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Prominent cycling reversibility and kinetics enabled by CaTiO3 protective layer on Zn metal for aqueous Zn-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 245-258页

作者： Gaeun Lee Yong Nam Ahn Seongjoon So Chanwoo park jong-Seong Bae Taehyun park Il Tae Kim Jaehyun Hur School of Chemical Biological and Battery Engineering Gachon University Seongnam Busan Center Korea Basic Science Institute

Aqueous Zn-ion batteries （AZIBs） have received considerable attention owing to their various advantages such as safety,low cost,simple battery assembly conditions,and high ionic ***,they still suffer from serious problems,including uncontrollable dendrite growth,corrosion,hydrogen evolution reaction （HER） from water decomposition,electrode passivation,and unexpected *** creation of a uniform artificial nanocrystal layer on the Zn anode surface is a promising strategy for resolving these ***,we propose the use of a perovskite CaTiO3（CTO） protective layer on Zn（CTO@Zn） as a promising approach for improving the performance of *** CTO artificial layer provides an efficient pathway for Zn ion diffusion towards the Zn metal because of the high dielectric constant （εr=180） and ferroelectric characteristics that enable the alignment of dipole moments and redistribute the Zn2+ions in the CTO *** avoiding the direct contact of the Zn anode with the electrolyte solution,the uneven dendrite growth,corrosion,parasitic side reactions,and HER are mitigated,while CTO retains its mechanical and chemical robustness during ***,CTO@Zn demonstrates an improved lifespan in a symmetric cell configuration compared with bare ***@Zn shows steady overpotential （～68 m V） for 1500 h at 1 mA cm-2/0.5 mA h cm-2,excelling bare ***,when paired with the V2O5-C cathode,the CTO@Zn//V2O5-C full battery delivers 148.4 mA h g-1（based on the mass of the cathode） after 300 *** study provides new insights into Zn metal anodes and the development of high-performance AZIBs.

关键词： Perovskite

Comprehensive molecular characterization to predict immunotherapy response in advanced biliary tract cancer:a phase II trial of pembrolizumab

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Oncology Research 2025年第1期33卷 57-65页

作者： RYUL KIM JOO kyung park MINSUK KWON MINAE AN JUNG YONG HONG JOON OH park SUNG HEE LIM SEUNG TAE KIM Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Division of Gastroenterology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulKorea Department of Hematology-Oncology Ajou University School of MedicineSuwon-siGyeonggi-doKorea Samsung Advanced Institute of Health Science and Technology Sungkyunkwan University School of MedicineSeoulKorea

Background:Immune checkpoint inhibitors(ICIs)are effective in a subset of patients with metastatic solid ***,the patients who would benefit most from ICIs in biliary tract cancer(BTC)are still *** and methods:We molecularly characterized tissues and blood from 32 patients with metastatic BTC treated with the ICI pembrolizumab as second-line ***:All patients had microsatellite stable(MSS)type *** of the 32 patients achieved partial response(PR),with an objective response rate(ORR)of 9.4%(95%confidence interval[CI],2.0–25.2)and nine showed stable disease(SD),exhibiting a disease control rate(DCR)of 37.5%(95%CI,21.1–56.3).For the 31 patients who had access to PD-1 ligand 1(PD-L1)combined positive score(CPS)testing(cut-off value≥1%),the ORR was not different between those who had PD-L1-positive(PD-L1+;1/11,9.1%)and PDL1-(2/20,10.0%)tumors(p=1.000).The tumor mutational burden(TMB)of PD-L1+BTC was comparable to that of PD-L1-BTC(p=0.630).TMB and any exonic somatic mutations were also not predictive of pembrolizumab *** analysis of blood and tumor samples demonstrated a relatively high natural killer(NK)cell proportion in the peripheral blood before pembrolizumab treatment in patients who achieved tumor ***,the tumors of these patients presented high enrichment scores for NK cells,antitumor cytokines,and Th1 signatures,and a low enrichment score for cancer-associated ***:This study shows the molecular characteristics associated with the efficacy of pembrolizumab in BTC of the MSS type.

关键词： Pembrolizumab Whole-exome sequencing Whole-transcriptome sequencing Biliary tract cancer

Effect of Fe_2P in LiFePO_4/Fe_2P composite on electrochemical properties synthesized by MA and control of heat condition

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Rare Metals 2006年第Z2期25卷 179-183页

作者： park jong Suk LEE kyung Tae LEE kyung Sub Department of Material Science and Engineering Hanyang University Seoul 133-731 Korea

In order to control the size and distribution of the high conductive Fe2P in LiFePO4/Fe2P composite, two different cooling rates (Fast: 15 ℃·min-1, Slow: 2 ℃·min-1) were employed after mechanical alloying. The discharge capacity of the fast cooled was 83 mAh·g-1 and the slow cooled 121 mAh·g-1. The particle size of the synthesized powder was examined by transmission electron microscopy and distribution of Fe2P was characterized using scanning electron microscopy (SEM). In addition, two-step heat treatment was carried out for better distribution of Fe2P. X-ray diffraction (XRD) and Rietveld refinement reveal that LiFePO4/Fe2P composite consists of 95.77% LiFePO4 and 4.33% of Fe2P.

