence microscopic imaging *** PCR was per-formed to determine the transcriptional levels of 5-HT receptors and endoplasmic reticulum(ER) proteins involved in Ca 2+ storage and release in cultured rat HSCs. RESULTS:Distinct from quiescent cells,activated HSCs exhibited[Ca 2+ ]i transients following treatment with 5-HT,which was abolished by U-73122,a phospholipase C *** of 5-HT2A and 5-HT2B receptors,but not 5-HT3,was prominent during trans-differentiation of *** with ritanserin,a 5-HT2 antagonist,inhibited[Ca 2+ ]i changes upon application of *** of type 1 inositol-5'-triphosphate receptor and type 2 sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase were also increased during activation of HSCs and serve as the major isotypes for ER Ca 2+ storage and release in activated *** 2+ binding chaperone proteins of the ER,including calreticulin,calnexin and calsequestrin,were up-regulated following activation of HSCs. CONCLUSION:The appearance of 5-HT-induced[Ca 2+ ]i response accompanied by upregulation of metabotropic 5-HT2 receptors and Ca 2+ transporting/chaperone ER proteins may participate in the activating process of HSCs.

关键词： Hepatic stellate cells 5-hydroxytryptamine Intracellular Ca 2+ transient Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase Inositol-5’-triphosphate receptor Endoplasmic reticulum chaperone

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World Journal of Gastroenterology 2023年第14期29卷 2127-2133页

作者： Sujani Yadlapati Simone A.Jarrett Daniel baik Adib Chaaya Department of Gastroenterology Cooper University HospitalCooper Medical School of Rowan UniversityCamdenNJ 08103United States Department of Internal Medicine Einstein Medical CenterSidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPA 19140United States

Since its emergence in 2019,it has become apparent that coronavirus 2019(COVID-19)infection can result in multi systemic *** addition to pulmonary symptoms,hepatobiliary involvement has been widely *** of hepatic involvement ranges from minor elevation in liver function tests(LFTs)to significant hepatocellular or cholestatic *** majority of cases,resolution of hepatic injury or improvement in LFTs is noted as patients recover from COVID-19 ***,severe biliary tract injury progressing to liver failure has been reported in patients requiring prolonged intensive care unit stay or mechanical *** to the timing of its presentation,this form of progressive cholestatic injury has been referred to as COVID-19 cholangiopathy or post-COVID-19 cholangiopathy,and can result in devastating consequences for ***-19 cholangiopathy is recognized by dramatic elevation in serum alkaline phosphatase and bilirubin and radiologic evidence of bile duct *** in COVID-19 occurs weeks to months after the initial infection and during the recovery *** findings and pathology often resemble bile duct injury associated with primary or secondary sclerosing *** of COVID-19 cholangiopathy is *** mechanisms have been proposed,including direct cholangiocyte injury,vascular compromise,and cytokine release *** review summarizes existing data on COVID-19 cholangiopathy,including reported cases in the literature,proposed pathophysiology,diagnostic testing,and long-term implications.

关键词： COVID-19 cholangiopathy Post COVID-19 cholangiopathy Cholestatic injury Liver transplant

Controllable substitutional vanadium doping in wafer-scale molybdenum disulfide films

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Nano Research 2023年第2期16卷 3415-3421页

作者： Jihyung Seo Eunbin Son Jiha Kim Sun-Woo Kim Jeong Min baik Hyesung Park Department of Materials Science and Engineering Graduate School of Semiconductor Materials and Devices EngineeringGraduate School of Carbon NeutralityLow Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea SKKU Institute of Energy Science and Technology Sungkyunkwan UniversitySuwon 16419Republic of Korea

Substitutional atomic doping of transition metal dichalcogenides(TMDs)in the chemical vapor deposition(CVD)process is a promising and effective strategy for modifying their physicochemical ***,the conventional CVD method only allows narrow-range modulation of the dopant concentration owing to the low reactivity of the ***,the growth of wafer-scale monolayer TMD films with high dopant concentrations is much more ***,we report a facile doping approach based on liquid precursor-mediated CVD process for achieving high vanadium(V)doping in the MoS_(2)lattice with excellent doping uniformity and *** lateral growth of the host MoS_(2)lattice and the reactivity of the V precursor were simultaneously improved by introducing an alkali metal halide as a reaction *** metal halide promoter enabled the wafer-scale synthesis of V-incorporated MoS_(2)monolayer film with excessively high doping *** excellent wafer-scale uniformity of the highly V-doped MoS_(2)film was confirmed through a series of microscopic,spectroscopic,and electrical analyses.

关键词： doping concentration reaction promoter substitutional doping transition metal dichalcogenides wafer-scale growth

Quality of healing of gastric ulcers: Natural products beyond acid suppression

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World Journal of Gastrointestinal Pathophysiology 2014年第1期5卷 40-47页

作者： Napapan Kangwan jong-Min Park Eun-Hee Kim Ki baik Hahm CHA Cancer Prevention Research Center CHA Cancer InstituteCHA University College of Pharmacy CHA University Department of Gastroenterology CHA University Bundang Medical Center

Gastric ulcer is a chronic disease featured with unexpected complications, including bleeding, stenosis and perforation, as well as a high incidence of recurrence. Clinical treatments for gastric ulcer have allowed the rapid development of potent anti-ulcer drugs during the last several decades. Gastric ulcer healing is successful with conventional treatments including H2-receptor antagonists, and proton pump inhibitors(PPIs) have been essential for ulcer healing and prevention of complications. Additionally, Helicobacter pylori eradication therapy is effective in reducing ulcer recurrence and leads to physiological changes in the gastric mucosa which affect the ulcer healing process. However, in spite of these advancements, some patients have suf-fered from recurrence or intractability in spite of continuous anti-ulcer therapy. A new concept of the quality of ulcer healing(QOUH) was initiated that considers the reconstruction of the mucosal structure and its function for preventing ulcer recurrence. Although several gastroprotection provided these achievements of the QOUH, which PPI or other acid suppressants did not accomplish, we found that gastroprotection that originated from natural products, such as a newer formulation from either Artemisia or S-allyl cysteine from garlic, were very effective in the QOUH, as well as improving clinical symptoms with fewer side effects. In this review, we will introduce the importance of the QOUH in ulcer healing and the achievements from natural products.

关键词： Quality of ulcer healing Natural products Gastric ulcers Acid suppression S-allyl cysteine Artemisia isopropanol extract