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Distant skeletal muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome

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World Journal of Gastroenterology 2007年第22期13卷 3141-3143页

作者： Oh Sung Kwon Dae Won Jun Sang Heum Kim Mee Yeon Chung Nam In Kim Moon Hee Song Han Hyo Lee Seung Hwan Kim Yoon Ju Jo Young Sook Park jong eun joo Department of Internal Medicine Eulji University Hospital Seoul Korea Department of Radiology Eulji University Hospital Seoul Korea Department of Pathology Eulji University Hospital Seoul Korea

Intrahepatic cholangiocarcinoma is a malignant neoplasm arising from the biliary epithelium, which frequently invades adjacent organs or metastasizes to other visceral organs such as the lungs, bones, adrenals, and brain. However, distant skeletal muscle metastasis of cholangiocarcinoma has never been described before to the best of our knowledge and, furthermore, Budd-Chiari syndrome secondary to intrahepatic cholangiocarcinoma is also extremely rare. Here we present the first case overall of distant muscle metastasis from intrahepatic cholangiocarcinoma presenting as Budd-Chiari syndrome. A 44-year-old man admitted to the hospital with complaints of abdominal distension, edema of both legs, back pain and anorexia of 30 d' duration. Computed tomography and ultrasonography-guided percutaneous muscle biopsy established intrahepatic cholangiocarcinoma with disseminated thrombosis from inferior vena cava to bilateral iliac and femoral veins, and multiple skeletal muscle metastases in bilateral buttock and erector spinal muscle.

关键词： Intrahepatic Cholangiocarcinoma Metastasis Skeletal muscle Budd-Chiari syndrome

Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

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World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang eunsil Yu eun Sun Jung Mee Soo Chang jong eun joo Mee joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词： Intraepithelial neoplasia Stomach Dysplasia Adenoma Carcinoma Japanese Western Consensus Vienna

Role of GABA plasticity in stroke recovery

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Neural Regeneration Research 2014年第23期9卷 2026-2028页

作者： Nam-jong Paik eun joo Yang Department of Rehabilitation Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital

Stroke is a leading cause of long-term disability. Most stroke patients regain their function partially or fully during the first 3-6 months depending on location and size of the lesion. During this functional recovery phase, cortical reorganization or plasticity occurs, and physiological responsiveness or neuronal excitability is altered in the ipsilesional and contralesional areas. However, how to drive successful plastic changes or successful stroke recovery are not fully elucidated yet.

关键词： GABA Role of GABA plasticity in stroke recovery

Robust and Reusable Fuzzy Extractors from Non-Uniform Learning with Errors Problem

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Computers, Materials & Continua 2023年第1期74卷 1985-2003页

作者： joo Woo jonghyun Kim jong Hwan Park Graduate School of Information Security Korea UniversitySeoul02841Korea Department of Computer Science Sangmyung UniversitySeoul03016Korea

Afuzzy extractor can extract an almost uniformrandom string from a noisy source with enough entropy such as biometric *** reproduce an identical key from repeated readings of biometric data,the fuzzy extractor generates a helper data and a random string from biometric data and uses the helper data to reproduce the random string from the second *** 2013,Fuller et *** a computational fuzzy extractor based on the learning with errors *** construction,however,can tolerate a sub-linear fraction of errors and has an inefficient decoding algorithm,which causes the reproducing time to increase *** 2016,Canetti et *** a fuzzy extractor with inputs from low-entropy distributions based on a strong primitive,which is called digital ***,their construction necessitates an excessive amount of storage space for the helper data,which is stored in authentication *** on these observations,we propose a new efficient computational fuzzy extractorwith small size of helper *** scheme supports reusability and robustness,which are security notions that must be satisfied in order to use a fuzzy extractor as a secure authentication method in real ***,it conceals no information about the biometric data and thanks to the new decoding algorithm can tolerate linear *** on the non-uniform learning with errors problem,we present a formal security proof for the proposed fuzzy ***,we analyze the performance of our fuzzy extractor scheme and provide parameter sets that meet the security *** a result of our implementation and analysis,we show that our scheme outperforms previous fuzzy extractor schemes in terms of the efficiency of the generation and reproduction algorithms,as well as the size of helper data.