关键词： LiFePO4/Fe2P composite mechanical alloying heat treatment discharge capacity

Arterial stiffness expressed as brachial–ankle pulse wave velocity and gait assessment independent of lower extremity strength:a cross-sectional study in the older men population

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Journal of Geriatric Cardiology 2023年第2期20卷 91-99页

作者： Tae kyung Yoo Seunghee Lee Sae-jong park jong-Young Lee Department of Medicine MetroWest Medical CenterFraminghamUSA Department of Physical Education Korea UniversitySeoulSouth Korea Division of Sports Science Korea Institute of Sport ScienceSeoulSouth Korea Division of Cardiology Department of Internal MedicineKangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulSouth Korea

BACKGROUND Older men are more vulnerable to fatal falls than women,and gait disturbances contribute to the risk of *** have assessed the association between arterial stiffness and gait dysfunction,but the results have been *** study aimed to conduct a cross-sectional analysis to evaluate the association between brachial–ankle pulse wave velocity(baPWV)and gait assessment in older *** Data from the 2014–2015 Korea Institute of Sport Science Fitness Standards project were used for the *** inclusion criteria were men aged>65 years with gait assessment[the 30-s chair stand test(30s-CST),the timed up and go(TUG)test,the figure-of-8 walk(F8W)test,the 2-min step test(2MST),and the 6-min walk test(6MWT)]and baPWV measurement *** linear regression analysis was conducted with multiple confounding factor adjustments,including lower extremity isometric *** A total of 291 participants were included in the *** mean age was 71.38±4.40 *** mean values were as follows:(1)30s-CST,17.48±5.00;(2)TUG test,6.01±1.10 s;(3)F8W test,25.65±4.71 s;(4)2MST,102.40±18.83 per 2 min;and(5)6MWT,500.02±85.65 *** multivariable adjustment,baPWV was associated with the 6MWT(β=−0.037,95%CI:−0.072–−0.002),TUG test(β=0,95%CI:0.000–0.001),and F8W test(β=0.002,95%CI:0.000–0.004).baPWV was not associated with the 30s-CST and *** The current study showed a statistically significant association between gait assessments and arterial stiffness,independent of lower extremity ***,this association was *** prospective studies are needed to elucidate the complex relationship between arterial stiffness and gait dysfunction.

关键词： stiffness sectional pulse

Variability of the Dokdo Abyssal Current observed in the Ulleung Interplain Gap of the East/Japan Sea

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Acta Oceanologica Sinica 2013年第1期32卷 12-23页

作者： KIM Yun-Bae CHANG kyung-Il park Jae-Hun park jong Jin East Sea Research Institute Korea Institute of Ocean Science and Technology Research Institute of Oceanography School of Earth and Environmental Sciences Seoul National University Ocean Science Research Department Korea Institute of Ocean Science and Technology Department of Oceanography Kyungpook National University

Subinertial fluctuation of a strong northward deep current, which is referred to the Dokdo Abyssal Current （DAC） by Chang et al. （2009）, is investigated from current records for about 16.5 and 8.0 months in the Ulle- ung Interplain Gap of the East/lapan Sea. The current below 300 m is bottom-intensified and has nearly depth-independent flow. Near bottom, the spectral peaks of the current were found near 10, 20, and 60 d. The DAC variability near 10 d and 20 d is reasonably consistent with the linear theory of topographic Rossby waves （TRWs） in the following aspects：（1） The motion is columnar and bottom-intensified; （2） the theo- retical cutoff frequency is similar to the observation; （3） The observation-based angles of the wavenumber vector are in good agreement with the theoretical ones. The wavelengths of the TRWs with periods of near 10 d and 20 d near Dokdo are significantly shorter than those with similar timescales in the open oceans （100-250 km）. It is primarily due to the weak stratification below 300 m in the East Sea. The deep cur- rent fluctuations with periods of near 10 d and 20 d were accompanied by warm events in the upper layer resulting from eddying processes and/or meandering of the Tsushima Warm Current.

关键词： East/Iapan Sea Ulleung Interplain Gap Deep currents Topographic Ressby waves

Impact of homeobox genes in gastrointestinal cancer

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World Journal of Gastroenterology 2016年第37期22卷 8247-8256页

作者： Moon kyung Joo jong-Jae park Hoon Jai Chun Division of Gastroenterology Department of Internal Medicine Korea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal Medicine Institute of Digestive Disease and Nutrition Korea University College of Medicine

Homeobox genes, including HOX and non-HOX genes, have been identified to be expressed aberrantly in solid tumors. In gastrointestinal(GI) cancers, most studies have focused on the function of non-HOX genes including caudal-related homeobox transcription factor 1(CDX1) and CDX2. CDX2 is a crucial factor in the development of pre-cancerous lesions such as Barrett's esophagus or intestinal metaplasia in the stomach, and its tumor suppressive role has been investigated in colorectal cancers. Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers. HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer. Thus, it is essential to examine the differential expression pattern of various homeobox genes in specific tumor types or cell lineages, and understand their underlying mechanisms. In this review, we summarize the available research on homeobox genes and present their potential value for the prediction of prognosis in GI cancers.

