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A Flexible Smart Healthcare Platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and Pressure Sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing Zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei Song Lin Xu jong seung kim State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTP)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTP)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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A lysosomal-targeted Pt(Ⅱ) metallacycle for NIR-Ⅱ fluorescence imaging guided highly efficient tumor immunogenic cell death

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Science China Chemistry 2024年第11期67卷 3508-3509页

作者： Qihang Ding Shuai Zhang jong seung kim Department of Chemistry Korea UniversitySeoul 02841Republic of Korea Department of Medical Oncology Harbin Medical University Cancer HospitalHarbin 150040China

Cisplatin, carboplatin, and oxaliplatin are well-known firstline antineoplastic drugs that have been approved worldwide. Recently, the successful integration of chemotherapy and immunotherapy in clinical trials has hi... 详细信息

关键词： drugs chemotherapy Cisplatin death

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NIR emissive Ru(Ⅱ)metallacycle as a sonosensitizer/sonocatalyst assisting in vivo bacterial diagnosis and eradicating multidrug-resistant biofilms

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Science China Chemistry 2024年第9期67卷 2785-2786页

作者： Chonglu Li Qihang Ding jong seung kim School of Medicine Wuhan University of Science and TechnologyWuhan 430065China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea

Microbial biofilm-related infections present a significant global health challenge,posing a major threat to public health systems[1].Biofilms,complex structures formed by the aggregation of microorganisms,are commonly found on medical devices,human tissue surfaces,and in natural environments[2].These biofilms exhibit high levels of antibiotic resistance and survival stability,rendering traditional antibiotic treatments ineffective in eradicating infections[3].

关键词： diagnosis dic rendering

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NIR-Ⅱ thiopyrylium dyads guided photodynamic inactivation of coronavirus

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Science China Chemistry 2023年第7期66卷 1877-1878页

作者： Yunjie Xu Changyu Yoon jong seung kim Department of Chemistry Korea UniversitySeoul 02841Korea

COVID-19,a highly contagious respiratory infection caused by the SARS-Co V-2 virus,was first identified in December 2019 and has rapidly expanded to become a global pandemic[1].From then on,millions of people were infected,while the exact number of infections is difficult to determine,as not all people who are infected with the virus get tested,and some may not show any symptoms,and the number is rising as the pandemic *** sickness is characterized by fever,cough.

关键词： respiratory infected infection

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Mitochondrial H_(2)S_(n)-Mediated Anti-Inflammatory Theranostics

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Nano-Micro Letters 2021年第12期13卷 1-13页

作者： Won Young kim Miae Won Seyoung Koo Xingcai Zhang jong seung kim Department of Chemistry Korea UniversitySeoul 02841Korea John A.Paulson School of Engineering and Applied Sciences Harvard UniversityCambridgeMA 02138USA School of Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA

The insistent demand for space-controllable delivery,which reduces the side effects of non-steroidal antiinflammatory drugs(NSAIDs),has led to the development of a new theranostics-based approach for anti-inflammatory *** current anti-inflammatory treatments can be improved by designing a drug delivery system responsive to the inflammatory site biomarker,hydrogen polysulfide(H_(2)S_(n)).Here,we report a noveltheranostic agent 1(TA1),consisting of three parts:H_(2)S_(n)-mediated triggering part,a two-photon fluorophore bearing mitochondria targeting unit(Rhodol-TPP),and anti-inflammatory COX inhibitor(indomethacin).In vitro experiments showed that TA1 selectively reacts with H_(2)S_(n)to concomitantly release both Rhodol-TPP and ***-microscopy imaging of inflammation-inducedlive cells suggested that TA1 is localized in the mitochondria where the H_(2)S_(n)is *** TA1 reacted with H_(2)S_(n)in the endogenous and exogenous H_(2)S_(n)environments and in lipopolysaccharide treated inflammatory ***,TA1 suppressed COX-2 level in the inflammatory-induced cells and prostaglandin E 2(PGE2)level in blood serum from inflammation-induced mouse *** vivo experiments with inflammation-induced mouse models suggested that TA1 exhibits inflammation-site-elective drug release followed by significant therapeutic e ects,showing its function as a theranostic agent,capable of both anti-inflammatory therapy and precise *** behavior of TA1 is highly applicable in vivo model therapeutics for the inflammatory disease.

关键词： Theranostics Anti-inflammation Mitochondria Hydrogen polysulfides

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Photo-Activated Ferroptosis for Cancer Therapy: Advances, Challenges, and Prospects

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CCS Chemistry 2023年第8期5卷 1718-1736页

作者： Le Yu Yunjie Xu jong seung kim Department of Chemistry Korea UniversitySeoul 02841

Ferroptosis, a recently identified form of non-apoptotic programmed cell death, has attracted significant attention in the field of cancer therapy due to its unique mechanism of cell death. To meet the demands of ferroptosis-mediated cancer treatment, several small molecule-based drugs have been reported for the implementation of ferroptosis. However, some cancer cells are inherently resistant to these drugs, and the lack of selectivity of these drugs against cancer cells can limit their clinical application. Recent advancements in light-mediated biomedical techniques offer a promising alternative for the development of ferroptotic therapy, that is photo-controlled activation of ferroptosis. In this review, we systematically summarize the current strategies for photo-controlled ferroptosis activation and detail analysis of the underlying mechanisms of those photo-controlled ferroptotic therapies. Finally, we discuss the challenges associated with photo-activated ferroptosis and provide an outlook on the future developments in ferroptotic cancer therapy.