关键词： Fuzzy extractor reusability robustness biometric authentication non-uniform learning with errors

Development of 3D bicontinuous metal-intermetallic composites through subsequent alloying process after liquid metal dealloying

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Journal of Magnesium and Alloys 2023年第11期11卷 4274-4281页

作者： Jee eun Jang Jihye Seong Soo-Hyun joo Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering Dankook UniversityCheonan 31116Republic of Korea

This study presents a novel process for the fabrication of metal-intermetallic composites with a 3D bicontinuous structure, achieved through a combination of liquid metal dealloying(LMD) and subsequent alloying. Initially, porous Ti structures are produced using the LMD process, followed by immersion in a molten Mg-3Al(wt%) metal. Due to the higher thermodynamic miscibility of Al with Ti compared to Mg, the concentration of Al in the Ti matrix increases as the immersion time increases. This results in a sequential phase transition within the Ti matrix: α-Ti → Ti_(3)Al → Ti Al. The phase transition considerably affects the hardness and strength of the composite material,with the Mg-Ti_(3)Al-Ti Al composite exhibiting a maximum hardness nearly twice as high as that of the conventional Mg-Ti composite. This innovative process holds potential for the development of various bicontinuous metal-intermetallic composites.

关键词： Liquid metal dealloying Subsequent alloying Metal–intermetallic composite 3D bicontinuous structure Hardness

Effects of tissue-cultured mountain ginseng （Panax ginseng CA Meyer） extract on male patients with erectile dysfunction

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Asian Journal of Andrology 2009年第3期11卷 356-361页

作者： Tae-Hwan Kim Seung Hyun Jeon eun-joo Hahn Kee-Yoeup Paek jong Kwan Park Nae Young Youn Hyung-Lae Lee Department of Urology School of Medicine Kyung Hee University Seoul 134-727 Korea Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-711 Korea Department of Urology Chonbuk National University Medical School Jeonju 561-712 Korea Infertility Clinic Sanbornjeil Women＇s Hospital Kunpo 435-042 Korea

Korean ginseng and mountain ginseng （Panax ginseng CA Meyer） are important traditional herbal plants whose ginsenosides are generally accepted as serving to improve sexual functions, such as penile erection. We investigated the effects of tissue-cultured mountain ginseng extract （TMGE） on male patients with erectile dysfunction （ED）. A double-blind, placebo-controlled study was conducted with 143 patients experiencing ED. Over the course of 8 weeks, one group took 1 000 mg of TMGE twice a day, and the other group took 1 000 mg of placebo twice a day. The effects of the TMGE and the placebo were analyzed using the Korean version of the International Index of Erectile Function （IIEF） questionnaire. A total of 86 patients completed 8 weeks of treatment. The scores on the five domains of the IIEF after medication were significantly higher than the baseline scores in the group treated with TMGE （P 〈 0.05）, whereas no significant improvement was observed in the placebo group （P 〉 0.05）. Erectile function and overall satisfaction scores after medication were significantly higher in the TMGE group than in the placebo group （P 〈 0.05）. Erectile function of patients in the TMGE-treated group significantly improved, suggesting that TMGE could be utilized for improving erectile function in male patients.

