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Efficacy and safety of newly developed cross-linked dextran gel injection for glans penis augmentation with a novel technique

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Asian Journal of Andrology 2018年第1期20卷 80-84页

作者： Dae Yul Yang Kyungtae Ko Seong Ho Lee Du Geon Moon jong wook kim Won Ki Lee Department of Urology College of Medicine Hallym University Chuncheon Korea Department of Urology College of Medicine Korea University Seoul Korea.

There is no safe and effective standard method for glans penis augmentation. Furthermore, there has been scant research on glans penis augmentation due to a poor understanding of glans anatomy, technical difficulty, and a lack of suitable substances for augmentation. Cross-linked dextran gel is a newly developed filler for soft-tissue augmentation. We evaluated the efficacy and safety of using a novel technique to inject cross-linked dextran gel for glans penis augmentation during a 24-week follow-up study. This prospective, single-arm, multicenter study enrolled twenty healthy adult men who underwent glans penis augmentation between June and August 2013. Cross-linked dextran gel was injected into the glans penis using a simple and easy technique. The sizes of the glans penis and individual satisfaction were assessed. Any adverse event was also reported. A total of 18 individuals were analyzed; two of them were lost to follow-up. The mean procedure time and injected volume were about 30 rain and 6.6 ＋- 0.9 ml, respectively. The mean surface areas of the glans at baseline and 24 weeks were 20.0 _＋ 3.5 cm2 and 33.6 -＋ 5.4 cm2, respectively, representing a mean increase of 68.7% _＋ 14.0% （P 〈 0.001）. Sixteen individuals （88.9%） were satisfied with the outcomes, and none were dissatisfied. There were no serious adverse events during the study. Cross-linked dextran gel injection for glans penis augmentation was easy and showed a significant augmentative effect on the glans penis, good durability, and was well tolerated without serious adverse events. Therefore, cross-linked dextran gel injection may be an effective, new technique for glans penis augmentation.

关键词： cosmetic technique dermal fillers dextran glans penis

Optimizing intrinsic cocatalyst activity and light absorption efficiency for efficient hydrogen evolution of 1D/2D ReS_(2)-CdS photocatalysts via control of ReS_(2)nanosheet layer growth

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Journal of Materials Science & Technology 2024年第1期168卷 103-113页

作者： Ghufran Aulia Bin Azizar jong wook Hong Department of Chemistry University of UlsanUlsan 44610Korea

The visible-light-driven hydrogen evolution is extremely important,but the poor charge transfer capa-bility,a sluggish evolution rate of hydrogen,and severe photo-corrosion make photocatalytic hydrogen evolution *** this study,we present 1D/2D ReS_(2)-CdS hybrid nanorods for photocatalytic hy-drogen evolution,comprised of a ReS_(2)nanosheet layer grown on CdS *** found that precise control of the contents of the ReS_(2)nanosheet layer allows for manipulating the electronic structure of Re in the ReS_(2)-CdS hybrid *** ReS_(2)-CdS hybrid nanorods with optimal ReS_(2)nanosheet layer content dramatically improve photocatalytic hydrogen evolution ***,photocatalytic hydro-gen evolution activity(64.93 mmol g^(−1)h^(−1))of ReS_(2)-CdS hybrid nanorods with ReS_(2)nanosheet layers(Re/Cd atomic ratio of 0.051)is approximately 136 times higher than that of pure CdS nanorods under visible light ***,intimated coupling of the ReS_(2)nanosheet layer with CdS nanorods reduced the surface trap-site of the CdS nanorods,resulting in enhanced photocatalytic *** de-tailed optical and electrical investigations demonstrate that the optimal ReS_(2)nanosheet layer contents in the ReS_(2)-CdS hybrid nanorods can provide improved charge transfer capability,catalytic activity,and light absorption *** study sheds light on the development of photocatalysts for highly efficient photocatalytic hydrogen evolution.

关键词： Photocatalyst Hydrogen evolution reaction ReS_(2)-CdS heterostructure Control of ReS_(2)nanosheet layer growth Optimization of cocatalyst activity and light absorption

Clinical course of ulcerative colitis patients who develop acute pancreatitis

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World Journal of Gastroenterology 2017年第19期23卷 3505-3512页

作者： jong wook kim Sung wook Hwang Sang Hyoung Park Tae Jun Song Myung-Hwan kim Ho-Su Lee Byong Duk Ye Dong-Hoon Yang Kyung-Jo kim Jeong-Sik Byeon Seung-Jae Myung Suk-Kyun Yang Department of Internal Medicine Inje University Ilsan Paik Hospital Department of Gastroenterology University of Ulsan College of MedicineAsan Medical Center Department of Biochemistry and Molecular Biology University of Ulsan College of Medicine