关键词： photo-activated ferroptosis ferroptoticcancer therapy photosensitizer photothermal agent photocatalyst

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Electric-field-controlled highly regioselective thiocyanation of N-containing heterocycles

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Science China Chemistry 2024年第4期67卷 1263-1269页

作者： Ming Gong Qian Wu Jung Keun kim Mengmeng Huang Yabo Li Yangjie Wu jong seung kim Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan UniversitiesCollege of ChemistryZhengzhou UniversityZhengzhou 450052China Department of Chemistry Korea UniversitySeoul 02841Korea

Achieving highly regioselective synthesis in organic chemistry is challenging due to the uncontrollable orientation between reacting *** electric fields(EEFs)can influence the reactivity and selectivity of the substrate by causing directional ***,scalable and efficient techniques for using EEFs as“smart catalysts”have been lacking,hindering their *** this study,we present a novel method for modifying the regioselectivity of quinoxaline-2(1H)-ones by functionalizing their C7-position using the electric double layer(EDL)*** approach led to moderate to good yields of the corresponding C7-thiocyanation *** calculations and control experiments demonstrated that EEFs could reverse the regioselectivity of quinoxaline-2(1H)-ones,allowing the C7-thiocyanation to proceed via a radical reaction ***,the resulting 7-thiocyano-1-methylquinoxaline-2(1H)-ones exhibited promising AIE *** work showcases a promising strategy for achieving highly regioselective functionalization by aligning the electric field with the desired reaction/bond axis.

关键词： electric fields reaction-axis rule electric double layer C7-thiocyanation C-S bond formation

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Lighting up plants with near-infrared fluorescence probes

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Science China Chemistry 2024年第3期67卷 774-787页

作者： Yida Pang Mengjiao Lu Hyeonji Rha Wenchao Yang Amit Sharma Yao Sun jong seung kim National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationCenter for R&D of Fine Chemicals of Guizhou UniversityGuiyang 550025China National Key Laboratory of Green Pesticide College of ChemistryCentral China Normal UniversityWuhan 430079China Department of Chemistry Korea UniversitySeoul 02841Korea CSIR-Central Scientific Instruments Organisation Sector-30CChandigarh160030India TheranoChem Incorporation Seongbuk-guSeoul02856Korea

Fluorescence imaging is a non-invasive and highly sensitive bioimaging technique that has shown remarkable strides in plant science. It enables real-time monitoring and analysis of biological and pathological processes in plants by labeling specific molecular or cellular structures with fluorescent probes. However, tissue scattering and phytochrome interference have been obstacles for conventional fluorescence imaging of plants in the ultraviolet and visible spectrum, resulting in unsatisfactory imaging quality. Fortunately, advances in near-infrared(NIR) fluorescence imaging technology(650-900 nm) offer superior spatial-temporal resolution and reduced tissue scattering, which is sure to improve plant imaging quality. In this review, we summarize recent progress in the development of NIR fluorescence imaging probes and their applications for in vivo plant imaging and the identification of plant-related biomolecules. We hope this review provides a new perspective for plant science research and highlights NIR fluorescence imaging as a powerful tool for analyzing plant physiology, adaptive mechanisms, and coping with environmental stress in the near future.

关键词： NIR fluorescent probe plant imaging biologic application

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Organic functional dyes

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Green Chemical Engineering 2023年第4期4卷 377-378页

作者： Zhi-Qian Guo Wei-Hong Zhu Jiangli Fan jong seung kim Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Fine Chemicals Frontiers Science Center for Smart Materials Oriented Chemical EngineeringDalian University of TechnologyDalian116024China Research Institute of Dalian University of Technology in Shenzhen Shenzhen518057China Department of Chemistry Korea UniversitySeoul02841South Korea

Functional dyes go beyond traditional color applications and offer distinctive properties and functionalities,making them suitable for a wide range of industrial applications such as healthcare,agriculture,textiles,and *** dyes can serve as fluorescent probes in medical research,photosensitizers in cancer therapy,pesticide markers in agriculture,antimicrobial agents on textiles,and charge transport materials in *** ongoing research into new functional dyes reflects the interest of industries in identifying novel applications for these materials.

关键词： materials. functional dyes

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Covalent organic framework nanomedicines:Biocompatibility for advanced nanocarriers and cancer theranostics applications

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Bioactive Materials 2023年第3期21卷 358-380页

作者： Nem Singh Jungryun kim Jaewon kim Kyungwoo Lee Zehra Zunbul Injun Lee Eunji kim Sung-Gil Chi jong seung kim Department of Chemistry Korea UniversitySeoul02841South Korea Department of Life Science Korea UniversitySeoul02841South Korea

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research *** unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs,such as poor localization at the tumor site,high drug doses and toxicity,recurrence,and poor immune ***,inadequate biocompatibility restricts their potential in clinical ***,advanced nanomaterials with high biocompat-ibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of *** properties of nanoscale covalent organic frameworks(nCOFs),such as suitable size,modular pore geometry and porosity,and straightforward post-synthetic modification via simple organic transformations,make them incredibly attractive for future *** ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted *** review summarizes recently published applications of COFs in drug delivery,photo-immuno therapy,sonodynamic therapy,photothermal therapy,chemotherapy,pyroptosis,and combination *** we mainly focused on modifications of COFs to enhance their biocompatibility,efficacy and potential clinical *** review will provide the fundamental knowledge in designing biocompatible nCOFs-based nano-medicines and will help in the rapid development of cancer drug carriers and theranostics.

关键词： doses medicines compatibility

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