关键词： erectile dysfunction Panax ginseng tissue-cultured mountain ginseng extract

Managing Traumatic Stress Using a Mental Health Care Mobile App: A Pilot Study

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International Journal of Mental Health Promotion 2021年第3期23卷 385-393页

作者： Yun-Jung Choi eun-jung Ko eun-joo Choi Youn-joo Um Red Cross College of Nursing Chung-Ang UniversitySeoul156-756Korea Graduate School of Nursing Chung-Ang UniversitySeoul156-756Korea

This study aims to contribute to improving mental health services and establishing a direction for disaster survivors by verifying the effectiveness of the TLS(Training for Life Skills)app,a mental health management mobile ***,22 disaster survivors received access to the app(with guidance)for eight weeks;we analyzed its effectiveness by examining each participant’s electroencephalography data,which were collected while they were utilizing the *** results of this study show that the use of the TLS app had a significant positive effect on emotional quotient,basic rhythm quotient(left brain,right brain),alpha blocking rate(left brain,right brain),and brain quotient of disaster *** TLS mobile app is expected to not only provide psychological first aid to disaster survivors but also to improve their life skills,which may allow them to gain information about their emotions;hence,it may provide the appropriate conditions needed to enable effective self-control and health management for disaster survivors.

关键词： Mobile applications trauma disasters mental health

Adventitious Roots and Secondary Metabolism

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生物工程学报 2008年第5期24卷 711-716页

作者： Hosakatte Niranjana Murthy eun joo Hahn Kee Yoeup Paek Research Center for the Development of Advanced Horticultural Technology Chungbuk National University Cheongju 361-763 South Korea Department of Botany Karnatak University Dharwad 580003 India

Plants are a rich source of valuable secondary metabolites and in the recent years plant cell, tissue and organ cultures have been developed as an important alternative sources for the production of these compounds. Adventitious roots have been successfully induced in many plant species and cultured for the production of high value secondary metabolites of pharmaceutical, nutraceutical and industrial importance. Adoption of elicitation methods have shown improved synthesis of secondary metabolites in adventitious root cultures. Development of large-scale culture methods using bioreactors has opened up feasibilities of production of secondary metabolites at the industrial levels. In the present review we summarize the progress made in recent past in the area of adventitious root cultures for the production of secondary metabolites.

关键词：次生代谢植物细胞基因

Is a split-dose regimen of 2 L polyethylene glycol plus ascorbic acid tolerable for colonoscopy in an early morning visit to a comprehensive medical check-up?

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World Journal of Gastroenterology 2017年第6期23卷 1030-1037页

作者： Ji Yeon Seo Changhyun Lee eun Hyo Jin Mi Hyun Yun joo Hyun Lim Hae Yeon Kang jong In Yang Su Jin Chung Sun Young Yang joo Sung Kim Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University Hospital Department of Nursing Healthcare System Gangnam CenterSeoul National University Hospital

To evaluate the effectiveness and tolerability of a split-dose 2 L polyethylene glycol (PEG)/ascorbic acid (AA) regimen for healthy examinees who visited for comprehensive medical check-up in the early *** February 2015 to March 2015, examinees of average risk who were scheduled for a colonoscopy in the morning were retrospectively *** 189 examinees were divided into split-dose and non-split-dose groups. The adequacy of bowel preparation for the split-dose group vs the non-split-dose group was 96.8% vs 85.2%, respectively, P < 0.001, and the compliance of the last meal restriction was 74.6% vs 58.2%, respectively, P < 0.001. The sleep disturbance (P < 0.001) was more prevalent in the split-dose group, however the willingness to repeat the same preparation method (P = 0.243) was not different in both groups. The split-dose regimen was the most important factor influencing adequate bowel preparation in multivariate analysis (HR = 10.89, 95%CI: 6.53-18.17, P < 0.001).CONCLUSIONA split-dose regimen of 2 L PEG/AA for an early morning colonoscopy was more effective and showed better compliance for diet restriction without any difference in satisfaction and discomfort. Introducing a split-dose regimen of 2 L PEG/AA to morning colonoscopy examinees is effective and tolerable in a comprehensive medical check-up setting.

关键词： Compliance Early morning colonoscopy Effectiveness Split-dose regimen Tolerability