To investigate the clinical course of ulcerative colitis (UC) patients who develop acute *** analyzed 3307 UC patients from the inflammatory bowel disease registry at Asan Medical Center from June 1989 to May 2015. The clinical course of UC patients who developed acute pancreatitis was compared with that of non-pancreatitis UC *** 51 patients who developed acute pancreatitis, 13 (0.40%) had autoimmune, 10 (0.30%) had aminosalicylate-induced, and 13 (1.73%) had thiopurine-induced pancreatitis. All 13 patients with autoimmune pancreatitis (AIP) had type 2 AIP. Two (15.4%) patients had pre-existing AIP, and three (23.1%) patients developed AIP and UC simultaneously. Compared to non-pancreatitis patients, AIP patients had UC diagnosed at a significantly younger age (median, 22.9 years vs 36.4 years; P = 0.001). AIP and aminosalicylate-induced pancreatitis patients had more extensive UC compared to non-pancreatitis patients. All patients with pancreatitis recovered uneventfully, and there were no recurrences. Biologics were used more frequently in aminosalicylate- and thiopurine-induced pancreatitis patients compared to non-pancreatitis patients [adjusted OR (95%CI), 5.16 (1.42-18.67) and 6.90 (1.83-25.98), respectively]. Biologic utilization rate was similar among AIP and non-pancreatitis patients [OR (95%CI), 0.84 (0.11-6.66)]. Colectomy rates for autoimmune, aminosalicylate-induced, and thiopurine-induced pancreatitis, and for non-pancreatitis patients were 15.4% (2/13), 20% (2/10), 15.4% (2/13), and 7.3% (239/3256), respectively; the rates were not significantly different after adjusting for baseline disease *** patients show a non-significant increase in colectomy, after adjusting for baseline disease extent.

关键词： Ulcerative colitis Pancreatitis Autoimmune Colectomy Clinical course

Effects of mesenchymal stem cell on dopaminergic neurons,motor and memory functions in animal models of Parkinson's disease:a systematic review and meta-analysis

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Neural Regeneration Research 2024年第7期19卷 1584-1592页

作者： jong Mi Park Masoud Rahmati Sang Chul Lee Jae Il Shin Yong wook kim Department and Research Institute of Rehabilitation Medicine Yonsei University College of MedicineSeoulSouth Korea Department of Physical Education and Sport Sciences Faculty of Literature and Human SciencesLorestan UniversityKhoramabadIran Department of Pediatrics Yonsei University College of MedicineSeoulSouth Korea

Parkinson’s disease is chara cterized by the loss of dopaminergic neurons in the substantia nigra pars com pacta,and although restoring striatal dopamine levels may improve symptoms,no treatment can cure or reve rse the disease *** cell therapy has a regenerative effect and is being actively studied as a candidate for the treatment of Parkinson’s *** stem cells are considered a promising option due to fewer ethical concerns,a lower risk of immune rejection,and a lower risk of *** performed a meta-analysis to evaluate the therapeutic effects of mesenchymal stem cells and their derivatives on motor function,memory,and preservation of dopamine rgic neurons in a Parkinson’s disease animal *** searched bibliographic databases(PubMed/MEDLINE,Embase,CENTRAL,Scopus,and Web of Science)to identify articles and included only pee r-reviewed in vivo interve ntional animal studies published in any language through J une 28,*** study utilized the random-effect model to estimate the 95%confidence intervals(CI)of the standard mean differences(SMD)between the treatment and control *** use the systematic review center for laboratory animal expe rimentation’s risk of bias tool and the collaborative approach to meta-analysis and review of animal studies checklist for study quality assessment.A total of 33studies with data from 840 Parkinson’s disease model animals were included in the *** with mesenchymal stem cells significantly improved motor function as assessed by the amphetamine-induced rotational *** the stem cell types,the bone marrow MSCs with neurotrophic factor group showed la rgest effect size(SMD[95%CI]=-6.21[-9.50 to-2.93],P=0.0001,I^(2)=0.0%).The stem cell treatment group had significantly more tyrosine hydroxylase positive dopamine rgic neurons in the striatum([95%CI]=1.04[0.59 to 1.49],P=0.0001,I^(2)=65.1%)and substantia nigra(SMD[95%CI]=1.38[0.89 to 1.87],P=0.0001,I^(2)=75.3%),indicating a

关键词： animal animal experimentation mesenchymal stem cells models Parkinson’s disease stem cell transplantation

Hyperreflective photonic crystals created by shearing colloidal dispersions at ultrahigh volume fraction

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Microsystems & Nanoengineering 2024年第1期10卷 161-173页

作者： Minji kim jong Bin kim Shin-Hyun kim Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology(KAIST)Daejeon 34141Republic of Korea