关键词： Homeobox genes HOX genes Caudalrelated homeobox transcription factor 2 Gastrointestinal cancers HOXB7

Recent updates of precision therapy for gastric cancer: Towards optimal tailored management

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World Journal of Gastroenterology 2016年第19期22卷 4638-4650页

Signaling pathways of gastric carcinogenesis and gastric cancer progression are being avidly studied to seek optimal treatment of gastric cancer. Among them, hepatocyte growth factor (HGF)/c-MET, phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) and janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathways have been widely investigated. Their aberrant expression or mutation has been significantly associated with advanced stage or poor prognosis of gastric cancer. Recently, aberrations of immune checkpoints including programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) have been suggested as an important step in the formation of a microenvironment favorable for gastric cancer. Accomplishments in basic research have led to the development of novel agents targeting these signaling pathways. However, phase III studies of selective anti-HGF/c-MET antibodies and mTOR inhibitor failed to show significant benefits in terms of overall survival and progression-free survival. Few agents directly targeting STAT3 have been developed. However, this target is still critical issue in terms of chemoresistance, and SH2-containing protein tyrosine phosphatase 1 might be a significant link to effectively inhibit STAT3 activity. Inhibition of PD-1/PD-L1 showed durable efficacy in phase I studies, and phase III evaluation is warranted. Therapeutic strategy to concurrently inhibit multiple tyrosine kinases is a reasonable option, however, lapatinib needs to be further evaluated to identify good responders. Regorafenib has shown promising effectiveness in prolonging progression-free survival in a phase II study. In this topic highlight, we review the biologic roles and outcomes of clinical studies targeting these signaling pathways.

关键词： Gastric cancer Hepatocyte growth factor Mammalian target of rapamycin Signal transducer and activator of transcription 3 Programmed cell death ligand-1

Proton pump inhibitor: The dual role in gastric cancer

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World Journal of Gastroenterology 2019年第17期25卷 2058-2070页

作者： Moon kyung Joo jong-Jae park Hoon Jai Chun Division of Gastroenterology Department of Internal MedicineKorea University College of Medicine Guro Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of Medicine

Proton pump inhibitors(PPIs) are one of the most frequently used medications for upper gastrointestinal diseases. However, a number of physicians have raised concern about the serious side effects of long-term use of PPIs, including the development of gastric cancer. Recent epidemiological studies have reported a significant association between long-term PPI intake and the risk of gastric cancer, even after successful Helicobacter pylori eradication. However, the effects of PPIs on the development of pre-malignant conditions such as atrophic gastritis or intestinal metaplasia are not fully known, suggesting the need for comprehensive and confirmative studies are needed in the future. Meanwhile,several experimental studies have demonstrated the effects of PPIs in reducing chemoresistance in gastric cancer cells by modulating the acidic microenvironment, cancer stemness and signal transducer and activator of transcription 3(STAT3) signaling pathway. The inhibitory effects of PPIs on STAT3 activity may overcome drug resistance and enhance the efficacy of conventional or targeted chemotherapeutic agents. Taken together, PPIs may"play dual role" in gastric carcinogenesis and treatment of gastric cancer.

关键词： Proton pump inhibitor Gastric cancer Drug resistance Signal transducer and activator of transcription 3

Agmatine reduces nitric oxide synthase expression and peroxynitrite formation in the cerebral cortex in a rat model of transient global cerebral ischemia

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Neural Regeneration Research 2010年第23期5卷 1773-1781页

作者： Chin Hee Mun Won Taek Lee kyung Ah park jong Eun Lee Department of Anatomy Yonsei University College of Medicine Brain Korea 21 Project for Medical Science Yonsei University College of Medicine

Agmatine, an analog of L-arginine, is an endogenous substance synthesized by arginine decarboxylase, which has been shown to possess neuroprotective effects following brain ischemia. Nitric oxide is generated by sequential oxidation of the guanidinium group in L-arginine, and agmatine might protect the brain from ischemic injury by interfering with nitric oxide signaling. This study investigated the effects of agmatine on cerebral cortex neuronal injury following transient global cerebral ischemia and also detected nitric oxide synthase expression and peroxynitrite formation. Results demonstrated that intraperitoneal injection of agmatine in global cerebral ischemia/reperfusion alleviated ischemia/reperfusion-induced cerebral cortical cortex neuronal injury and cellular apoptosis, decreased neuronal and inducible nitric oxide synthase expression at 24, 48, and 72 hours following global cerebral ischemia and reperfusion, and greatly inhibited nitrotyrosine levels, which reflect the amount of peroxynitrite formed. These findings indicated that agmatine alleviates cerebral cortex neuronal injury following global cerebral ischemia and decreases nitric oxide synthase expression and peroxynitrite formation following ischemia/repeffusion.

关键词： agmatine global cerebral ischemia cerebral cortex nitric oxide nitric oxide synthase neuroprotection