Colloidal crystallization serves as one of the most economic and scalable production methods for photonic ***,insufficient optical performance,nonuniformity and low reproducibility remain challenges for advanced high-value *** this study,we optimally formulate a photocurable dispersion of silica particles and apply shear flow to unify the orientation of the colloidal crystals,ensuring high optical performance and *** silica particles experience strong repulsion at ultrahigh volume fractions of 50%but demonstrate low mobility,leading to polycrystalline *** shear flow to the dispersions allows the silica particles to rearrange into larger crystalline domains with a unidirectional orientation along the *** shear-induced structural change produces absolute reflectivity at the stopband as high as 90%and a high transparency of 90%at off-resonant wavelengths with minimal diffusive ***,the strong interparticle repulsion ensures a uniform volume fraction of particles throughout the dispersion,reducing deviations in the optical *** intricately micropattern the photocurable dispersions using ***,the photonic films and patterns can be stacked to form multiple layers,displaying mixed structural colors and multiple reflectance peaks without sacrificing *** superior photonic materials hold promise for various optical applications,including optical components and anticounterfeiting patches.

关键词： properties. dispersion reflectivity

Incorporation of Ionic Conductive Polymers into Sulfide Electrolyte-Based Solid-State Batteries to Enhance Electrochemical Stability and Cycle Life

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Energy & Environmental Materials 2024年第6期7卷 4-12页

作者： Juhyoung kim Woonghee Choi Seong-Ju Hwang Dong wook kim Advanced Materials Division Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Korea Department of Material Science and Engineering Yonsei UniversitySeoul 03722Korea Department of Material Science and Engineering Seoul National UniversitySeoul 08826Korea Advanced Materials and Chemical Engineering University of Science and Technology(UST)Daejeon 34113Korea

Sulfide-based inorganic solid electrolytes are promising materials for high-performance safe solid-state *** high ion conductivity,mechanical characteristics,and good processability of sulfide-based inorganic solid electrolytes are desirable properties for realizing high-performance safe solid-state batteries by replacing conventional liquid ***,the low chemical and electrochemical stability of sulfide-based inorganic solid electrolytes hinder the commercialization of sulfide-based safe solid-state ***,the instability of sulfide-based inorganic solid electrolytes is intensified in the cathode,comprising various *** this study,carbonate-based ionic conductive polymers are introduced to the cathode to protect cathode materials and suppress the reactivity of sulfide *** instruments,including electrochemical spectroscopy,X-ray photoelectron spectroscopy,and scanning electron microscopy,confirm the chemical and electrochemical stability of the polymer electrolytes in contact with sulfide-based inorganic solid ***-based solid-state cells show stable electrochemical performance over 100 cycles when the ionic conductive polymers were applied to the cathode.

关键词： composite cathode electrochemical stability ionic conductive polymer solid-state battery sulfide solid electrolyte

A case of Clostridium difficile infection complicated by acute respiratory distress syndrome treated with fecal microbiota transplantation

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World Journal of Gastroenterology 2014年第35期20卷 12687-12690页

作者： Ji Eun kim Tae-Geun Gweon Chang Dong Yeo Young-Seok Cho Gi Jun kim Jae Young kim jong wook kim Hyunho kim Hye Won Lee Taeseok Lim Hyoju Ham Hyun Jin Oh Yeongbok Lee Jaeho Byeon Sung Soo Park Department of Internal Medicine Seoul St Mary’s hospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineSeoul St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Pulmonology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine Division of Gastroenterology Department of Internal MedicineUijeongbu St.Mary’s HospitalThe Catholic University of KoreaCollege of Medicine

Acute respiratory distress syndrome is a life-threatening disorder caused mainly by *** difficile infection(CDI)is a common nosocomial diarrheal *** of normal intestinal flora by antibiotics is the main risk factor for *** use of broadspectrum antibiotics for serious medical conditions can make it difficult to treat CDI complicated by acute respiratory distress *** microbiota transplantation is a highly effective treatment in patients with refractory *** we report on a patient with refractory CDI and acute respiratory distress syndrome caused by pneumonia who was treated with fecal microbiota transplantation.

关键词： Clostridium difficile infection Acute respiratory distress syndrome Fecal microbiota transplantation

Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2)Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun Yoo Hoang Van Quy Inpyo Lee Seung Taek Jo Tae Ei Hong JunHo kim Dae-Hwang Yoo Jinwook Shin Walter Commerell Dae-Hwan kim jong wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

NIR emissive Ru(Ⅱ)metallacycle as a sonosensitizer/sonocatalyst assisting in vivo bacterial diagnosis and eradicating multidrug-resistant biofilms

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Science China Chemistry 2024年第9期67卷 2785-2786页

作者： Chonglu Li Qihang Ding jong Seung kim School of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea

Microbial biofilm-related infections present a significant global health challenge,posing a major threat to public health systems[1].Biofilms,complex structures formed by the aggregation of microorganisms,are commonly found on medical devices,human tissue surfaces,and in natural environments[2].These biofilms exhibit high levels of antibiotic resistance and survival stability,rendering traditional antibiotic treatments ineffective in eradicating infections[3].

关键词： diagnosis dic rendering